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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZNF282

Z-value: 0.84

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Transcription factors associated with ZNF282

Gene Symbol Gene ID Gene Info
ZNF282
ENSG00000170265.7 zinc finger protein 282

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF282hg19_v2_chr7_+_148892557_1488925800.502.6e-15Click!

Activity profile of ZNF282 motif

Sorted Z-values of ZNF282 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_58711539 27.19 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr2_+_242289502 21.56 ENST00000451310.1
SEPT2
septin 2
chr6_-_79944336 18.38 ENST00000344726.5
ENST00000275036.7
HMGN3
high mobility group nucleosomal binding domain 3
chr17_+_66509019 17.54 ENST00000585981.1
ENST00000589480.1
ENST00000585815.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr14_+_55590646 17.10 ENST00000553493.1
LGALS3
lectin, galactoside-binding, soluble, 3
chr19_-_40336969 16.83 ENST00000599134.1
ENST00000597634.1
ENST00000598417.1
ENST00000601274.1
ENST00000594309.1
ENST00000221801.3
FBL
fibrillarin
chr19_-_49121054 14.72 ENST00000546623.1
ENST00000084795.5
RPL18
ribosomal protein L18
chr6_+_106959718 14.58 ENST00000369066.3
AIM1
absent in melanoma 1
chr18_-_54318353 14.33 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr6_+_32938692 13.25 ENST00000443797.2
BRD2
bromodomain containing 2
chr6_+_10747986 12.86 ENST00000379542.5
TMEM14B
transmembrane protein 14B
chr6_-_17706618 12.67 ENST00000262077.2
ENST00000537253.1
NUP153
nucleoporin 153kDa
chr20_-_33872518 12.66 ENST00000374436.3
EIF6
eukaryotic translation initiation factor 6
chr20_-_33872548 12.38 ENST00000374443.3
EIF6
eukaryotic translation initiation factor 6
chr6_+_10748019 11.98 ENST00000543878.1
ENST00000461342.1
ENST00000475942.1
ENST00000379530.3
ENST00000473276.1
ENST00000481240.1
ENST00000467317.1
SYCP2L
TMEM14B
synaptonemal complex protein 2-like
transmembrane protein 14B
chr17_+_42422637 11.21 ENST00000053867.3
ENST00000588143.1
GRN
granulin
chr19_+_30097181 11.00 ENST00000586420.1
ENST00000221770.3
ENST00000392279.3
ENST00000590688.1
POP4
processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
chr18_-_47017956 10.74 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr1_-_108735440 10.58 ENST00000370041.4
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr1_+_47799446 10.51 ENST00000371873.5
CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr6_+_32938665 10.35 ENST00000374831.4
ENST00000395289.2
BRD2
bromodomain containing 2
chr12_-_46766577 10.02 ENST00000256689.5
SLC38A2
solute carrier family 38, member 2
chr1_+_40723779 9.78 ENST00000372759.3
ZMPSTE24
zinc metallopeptidase STE24
chr2_+_233415363 9.74 ENST00000409514.1
ENST00000409098.1
ENST00000409495.1
ENST00000409167.3
ENST00000409322.1
ENST00000409394.1
EIF4E2
eukaryotic translation initiation factor 4E family member 2
chr17_+_42422662 9.55 ENST00000593167.1
ENST00000585512.1
ENST00000591740.1
ENST00000592783.1
ENST00000587387.1
ENST00000588237.1
ENST00000589265.1
GRN
granulin
chr15_-_83736091 9.08 ENST00000261721.4
BTBD1
BTB (POZ) domain containing 1
chr10_+_51572408 9.01 ENST00000374082.1
NCOA4
nuclear receptor coactivator 4
chr10_+_51572339 8.77 ENST00000344348.6
NCOA4
nuclear receptor coactivator 4
chr17_+_8191815 8.61 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
RANGRF
RAN guanine nucleotide release factor
chr20_-_2451395 7.88 ENST00000339610.6
ENST00000381342.2
ENST00000438552.2
SNRPB
small nuclear ribonucleoprotein polypeptides B and B1
chr17_-_76899275 7.80 ENST00000322630.2
ENST00000586713.1
DDC8
Protein DDC8 homolog
chr17_-_61996136 7.69 ENST00000342364.4
GH1
growth hormone 1
chr12_+_4758264 7.64 ENST00000266544.5
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr2_-_197664366 7.59 ENST00000409364.3
ENST00000263956.3
GTF3C3
general transcription factor IIIC, polypeptide 3, 102kDa
chr1_+_226250379 7.53 ENST00000366815.3
ENST00000366814.3
H3F3A
H3 histone, family 3A
chr5_-_7869108 7.33 ENST00000264669.5
ENST00000507572.1
ENST00000504695.1
FASTKD3
FAST kinase domains 3
chr11_-_6633799 7.17 ENST00000299424.4
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr18_-_47018869 7.14 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr18_-_47018897 6.66 ENST00000418495.1
RPL17
ribosomal protein L17
chr13_+_31309645 6.59 ENST00000380490.3
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr17_-_61988556 6.57 ENST00000309894.5
ENST00000438387.2
ENST00000346606.6
ENST00000561003.1
ENST00000450719.3
ENST00000259003.10
CSHL1
chorionic somatomammotropin hormone-like 1
chr4_+_88343952 6.28 ENST00000440591.2
NUDT9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr16_+_66586461 6.19 ENST00000264001.4
ENST00000351137.4
ENST00000345436.4
ENST00000362093.4
ENST00000417030.2
ENST00000527729.1
ENST00000532838.1
CKLF
CKLF-CMTM1
chemokine-like factor
CKLF-CMTM1 readthrough
chrX_+_47004639 5.77 ENST00000345781.6
RBM10
RNA binding motif protein 10
chr7_-_158497431 5.76 ENST00000449727.2
ENST00000409339.3
ENST00000409423.1
ENST00000356309.3
NCAPG2
non-SMC condensin II complex, subunit G2
chr17_-_61996160 5.44 ENST00000458650.2
ENST00000351388.4
ENST00000323322.5
GH1
growth hormone 1
chr12_-_9102549 5.06 ENST00000000412.3
M6PR
mannose-6-phosphate receptor (cation dependent)
chr18_-_47018769 4.85 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr10_-_114206649 4.83 ENST00000369404.3
ENST00000369405.3
ZDHHC6
zinc finger, DHHC-type containing 6
chr8_+_74888417 4.43 ENST00000517439.1
ENST00000312184.5
TMEM70
transmembrane protein 70
chr17_-_61959202 4.42 ENST00000449787.2
ENST00000456543.2
ENST00000423893.2
ENST00000332800.7
GH2
growth hormone 2
chr4_+_88343717 4.41 ENST00000302174.4
ENST00000512216.1
ENST00000473942.1
NUDT9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr9_+_34652164 4.34 ENST00000441545.2
ENST00000553620.1
IL11RA
interleukin 11 receptor, alpha
chr1_+_150122034 4.30 ENST00000025469.6
ENST00000369124.4
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr17_+_55183261 4.11 ENST00000576295.1
AKAP1
A kinase (PRKA) anchor protein 1
chr8_-_23261589 4.11 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
LOXL2
lysyl oxidase-like 2
chr11_+_111957497 4.06 ENST00000375549.3
ENST00000528182.1
ENST00000528048.1
ENST00000528021.1
ENST00000526592.1
ENST00000525291.1
SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr20_-_43150601 4.04 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
SERINC3
serine incorporator 3
chr6_+_44187334 3.83 ENST00000313248.7
ENST00000427851.2
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr11_-_111957451 3.83 ENST00000504148.2
ENST00000541231.1
TIMM8B
translocase of inner mitochondrial membrane 8 homolog B (yeast)
chr14_-_36989336 3.78 ENST00000522719.2
NKX2-1
NK2 homeobox 1
chr12_-_49582978 3.75 ENST00000301071.7
TUBA1A
tubulin, alpha 1a
chr13_+_50656307 3.73 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr2_+_233415488 3.65 ENST00000454501.1
EIF4E2
eukaryotic translation initiation factor 4E family member 2
chr1_-_54304212 3.59 ENST00000540001.1
NDC1
NDC1 transmembrane nucleoporin
chr15_-_44955842 3.29 ENST00000427534.2
ENST00000559193.1
ENST00000261866.7
ENST00000535302.2
ENST00000558319.1
SPG11
spastic paraplegia 11 (autosomal recessive)
chr4_+_169753156 3.15 ENST00000393726.3
ENST00000507735.1
PALLD
palladin, cytoskeletal associated protein
chr2_-_188378368 3.12 ENST00000392365.1
ENST00000435414.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr17_-_61996192 2.98 ENST00000392824.4
CSHL1
chorionic somatomammotropin hormone-like 1
chr21_-_35014027 2.93 ENST00000399442.1
ENST00000413017.2
ENST00000445393.1
ENST00000417979.1
ENST00000426935.1
ENST00000381540.3
ENST00000361534.2
ENST00000381554.3
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr1_-_9129631 2.81 ENST00000377414.3
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr17_-_73389854 2.74 ENST00000578961.1
ENST00000392564.1
ENST00000582582.1
GRB2
growth factor receptor-bound protein 2
chr14_-_24911448 2.53 ENST00000555355.1
ENST00000553343.1
ENST00000556523.1
ENST00000556249.1
ENST00000538105.2
ENST00000555225.1
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chrX_-_135849484 2.51 ENST00000370620.1
ENST00000535227.1
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr5_+_167718604 2.50 ENST00000265293.4
WWC1
WW and C2 domain containing 1
chr1_-_54303934 2.46 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr17_-_77924627 2.29 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1D16
TBC1 domain family, member 16
chr5_+_7869217 1.98 ENST00000264668.2
ENST00000514220.1
ENST00000341013.6
ENST00000440940.2
ENST00000502550.1
ENST00000506877.1
MTRR
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr14_-_36989427 1.97 ENST00000354822.5
NKX2-1
NK2 homeobox 1
chr1_-_160313025 1.90 ENST00000368069.3
ENST00000241704.7
COPA
coatomer protein complex, subunit alpha
chr1_+_145507587 1.64 ENST00000330165.8
ENST00000369307.3
RBM8A
RNA binding motif protein 8A
chr11_-_321340 1.27 ENST00000526811.1
IFITM3
interferon induced transmembrane protein 3
chrX_-_47004878 1.20 ENST00000377811.3
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr17_+_41323204 1.12 ENST00000542611.1
ENST00000590996.1
ENST00000389312.4
ENST00000589872.1
NBR1
neighbor of BRCA1 gene 1
chr3_+_45927994 0.90 ENST00000357632.2
ENST00000395963.2
CCR9
chemokine (C-C motif) receptor 9
chr13_-_95248511 0.87 ENST00000261296.5
TGDS
TDP-glucose 4,6-dehydratase
chr1_-_54303949 0.05 ENST00000234725.8
NDC1
NDC1 transmembrane nucleoporin

