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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZSCAN4

Z-value: 0.70

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Transcription factors associated with ZSCAN4

Gene Symbol Gene ID Gene Info
ZSCAN4
ENSG00000180532.6 zinc finger and SCAN domain containing 4

Activity profile of ZSCAN4 motif

Sorted Z-values of ZSCAN4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_58572760 11.54 ENST00000447756.2
FAM107A
family with sequence similarity 107, member A
chr16_+_23847267 9.73 ENST00000321728.7
PRKCB
protein kinase C, beta
chr1_+_2036149 8.22 ENST00000482686.1
ENST00000400920.1
ENST00000486681.1
PRKCZ
protein kinase C, zeta
chr14_-_21493884 7.68 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG2
NDRG family member 2
chr14_-_21493649 7.68 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG2
NDRG family member 2
chr1_-_161600990 7.12 ENST00000531221.1
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr1_-_154580616 7.02 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr8_+_85095769 6.18 ENST00000518566.1
RALYL
RALY RNA binding protein-like
chr1_-_177133818 6.17 ENST00000424564.2
ENST00000361833.2
ASTN1
astrotactin 1
chr17_+_2699697 5.76 ENST00000254695.8
ENST00000366401.4
ENST00000542807.1
RAP1GAP2
RAP1 GTPase activating protein 2
chr10_+_80828774 5.73 ENST00000334512.5
ZMIZ1
zinc finger, MIZ-type containing 1
chr1_-_21978312 5.65 ENST00000359708.4
ENST00000290101.4
RAP1GAP
RAP1 GTPase activating protein
chr1_-_161600942 5.58 ENST00000421702.2
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr6_-_41909561 5.33 ENST00000372991.4
CCND3
cyclin D3
chr1_-_161519682 5.32 ENST00000367969.3
ENST00000443193.1
FCGR3A
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr7_-_10979750 5.32 ENST00000339600.5
NDUFA4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
chr16_+_4674814 5.27 ENST00000415496.1
ENST00000587747.1
ENST00000399577.5
ENST00000588994.1
ENST00000586183.1
MGRN1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr6_-_41909466 5.26 ENST00000414200.2
CCND3
cyclin D3
chr16_+_4674787 5.23 ENST00000262370.7
MGRN1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr1_-_161600822 5.20 ENST00000534776.1
ENST00000540048.1
FCGR3B
FCGR3A
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr1_+_233765353 5.04 ENST00000366620.1
KCNK1
potassium channel, subfamily K, member 1
chr1_-_161519579 4.98 ENST00000426740.1
FCGR3A
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr17_+_72462525 4.83 ENST00000360141.3
CD300A
CD300a molecule
chr8_-_134115118 4.78 ENST00000395352.3
ENST00000338087.5
SLA
Src-like-adaptor
chr8_+_85095497 4.60 ENST00000522455.1
ENST00000521695.1
RALYL
RALY RNA binding protein-like
chr16_+_6069664 4.34 ENST00000422070.4
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_-_33774944 4.17 ENST00000532057.1
ENST00000531080.1
FBXO3
F-box protein 3
chr8_+_85095553 3.65 ENST00000521268.1
RALYL
RALY RNA binding protein-like
chr19_+_14491948 3.65 ENST00000358600.3
CD97
CD97 molecule
chr12_-_54694807 3.37 ENST00000435572.2
NFE2
nuclear factor, erythroid 2
chr16_+_16472912 3.32 ENST00000530217.2
NPIPA7
nuclear pore complex interacting protein family, member A7
chr19_+_571277 3.22 ENST00000346916.4
ENST00000545507.2
BSG
basigin (Ok blood group)
chr4_+_74718906 3.09 ENST00000226524.3
PF4V1
platelet factor 4 variant 1
chr1_+_226736446 3.08 ENST00000366788.3
ENST00000366789.4
C1orf95
chromosome 1 open reading frame 95
chr16_+_56385290 3.01 ENST00000564727.1
GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr2_-_160473114 2.90 ENST00000392783.2
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr3_+_52009110 2.83 ENST00000491470.1
ABHD14A
abhydrolase domain containing 14A
chr19_+_30863271 2.71 ENST00000355537.3
ZNF536
zinc finger protein 536
chr17_-_34207295 2.58 ENST00000463941.1
ENST00000293272.3
CCL5
chemokine (C-C motif) ligand 5
chr19_-_3801789 2.54 ENST00000590849.1
ENST00000395045.2
MATK
megakaryocyte-associated tyrosine kinase
chr8_+_26247878 2.49 ENST00000518611.1
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr7_-_99063769 2.42 ENST00000394186.3
ENST00000359832.4
ENST00000449683.1
ENST00000488775.1
ENST00000523680.1
ENST00000292475.3
ENST00000430982.1
ENST00000555673.1
ENST00000413834.1
ATP5J2
PTCD1
ATP5J2-PTCD1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
pentatricopeptide repeat domain 1
ATP5J2-PTCD1 readthrough
chr19_-_17516449 2.41 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr3_-_53290016 2.18 ENST00000423525.2
ENST00000423516.1
ENST00000296289.6
ENST00000462138.1
TKT
transketolase
chr13_-_79980315 2.16 ENST00000438737.2
RBM26
RNA binding motif protein 26
