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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZNF274

Z-value: 0.62

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Transcription factors associated with ZNF274

Gene Symbol Gene ID Gene Info
ZNF274
ENSG00000171606.13 zinc finger protein 274

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF274hg19_v2_chr19_+_58694396_586944850.401.0e-09Click!

Activity profile of ZNF274 motif

Sorted Z-values of ZNF274 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_119737806 18.15 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr5_+_32531893 16.05 ENST00000512913.1
SUB1
SUB1 homolog (S. cerevisiae)
chr18_+_9103957 15.47 ENST00000400033.1
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr12_-_54653313 14.24 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chr1_+_45205498 13.68 ENST00000372218.4
KIF2C
kinesin family member 2C
chr11_+_16760161 13.51 ENST00000524439.1
ENST00000422258.2
ENST00000528634.1
ENST00000525684.1
C11orf58
chromosome 11 open reading frame 58
chr1_+_45205478 13.17 ENST00000452259.1
ENST00000372224.4
KIF2C
kinesin family member 2C
chr16_+_29819096 11.69 ENST00000568411.1
ENST00000563012.1
ENST00000562557.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_-_96971259 10.72 ENST00000349783.5
SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr12_+_113344755 10.71 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr22_-_43036607 10.70 ENST00000505920.1
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr6_+_30687978 9.94 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr16_+_29819372 9.01 ENST00000568544.1
ENST00000569978.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr16_+_29818857 8.46 ENST00000567444.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr16_+_29819446 8.29 ENST00000568282.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr10_+_5488564 4.65 ENST00000449083.1
ENST00000380359.3
NET1
neuroepithelial cell transforming 1
chr6_+_31553901 4.04 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr17_-_7145106 4.03 ENST00000577035.1
GABARAP
GABA(A) receptor-associated protein
chr3_+_37903432 3.66 ENST00000443503.2
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr17_-_41132410 3.28 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr3_+_50284321 2.98 ENST00000451956.1
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr1_-_114414316 2.98 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr6_+_31553978 2.73 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr22_+_39353527 2.68 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr4_+_15704679 2.23 ENST00000382346.3
BST1
bone marrow stromal cell antigen 1
chr4_-_121993673 1.89 ENST00000379692.4
NDNF
neuron-derived neurotrophic factor
chr19_+_40195101 1.83 ENST00000360675.3
ENST00000601802.1
LGALS14
lectin, galactoside-binding, soluble, 14
chr12_+_50135327 1.82 ENST00000549966.1
ENST00000547832.1
ENST00000547187.1
ENST00000548894.1
ENST00000546914.1
ENST00000552699.1
ENST00000267115.5
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr19_-_19774473 1.56 ENST00000357324.6
ATP13A1
ATPase type 13A1
chr20_+_60174827 1.41 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr2_+_11864458 1.20 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
LPIN1
lipin 1
chr2_-_89292422 1.05 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr19_+_6887571 0.96 ENST00000250572.8
ENST00000381407.5
ENST00000312053.4
ENST00000450315.3
ENST00000381404.4
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr4_+_15704573 0.77 ENST00000265016.4
BST1
bone marrow stromal cell antigen 1
chr6_-_32784687 0.46 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF274

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.2 GO:0002188 translation reinitiation(GO:0002188)
3.6 10.7 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
2.7 26.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.0 3.0 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.4 2.7 GO:0070383 DNA cytosine deamination(GO:0070383)
0.4 16.0 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.4 37.4 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.4 4.7 GO:0051451 myoblast migration(GO:0051451)
0.3 1.8 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.3 10.7 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 4.0 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 15.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 3.0 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.2 1.2 GO:0006642 triglyceride mobilization(GO:0006642)
0.2 1.9 GO:0061042 vascular wound healing(GO:0061042)
0.2 1.6 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.2 0.5 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1 9.9 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 10.7 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 3.0 GO:2001044 regulation of integrin-mediated signaling pathway(GO:2001044)
0.1 6.8 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 0.4 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.0 14.2 GO:0007596 blood coagulation(GO:0007596)
0.0 1.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 3.7 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 15.5 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
1.0 14.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.8 26.9 GO:0035371 microtubule plus-end(GO:0035371)
0.7 9.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.6 10.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.4 10.7 GO:0005682 U5 snRNP(GO:0005682)
0.2 18.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 4.0 GO:0097225 sperm midpiece(GO:0097225)
0.1 3.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 3.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 11.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.7 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 26.9 GO:0019237 centromeric DNA binding(GO:0019237)
1.1 10.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
1.0 3.0 GO:0003953 NAD+ nucleosidase activity(GO:0003953) NAD(P)+ nucleosidase activity(GO:0050135)
0.7 15.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.5 2.7 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.5 9.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.4 1.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.4 10.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 16.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 37.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3 1.8 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.3 4.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 18.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 14.2 GO:0035064 methylated histone binding(GO:0035064)
0.2 4.0 GO:0050811 GABA receptor binding(GO:0050811)
0.2 1.6 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 10.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 3.0 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 6.6 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 41.1 PID AURORA B PATHWAY Aurora B signaling
0.2 3.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 3.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 4.7 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 26.9 REACTOME KINESINS Genes involved in Kinesins
0.2 10.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 15.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 3.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 10.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 14.2 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 9.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 4.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions