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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZIC2_GLI1

Z-value: 1.42

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Transcription factors associated with ZIC2_GLI1

Gene Symbol Gene ID Gene Info
ZIC2
ENSG00000043355.6 Zic family member 2
GLI1
ENSG00000111087.5 GLI family zinc finger 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GLI1hg19_v2_chr12_+_57857475_578574750.781.6e-46Click!

Activity profile of ZIC2_GLI1 motif

Sorted Z-values of ZIC2_GLI1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_111783919 88.55 ENST00000531198.1
ENST00000533879.1
CRYAB
crystallin, alpha B
chr11_-_111783595 76.97 ENST00000528628.1
CRYAB
crystallin, alpha B
chr3_+_153839149 44.41 ENST00000465093.1
ENST00000465817.1
ARHGEF26
Rho guanine nucleotide exchange factor (GEF) 26
chr12_-_6798616 40.01 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr20_+_36149602 37.54 ENST00000062104.2
ENST00000346199.2
NNAT
neuronatin
chr3_+_10068095 36.08 ENST00000287647.3
ENST00000383807.1
ENST00000383806.1
ENST00000419585.1
FANCD2
Fanconi anemia, complementation group D2
chr17_+_40834580 32.81 ENST00000264638.4
CNTNAP1
contactin associated protein 1
chr12_-_6798523 31.88 ENST00000319770.3
ZNF384
zinc finger protein 384
chr12_-_6798410 31.62 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
ZNF384
zinc finger protein 384
chr3_+_187871060 31.35 ENST00000448637.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr12_-_45270151 30.82 ENST00000429094.2
NELL2
NEL-like 2 (chicken)
chr12_-_45270077 29.99 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NELL2
NEL-like 2 (chicken)
chr4_-_134070250 26.28 ENST00000505289.1
ENST00000509715.1
RP11-9G1.3
RP11-9G1.3
chr14_+_24583836 25.90 ENST00000559115.1
ENST00000558215.1
ENST00000557810.1
ENST00000561375.1
ENST00000446197.3
ENST00000559796.1
ENST00000560713.1
ENST00000560901.1
ENST00000559382.1
DCAF11
DDB1 and CUL4 associated factor 11
chr11_-_111784005 24.43 ENST00000527899.1
CRYAB
crystallin, alpha B
chr14_-_24584138 24.15 ENST00000558280.1
ENST00000561028.1
NRL
neural retina leucine zipper
chr11_-_111782696 23.38 ENST00000227251.3
ENST00000526180.1
CRYAB
crystallin, alpha B
chr4_-_176733897 22.15 ENST00000393658.2
GPM6A
glycoprotein M6A
chr9_-_98079965 21.76 ENST00000289081.3
FANCC
Fanconi anemia, complementation group C
chr6_-_29600832 21.15 ENST00000377016.4
ENST00000376977.3
ENST00000377034.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr11_+_111783450 21.14 ENST00000537382.1
HSPB2
Homo sapiens heat shock 27kDa protein 2 (HSPB2), mRNA.
chr11_+_111782934 20.89 ENST00000304298.3
HSPB2
Homo sapiens heat shock 27kDa protein 2 (HSPB2), mRNA.
chr20_+_57430162 20.89 ENST00000450130.1
ENST00000349036.3
ENST00000423897.1
GNAS
GNAS complex locus
chr2_+_25016282 19.84 ENST00000260662.1
CENPO
centromere protein O
chr5_+_175792459 19.21 ENST00000310389.5
ARL10
ADP-ribosylation factor-like 10
chr17_-_27278304 18.70 ENST00000577226.1
PHF12
PHD finger protein 12
chr2_+_25015968 18.68 ENST00000380834.2
ENST00000473706.1
CENPO
centromere protein O
chr11_-_111782484 18.48 ENST00000533971.1
CRYAB
crystallin, alpha B
chr6_+_163148973 18.17 ENST00000366888.2
PACRG
PARK2 co-regulated
chrX_+_51928002 17.40 ENST00000375626.3
MAGED4
melanoma antigen family D, 4
chr10_-_95360983 16.97 ENST00000371464.3
RBP4
retinol binding protein 4, plasma
chr5_+_71403061 16.45 ENST00000512974.1
ENST00000296755.7
MAP1B
microtubule-associated protein 1B
chr11_-_12030629 16.31 ENST00000396505.2
DKK3
dickkopf WNT signaling pathway inhibitor 3
chr14_+_101292445 16.23 ENST00000429159.2
ENST00000520714.1
ENST00000522771.2
ENST00000424076.3
ENST00000423456.1
ENST00000521404.1
ENST00000556736.1
ENST00000451743.2
ENST00000398518.2
ENST00000554639.1
ENST00000452120.2
ENST00000519709.1
ENST00000412736.2
MEG3
maternally expressed 3 (non-protein coding)
chr9_-_123476612 16.17 ENST00000426959.1
MEGF9
multiple EGF-like-domains 9
chr19_-_40919271 14.91 ENST00000291825.7
ENST00000324001.7
PRX
periaxin
chr8_-_17555164 14.66 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr17_-_7137582 14.07 ENST00000575756.1
ENST00000575458.1
DVL2
dishevelled segment polarity protein 2
chr1_+_36690011 14.02 ENST00000354618.5
ENST00000469141.2
ENST00000478853.1
THRAP3
thyroid hormone receptor associated protein 3
chr1_-_38512450 13.36 ENST00000373012.2
POU3F1
POU class 3 homeobox 1
chr5_+_161495038 13.29 ENST00000393933.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr12_+_57522258 13.05 ENST00000553277.1
ENST00000243077.3
LRP1
low density lipoprotein receptor-related protein 1
chr5_+_161275320 12.02 ENST00000437025.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_-_183387723 11.95 ENST00000287713.6
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chrX_-_107979616 11.67 ENST00000372129.2
IRS4
insulin receptor substrate 4
chr10_-_90712520 11.63 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr7_+_119913688 11.27 ENST00000331113.4
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr9_-_86571628 11.11 ENST00000376344.3
C9orf64
chromosome 9 open reading frame 64
chr2_-_51259292 10.70 ENST00000401669.2
NRXN1
neurexin 1
chr6_+_31620191 10.68 ENST00000375918.2
ENST00000375920.4
APOM
apolipoprotein M
chr1_+_226736446 10.50 ENST00000366788.3
ENST00000366789.4
C1orf95
chromosome 1 open reading frame 95
chr11_+_45868957 9.98 ENST00000443527.2
CRY2
cryptochrome 2 (photolyase-like)
chr14_+_29236269 9.91 ENST00000313071.4
FOXG1
forkhead box G1
chr2_-_51259229 9.79 ENST00000405472.3
NRXN1
neurexin 1
chr15_-_81282133 9.74 ENST00000261758.4
MESDC2
mesoderm development candidate 2
chr19_+_58790314 9.54 ENST00000196548.5
ENST00000608843.1
ZNF8
ZNF8
Zinc finger protein 8
zinc finger protein 8
chr19_-_13617037 9.41 ENST00000360228.5
CACNA1A
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr7_-_108096822 9.34 ENST00000379028.3
ENST00000413765.2
ENST00000379022.4
NRCAM
neuronal cell adhesion molecule
chr5_-_168727786 9.33 ENST00000332966.8
SLIT3
slit homolog 3 (Drosophila)
chrX_-_37706661 9.30 ENST00000432389.2
ENST00000378581.3
DYNLT3
dynein, light chain, Tctex-type 3
chr7_-_108096765 9.11 ENST00000379024.4
ENST00000351718.4
NRCAM
neuronal cell adhesion molecule
chr17_-_17875688 9.02 ENST00000379504.3
ENST00000318094.10
ENST00000540946.1
ENST00000542206.1
ENST00000395739.4
ENST00000581396.1
ENST00000535933.1
ENST00000579586.1
TOM1L2
target of myb1-like 2 (chicken)
chr17_-_15244894 8.97 ENST00000338696.2
ENST00000543896.1
ENST00000539245.1
ENST00000539316.1
ENST00000395930.1
TEKT3
tektin 3
chr1_-_45308616 8.92 ENST00000447098.2
ENST00000372192.3
PTCH2
patched 2
chr10_+_99344104 8.91 ENST00000555577.1
ENST00000370649.3
PI4K2A
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein
chr9_-_124989804 8.87 ENST00000373755.2
ENST00000373754.2
LHX6
LIM homeobox 6
chr3_+_49449636 8.86 ENST00000273590.3
TCTA
T-cell leukemia translocation altered
chr16_+_28834303 8.75 ENST00000340394.8
ENST00000325215.6
ENST00000395547.2
ENST00000336783.4
ENST00000382686.4
ENST00000564304.1
ATXN2L
ataxin 2-like
chrX_-_140271249 8.74 ENST00000370526.2
LDOC1
leucine zipper, down-regulated in cancer 1
chr12_+_117176090 8.45 ENST00000257575.4
ENST00000407967.3
ENST00000392549.2
RNFT2
ring finger protein, transmembrane 2
chr16_+_75256507 8.39 ENST00000495583.1
CTRB1
chymotrypsinogen B1
chr5_+_161494770 8.22 ENST00000414552.2
ENST00000361925.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr9_-_123476719 8.09 ENST00000373930.3
MEGF9
multiple EGF-like-domains 9
chr9_-_122131696 7.98 ENST00000373964.2
ENST00000265922.3
BRINP1
bone morphogenetic protein/retinoic acid inducible neural-specific 1
chr2_-_28113965 7.69 ENST00000302188.3
RBKS
ribokinase
chr9_+_131218336 7.65 ENST00000372814.3
ODF2
outer dense fiber of sperm tails 2
chr2_-_51259641 7.53 ENST00000406316.2
ENST00000405581.1
NRXN1
neurexin 1
chr17_+_17876127 7.47 ENST00000582416.1
ENST00000313838.8
ENST00000411504.2
ENST00000581264.1
ENST00000399187.1
ENST00000479684.2
ENST00000584166.1
ENST00000585108.1
ENST00000399182.1
ENST00000579977.1
LRRC48
leucine rich repeat containing 48
chr21_-_34100244 7.44 ENST00000382491.3
ENST00000357345.3
ENST00000429236.1
SYNJ1
synaptojanin 1
chr9_-_98279241 7.43 ENST00000437951.1
ENST00000375274.2
ENST00000430669.2
ENST00000468211.2
PTCH1
patched 1
chr14_-_23834411 7.25 ENST00000429593.2
EFS
embryonal Fyn-associated substrate
chr4_-_186697044 7.25 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr3_-_73673991 7.16 ENST00000308537.4
ENST00000263666.4
PDZRN3
PDZ domain containing ring finger 3
chr21_-_28217721 7.13 ENST00000284984.3
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr2_-_51259528 7.10 ENST00000404971.1
NRXN1
neurexin 1
chr1_-_111217603 7.05 ENST00000369769.2
KCNA3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr4_+_77870960 6.96 ENST00000505788.1
ENST00000510515.1
ENST00000504637.1
SEPT11
septin 11
chr14_+_22984601 6.88 ENST00000390509.1
TRAJ28
T cell receptor alpha joining 28
chr9_-_115818951 6.85 ENST00000553380.1
ENST00000374227.3
ZFP37
ZFP37 zinc finger protein
chr21_-_34100341 6.85 ENST00000382499.2
ENST00000433931.2
SYNJ1
synaptojanin 1
chr1_-_40105617 6.84 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr15_-_26108355 6.81 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chr19_+_36208877 6.67 ENST00000420124.1
ENST00000222270.7
ENST00000341701.1
KMT2B
Histone-lysine N-methyltransferase 2B
chr2_+_26915584 6.67 ENST00000302909.3
KCNK3
potassium channel, subfamily K, member 3
chr19_+_42772659 6.58 ENST00000572681.2
CIC
capicua transcriptional repressor
chr4_+_72052964 6.58 ENST00000264485.5
ENST00000425175.1
SLC4A4
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr17_+_4843654 6.39 ENST00000575111.1
RNF167
ring finger protein 167
chr2_-_68694390 6.36 ENST00000377957.3
FBXO48
F-box protein 48
chr6_+_43739697 6.25 ENST00000230480.6
VEGFA
vascular endothelial growth factor A
chr3_+_4535155 6.15 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr14_+_24584508 6.11 ENST00000559354.1
ENST00000560459.1
ENST00000559593.1
ENST00000396941.4
ENST00000396936.1
DCAF11
DDB1 and CUL4 associated factor 11
chr6_-_26027480 5.98 ENST00000377364.3
HIST1H4B
histone cluster 1, H4b
chr5_-_137090028 5.96 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr11_-_64527425 5.80 ENST00000377432.3
PYGM
phosphorylase, glycogen, muscle
chr9_+_8858102 5.78 ENST00000447950.1
ENST00000430766.1
RP11-75C9.1
RP11-75C9.1
chr2_-_208989225 5.77 ENST00000264376.4
CRYGD
crystallin, gamma D
chrX_-_51812268 5.76 ENST00000486010.1
ENST00000497164.1
ENST00000360134.6
ENST00000485287.1
ENST00000335504.5
ENST00000431659.1
MAGED4B
melanoma antigen family D, 4B
chrX_-_153236620 5.74 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chr1_-_182573514 5.70 ENST00000367558.5
RGS16
regulator of G-protein signaling 16
chr4_+_62067860 5.47 ENST00000514591.1
LPHN3
latrophilin 3
chrX_+_70364667 5.33 ENST00000536169.1
ENST00000395855.2
ENST00000374051.3
ENST00000358741.3
NLGN3
neuroligin 3
chr9_-_115819039 5.32 ENST00000555206.1
ZFP37
ZFP37 zinc finger protein
chr22_-_28197486 5.23 ENST00000302326.4
MN1
meningioma (disrupted in balanced translocation) 1
chr7_-_4901625 5.14 ENST00000404991.1
PAPOLB
poly(A) polymerase beta (testis specific)
chr7_-_92465868 5.13 ENST00000424848.2
CDK6
cyclin-dependent kinase 6
chr9_+_131219179 5.09 ENST00000372791.3
ODF2
outer dense fiber of sperm tails 2
chr3_-_33759541 5.06 ENST00000468888.2
CLASP2
cytoplasmic linker associated protein 2
chr19_-_13617247 5.03 ENST00000573710.2
CACNA1A
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr2_-_213403565 5.00 ENST00000342788.4
ENST00000436443.1
ERBB4
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
chr16_+_30675654 4.96 ENST00000287468.5
ENST00000395073.2
FBRS
fibrosin
chr16_+_19183671 4.95 ENST00000562711.2
SYT17
synaptotagmin XVII
chr12_-_4554780 4.93 ENST00000228837.2
FGF6
fibroblast growth factor 6
chr15_-_78526855 4.89 ENST00000541759.1
ENST00000558130.1
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr1_+_164528866 4.86 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr17_+_4843679 4.85 ENST00000576229.1
RNF167
ring finger protein 167
chr11_+_33278811 4.85 ENST00000303296.4
ENST00000379016.3
HIPK3
homeodomain interacting protein kinase 3
chr3_+_113616317 4.84 ENST00000440446.2
ENST00000488680.1
GRAMD1C
GRAM domain containing 1C
chr11_+_10477733 4.74 ENST00000528723.1
AMPD3
adenosine monophosphate deaminase 3
chr12_+_117176113 4.68 ENST00000319176.7
RNFT2
ring finger protein, transmembrane 2
chr7_-_99679324 4.67 ENST00000292393.5
ENST00000413658.2
ENST00000412947.1
ENST00000441298.1
ENST00000449785.1
ENST00000299667.4
ENST00000424697.1
ZNF3
zinc finger protein 3
chr4_-_186696425 4.54 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr9_-_33264676 4.51 ENST00000472232.3
ENST00000379704.2
BAG1
BCL2-associated athanogene
chr12_+_100661156 4.39 ENST00000360820.2
SCYL2
SCY1-like 2 (S. cerevisiae)
chr13_+_20532807 4.38 ENST00000382869.3
ENST00000382881.3
ZMYM2
zinc finger, MYM-type 2
chr1_-_201081579 4.36 ENST00000367338.3
ENST00000362061.3
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr17_+_7608511 4.23 ENST00000226091.2
EFNB3
ephrin-B3
chr12_-_117175819 4.18 ENST00000261318.3
ENST00000536380.1
C12orf49
chromosome 12 open reading frame 49
chr1_-_12677714 4.11 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr15_-_78526942 4.04 ENST00000258873.4
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr17_-_40835076 3.99 ENST00000591765.1
CCR10
chemokine (C-C motif) receptor 10
chr15_+_101142722 3.92 ENST00000332783.7
ENST00000558747.1
ENST00000343276.4
ASB7
ankyrin repeat and SOCS box containing 7
chr1_-_112046289 3.88 ENST00000241356.4
ADORA3
adenosine A3 receptor
chr17_-_76778339 3.82 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
CYTH1
cytohesin 1
chr3_-_33759699 3.78 ENST00000399362.4
ENST00000359576.5
ENST00000307312.7
CLASP2
cytoplasmic linker associated protein 2
chr1_-_156460391 3.71 ENST00000360595.3
MEF2D
myocyte enhancer factor 2D
chr11_-_119991589 3.71 ENST00000526881.1
TRIM29
tripartite motif containing 29
chr22_+_38035459 3.48 ENST00000357436.4
SH3BP1
SH3-domain binding protein 1
chr1_-_21606013 3.42 ENST00000357071.4
ECE1
endothelin converting enzyme 1
chr11_+_118478313 3.41 ENST00000356063.5
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr8_+_75736761 3.33 ENST00000260113.2
PI15
peptidase inhibitor 15
chr19_+_4969116 3.24 ENST00000588337.1
ENST00000159111.4
ENST00000381759.4
KDM4B
lysine (K)-specific demethylase 4B
chr17_+_7211280 3.23 ENST00000419711.2
ENST00000571955.1
ENST00000573714.1
EIF5A
eukaryotic translation initiation factor 5A
chr18_-_3880051 3.23 ENST00000584874.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr9_+_34989638 3.22 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr12_+_57853918 3.22 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
GLI1
GLI family zinc finger 1
chr9_-_33264557 3.19 ENST00000473781.1
ENST00000488499.1
BAG1
BCL2-associated athanogene
chr1_-_112531777 3.18 ENST00000315987.2
ENST00000302127.4
KCND3
potassium voltage-gated channel, Shal-related subfamily, member 3
chr19_+_45312347 3.15 ENST00000270233.6
ENST00000591520.1
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr17_-_7137857 3.15 ENST00000005340.5
DVL2
dishevelled segment polarity protein 2
chr9_+_131218408 3.13 ENST00000351030.3
ENST00000604420.1
ENST00000535026.1
ENST00000448249.3
ENST00000393527.3
ODF2
outer dense fiber of sperm tails 2
chr3_+_4535025 3.10 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr1_+_47264711 3.09 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
CYP4B1
cytochrome P450, family 4, subfamily B, polypeptide 1
chr14_-_64971288 3.08 ENST00000394715.1
ZBTB25
zinc finger and BTB domain containing 25
chrX_+_107334895 3.07 ENST00000372232.3
ENST00000345734.3
ENST00000372254.3
ATG4A
autophagy related 4A, cysteine peptidase
chr13_+_20532848 2.96 ENST00000382874.2
ZMYM2
zinc finger, MYM-type 2
chr12_+_31477250 2.92 ENST00000313737.4
AC024940.1
AC024940.1
chr6_-_31620403 2.91 ENST00000451898.1
ENST00000439687.2
ENST00000362049.6
ENST00000424480.1
BAG6
BCL2-associated athanogene 6
chr5_+_52776449 2.72 ENST00000396947.3
FST
follistatin
chr20_+_3451650 2.66 ENST00000262919.5
ATRN
attractin
chr9_+_131218698 2.65 ENST00000434106.3
ENST00000546203.1
ENST00000446274.1
ENST00000421776.2
ENST00000432065.2
ODF2
outer dense fiber of sperm tails 2
chr17_+_17380294 2.54 ENST00000268711.3
ENST00000580462.1
MED9
mediator complex subunit 9
chr3_+_6902794 2.53 ENST00000357716.4
ENST00000486284.1
ENST00000389336.4
ENST00000403881.1
ENST00000402647.2
GRM7
glutamate receptor, metabotropic 7
chr20_-_50722183 2.47 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr20_+_3451732 2.30 ENST00000446916.2
ATRN
attractin
chr16_-_68002456 2.24 ENST00000576616.1
ENST00000572037.1
ENST00000338335.3
ENST00000422611.2
ENST00000316341.3
SLC12A4
solute carrier family 12 (potassium/chloride transporter), member 4
chr6_-_33160231 2.24 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr13_+_20532900 2.23 ENST00000382871.2
ZMYM2
zinc finger, MYM-type 2
chr16_-_16317321 2.14 ENST00000205557.7
ENST00000575728.1
ABCC6
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
chr12_-_7848364 2.13 ENST00000329913.3
GDF3
growth differentiation factor 3
chrX_-_30327495 2.10 ENST00000453287.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr6_-_31620455 2.07 ENST00000437771.1
ENST00000404765.2
ENST00000375964.6
ENST00000211379.5
BAG6
BCL2-associated athanogene 6
chr17_-_50237343 2.05 ENST00000575181.1
ENST00000570565.1
CA10
carbonic anhydrase X
chr6_-_43337180 1.95 ENST00000318149.3
ENST00000361428.2
ZNF318
zinc finger protein 318
chr6_-_29595779 1.93 ENST00000355973.3
ENST00000377012.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr3_+_170136642 1.74 ENST00000064724.3
ENST00000486975.1
CLDN11
claudin 11
chr3_+_47844615 1.65 ENST00000348968.4
DHX30
DEAH (Asp-Glu-Ala-His) box helicase 30
chr19_+_3708376 1.64 ENST00000539908.2
TJP3
tight junction protein 3
chr17_-_50237374 1.58 ENST00000442502.2
CA10
carbonic anhydrase X
chr17_+_73997419 1.52 ENST00000425876.2
CDK3
cyclin-dependent kinase 3
chr19_-_51456321 1.48 ENST00000391809.2