chr10_+_18549645 2.12 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr3_+_50284321 2.10 ENST00000451956.1
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr8_+_107670064 2.08 ENST00000312046.6
OXR1
oxidation resistance 1
chr17_-_56406117 2.04 ENST00000268893.6
ENST00000355701.3
BZRAP1
benzodiazepine receptor (peripheral) associated protein 1
chr3_+_130569592 2.02 ENST00000533801.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr9_+_103790991 1.92 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr22_-_24384260 1.90 ENST00000248935.5
GSTT1
glutathione S-transferase theta 1
chr2_+_237994519 1.76 ENST00000392008.2
ENST00000409334.1
ENST00000409629.1
COPS8
COP9 signalosome subunit 8
chr1_+_209929377 1.73 ENST00000400959.3
ENST00000367025.3
TRAF3IP3
TRAF3 interacting protein 3
chr11_+_61717842 1.61 ENST00000449131.2
BEST1
bestrophin 1
chr15_+_78632666 1.59 ENST00000299529.6
CRABP1
cellular retinoic acid binding protein 1
chr14_+_53173910 1.58 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr14_+_53173890 1.56 ENST00000445930.2
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr4_-_103682071 1.56 ENST00000505239.1
MANBA
mannosidase, beta A, lysosomal
chr5_+_176784837 1.53 ENST00000408923.3
RGS14
regulator of G-protein signaling 14
chr17_+_63133587 1.52 ENST00000449996.3
ENST00000262406.9
RGS9
regulator of G-protein signaling 9
chr19_+_17516624 1.51 ENST00000596322.1
ENST00000600008.1
ENST00000601885.1
CTD-2521M24.9
CTD-2521M24.9
chr19_+_17516531 1.43 ENST00000528911.1
ENST00000528604.1
ENST00000595892.1
ENST00000500836.2
ENST00000598546.1
ENST00000600369.1
ENST00000598356.1
ENST00000594426.1
MVB12A
CTD-2521M24.9
multivesicular body subunit 12A
CTD-2521M24.9
chr16_+_16481306 1.41 ENST00000422673.2
NPIPA7
nuclear pore complex interacting protein family, member A7
chr5_+_61602055 1.40 ENST00000381103.2
KIF2A
kinesin heavy chain member 2A
chr11_-_75062730 1.39 ENST00000420843.2
ENST00000360025.3
ARRB1
arrestin, beta 1
chr11_+_111807863 1.36 ENST00000440460.2
DIXDC1
DIX domain containing 1
chr22_+_18121356 1.34 ENST00000317582.5
ENST00000543133.1
ENST00000538149.1
ENST00000337612.5
ENST00000493680.1
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr1_+_209929494 1.33 ENST00000367026.3
TRAF3IP3
TRAF3 interacting protein 3
chr12_-_96390108 1.29 ENST00000538703.1
ENST00000261208.3
HAL
histidine ammonia-lyase
chr19_-_38714847 1.27 ENST00000420980.2
ENST00000355526.4
DPF1
D4, zinc and double PHD fingers family 1
chr1_+_231376941 1.20 ENST00000436239.1
ENST00000366647.4
ENST00000366646.3
ENST00000416000.1
GNPAT
glyceronephosphate O-acyltransferase
chr15_+_63414017 1.19 ENST00000413507.2
LACTB
lactamase, beta
chr19_+_17516494 1.12 ENST00000534306.1
CTD-2521M24.9
CTD-2521M24.9
chr1_+_94883931 1.09 ENST00000394233.2
ENST00000454898.2
ENST00000536817.1
ABCD3
ATP-binding cassette, sub-family D (ALD), member 3
chr2_-_101034070 1.08 ENST00000264249.3
CHST10
carbohydrate sulfotransferase 10
chr1_+_104615595 1.06 ENST00000418362.1
RP11-364B6.1
RP11-364B6.1
chr21_-_46221684 1.06 ENST00000330942.5
UBE2G2
ubiquitin-conjugating enzyme E2G 2
chr12_-_96390063 1.04 ENST00000541929.1
HAL
histidine ammonia-lyase
chr1_+_94883991 1.03 ENST00000370214.4
ABCD3
ATP-binding cassette, sub-family D (ALD), member 3
chr4_-_103682145 1.02 ENST00000226578.4
MANBA
mannosidase, beta A, lysosomal
chr16_+_15737124 0.97 ENST00000396355.1
ENST00000396353.2
NDE1
nudE neurodevelopment protein 1
chr19_-_10530784 0.95 ENST00000593124.1
CDC37
cell division cycle 37
chr20_-_21494654 0.92 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr12_-_10022735 0.92 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr5_-_82969405 0.90 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chrX_+_1387693 0.89 ENST00000381529.3
ENST00000432318.2
ENST00000361536.3
ENST00000501036.2
ENST00000381524.3
ENST00000412290.1
CSF2RA
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr11_-_77791156 0.86 ENST00000281031.4
NDUFC2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
chr11_+_61717535 0.83 ENST00000534553.1
ENST00000301774.9
BEST1
bestrophin 1
chr12_+_122242597 0.80 ENST00000267197.5
SETD1B
SET domain containing 1B
chr1_-_110283138 0.70 ENST00000256594.3
GSTM3
glutathione S-transferase mu 3 (brain)
chr11_-_4414880 0.70 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr10_-_62332357 0.69 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr10_-_101989315 0.69 ENST00000370397.7
CHUK
conserved helix-loop-helix ubiquitous kinase
chr15_+_28623784 0.67 ENST00000526619.2
ENST00000337838.7
ENST00000532622.2
GOLGA8F
golgin A8 family, member F
chr2_-_175462934 0.63 ENST00000392546.2
ENST00000436221.1
WIPF1
WAS/WASL interacting protein family, member 1
chr11_+_120039685 0.62 ENST00000530303.1
ENST00000319763.1
AP000679.2
Uncharacterized protein
chr19_+_36426452 0.55 ENST00000588831.1
LRFN3
leucine rich repeat and fibronectin type III domain containing 3
chr6_-_34113856 0.51 ENST00000538487.2
GRM4
glutamate receptor, metabotropic 4
chr9_+_125137565 0.50 ENST00000373698.5
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_-_152682129 0.49 ENST00000512306.1
ENST00000508611.1
ENST00000515812.1
ENST00000263985.6
PET112
PET112 homolog (yeast)
chr2_-_99952769 0.48 ENST00000409434.1
ENST00000434323.1
ENST00000264255.3
TXNDC9
thioredoxin domain containing 9
chr10_+_133753533 0.44 ENST00000422256.2
PPP2R2D
protein phosphatase 2, regulatory subunit B, delta
chr6_-_42690312 0.42 ENST00000230381.5
PRPH2
peripherin 2 (retinal degeneration, slow)
chr3_+_130569429 0.40 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr1_+_159141397 0.38 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr20_-_16554078 0.35 ENST00000354981.2
ENST00000355755.3
ENST00000378003.2
ENST00000408042.1
KIF16B
kinesin family member 16B
chr19_-_40596767 0.33 ENST00000599972.1
ENST00000450241.2
ENST00000595687.2
ZNF780A
zinc finger protein 780A
chr12_-_48164812 0.32 ENST00000549151.1
ENST00000548919.1
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr18_+_32173276 0.31 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chrX_+_1387721 0.26 ENST00000419094.1
ENST00000381509.3
ENST00000494969.2
ENST00000355805.2
ENST00000355432.3
CSF2RA
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr19_-_9649253 0.26 ENST00000593003.1
ZNF426
zinc finger protein 426
chr7_-_148823387 0.23 ENST00000483014.1
ENST00000378061.2
ZNF425
zinc finger protein 425
chr6_-_76203345 0.21 ENST00000393004.2
FILIP1
filamin A interacting protein 1
chr6_+_114178512 0.21 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr15_-_37392703 0.20 ENST00000382766.2
ENST00000444725.1
MEIS2
Meis homeobox 2
chr11_+_71938925 0.20 ENST00000538751.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr4_-_168155730 0.20 ENST00000502330.1
ENST00000357154.3
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr19_-_40596828 0.20 ENST00000414720.2
ENST00000455521.1
ENST00000340963.5
ENST00000595773.1
ZNF780A
zinc finger protein 780A
chr1_-_193075180 0.15 ENST00000367440.3
GLRX2
glutaredoxin 2
chr17_-_7080227 0.15 ENST00000574330.1
ASGR1
asialoglycoprotein receptor 1
chr17_+_73089382 0.14 ENST00000538213.2
ENST00000584118.1
SLC16A5
solute carrier family 16 (monocarboxylate transporter), member 5
chr1_-_8000872 0.11 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr4_-_168155700 0.10 ENST00000357545.4
ENST00000512648.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr3_+_151531810 0.09 ENST00000232892.7
AADAC
arylacetamide deacetylase
chr17_+_9728828 0.08 ENST00000262441.5
GLP2R
glucagon-like peptide 2 receptor
chr6_-_31620149 0.07 ENST00000435080.1
ENST00000375976.4
ENST00000441054.1
BAG6
BCL2-associated athanogene 6
chr11_-_62783276 0.04 ENST00000535878.1
ENST00000545207.1
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr19_+_51630287 0.03 ENST00000599948.1
SIGLEC9
sialic acid binding Ig-like lectin 9
chr12_+_7033616 0.01 ENST00000356654.4
ATN1
atrophin 1
chr17_-_19648916 0.00 ENST00000444455.1
ENST00000439102.2
ALDH3A1
aldehyde dehydrogenase 3 family, member A1

Network of associatons between targets according to the STRING database.

First level regulatory network of ZSCAN4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
2.3 7.0 GO:1900368 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
1.9 5.7 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
1.6 4.8 GO:1905154 negative regulation of eosinophil activation(GO:1902567) negative regulation of membrane invagination(GO:1905154) negative regulation of eosinophil migration(GO:2000417)
1.4 8.2 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
1.0 15.4 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
1.0 5.7 GO:0007296 vitellogenesis(GO:0007296)
0.9 10.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.8 2.4 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
0.8 2.3 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.7 2.2 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.6 2.6 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.6 5.0 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.5 1.6 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.5 2.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.4 2.5 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.4 2.4 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.4 2.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.4 1.2 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.4 1.4 GO:1903772 regulation of viral budding via host ESCRT complex(GO:1903772)
