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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZFHX3

Z-value: 0.42

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Transcription factors associated with ZFHX3

Gene Symbol Gene ID Gene Info
ENSG00000140836.10 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZFHX3hg19_v2_chr16_-_73082274_73082274,
hg19_v2_chr16_-_73093597_73093597
0.045.9e-01Click!

Activity profile of ZFHX3 motif

Sorted Z-values of ZFHX3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_95027772 5.41 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr17_-_64225508 5.40 ENST00000205948.6
apolipoprotein H (beta-2-glycoprotein I)
chr4_-_155511887 5.02 ENST00000302053.3
ENST00000403106.3
fibrinogen alpha chain
chr7_+_130126012 4.55 ENST00000341441.5
mesoderm specific transcript
chr17_-_26697304 4.44 ENST00000536498.1
vitronectin
chr7_+_130126165 4.30 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
mesoderm specific transcript
chr6_+_161123270 4.06 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
plasminogen
chr15_+_58724184 3.92 ENST00000433326.2
lipase, hepatic
chr17_+_41052808 3.19 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
glucose-6-phosphatase, catalytic subunit
chr9_-_123812542 2.88 ENST00000223642.1
complement component 5
chr1_+_63063152 2.87 ENST00000371129.3
angiopoietin-like 3
chr19_-_36304201 2.86 ENST00000301175.3
proline dehydrogenase (oxidase) 2
chr1_+_159557607 2.45 ENST00000255040.2
amyloid P component, serum
chr2_+_234621551 2.40 ENST00000608381.1
ENST00000373414.3
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr11_+_22696314 2.37 ENST00000532398.1
ENST00000433790.1
growth arrest-specific 2
chr2_+_234637754 2.28 ENST00000482026.1
ENST00000609767.1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr2_+_234627424 2.20 ENST00000373409.3
UDP glucuronosyltransferase 1 family, polypeptide A4
chr22_-_30970560 2.03 ENST00000402369.1
ENST00000406361.1
galactose-3-O-sulfotransferase 1
chr2_+_88047606 1.96 ENST00000359481.4
plasminogen-like B2
chr7_-_100026280 1.94 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
zinc finger, CW type with PWWP domain 1
chr2_-_87248975 1.86 ENST00000409310.2
ENST00000355705.3
plasminogen-like B1
chr6_-_161085291 1.72 ENST00000316300.5
lipoprotein, Lp(a)
chr4_-_149365827 1.61 ENST00000344721.4
nuclear receptor subfamily 3, group C, member 2
chrX_-_18690210 1.58 ENST00000379984.3
retinoschisin 1
chr3_-_114477787 1.53 ENST00000464560.1
zinc finger and BTB domain containing 20
chr3_+_35722487 1.34 ENST00000441454.1
cAMP-regulated phosphoprotein, 21kDa
chrX_-_110655306 1.34 ENST00000371993.2
doublecortin
chr19_+_50016610 1.26 ENST00000596975.1
Fc fragment of IgG, receptor, transporter, alpha
chr4_+_3443614 1.25 ENST00000382774.3
ENST00000511533.1
HGF activator
chr3_+_46919235 1.23 ENST00000449590.1
parathyroid hormone 1 receptor
chr11_+_8040739 1.15 ENST00000534099.1
tubby bipartite transcription factor
chr8_+_104831472 1.05 ENST00000262231.10
ENST00000507740.1
regulating synaptic membrane exocytosis 2
chr4_+_74347400 1.04 ENST00000226355.3
afamin
chr7_-_44580861 1.03 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1-like 1
chrX_-_32173579 0.99 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
dystrophin
chr2_-_60780536 0.98 ENST00000538214.1
B-cell CLL/lymphoma 11A (zinc finger protein)
chr20_+_42187608 0.91 ENST00000373100.1
serum/glucocorticoid regulated kinase 2
chr20_+_42187682 0.88 ENST00000373092.3
ENST00000373077.1
serum/glucocorticoid regulated kinase 2
chr11_-_61687739 0.85 ENST00000531922.1
ENST00000301773.5
RAB3A interacting protein (rabin3)-like 1
chr4_+_100495864 0.82 ENST00000265517.5
ENST00000422897.2
microsomal triglyceride transfer protein
chr6_+_28317685 0.79 ENST00000252211.2
ENST00000341464.5
ENST00000377255.3
zinc finger with KRAB and SCAN domains 3
chr5_+_95066823 0.79 ENST00000506817.1
ENST00000379982.3
Rho-related BTB domain containing 3
chr2_-_60780702 0.77 ENST00000359629.5
B-cell CLL/lymphoma 11A (zinc finger protein)
chrX_+_84258832 0.75 ENST00000373173.2
apolipoprotein O-like
chr12_+_59989791 0.72 ENST00000552432.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr7_+_150725510 0.70 ENST00000461373.1
ENST00000358849.4
ENST00000297504.6
ENST00000542328.1
ENST00000498578.1
ENST00000356058.4
ENST00000477719.1
ENST00000477092.1
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr6_-_32374900 0.69 ENST00000374995.3
ENST00000374993.1
ENST00000414363.1
ENST00000540315.1
ENST00000544175.1
ENST00000429232.2
ENST00000454136.3
ENST00000446536.2
butyrophilin-like 2 (MHC class II associated)
chr9_-_95298314 0.68 ENST00000344604.5
ENST00000375540.1
extracellular matrix protein 2, female organ and adipocyte specific
chr2_-_60780607 0.67 ENST00000537768.1
ENST00000335712.6
ENST00000356842.4
B-cell CLL/lymphoma 11A (zinc finger protein)
chr4_-_100356291 0.66 ENST00000476959.1
ENST00000482593.1
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr12_-_7818474 0.66 ENST00000229304.4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr5_-_125930929 0.63 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
aldehyde dehydrogenase 7 family, member A1
chr5_+_140625147 0.60 ENST00000231173.3
protocadherin beta 15
chr6_+_126070726 0.58 ENST00000368364.3
hes-related family bHLH transcription factor with YRPW motif 2
chr16_+_87636474 0.57 ENST00000284262.2
junctophilin 3
chr22_-_22337204 0.56 ENST00000430142.1
ENST00000357179.5
topoisomerase (DNA) III beta
chr8_-_70745575 0.54 ENST00000524945.1
solute carrier organic anion transporter family, member 5A1
chr21_+_40824003 0.53 ENST00000452550.1
SH3 domain binding glutamic acid-rich protein
chr20_-_7921090 0.44 ENST00000378789.3
hydroxyacid oxidase (glycolate oxidase) 1
chrX_+_16668278 0.42 ENST00000380200.3
S100 calcium binding protein G
chr6_+_25754927 0.38 ENST00000377905.4
ENST00000439485.2
solute carrier family 17, member 4
chr11_-_125366089 0.32 ENST00000366139.3
ENST00000278919.3
fasciculation and elongation protein zeta 1 (zygin I)
chr3_-_108248169 0.30 ENST00000273353.3
myosin, heavy chain 15
chr7_+_100026406 0.28 ENST00000414441.1
methylphosphate capping enzyme
chr1_-_160549235 0.27 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84 molecule
chr1_-_227505289 0.19 ENST00000366765.3
CDC42 binding protein kinase alpha (DMPK-like)
chrX_+_1710484 0.16 ENST00000313871.3
ENST00000381261.3
A kinase (PRKA) anchor protein 17A
chr8_+_98900132 0.15 ENST00000520016.1
matrilin 2
chr2_+_185463093 0.15 ENST00000302277.6
zinc finger protein 804A
chr19_-_46234119 0.14 ENST00000317683.3
F-box protein 46
chr6_-_116447283 0.13 ENST00000452729.1
ENST00000243222.4
