Motif ID: AIRE.p2

Z-value: 0.686


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
AIREchr21_+_45710147-0.213.2e-01Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_15704752 1.502 BST1
bone marrow stromal cell antigen 1
chr22_-_36556781 1.423 NM_145640
APOL3
apolipoprotein L, 3
chr1_-_7973286 1.324 UTS2
urotensin 2
chr1_-_89664510 1.240 NM_052941
GBP4
guanylate binding protein 4
chr2_+_152214105 1.192 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr13_+_50070096 1.120 PHF11
PHD finger protein 11
chr4_+_70916158 1.020 NM_002159
HTN1
histatin 1
chr11_-_64727608 0.978 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr19_+_13135368 0.749 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr7_-_77045706 0.741 NM_017439
PION
pigeon homolog (Drosophila)
chr4_-_139163222 0.735 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr4_+_70146216 0.711 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr1_-_8003224 0.700 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr8_+_144731829 0.685 NM_014789
ZNF623
zinc finger protein 623
chr17_-_34207308 0.629 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr4_-_123542165 0.626 NM_001207006
NM_021803
IL21

interleukin 21

chr7_-_45151272 0.609 TBRG4
transforming growth factor beta regulator 4
chr9_-_85946875 0.601 NM_001244961
FRMD3
FERM domain containing 3
chr16_-_11680756 0.555 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr3_+_29322802 0.547 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr6_+_31683084 0.540 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr4_+_15704691 0.519 BST1
bone marrow stromal cell antigen 1
chr13_-_33859835 0.503 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr6_+_4890225 0.493 NM_001143971
CDYL
chromodomain protein, Y-like
chr3_-_123339423 0.488 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr7_-_64467006 0.463 NM_001007253
ERV3-1
endogenous retrovirus group 3, member 1
chr14_-_58893867 0.460 TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr2_+_29038862 0.442 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr2_+_65215577 0.435 NM_001193493
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr3_-_150920946 0.421 NM_013308
GPR171
G protein-coupled receptor 171
chr10_-_94003002 0.392 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr17_-_40021616 0.391 NM_018143
KLHL11
kelch-like 11 (Drosophila)
chr7_-_115608366 0.389 NM_001244583
TFEC
transcription factor EC
chr11_+_73661363 0.388 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr12_+_55248298 0.387 NM_058173
MUCL1
mucin-like 1
chr1_-_247921707 0.380 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr18_+_29171729 0.372 NM_000371
TTR
transthyretin
chr8_-_13134028 0.368 DLC1
deleted in liver cancer 1
chr4_+_15704572 0.367 NM_004334
BST1
bone marrow stromal cell antigen 1
chr9_+_118916069 0.364 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr6_+_26365397 0.361 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr7_-_122339186 0.360 NM_139175
RNF133
ring finger protein 133
chr22_+_36649116 0.345 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr18_-_58040000 0.338 NM_005912
MC4R
melanocortin 4 receptor
chr4_+_89299874 0.335 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr12_+_21168629 0.330 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr11_-_102668892 0.319 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr3_-_15382874 0.316 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr15_+_100173182 0.315 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr11_-_4629371 0.314 NM_018073
TRIM68
tripartite motif containing 68
chr15_-_99789585 0.295 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr14_-_60632019 0.292 DHRS7
dehydrogenase/reductase (SDR family) member 7
chr9_-_77502635 0.290 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr15_+_41576150 0.288 OIP5-AS1
OIP5 antisense RNA 1 (non-protein coding)
chr7_-_92777657 0.287 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr21_-_19775958 0.286 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr8_-_37727937 0.284 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr11_+_55029657 0.283 NM_024114
TRIM48
tripartite motif containing 48
chr18_-_61311465 0.282 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr19_+_7599037 0.282 NM_006702
NM_001166112
PNPLA6

patatin-like phospholipase domain containing 6

chr4_+_87968191 0.279 AFF1
AF4/FMR2 family, member 1
chr22_+_36649172 0.276 APOL1
apolipoprotein L, 1
chr14_-_45431121 0.276 NM_017658
KLHL28
kelch-like 28 (Drosophila)
chr9_+_71650478 0.275 NM_000144
NM_001161706
NM_181425
FXN


frataxin


chr10_+_135207607 0.267 NM_138384
MTG1
mitochondrial GTPase 1 homolog (S. cerevisiae)
chr10_+_91087601 0.267 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr3_-_14583587 0.264 NM_001080423
GRIP2
glutamate receptor interacting protein 2
chr12_-_53600999 0.261 NM_000889
ITGB7
integrin, beta 7
chr19_-_43421944 0.260 NM_002782
NM_001031850
PSG6