0.4 2.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.3 0.7 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.3 0.9 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.3 1.5 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.3 5.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 17.9 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.2 2.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 10.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.2 3.2 GO:0046689 response to mercury ion(GO:0046689)
0.2 6.2 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.2 2.4 GO:0030321 transepithelial chloride transport(GO:0030321)
0.2 0.7 GO:0072658 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 2.6 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.2 1.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 2.1 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.1 0.7 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.1 2.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 3.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 1.4 GO:0090240 positive regulation of histone H4 acetylation(GO:0090240)
0.1 3.1 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 1.4 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.5 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.1 0.7 GO:1902739 interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.1 1.8 GO:0000338 protein deneddylation(GO:0000338)
0.1 3.1 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 0.3 GO:0030822 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.1 7.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 10.9 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.1 4.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 4.5 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 1.9 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1 1.0 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 1.0 GO:0098779 mitophagy in response to mitochondrial depolarization(GO:0098779)
0.0 0.5 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 5.3 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 2.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.1 GO:2001179 regulation of interleukin-10 secretion(GO:2001179)
0.0 0.1 GO:1904327 maintenance of unfolded protein(GO:0036506) protein localization to cytosolic proteasome complex(GO:1904327) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.0 1.4 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 0.2 GO:0042262 DNA protection(GO:0042262)
0.0 0.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.8 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.2 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 6.5 GO:0001558 regulation of cell growth(GO:0001558)
0.0 1.0 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 7.0 GO:0044530 supraspliceosomal complex(GO:0044530)
1.0 8.2 GO:0045179 apical cortex(GO:0045179)
1.0 5.0 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.3 4.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 3.1 GO:0031595 nuclear proteasome complex(GO:0031595)
0.2 1.4 GO:0000813 ESCRT I complex(GO:0000813)
0.2 2.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 10.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 8.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 20.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.2 GO:0002080 acrosomal membrane(GO:0002080)
0.1 15.4 GO:0030426 growth cone(GO:0030426)
0.1 1.4 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.8 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 7.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 3.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 4.8 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 3.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 0.7 GO:0043194 axon initial segment(GO:0043194)
0.1 0.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 1.3 GO:0071565 nBAF complex(GO:0071565)
0.0 21.9 GO:0016607 nuclear speck(GO:0016607)
0.0 13.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 4.9 GO:0016605 PML body(GO:0016605)
0.0 2.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 9.4 GO:0005769 early endosome(GO:0005769)
0.0 6.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.7 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 0.1 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.2 GO:0043073 germ cell nucleus(GO:0043073)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 4.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
1.8 7.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
1.6 28.2 GO:0019864 IgG binding(GO:0019864)
0.7 2.2 GO:0004802 transketolase activity(GO:0004802)