collagen, type X, alpha 1
chr12_-_2944184 0.05 ENST00000337508.4
nuclear receptor interacting protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:2000048 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
1.1 6.9 GO:0006789 bilirubin conjugation(GO:0006789)
1.1 5.4 GO:0061107 seminal vesicle development(GO:0061107)
1.0 2.9 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.8 2.4 GO:1903860 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.6 4.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.5 5.4 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.5 5.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.5 2.4 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.5 2.9 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.5 3.2 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.4 2.9 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.3 5.6 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.2 2.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 0.6 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.2 1.3 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.2 0.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 1.6 GO:0009642 response to light intensity(GO:0009642)
0.1 1.0 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 1.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to photoreceptor outer segment(GO:1903546)
0.1 0.7 GO:0016554 cytidine to uridine editing(GO:0016554) DNA cytosine deamination(GO:0070383)
0.1 0.8 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.6 GO:0042426 choline catabolic process(GO:0042426)
0.1 1.0 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.8 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.1 1.0 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.1 0.5 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 0.4 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.3 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.1 0.3 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 8.9 GO:0007498 mesoderm development(GO:0007498)
0.0 0.3 GO:0040031 snRNA modification(GO:0040031)
0.0 1.2 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 1.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.6 GO:0006265 DNA topological change(GO:0006265)
0.0 1.0 GO:0051180 vitamin transport(GO:0051180)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.6 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0 1.8 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 0.8 GO:0042407 cristae formation(GO:0042407)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0097182 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
1.1 4.4 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.7 4.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.4 5.0 GO:0005577 fibrinogen complex(GO:0005577)
0.3 2.9 GO:0005579 membrane attack complex(GO:0005579)
0.3 5.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.2 4.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.6 GO:0030314 junctional membrane complex(GO:0030314)
0.1 1.0 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.8 GO:0061617 MICOS complex(GO:0061617)
0.1 3.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 1.7 GO:0034358 plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.1 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.7 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 2.3 GO:0031526 brush border membrane(GO:0031526)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 3.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 3.5 GO:0072562 blood microparticle(GO:0072562)
0.0 2.4 GO:0005884 actin filament(GO:0005884)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 12.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.3 GO:0032982 myosin filament(GO:0032982)
0.0 0.7 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.8 3.2 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.7 2.9 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.6 5.4 GO:0032190 acrosin binding(GO:0032190)
0.5 4.1 GO:1990405 protein antigen binding(GO:1990405)
0.3 1.3 GO:0019770 IgG receptor activity(GO:0019770)
0.3 2.2 GO:0001849 complement component C1q binding(GO:0001849)
0.3 2.0 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.3 5.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.3 4.4 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3 1.0 GO:0008431 vitamin E binding(GO:0008431)
0.2 1.2 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.2 0.7 GO:0070052 collagen V binding(GO:0070052)
0.2 6.9 GO:0001972 retinoic acid binding(GO:0001972) glucuronosyltransferase activity(GO:0015020)
0.2 0.9 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.2 1.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.6 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.5 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 2.9 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 0.7 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.6 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 1.8 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 0.4 GO:0005499 vitamin D binding(GO:0005499)
0.1 2.9 GO:0008009 chemokine activity(GO:0008009)
0.0 1.0 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 1.0 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.6 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 4.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.6 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 5.6 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.8 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 0.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 3.7 GO:0008017 microtubule binding(GO:0008017)
0.0 1.8 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 13.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 5.4 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 3.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.7 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 2.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.5 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.3 4.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 4.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 4.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.7 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.1 2.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 3.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 2.6 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 2.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 4.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.3 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions