Motif ID: AGUGGUU

Z-value: 0.709


Mature miRNA associated with seed AGUGGUU:

NamemiRBase Accession
hsa-miR-140-5p MIMAT0000431



Activity profile for motif AGUGGUU.

activity profile for motif AGUGGUU


Sorted Z-values histogram for motif AGUGGUU

Sorted Z-values for motif AGUGGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of AGUGGUU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_141704575 1.452 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr1_-_33336289 1.124 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr1_-_33338081 1.034 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr9_-_107690526 0.981 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr12_-_111021026 0.880 NM_139283
PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr20_+_6748744 0.877 NM_001200
BMP2
bone morphogenetic protein 2
chr11_-_8932497 0.841 NM_005418
ST5
suppression of tumorigenicity 5
chr11_-_8832881 0.825 NM_139157
ST5
suppression of tumorigenicity 5
chr11_-_8832189 0.811 NM_213618
ST5
suppression of tumorigenicity 5
chr8_+_81398416 0.766 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr9_-_73029539 0.753 NM_001206
KLF9
Kruppel-like factor 9
chr7_-_98741681 0.737 NM_001199847
NM_020429
NM_181349
SMURF1


SMAD specific E3 ubiquitin protein ligase 1


chr9_-_22009270 0.706 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr12_-_12715244 0.633 NM_030640
DUSP16
dual specificity phosphatase 16
chr19_+_11200037 0.614 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr9_-_115095933 0.558 NM_001163788
NM_001163790
NM_001244896
NM_001244897
NM_005156
PTBP3




polypyrimidine tract binding protein 3




chr5_+_38845962 0.554 NM_003999
OSMR
oncostatin M receptor
chr6_+_106534188 0.549 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr6_+_4776641 0.530 NM_004824
CDYL
chromodomain protein, Y-like
chr8_-_101322245 0.517 NM_183419
RNF19A
ring finger protein 19A
chr7_-_32931409 0.512 NM_015483
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr5_-_38595506 0.508 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chr17_-_63052884 0.504 NM_006572
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr6_+_4890225 0.494 NM_001143971
CDYL
chromodomain protein, Y-like
chr5_-_38556682 0.491 NM_001127671
LIFR
leukemia inhibitory factor receptor alpha
chr8_-_101315457 0.490 NM_015435
RNF19A
ring finger protein 19A
chr12_+_45609767 0.470 NM_001025356
NM_001142679
NM_001204803
ANO6


anoctamin 6


chr17_-_53499055 0.464 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr14_+_70078309 0.462 NM_014734
KIAA0247
KIAA0247
chr11_-_47516072 0.449 NM_198700
CELF1
CUGBP, Elav-like family member 1
chr9_+_101867401 0.445 NM_001130916
NM_004612
TGFBR1

transforming growth factor, beta receptor 1

chr5_-_16936371 0.437 NM_012334
MYO10
myosin X
chr8_+_70378858 0.433 NM_001128204
NM_015170
SULF1

sulfatase 1

chr6_+_4836331 0.432 NM_001143970
CDYL
chromodomain protein, Y-like
chr15_-_59041933 0.425 NM_001110
ADAM10
ADAM metallopeptidase domain 10
chr9_+_112810877 0.421 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr12_+_45686465 0.417 NM_001142678
ANO6
anoctamin 6
chr17_+_26369617 0.415 NM_016231
NLK
nemo-like kinase
chr20_-_10654429 0.412 NM_000214
JAG1
jagged 1
chr6_-_131291480 0.409 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr3_-_52713728 0.403 NM_018165
NM_181042
PBRM1

polybromo 1

chr9_+_112887780 0.396 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr11_+_109964086 0.394 NM_033390
ZC3H12C
zinc finger CCCH-type containing 12C
chr21_-_15755439 0.394 NM_006948
HSPA13
heat shock protein 70kDa family, member 13
chr1_-_68299047 0.389 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr12_-_105322056 0.384 NM_032148
SLC41A2
solute carrier family 41, member 2
chr8_+_70405027 0.382 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr15_-_48937795 0.381 NM_000138
FBN1
fibrillin 1
chr4_-_146859568 0.378 NM_178835
ZNF827
zinc finger protein 827
chr10_+_102106771 0.377 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr8_+_38854431 0.371 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chrX_-_154563735 0.367 NM_001289
CLIC2
chloride intracellular channel 2
chr6_+_106546736 0.361 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chrX_+_70752911 0.346 NM_181672
NM_181673
OGT

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr2_+_242254722 0.340 NM_001008491
NM_006155
SEPT2

septin 2

chr1_-_182361311 0.330 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr6_+_143929316 0.329 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr15_-_23086842 0.321 NM_001142275
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr1_+_182992329 0.321 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr1_-_55681024 0.319 NM_015306
USP24
ubiquitin specific peptidase 24
chr20_-_30310597 0.312 NM_001191
NM_138578
BCL2L1

BCL2-like 1

chr6_-_131384387 0.309 NM_001135554
NM_001135555
NM_001199388
NM_001431
EPB41L2



erythrocyte membrane protein band 4.1-like 2



chr6_-_110501164 0.308 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr14_-_82000198 0.307 NM_001244984
NM_005065
SEL1L

sel-1 suppressor of lin-12-like (C. elegans)

chr2_+_208394615 0.305 NM_004379
NM_134442
CREB1

cAMP responsive element binding protein 1

chr15_+_99192696 0.303 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr15_-_23086290 0.302 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr2_+_111878450 0.296 NM_001204106
NM_001204107
NM_001204108
NM_001204109
NM_001204110
NM_001204111
NM_001204112
NM_001204113
NM_006538
NM_138621
NM_138622
NM_138623
NM_138624
NM_138625
NM_138626
NM_138627
NM_207002
NM_207003
BCL2L11

















BCL2-like 11 (apoptosis facilitator)

















chr1_+_33116748 0.291 NM_001135255
NM_005610
NM_001135256
RBBP4


retinoblastoma binding protein 4


chr6_+_37225506 0.287 NM_017772
TBC1D22B
TBC1 domain family, member 22B
chr11_-_47574766 0.287 NM_006560
CELF1
CUGBP, Elav-like family member 1
chr15_+_42787457 0.283 NM_003825
NM_130798
SNAP23

synaptosomal-associated protein, 23kDa

chr17_+_31254927 0.279 NM_001033504
NM_015544
TMEM98

transmembrane protein 98

chr2_-_178129858 0.276 NM_006164
NFE2L2
nuclear factor (erythroid-derived 2)-like 2
chr3_-_52719514 0.274 NM_018313
PBRM1
polybromo 1
chr12_-_96794207 0.270 NM_001170464
NM_002595
CDK17

cyclin-dependent kinase 17

chr6_-_90062610 0.269 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr5_+_65222381 0.269 NM_001006600
NM_001253697
NM_001253698
NM_001253699
NM_001253701
NM_018695
ERBB2IP





erbb2 interacting protein





chr11_-_47510518 0.268 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr10_+_97471535 0.268 NM_001098175
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr10_-_116286661 0.268 NM_006720
ABLIM1
actin binding LIM protein 1
chr1_-_182360400 0.260 NM_001033056
GLUL
glutamate-ammonia ligase
chr16_-_20911560 0.259 NM_173475
DCUN1D3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr2_+_208576239 0.257 NM_001142300
NM_152523
CCNYL1

cyclin Y-like 1

chr1_+_117910052 0.256 NM_006699
MAN1A2
mannosidase, alpha, class 1A, member 2
chr14_-_88460008 0.250 NM_001201402
GALC
galactosylceramidase
chr2_+_242255270 0.250 NM_001008492
NM_004404
SEPT2

septin 2

chr3_+_42132707 0.247 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chrX_-_77395108 0.243 NM_015975
TAF9B
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
chr8_-_12612968 0.242 NM_152271
LONRF1
LON peptidase N-terminal domain and ring finger 1
chr1_-_173962050 0.242 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chr10_-_116418056 0.240 NM_002313
ABLIM1
actin binding LIM protein 1
chr19_-_47735858 0.239 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr10_+_97515408 0.239 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr18_-_55253785 0.238 NM_000140
NM_001012515
FECH

ferrochelatase

chr4_-_113206883 0.236 NM_052864
TIFA
TRAF-interacting protein with forkhead-associated domain
chr6_+_143999058 0.231 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr12_-_25055966 0.228 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr14_+_69865380 0.227 NM_001252148
NM_001252150
NM_018375
SLC39A9


solute carrier family 39 (zinc transporter), member 9


chr9_+_112542496 0.226 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr14_-_88459469 0.222 NM_000153
NM_001201401
GALC

galactosylceramidase

chr2_-_197457250 0.219 NM_020760
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr5_-_56247915 0.218 NM_152622
MIER3
mesoderm induction early response 1, family member 3
chr1_-_236228476 0.216 NM_002508
NID1
nidogen 1
chr10_-_116444374 0.216 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr1_-_86043932 0.211 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_-_200820458 0.209 NM_001039693
TYW5
tRNA-yW synthesizing protein 5
chr1_+_178694273 0.208 NM_152663
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr8_+_75262616 0.206 NM_018972
NM_001040875
GDAP1

ganglioside-induced differentiation-associated protein 1

chr7_-_66460403 0.206 NM_016038
SBDS
Shwachman-Bodian-Diamond syndrome
chr6_+_41040687 0.205 NM_002505
NM_021705
NFYA

nuclear transcription factor Y, alpha

chrX_+_41192650 0.203 NM_001193416
NM_001193417
NM_001356
DDX3X


DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked


chr6_-_35656677 0.202 NM_001145776
NM_001145777
NM_004117
FKBP5


FK506 binding protein 5


chr16_-_23160509 0.200 NM_020718
USP31
ubiquitin specific peptidase 31
chr13_+_46039024 0.200 NM_031431
COG3
component of oligomeric golgi complex 3
chr18_-_45457454 0.199 NM_001003652
NM_001135937
SMAD2

SMAD family member 2

chr9_+_132815984 0.197 NM_001136557
NM_001136558
NM_020960
GPR107


G protein-coupled receptor 107


chr18_-_45456925 0.196 NM_005901
SMAD2
SMAD family member 2
chr1_-_85930733 0.186 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr4_-_76823575 0.186 NM_006239
PPEF2
protein phosphatase, EF-hand calcium binding domain 2
chr21_+_40759688 0.186 NM_001146218
WRB
tryptophan rich basic protein
chr19_-_47734215 0.185 NM_014417
BBC3
BCL2 binding component 3
chr3_-_195808958 0.183 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr5_+_149887673 0.182 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr11_-_10830581 0.180 NM_001042559
NM_001418
EIF4G2

eukaryotic translation initiation factor 4 gamma, 2

chrX_-_30907408 0.180 NM_152787
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr11_-_47545539 0.180 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr7_-_112430408 0.178 NM_022484
TMEM168
transmembrane protein 168
chr12_-_25055228 0.177 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr21_-_16437125 0.176 NM_003489
NRIP1
nuclear receptor interacting protein 1
chr10_+_31608097 0.176 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr13_+_113344354 0.175 NM_015205
NM_032189
ATP11A

ATPase, class VI, type 11A

chr8_-_80679897 0.174 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr1_+_203764750 0.174 NM_014827
ZC3H11A
zinc finger CCCH-type containing 11A
chrX_+_57618268 0.171 NM_007157
ZXDB
zinc finger, X-linked, duplicated B
chr6_-_108395939 0.169 NM_014028
OSTM1
osteopetrosis associated transmembrane protein 1
chr6_+_57037058 0.169 NM_004282
BAG2
BCL2-associated athanogene 2
chr12_-_25102281 0.169 NM_001178091
NM_001178092
NM_005504
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr11_-_64646053 0.166 NM_006795
EHD1
EH-domain containing 1
chr20_-_48732479 0.166 NM_022442
NM_021988
NM_199144
UBE2V1


ubiquitin-conjugating enzyme E2 variant 1


chr8_-_67579446 0.166 NM_025054
VCPIP1
valosin containing protein (p97)/p47 complex interacting protein 1
chr6_-_31628509 0.165 NM_021184
C6orf47
chromosome 6 open reading frame 47
chrX_+_103411065 0.163 NM_207318
FAM199X
family with sequence similarity 199, X-linked
chr17_-_60142598 0.163 NM_005121
MED13
mediator complex subunit 13
chr6_-_47277646 0.162 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr7_+_128379345 0.161 NM_001130674
NM_001199671
NM_001199672
NM_001199673
NM_001199674
NM_001219
CALU





calumenin





chr9_+_132962871 0.153 NM_001128826
NCS1
neuronal calcium sensor 1
chr14_+_23775970 0.152 NM_001199864
NM_004050
NM_001199839
BCL2L2-PABPN1
BCL2L2

BCL2L2-PABPN1 readthrough
BCL2-like 2

chr20_+_43990576 0.149 NM_001197129
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr10_+_101419169 0.148 NM_020354
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr20_+_49348050 0.145 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr7_-_25164902 0.144 NM_018947
CYCS
cytochrome c, somatic
chr4_+_142557722 0.143 NM_000585
NM_172175
IL15

interleukin 15

chr20_-_48729664 0.141 NM_001032288
UBE2V1
ubiquitin-conjugating enzyme E2 variant 1
chr11_-_10829519 0.139 NM_001172705
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr18_+_9136742 0.138 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr10_+_31610063 0.137 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr13_+_102104941 0.137 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr1_+_166808721 0.137 NM_017542
POGK
pogo transposable element with KRAB domain
chr19_-_44143943 0.137 NM_145296
CADM4
cell adhesion molecule 4
chr16_+_69599868 0.136 NM_001113178
NM_006599
NM_138713
NM_138714
NM_173214
NM_173215
NFAT5





nuclear factor of activated T-cells 5, tonicity-responsive





chr10_-_104262404 0.135 NM_005736
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr22_-_36784055 0.135 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr11_+_30252562 0.134 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr21_+_40752212 0.134 NM_004627
WRB
tryptophan rich basic protein
chr12_-_50101192 0.133 NM_175736
NM_198900
FMNL3

formin-like 3

chr11_+_46299161 0.132 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr18_+_9137560 0.131 NM_001204056
ANKRD12
ankyrin repeat domain 12
chr18_-_57026465 0.128 NM_005570
LMAN1
lectin, mannose-binding, 1
chr1_+_100503654 0.128 NM_033055
HIAT1
hippocampus abundant transcript 1
chr4_-_152096655 0.128 NM_001128924
SH3D19
SH3 domain containing 19
chr16_-_48419148 0.128 NM_003031
SIAH1
seven in absentia homolog 1 (Drosophila)
chr1_+_155100304 0.127 NM_004428
NM_182685
EFNA1

ephrin-A1

chr2_-_178128527 0.123 NM_001145412
NM_001145413
NFE2L2

nuclear factor (erythroid-derived 2)-like 2

chr13_-_95953572 0.123 NM_001105515
NM_005845
ABCC4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

chr15_+_81071708 0.123 NM_018689
KIAA1199
KIAA1199
chr1_-_207224298 0.121 NM_018566
YOD1
YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae)
chr9_+_132934685 0.120 NM_014286
NCS1
neuronal calcium sensor 1
chr7_-_106301329 0.119 NM_175884
C7orf74
chromosome 7 open reading frame 74
chr4_+_155665150 0.118 NM_004744
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr20_-_4804067 0.117 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr1_+_10270680 0.117 NM_015074
NM_183416
KIF1B

kinesin family member 1B

chr12_+_12764755 0.117 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr20_-_57617836 0.116 NM_016045
SLMO2
slowmo homolog 2 (Drosophila)
chr1_-_117210301 0.116 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr12_-_56652118 0.115 NM_173595
ANKRD52
ankyrin repeat domain 52
chr20_-_4795768 0.114 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr22_-_18507151 0.113 NM_001122731
NM_001136004
NM_015241
MICAL3


microtubule associated monoxygenase, calponin and LIM domain containing 3


chrX_+_37208527 0.113 NM_000950
NM_001142395
NM_001173486
NM_001173489
NM_001173490
PRRG1




proline rich Gla (G-carboxyglutamic acid) 1




chr4_-_111563278 0.110 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr12_-_498428 0.110 NM_001042603
KDM5A
lysine (K)-specific demethylase 5A
chr9_-_99801924 0.108 NM_001201575
CTSL2
cathepsin L2
chr9_-_99801365 0.104 NM_001333
CTSL2
cathepsin L2
chr7_-_44924946 0.103 NM_033224
PURB
purine-rich element binding protein B
chr21_-_34100228 0.102 NM_001160302
NM_001160306
SYNJ1

synaptojanin 1

chr3_+_111578026 0.102 NM_001134438
NM_145753
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr7_+_94536926 0.102 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr16_-_48399783 0.101 NM_001006610
SIAH1
seven in absentia homolog 1 (Drosophila)
chrX_-_63425484 0.101 NM_152424
FAM123B
family with sequence similarity 123B
chr6_+_47445440 0.099 NM_012120
CD2AP
CD2-associated protein

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.38 1.35e-02 GO:0045165 cell fate commitment
1.72 4.40e-02 GO:0006464 protein modification process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.56 9.78e-03 GO:0005768 endosome
1.15 1.87e-02 GO:0044424 intracellular part
1.15 2.23e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.29 2.88e-03 GO:0005515 protein binding
7.44 1.18e-02 GO:0046332 SMAD binding
17.40 1.71e-02 GO:0070411 I-SMAD binding
1.14 2.59e-02 GO:0005488 binding
14.72 3.58e-02 GO:0070412 R-SMAD binding