Motif ID: AGCUUAU

Z-value: 1.037


Mature miRNA associated with seed AGCUUAU:

NamemiRBase Accession
hsa-miR-21 MIMAT0000076
hsa-miR-590-5p MIMAT0003258



Activity profile for motif AGCUUAU.

activity profile for motif AGCUUAU


Sorted Z-values histogram for motif AGCUUAU

Sorted Z-values for motif AGCUUAU



Network of associatons between targets according to the STRING database.



First level regulatory network of AGCUUAU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_18466759 4.526 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr3_-_18480203 4.522 NM_001131010
SATB1
SATB homeobox 1
chr20_-_23030141 3.635 NM_000361
THBD
thrombomodulin
chr9_-_14398981 3.267 NM_001190738
NFIB
nuclear factor I/B
chr10_+_112631552 3.091 NM_001199492
NM_014456
NM_145341
PDCD4


programmed cell death 4 (neoplastic transformation inhibitor)


chr9_-_14314036 2.994 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr8_-_9008138 2.750 NM_024607
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr5_-_88179278 2.613 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr5_-_88199868 2.471 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr8_-_9009050 2.432 NM_001201329
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr1_+_61542928 2.420 NM_001145511
NFIA
nuclear factor I/A
chr1_+_61547625 2.315 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr8_-_22549901 2.208 NM_001199880
EGR3
early growth response 3
chr1_+_61547388 2.177 NM_001145512
NFIA
nuclear factor I/A
chr8_-_22550708 2.172 NM_004430
EGR3
early growth response 3
chr8_-_22550057 2.125 NM_001199881
EGR3
early growth response 3
chr5_-_88119604 2.010 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr1_+_203274646 1.738 NM_006763
BTG2
BTG family, member 2
chr2_+_203241044 1.719 NM_001204
BMPR2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr1_+_2160133 1.653 NM_003036
SKI
v-ski sarcoma viral oncogene homolog (avian)
chr12_+_32654976 1.612 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr2_+_66662516 1.360 NM_002398
MEIS1
Meis homeobox 1
chr4_-_89744154 1.292 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr9_+_133971862 1.291 NM_001185095
NM_001185096
NM_031426
AIF1L


allograft inflammatory factor 1-like


chr8_+_98881277 1.260 NM_002380
NM_030583
MATN2

matrilin 2

chr4_-_102268626 1.222 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr4_+_4861371 1.038 NM_002448
MSX1
msh homeobox 1
chr1_+_178694273 0.962 NM_152663
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr11_-_63536112 0.955 NM_001144936
C11orf95
chromosome 11 open reading frame 95
chr2_+_45878912 0.890 NM_005400
PRKCE
protein kinase C, epsilon
chr21_-_40033617 0.889 NM_001243432
NM_001136154
NM_004449
ERG


v-ets erythroblastosis virus E26 oncogene homolog (avian)


chr12_+_27397077 0.884 NM_015000
STK38L
serine/threonine kinase 38 like
chrX_-_18372777 0.871 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chrX_-_24045302 0.866 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr21_-_39870303 0.865 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr13_+_35516390 0.860 NM_015678
NBEA
neurobeachin
chr13_+_36050885 0.835 NM_001204197
NBEA
neurobeachin
chr12_+_48516428 0.804 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr22_+_33196801 0.803 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr12_+_48499655 0.775 NM_001166686
PFKM
phosphofructokinase, muscle
chr12_+_48513012 0.736 NM_000289
PFKM
phosphofructokinase, muscle
chr6_+_148663728 0.734 NM_015278
SASH1
SAM and SH3 domain containing 1
chr2_-_43453737 0.717 NM_006887
ZFP36L2
zinc finger protein 36, C3H type-like 2
chr4_+_144257982 0.700 NM_002039
NM_207123
GAB1

GRB2-associated binding protein 1

chr2_-_55459406 0.695 NM_152385
C2orf63
chromosome 2 open reading frame 63
chr8_-_81787015 0.688 NM_001033723
ZNF704
zinc finger protein 704
chr12_-_12419702 0.669 NM_002336
LRP6
low density lipoprotein receptor-related protein 6
chr2_-_55459698 0.665 NM_001135598
C2orf63
chromosome 2 open reading frame 63
chr10_-_14816895 0.656 NM_031453
FAM107B
family with sequence similarity 107, member B
chr1_+_154377668 0.648 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr18_-_72921280 0.644 NM_175907
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr18_-_46475702 0.638 NM_001190822
SMAD7
SMAD family member 7
chr10_+_70320044 0.633 NM_030625
TET1
tet methylcytosine dioxygenase 1
chr2_+_47630246 0.624 NM_000251
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr2_-_48115846 0.624 NM_025133
FBXO11
F-box protein 11
chr18_-_46469118 0.600 NM_001190823
SMAD7
SMAD family member 7
chr9_-_98269480 0.595 NM_001083607
PTCH1
patched 1
chr18_-_33647336 0.593 NM_018170
RPRD1A
regulation of nuclear pre-mRNA domain containing 1A
chr9_-_98270321 0.593 NM_001083604
NM_001083605
PTCH1

patched 1

chr11_+_101983170 0.547 NM_001195045
YAP1
Yes-associated protein 1
chr9_-_98270830 0.540 NM_000264
PTCH1
patched 1
chr17_+_38278789 0.534 NM_001012241
MSL1
male-specific lethal 1 homolog (Drosophila)
chr1_+_65210724 0.530 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chrX_-_20284708 0.519 NM_004586
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr2_+_65283485 0.517 NM_015147
CEP68
centrosomal protein 68kDa
chr7_-_156685875 0.496 NM_022458
LMBR1
limb region 1 homolog (mouse)
chrX_+_123095555 0.494 NM_001042750
NM_001042751
NM_006603
STAG2


stromal antigen 2


chr11_+_101980736 0.487 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr9_+_36036900 0.478 NM_021111
RECK
reversion-inducing-cysteine-rich protein with kazal motifs
chr5_-_38595506 0.473 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr6_+_119215240 0.472 NM_014034
ASF1A
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
chr1_-_68299047 0.462 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr7_+_11013453 0.450 NM_014660
PHF14
PHD finger protein 14
chr2_+_86947387 0.448 NM_022780
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr11_+_121163501 0.438 NM_001024956
SC5DL
sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like
chr5_-_38556682 0.435 NM_001127671
LIFR
leukemia inhibitory factor receptor alpha
chr18_-_46477080 0.415 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr3_+_43328001 0.409 NM_001100594
NM_017719
SNRK

SNF related kinase

chr22_+_40573879 0.409 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr8_-_97247757 0.406 NM_001199975
NM_006294
UQCRB

ubiquinol-cytochrome c reductase binding protein

chr3_+_49506079 0.396 NM_001177643
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr14_+_57046490 0.390 NM_017799
C14orf101
chromosome 14 open reading frame 101
chr9_+_115513050 0.389 NM_001012994
SNX30
sorting nexin family member 30
chr10_+_72163860 0.378 NM_004096
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr11_+_121163343 0.377 NM_006918
SC5DL
sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like
chr16_-_4588379 0.377 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr10_+_30722856 0.373 NM_001244134
NM_005204
MAP3K8

mitogen-activated protein kinase kinase kinase 8

chr16_+_69220940 0.370 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr11_+_120207617 0.354 NM_001198665
NM_015313
ARHGEF12

Rho guanine nucleotide exchange factor (GEF) 12

chr4_+_113152838 0.351 NM_001128426
NM_018569
AP1AR

adaptor-related protein complex 1 associated regulatory protein

chr2_-_180129245 0.345 NM_178123
SESTD1
SEC14 and spectrin domains 1
chr2_+_20646831 0.339 NM_004040
RHOB
ras homolog gene family, member B
chr2_+_170683900 0.339 NM_172070
UBR3
ubiquitin protein ligase E3 component n-recognin 3 (putative)
chr5_+_56110899 0.337 NM_005921
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr9_-_98269686 0.337 NM_001083606
PTCH1
patched 1
chr17_-_30669133 0.333 NM_022344
C17orf75
chromosome 17 open reading frame 75
chr7_-_30029904 0.327 NM_001145514
SCRN1
secernin 1
chr1_+_33004771 0.324 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr14_+_37667116 0.323 NM_001195296
NM_001195297
NM_138731
MIPOL1


mirror-image polydactyly 1


chr1_-_153895450 0.319 NM_020699
GATAD2B
GATA zinc finger domain containing 2B
chr7_+_8008416 0.316 NM_138426
GLCCI1
glucocorticoid induced transcript 1
chr3_+_49507470 0.304 NM_001165928
NM_001177634
NM_001177635
NM_001177636
NM_001177637
NM_001177638
NM_001177639
NM_001177640
NM_001177641
NM_001177642
NM_001177644
NM_004393
DAG1











dystroglycan 1 (dystrophin-associated glycoprotein 1)











chr7_-_30029284 0.299 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr16_-_4588738 0.297 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr8_-_11058847 0.283 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr5_-_89770432 0.282 NM_203406
MBLAC2
metallo-beta-lactamase domain containing 2
chr12_-_76425375 0.278 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr8_-_57123858 0.278 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr1_-_47134039 0.278 NM_001042546
NM_022745
ATPAF1

ATP synthase mitochondrial F1 complex assembly factor 1

chr8_-_10587942 0.270 NM_031439
SOX7
SRY (sex determining region Y)-box 7
chr15_+_66161769 0.268 NM_001206836
NM_004663
RAB11A

RAB11A, member RAS oncogene family

chr12_-_9913415 0.267 NM_001781
CD69
CD69 molecule
chr3_+_151985828 0.260 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr3_+_98451537 0.258 NM_006100
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr2_-_218808705 0.255 NM_022648
TNS1
tensin 1
chr10_-_3827418 0.249 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr5_-_54281345 0.243 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr13_+_73633097 0.240 NM_001730
KLF5
Kruppel-like factor 5 (intestinal)
chr1_-_26680620 0.235 NM_001039775
AIM1L
absent in melanoma 1-like
chr9_-_99180661 0.232 NM_153695
ZNF367
zinc finger protein 367
chr6_+_32939371 0.230 NM_001199455
BRD2
bromodomain containing 2
chr17_-_77813049 0.227 NM_003655
CBX4
chromobox homolog 4
chr20_+_278200 0.225 NM_033089
ZCCHC3
zinc finger, CCHC domain containing 3
chr15_-_49338496 0.223 NM_001193489
NM_014701
SECISBP2L

SECIS binding protein 2-like

chrX_+_123094377 0.213 NM_001042749
STAG2
stromal antigen 2
chr1_-_214724974 0.213 NM_005401
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr22_+_40440664 0.212 NM_001024843
TNRC6B
trinucleotide repeat containing 6B
chr6_-_116575170 0.212 NM_021648
TSPYL4
TSPY-like 4
chr5_+_86564727 0.210 NM_022650
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr4_+_86699846 0.209 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr2_-_48132656 0.209 NM_001190274
FBXO11
F-box protein 11
chr12_+_85673884 0.207 NM_006982
ALX1
ALX homeobox 1
chr3_-_52719514 0.207 NM_018313
PBRM1
polybromo 1
chr4_+_86396251 0.203 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr7_+_72349925 0.202 NM_172020
POM121
POM121 membrane glycoprotein
chr7_-_91875296 0.198 NM_194455
NM_194456
KRIT1

KRIT1, ankyrin repeat containing

chr19_+_14491920 0.190 NM_001025160
NM_001784
NM_078481
CD97


CD97 molecule


chr16_-_4897265 0.184 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr3_+_182511284 0.184 NM_014616
ATP11B
ATPase, class VI, type 11B
chr3_+_152017193 0.183 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr5_+_86564044 0.181 NM_002890
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr9_-_123476578 0.177 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr16_-_20911560 0.176 NM_173475
DCUN1D3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr9_-_34589679 0.173 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chr12_+_27175482 0.167 NM_004264
MED21
mediator complex subunit 21
chr9_-_34590137 0.164 NM_001207011
CNTFR
ciliary neurotrophic factor receptor
chr6_-_46889620 0.163 NM_001098518
GPR116
G protein-coupled receptor 116
chr9_-_98279246 0.162 NM_001083602
NM_001083603
PTCH1

patched 1

chr1_+_53192021 0.161 NM_024646
ZYG11B
zyg-11 homolog B (C. elegans)
chr4_-_129209983 0.158 NM_006320
PGRMC2
progesterone receptor membrane component 2
chr4_+_81952118 0.157 NM_001201
BMP3
bone morphogenetic protein 3
chr6_-_134373618 0.155 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr4_+_124317884 0.154 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr7_+_101460881 0.154 NM_181552
CUX1
cut-like homeobox 1
chr12_+_5019048 0.153 NM_000217
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chr3_-_52713728 0.150 NM_018165
NM_181042
PBRM1

polybromo 1

chr8_+_9413439 0.148 NM_003747
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr19_+_34745452 0.147 NM_014686
KIAA0355
KIAA0355
chr6_+_32938658 0.144 NM_001113182
BRD2
bromodomain containing 2
chr11_+_118230292 0.144 NM_001204077
NM_004788
UBE4A

ubiquitination factor E4A

chr11_-_130786374 0.140 NM_014758
SNX19
sorting nexin 19
chr16_-_2246464 0.140 NM_020764
CASKIN1
CASK interacting protein 1
chr9_-_16870719 0.138 NM_017637
BNC2
basonuclin 2
chr14_-_68162419 0.136 NM_001252650
NM_016026
RDH11

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

chr7_+_138916230 0.132 NM_173569
UBN2
ubinuclein 2
chr16_+_69599868 0.129 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NM_173215
NFAT5





nuclear factor of activated T-cells 5, tonicity-responsive





chr6_+_32940860 0.128 NM_001199456
BRD2
bromodomain containing 2
chr7_-_75115536 0.124 NM_001099415
POM121C
POM121 membrane glycoprotein C
chrX_-_100641143 0.122 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr17_+_61627818 0.122 NM_005828
DCAF7
DDB1 and CUL4 associated factor 7
chr4_+_124320664 0.122 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr8_+_87354958 0.122 NM_007013
WWP1
WW domain containing E3 ubiquitin protein ligase 1
chr4_-_111544206 0.122 NM_000325
PITX2
paired-like homeodomain 2
chr1_+_222791151 0.120 NM_198551
MIA3
melanoma inhibitory activity family, member 3
chr4_+_86851425 0.120 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr10_+_6130936 0.113 NM_032905
RBM17
RNA binding motif protein 17
chr11_-_44331612 0.112 NM_021926
ALX4
ALX homeobox 4
chr13_+_20532906 0.108 NM_001190965
ZMYM2
zinc finger, MYM-type 2
chr13_+_28712379 0.108 NM_175854
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr9_+_115142188 0.108 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr7_-_44924946 0.107 NM_033224
PURB
purine-rich element binding protein B
chr6_+_32936400 0.107 NM_005104
BRD2
bromodomain containing 2
chr1_+_224301790 0.105 NM_001136115
NM_015176
FBXO28

F-box protein 28

chr10_+_6131034 0.103 NM_001145547
RBM17
RNA binding motif protein 17
chr6_-_159466019 0.102 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr3_+_159706622 0.098 NM_000882
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr12_+_65563339 0.094 NM_001167614
NM_014319
LEMD3

LEM domain containing 3

chr3_+_10183318 0.092 NM_000551
NM_198156
VHL

von Hippel-Lindau tumor suppressor

chr5_-_150080597 0.086 NM_018047
RBM22
RNA binding motif protein 22
chr13_+_20532788 0.080 NM_003453
NM_197968
NM_001190964
ZMYM2


zinc finger, MYM-type 2


chr1_-_151735971 0.074 NM_031420
MRPL9
mitochondrial ribosomal protein L9
chr1_-_151966713 0.072 NM_002966
S100A10
S100 calcium binding protein A10
chr4_-_89978117 0.071 NM_014883
FAM13A
family with sequence similarity 13, member A
chr15_+_51200864 0.069 NM_001252127
NM_007347
AP4E1

adaptor-related protein complex 4, epsilon 1 subunit

chr20_-_49547451 0.068 NM_015339
NM_181442
ADNP

activity-dependent neuroprotector homeobox

chr16_-_4292052 0.066 NM_001098814
SRL
sarcalumenin
chr1_-_207224298 0.066 NM_018566
YOD1
YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae)
chr5_+_60628085 0.056 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chrX_+_72782961 0.054 NM_001039840
CHIC1
cysteine-rich hydrophobic domain 1
chr2_+_148602569 0.052 NM_001616
ACVR2A
activin A receptor, type IIA

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.82 1.54e-03 GO:0042981 regulation of apoptosis
2.80 1.80e-03 GO:0043067 regulation of programmed cell death
1.48 2.23e-03 GO:0050794 regulation of cellular process
2.76 2.41e-03 GO:0010941 regulation of cell death
1.96 2.62e-03 GO:0048518 positive regulation of biological process
9.10 2.67e-03 GO:0030326 embryonic limb morphogenesis
9.10 2.67e-03 GO:0035113 embryonic appendage morphogenesis
1.82 3.76e-03 GO:0060255 regulation of macromolecule metabolic process
2.01 5.81e-03 GO:0048519 negative regulation of biological process
31.12 5.93e-03 GO:0032925 regulation of activin receptor signaling pathway
12.91 6.33e-03 GO:0030510 regulation of BMP signaling pathway
8.02 6.92e-03 GO:0035107 appendage morphogenesis
8.02 6.92e-03 GO:0035108 limb morphogenesis
1.43 8.92e-03 GO:0050789 regulation of biological process
60.68 9.01e-03 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
2.05 9.11e-03 GO:0048523 negative regulation of cellular process
7.71 9.23e-03 GO:0048736 appendage development
7.71 9.23e-03 GO:0060173 limb development
1.95 1.34e-02 GO:0048522 positive regulation of cellular process
2.27 1.78e-02 GO:0009653 anatomical structure morphogenesis
50.57 1.79e-02 GO:0010224 response to UV-B
14.05 2.53e-02 GO:0045768 positive regulation of anti-apoptosis
1.70 3.83e-02 GO:0080090 regulation of primary metabolic process
37.93 4.94e-02 GO:0051593 response to folic acid

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
75.85 6.05e-04 GO:0004897 ciliary neurotrophic factor receptor activity
2.51 7.18e-03 GO:0001071 nucleic acid binding transcription factor activity
2.51 7.18e-03 GO:0003700 sequence-specific DNA binding transcription factor activity