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF282

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 25.0 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
5.7 17.1 GO:2000521 negative regulation of immunological synapse formation(GO:2000521)
4.2 16.8 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
3.3 9.8 GO:0030327 prenylated protein catabolic process(GO:0030327)
2.2 8.6 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
2.1 10.7 GO:0009137 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
2.0 6.1 GO:0071789 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
1.9 7.5 GO:0060623 regulation of chromosome condensation(GO:0060623)
1.8 10.5 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
1.7 10.0 GO:0032328 alanine transport(GO:0032328)
1.6 13.1 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
1.5 4.4 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
1.4 4.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.3 10.6 GO:0015866 ADP transport(GO:0015866)
1.2 5.8 GO:0021759 globus pallidus development(GO:0021759)
1.1 17.5 GO:2000480 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.1 7.6 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
1.0 12.7 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.8 5.1 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.8 3.3 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.8 3.8 GO:0015862 uridine transport(GO:0015862)
0.7 6.6 GO:2001300 lipoxin metabolic process(GO:2001300)
0.6 11.0 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.6 4.0 GO:0009597 detection of virus(GO:0009597)
0.6 5.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.6 7.2 GO:0070365 hepatocyte differentiation(GO:0070365)
0.5 17.8 GO:0006622 protein targeting to lysosome(GO:0006622)
0.4 7.6 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.4 3.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.4 4.3 GO:0051451 myoblast migration(GO:0051451)
0.4 2.5 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.3 3.8 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.3 2.0 GO:0043418 homocysteine catabolic process(GO:0043418)
0.3 4.8 GO:0018345 protein palmitoylation(GO:0018345)
0.3 44.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3 7.9 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.3 27.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.2 18.4 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.2 4.4 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.2 23.6 GO:0006334 nucleosome assembly(GO:0006334)
0.2 4.1 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.2 14.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 1.1 GO:0015755 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.2 2.7 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.2 6.2 GO:0048246 macrophage chemotaxis(GO:0048246)
0.1 20.9 GO:0007224 smoothened signaling pathway(GO:0007224)
0.1 3.2 GO:0003334 keratinocyte development(GO:0003334)
0.1 1.9 GO:0030157 pancreatic juice secretion(GO:0030157)
0.1 2.9 GO:1901661 quinone metabolic process(GO:1901661)
0.1 7.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 4.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.9 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.1 13.4 GO:0006413 translational initiation(GO:0006413)
0.1 1.3 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 2.3 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 8.5 GO:0045333 cellular respiration(GO:0045333)
0.0 1.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 9.1 GO:0043393 regulation of protein binding(GO:0043393)
0.0 2.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 20.7 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 3.8 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 16.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
4.4 13.1 GO:0070195 growth hormone receptor complex(GO:0070195)
2.3 27.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
2.0 6.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
1.6 11.0 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.4 4.3 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
1.3 7.5 GO:0001740 Barr body(GO:0001740)
1.2 17.8 GO:0044754 autolysosome(GO:0044754)
1.1 15.7 GO:0097227 sperm annulus(GO:0097227)
1.1 7.6 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
1.1 12.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
1.0 4.1 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.0 7.9 GO:0071204 U7 snRNP(GO:0005683) histone pre-mRNA 3'end processing complex(GO:0071204)
0.9 17.5 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.8 13.4 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.8 25.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.8 7.2 GO:0000125 PCAF complex(GO:0000125)
0.6 5.8 GO:0000796 condensin complex(GO:0000796)
0.5 3.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.5 2.7 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.4 44.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 17.1 GO:0001772 immunological synapse(GO:0001772)
0.2 5.1 GO:0030904 retromer complex(GO:0030904)
0.2 20.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.2 1.9 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 14.3 GO:0000502 proteasome complex(GO:0000502)
0.1 8.8 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 8.6 GO:0014704 intercalated disc(GO:0014704)
0.1 5.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 9.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 4.3 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.1 9.3 GO:0005903 brush border(GO:0005903)
0.1 17.3 GO:0031965 nuclear membrane(GO:0031965)