KLK5
kallikrein-related peptidase 5
chr10_-_69455873 1.44 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr8_-_41522779 1.44 ENST00000522231.1
ENST00000314214.8
ENST00000348036.4
ENST00000457297.1
ENST00000522543.1
ANK1
ankyrin 1, erythrocytic
chr11_+_117049910 1.27 ENST00000431081.2
ENST00000524842.1
SIDT2
SID1 transmembrane family, member 2
chr1_-_171621815 1.21 ENST00000037502.6
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr16_+_86612112 1.16 ENST00000320241.3
FOXL1
forkhead box L1
chr10_-_86001210 1.16 ENST00000372105.3
LRIT1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr9_-_73483958 1.13 ENST00000377101.1
ENST00000377106.1
ENST00000360823.2
ENST00000377105.1
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr14_-_88789581 1.11 ENST00000319231.5
KCNK10
potassium channel, subfamily K, member 10
chr9_-_130639997 1.04 ENST00000373176.1
AK1
adenylate kinase 1
chr3_+_137717571 1.03 ENST00000343735.4
CLDN18
claudin 18

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC2_GLI1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
12.9 231.8 GO:0007021 tubulin complex assembly(GO:0007021)
6.0 24.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
6.0 36.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
5.7 17.2 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
4.7 32.8 GO:0002175 protein localization to paranode region of axon(GO:0002175)
4.4 35.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
4.4 13.1 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
4.3 60.8 GO:0070050 neuron cellular homeostasis(GO:0070050)
4.1 16.3 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
3.9 19.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
3.8 37.5 GO:0009249 protein lipoylation(GO:0009249)
3.6 14.3 GO:1904978 regulation of endosome organization(GO:1904978)
3.4 17.0 GO:0048807 female genitalia morphogenesis(GO:0048807)
3.4 40.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
3.3 10.0 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
3.0 8.9 GO:0002276 basophil activation involved in immune response(GO:0002276)
3.0 20.8 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
2.7 10.7 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
2.6 7.7 GO:0006014 D-ribose metabolic process(GO:0006014)
2.3 6.8 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
2.2 8.9 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
2.1 6.2 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
2.0 16.3 GO:0009957 epidermal cell fate specification(GO:0009957)
1.9 11.6 GO:0090131 mesenchyme migration(GO:0090131)
1.8 9.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
1.7 33.5 GO:0071420 cellular response to histamine(GO:0071420)
1.7 5.0 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
1.5 7.7 GO:0042026 protein refolding(GO:0042026) chaperone cofactor-dependent protein refolding(GO:0070389)
1.4 5.7 GO:0019046 release from viral latency(GO:0019046)
1.3 5.3 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
1.3 11.9 GO:0006531 aspartate metabolic process(GO:0006531)
1.3 9.0 GO:0060294 cilium movement involved in cell motility(GO:0060294)
1.2 38.5 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.1 9.0 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
1.1 12.2 GO:1904261 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
1.0 5.2 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
1.0 3.1 GO:0051697 protein delipidation(GO:0051697)
1.0 21.8 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
1.0 16.5 GO:0061339 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.9 8.9 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.9 3.4 GO:1904379 maintenance of unfolded protein(GO:0036506) protein localization to cytosolic proteasome complex(GO:1904327) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.9 3.4 GO:0010816 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.8 3.2 GO:0007418 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.8 23.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.8 4.7 GO:0006196 AMP catabolic process(GO:0006196)
0.7 2.9 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.7 2.1 GO:0048859 formation of anatomical boundary(GO:0048859)
0.7 11.3 GO:0045475 locomotor rhythm(GO:0045475)
0.7 8.8 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.7 8.7 GO:0060137 maternal process involved in parturition(GO:0060137)
0.7 7.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.6 7.1 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.6 14.0 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.6 4.4 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.6 8.0 GO:0042711 maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.6 2.2 GO:0060023 soft palate development(GO:0060023)
0.5 1.0 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.5 6.7 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096) histone H3-K4 trimethylation(GO:0080182)
0.4 3.1 GO:0018879 biphenyl metabolic process(GO:0018879)
0.4 4.4 GO:0071313 cellular response to caffeine(GO:0071313)
0.4 3.9 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.4 4.2 GO:0016198 axon choice point recognition(GO:0016198)