0.6 2.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.5 5.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.5 1.4 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.4 8.2 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.4 4.8 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.4 2.6 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.3 2.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 2.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 5.8 GO:0005537 mannose binding(GO:0005537)
0.3 3.1 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.3 3.0 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.3 2.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 3.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 10.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 0.7 GO:0008384 IkappaB kinase activity(GO:0008384)
0.2 4.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 2.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 1.2 GO:0016413 palmitoyl-CoA hydrolase activity(GO:0016290) O-acetyltransferase activity(GO:0016413)
0.1 1.6 GO:0016918 retinal binding(GO:0016918)
0.1 0.5 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 1.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 2.5 GO:0005521 lamin binding(GO:0005521)
0.1 7.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 2.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 2.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 3.4 GO:0050699 WW domain binding(GO:0050699)
0.1 1.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 1.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.7 GO:0043295 glutathione binding(GO:0043295)
0.0 2.4 GO:0000049 tRNA binding(GO:0000049)
0.0 0.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 1.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.6 GO:0005522 profilin binding(GO:0005522)
0.0 11.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.2 GO:0030613 oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 7.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 1.7 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.2 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 1.0 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.9 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.0 4.3 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.5 GO:0043130 ubiquitin binding(GO:0043130)
0.0 2.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.5 GO:0008066 glutamate receptor activity(GO:0008066)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 15.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4 9.7 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 5.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 8.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 10.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 17.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.5 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.2 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 3.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 5.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 2.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.7 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 4.8 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.0 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.3 9.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 8.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 11.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.2 7.2 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.2 3.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 14.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 8.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 3.2 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.1 2.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 2.1 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 7.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 6.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 1.4 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 0.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.1 1.4 REACTOME KINESINS Genes involved in Kinesins
0.0 3.1 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 2.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 2.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 3.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 5.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.2 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 3.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 2.5 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 0.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events