0.1 3.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 7.3 GO:0005739 mitochondrion(GO:0005739)
0.0 2.5 GO:0002102 podosome(GO:0002102)
0.0 1.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 2.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 3.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.5 GO:0030027 lamellipodium(GO:0030027)
0.0 3.0 GO:0005741 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.0 6.5 GO:0019866 mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866)
0.0 1.1 GO:0035579 specific granule membrane(GO:0035579)
0.0 4.4 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 25.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
4.4 13.1 GO:0005148 prolactin receptor binding(GO:0005148)
3.6 10.7 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
2.5 7.6 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
2.2 6.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
2.1 17.1 GO:0019863 IgE binding(GO:0019863)
2.0 14.3 GO:0047134 protein-disulfide reductase activity(GO:0047134)
1.8 10.5 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
1.6 7.9 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
1.4 4.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.3 10.6 GO:0015217 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
1.2 8.6 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
1.1 16.8 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.9 27.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 17.5 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.7 11.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.6 18.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.6 25.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.6 13.4 GO:0000339 RNA cap binding(GO:0000339)
0.6 23.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.5 2.9 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.4 5.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.4 4.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.3 4.0 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3 4.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 3.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.3 5.1 GO:0005537 mannose binding(GO:0005537)
0.2 17.8 GO:0050681 androgen receptor binding(GO:0050681)
0.2 2.0 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.2 44.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 2.7 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.2 4.1 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 1.1 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.1 7.2 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 7.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 9.8 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.1 3.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 5.6 GO:0008009 chemokine activity(GO:0008009)
0.1 14.7 GO:0005179 hormone activity(GO:0005179)
0.1 20.8 GO:0005125 cytokine activity(GO:0005125)
0.1 5.8 GO:0035064 methylated histone binding(GO:0035064)
0.1 4.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 0.9 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 21.6 GO:0045296 cadherin binding(GO:0045296)
0.0 4.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 2.5 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 3.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.9 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 3.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 27.2 PID AURORA B PATHWAY Aurora B signaling
0.4 12.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3 14.3 PID RAS PATHWAY Regulation of Ras family activation
0.2 17.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 24.1 PID CDC42 PATHWAY CDC42 signaling events
0.2 23.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 17.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 3.8 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 5.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 25.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 7.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 13.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.5 16.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.5 17.5 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.5 7.9 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.4 10.0 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.4 27.2 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3 12.7 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.3 10.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 44.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 7.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.2 13.4 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 1.9 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.2 4.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.2 4.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 2.7 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 7.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 3.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 7.5 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 5.1 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 7.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 2.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 3.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 3.1 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.1 3.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.6 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.1 1.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production