0.4 3.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.4 3.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.4 2.8 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.4 0.7 GO:0035995 detection of muscle stretch(GO:0035995)
0.4 10.5 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.4 2.5 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.4 11.8 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.4 13.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.3 4.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 8.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 36.7 GO:0007286 spermatid development(GO:0007286)
0.3 0.9 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) positive regulation of vascular wound healing(GO:0035470) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.3 3.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.3 6.8 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.2 3.7 GO:0007512 adult heart development(GO:0007512)
0.2 4.8 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.2 6.0 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.2 2.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.2 14.4 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.2 1.2 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.2 3.2 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.2 4.9 GO:0001502 cartilage condensation(GO:0001502)
0.2 4.9 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.2 3.6 GO:0007420 brain development(GO:0007420)
0.2 1.0 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.2 1.4 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.2 5.0 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 3.7 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.1 0.7 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 5.8 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 7.2 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 6.6 GO:0015701 bicarbonate transport(GO:0015701)
0.1 7.7 GO:0006400 tRNA modification(GO:0006400)
0.1 2.9 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 1.3 GO:0033227 dsRNA transport(GO:0033227)
0.1 3.0 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 2.2 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 2.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.8 GO:0045023 G0 to G1 transition(GO:0045023)
0.1 3.7 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.1 0.9 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.1 13.6 GO:0043085 positive regulation of catalytic activity(GO:0043085)
0.1 0.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 12.1 GO:0007601 visual perception(GO:0007601)
0.1 0.4 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.1 0.3 GO:0070831 basement membrane assembly(GO:0070831)
0.1 5.0 GO:0021549 cerebellum development(GO:0021549)
0.1 0.7 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.1 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0 0.9 GO:0006109 regulation of carbohydrate metabolic process(GO:0006109)
0.0 4.0 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 1.1 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 13.5 GO:0022610 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.0 0.2 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 7.1 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 2.3 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.3 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.3 GO:0036315 cellular response to sterol(GO:0036315)
0.0 1.0 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 2.7 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.3 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.0 0.1 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.7 GO:0007272 ensheathment of neurons(GO:0007272) axon ensheathment(GO:0008366)
0.0 0.6 GO:0042476 odontogenesis(GO:0042476)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
14.5 231.8 GO:0097512 cardiac myofibril(GO:0097512)
7.7 23.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
3.6 10.7 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
3.1 21.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
2.9 11.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
2.7 32.8 GO:0033010 paranodal junction(GO:0033010)
2.6 18.5 GO:0001520 outer dense fiber(GO:0001520)
2.2 8.9 GO:0035838 growing cell tip(GO:0035838)
1.2 12.2 GO:0045180 basal cortex(GO:0045180)
1.2 26.7 GO:0044295 axonal growth cone(GO:0044295)
1.2 18.5 GO:0043194 axon initial segment(GO:0043194)
1.0 32.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
1.0 33.5 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
1.0 18.2 GO:0097225 sperm midpiece(GO:0097225)
0.9 3.4 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.9 3.4 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.8 18.7 GO:0016580 Sin3 complex(GO:0016580)
0.6 2.5 GO:0032279 asymmetric synapse(GO:0032279)
0.6 11.3 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.6 9.2 GO:0031088 platelet dense granule membrane(GO:0031088)