pregnancy specific beta-1-glycoprotein 6

chr16_-_11680146 0.259 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr4_+_17578838 0.258 NM_015907
LAP3
leucine aminopeptidase 3
chrX_+_52926334 0.254 FAM156A
FAM156B
family with sequence similarity 156, member A
family with sequence similarity 156, member B
chr9_-_77503009 0.250 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr6_-_37467621 0.249 CCDC167
coiled-coil domain containing 167
chr7_+_76109826 0.246 NM_001102596
DTX2
deltex homolog 2 (Drosophila)
chr1_-_32385258 0.245 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chrX_-_52987610 0.244 NM_001242491
FAM156A
FAM156B
family with sequence similarity 156, member A
family with sequence similarity 156, member B
chr5_+_60933635 0.239 NM_173667
C5orf64
chromosome 5 open reading frame 64
chr14_-_45431090 0.239 KLHL28
kelch-like 28 (Drosophila)
chr3_-_194119994 0.237 NM_004488
GP5
glycoprotein V (platelet)
chr13_-_99910548 0.237 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chrX_+_52926317 0.236 NM_001242491
FAM156A
family with sequence similarity 156, member A
chr6_-_33756905 0.236 NM_181336
LEMD2
LEM domain containing 2
chr6_+_31590468 0.233


chr19_-_14939275 0.230 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr18_+_21572736 0.229 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr3_-_186262114 0.229 NM_017541
CRYGS
crystallin, gamma S
chr13_+_23755059 0.228 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr5_+_140529619 0.228 NM_018939
PCDHB6
protocadherin beta 6
chr17_-_26127395 0.226 NOS2
nitric oxide synthase 2, inducible
chr14_+_39734475 0.225 NM_203354
CTAGE5
CTAGE family, member 5
chr1_-_170043608 0.225 NM_001204514
NM_001204516
NM_014970
KIFAP3


kinesin-associated protein 3


chr3_+_189507448 0.221 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr19_-_12834628 0.221 NM_001136195
TNPO2
transportin 2
chr11_+_65479685 0.217 KAT5
K(lysine) acetyltransferase 5
chrX_+_50027539 0.217 NM_033031
NM_033670
CCNB3

cyclin B3

chr3_+_46395224 0.216 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr17_-_50237342 0.216 NM_001082534
CA10
carbonic anhydrase X
chr11_+_125756954 0.216 NM_001134793
HYLS1
hydrolethalus syndrome 1
chr6_-_90062450 0.215 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr12_-_67072881 0.213 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1

chr5_-_119740531 0.211


chr5_-_96149804 0.209 NM_001198541
ERAP1
endoplasmic reticulum aminopeptidase 1
chr15_-_20747113 0.209 NM_001145004
GOLGA6L6
golgin A6 family-like 6
chr11_-_102668822 0.209 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr5_-_149792370 0.209 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr7_-_45151297 0.208 NM_004749
NM_030900
NM_199122
TBRG4


transforming growth factor beta regulator 4


chr3_-_123339178 0.206 MYLK
myosin light chain kinase
chr19_+_21264952 0.206 NM_182515
ZNF714
zinc finger protein 714
chr5_+_173472692 0.206 NM_015980
HMP19
HMP19 protein
chr17_-_50237160 0.206 NM_001082533
CA10
carbonic anhydrase X
chr3_+_39424766 0.202 NM_017875
SLC25A38
solute carrier family 25, member 38
chr6_+_27292539 0.202 NM_032030
FKSG83
FKSG83
chr6_-_37467688 0.200 NM_138493
CCDC167
coiled-coil domain containing 167
chr19_-_23869939 0.196 NM_138330
ZNF675
zinc finger protein 675
chr20_-_3766905 0.196 NM_001810
CENPB
centromere protein B, 80kDa
chr14_-_60632058 0.195 NM_016029
DHRS7
dehydrogenase/reductase (SDR family) member 7
chr3_-_71180061 0.195 NM_001244815
FOXP1
forkhead box P1
chr12_-_89920038 0.191 NM_001199781
NM_001199782
NM_172240
POC1B-GALNT4

POC1B
POC1B-GALNT4 readthrough

POC1 centriolar protein homolog B (Chlamydomonas)
chr9_+_4662285 0.191 NM_203453
PPAPDC2
phosphatidic acid phosphatase type 2 domain containing 2
chr5_+_126859157 0.191 PRRC1
proline-rich coiled-coil 1
chr4_-_70080448 0.190 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr5_+_173472737 0.189 HMP19
HMP19 protein
chr3_-_182880463 0.187 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr1_-_89591685 0.187 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr15_-_72501017 0.186 PKM2
pyruvate kinase, muscle
chr18_-_47814691 0.185 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr4_+_74606222 0.183 NM_000584
IL8
interleukin 8
chr21_-_35884503 0.183 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chrM_+_8857 0.182


chr11_-_55703875 0.180 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr1_+_948846 0.180 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr8_+_132991171 0.179 EFR3A
EFR3 homolog A (S. cerevisiae)
chr22_-_24951842 0.176 C22orf13
chromosome 22 open reading frame 13
chr3_-_170744458 0.176 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr19_+_10362598 0.176 NM_015956
NM_146387
NM_146388
MRPL4


mitochondrial ribosomal protein L4


chr10_-_13276327 0.175 NM_145314
UCMA
upper zone of growth plate and cartilage matrix associated
chr4_-_74847669 0.175 NM_002619
PF4
platelet factor 4
chr7_-_97601654 0.174


chrX_+_22050920 0.174 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr12_+_26348268 0.173 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr4_-_159956332 0.173 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr9_+_117373622 0.172 NM_153045
C9orf91
chromosome 9 open reading frame 91
chr2_-_214015053 0.171 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr7_+_2598646 0.169 IQCE
IQ motif containing E
chr19_-_8408120 0.169 NM_198471
KANK3
KN motif and ankyrin repeat domains 3
chrM_+_9217 0.169


chr9_-_130700762 0.168 NM_003863
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr10_-_99161013 0.166 NM_001145114
NM_015179
RRP12

ribosomal RNA processing 12 homolog (S. cerevisiae)

chr16_+_20420854 0.164 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr5_+_161494647 0.164 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr16_-_58328879 0.163 NM_001080492
PRSS54
protease, serine, 54
chr7_+_76054251 0.162 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr18_-_61329113 0.160 NM_006919
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr17_+_4692226 0.160 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr5_-_147162056 0.157 JAKMIP2
janus kinase and microtubule interacting protein 2
chr10_+_97759847 0.157 NM_001001732
NM_001159747
CC2D2B

coiled-coil and C2 domain containing 2B

chr15_+_22736245 0.156 NM_001001413
GOLGA6L1
golgin A6 family-like 1
chr4_+_69681709 0.155 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr14_-_78174320 0.155 NM_006020
ALKBH1
alkB, alkylation repair homolog 1 (E. coli)
chr3_+_119298522 0.154 NM_001125
ADPRH
ADP-ribosylarginine hydrolase
chr1_+_47533046 0.153 NM_178134
CYP4Z1
cytochrome P450, family 4, subfamily Z, polypeptide 1
chr16_-_28621279 0.152 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chrM_+_9182 0.149


chr19_+_52266640 0.148 NM_001462
FPR2
formyl peptide receptor 2
chrM_+_4770 0.147


chr17_-_6983503 0.146 NM_006344
NM_182906
CLEC10A

C-type lectin domain family 10, member A

chr17_-_33390676 0.144 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr8_-_7673137 0.143 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr1_-_201465700 0.142 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr8_+_7353367 0.142 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr6_-_33756885 0.138 LEMD2
LEM domain containing 2
chr15_+_65337707 0.136 NM_178859
OSTBETA
organic solute transporter beta
chr2_-_31637553 0.136 XDH
xanthine dehydrogenase
chr10_+_121652084 0.134 NM_007190
SEC23IP
SEC23 interacting protein
chr4_+_159442865 0.132 NM_001253727
NM_001253728
NM_001253729
NM_001253730
NM_001253732
NM_001253733
NM_021634
RXFP1






relaxin/insulin-like family peptide receptor 1






chr17_-_72709010 0.132 NM_139018
CD300LF
CD300 molecule-like family member f
chr6_+_64286348 0.131 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr4_+_187148624 0.131 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chrX_-_102531673 0.130 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr7_-_102283237 0.130 NM_001114403
UPK3BL
uroplakin 3B-like
chr4_+_95128994 0.127 NM_001128429
NM_020159
SMARCAD1

SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1

chr5_-_135290521 0.126 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr7_+_141695678 0.126 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr3_+_63884074 0.125 NM_001177387
ATXN7
ataxin 7
chr1_+_181002560 0.125 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr3_+_132036276 0.124 ACPP
acid phosphatase, prostate
chr9_-_21305311 0.123 NM_002169
IFNA5
interferon, alpha 5
chr6_-_53213747 0.121 NM_001242828
NM_001242830
NM_001242831
NM_021814
ELOVL5



ELOVL fatty acid elongase 5



chrM_+_9725 0.119


chr5_-_58882274 0.117 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_90062610 0.117 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr19_-_55628780 0.116 NM_017607
PPP1R12C
protein phosphatase 1, regulatory subunit 12C
chr4_-_177241488 0.115


chr10_+_7745284 0.114 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_-_26189303 0.113 NM_003539
HIST1H4D
histone cluster 1, H4d
chr4_+_72102249 0.112 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr9_+_96846710 0.112 NM_001253829
NM_152422
PTPDC1

protein tyrosine phosphatase domain containing 1

chr18_-_13915534 0.111 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr9_-_104147261 0.111 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.