0.5 14.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.5 14.3 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.4 5.7 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.4 20.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 41.5 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.4 35.1 GO:0042734 presynaptic membrane(GO:0042734)
0.4 17.2 GO:0016235 aggresome(GO:0016235)
0.3 18.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 9.0 GO:0002080 acrosomal membrane(GO:0002080)
0.3 4.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.3 2.1 GO:0042788 polysomal ribosome(GO:0042788)
0.3 7.2 GO:0031594 neuromuscular junction(GO:0031594)
0.3 3.2 GO:0005642 annulate lamellae(GO:0005642)
0.2 16.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 2.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 13.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 1.2 GO:0033268 node of Ranvier(GO:0033268)
0.1 35.9 GO:0001726 ruffle(GO:0001726)
0.1 1.0 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 1.4 GO:0005916 fascia adherens(GO:0005916)
0.1 14.3 GO:0005604 basement membrane(GO:0005604)
0.1 15.5 GO:0000793 condensed chromosome(GO:0000793)
0.1 1.7 GO:0045178 basal part of cell(GO:0045178)
0.1 14.4 GO:0016605 PML body(GO:0016605)
0.1 6.7 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 9.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 3.2 GO:0097546 ciliary base(GO:0097546)
0.1 2.5 GO:0016592 mediator complex(GO:0016592)
0.0 11.9 GO:0005770 late endosome(GO:0005770)
0.0 8.9 GO:0030027 lamellipodium(GO:0030027)
0.0 3.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 14.8 GO:0016607 nuclear speck(GO:0016607)
0.0 7.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.3 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 2.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 3.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.3 GO:0030904 retromer complex(GO:0030904)
0.0 0.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.6 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 23.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
7.6 236.1 GO:0005212 structural constituent of eye lens(GO:0005212)
4.0 11.9 GO:0004515 nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
3.6 14.3 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
3.3 16.3 GO:0097108 hedgehog family protein binding(GO:0097108)
3.3 13.1 GO:0042954 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
2.3 9.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
2.2 8.9 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
2.2 35.1 GO:0097109 neuroligin family protein binding(GO:0097109)
1.9 9.7 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
1.9 20.8 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.8 14.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
1.7 6.8 GO:0035939 microsatellite binding(GO:0035939)
1.7 21.5 GO:0008503 benzodiazepine receptor activity(GO:0008503)
1.5 19.9 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
1.5 12.0 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.5 5.8 GO:0008184 glycogen phosphorylase activity(GO:0008184)
1.3 24.1 GO:0043522 leucine zipper domain binding(GO:0043522)
1.2 18.7 GO:0001222 transcription corepressor binding(GO:0001222)
1.1 17.0 GO:0016918 retinal binding(GO:0016918)
1.0 36.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.9 2.8 GO:0098770 FBXO family protein binding(GO:0098770)
0.9 18.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.9 14.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.8 7.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.8 7.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.7 10.0 GO:0009881 photoreceptor activity(GO:0009881)
0.6 7.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.6 8.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.6 4.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.6 18.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.6 3.9 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.5 4.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.5 2.5 GO:0070905 serine binding(GO:0070905)
0.5 5.7 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.5 17.2 GO:0005109 frizzled binding(GO:0005109)
0.4 2.6 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.4 4.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.4 6.5 GO:0015643 toxic substance binding(GO:0015643)
0.4 3.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.4 6.7 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.4 5.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 37.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 8.8 GO:0002162 dystroglycan binding(GO:0002162)
0.4 6.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 11.7 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.3 5.0 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.3 2.9 GO:0048495 Roundabout binding(GO:0048495)
0.3 2.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.3 6.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 2.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.3 9.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 13.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 43.5 GO:0017124 SH3 domain binding(GO:0017124)
0.2 4.0 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.2 7.7 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.2 1.3 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 20.8 GO:0005262 calcium channel activity(GO:0005262)
0.2 2.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 14.0 GO:0030276 clathrin binding(GO:0030276)
0.2 2.1 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.2 3.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 4.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 5.6 GO:0017091 AU-rich element binding(GO:0017091)
0.1 3.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 12.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 10.7 GO:0005319 lipid transporter activity(GO:0005319)
0.1 3.2 GO:0043236 laminin binding(GO:0043236)
0.1 10.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.0 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.3 GO:0008142 oxysterol binding(GO:0008142)
0.1 2.1 GO:0000217 DNA secondary structure binding(GO:0000217)
0.1 3.7 GO:0002039 p53 binding(GO:0002039)
0.1 2.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 13.2 GO:0008017 microtubule binding(GO:0008017)
0.0 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.2 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 3.0 GO:0051087 chaperone binding(GO:0051087)
0.0 1.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 0.8 GO:0030332 cyclin binding(GO:0030332)
0.0 20.9 GO:0008047 enzyme activator activity(GO:0008047)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 12.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 2.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 18.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.1 GO:0031781 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.6 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 57.8 PID BARD1 PATHWAY BARD1 signaling events
0.8 29.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.8 26.1 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.6 16.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.6 5.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.4 10.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.3 13.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 18.5 PID PLK1 PATHWAY PLK1 signaling events
0.3 9.2 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 6.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.2 14.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 12.5 PID EPHB FWD PATHWAY EPHB forward signaling
0.2 39.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 8.8 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 4.5 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 7.7 PID AP1 PATHWAY AP-1 transcription factor network
0.1 2.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 1.0 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 3.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 4.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 2.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 4.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.9 PID BMP PATHWAY BMP receptor signaling
0.0 0.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 36.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.6 21.8 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
1.4 25.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.1 7.8 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
1.1 33.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.8 20.8 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.7 40.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.6 8.9 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.6 17.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.5 17.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 21.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.4 14.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.4 4.9 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.3 32.8 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.2 7.9 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.2 11.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 5.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 2.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 10.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 4.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 11.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 3.9 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 13.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 14.4 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.1 6.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 6.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.7 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.1 2.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 3.2 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 4.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 8.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 4.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 2.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 3.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 2.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 3.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing