Motif ID: ATF4.p2

Z-value: 1.094


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ATF4chr22_+_399165630.611.2e-03Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_23386386 2.250 SLC25A37
solute carrier family 25, member 37
chr19_+_45504686 2.213 NM_006509
 RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr8_+_23386362 2.170 NM_016612
 SLC25A37
solute carrier family 25, member 37
chr8_+_23386468 1.932 SLC25A37
solute carrier family 25, member 37
chr18_+_20513277 1.857 NM_002894
 RBBP8
retinoblastoma binding protein 8
chr8_+_90770201 1.803 RIPK2
receptor-interacting serine-threonine kinase 2
chr11_+_73087396 1.793 NM_152222
 RELT
RELT tumor necrosis factor receptor
chr5_+_113698304 1.777 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr7_+_28448970 1.646 LOC401317
uncharacterized LOC401317
chrX_-_83757398 1.586 NM_001177478
NM_001177479
NM_144657
 HDX


highly divergent homeobox


chr8_+_17104384 1.516 NM_001145152
NM_152415
 VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr11_+_43963809 1.506 NM_001145033
 C11orf96
chromosome 11 open reading frame 96
chr12_+_132629014 1.342 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr8_-_101322180 1.318 RNF19A
ring finger protein 19A
chr7_-_22396511 1.311 NM_012294
 RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr16_+_11762235 1.269 NM_003498
 SNN
stannin
chr8_+_90769974 1.262 NM_003821
 RIPK2
receptor-interacting serine-threonine kinase 2
chr12_+_132628978 1.210 NM_024078
 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr18_+_57567191 1.202 NM_021127
 PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr15_-_64338519 1.200 NM_014326
 DAPK2
death-associated protein kinase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
3.26 5.20e-04 GO:0050657 nucleic acid transport
3.26 5.20e-04 GO:0050658 RNA transport
3.26 5.20e-04 GO:0051236 establishment of RNA localization
3.26 1.59e-03 GO:0051028 mRNA transport
3.15 9.95e-04 GO:0006403 RNA localization
2.92 2.52e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
2.10 4.61e-02 GO:0006366 transcription from RNA polymerase II promoter
1.98 4.39e-05 GO:0006396 RNA processing
1.81 1.50e-04 GO:0033554 cellular response to stress
1.77 3.96e-02 GO:0000278 mitotic cell cycle
1.73 1.86e-02 GO:0022403 cell cycle phase
1.71 6.85e-03 GO:0046907 intracellular transport
1.62 3.29e-07 GO:0010467 gene expression
1.60 9.58e-09 GO:0090304 nucleic acid metabolic process
1.57 1.71e-10 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.57 2.09e-05 GO:0016070 RNA metabolic process
1.49 3.39e-09 GO:0034641 cellular nitrogen compound metabolic process
1.47 1.39e-13 GO:0044260 cellular macromolecule metabolic process
1.47 5.30e-03 GO:0034645 cellular macromolecule biosynthetic process
1.46 1.78e-08 GO:0006807 nitrogen compound metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
2.91 3.80e-02 GO:0000776 kinetochore
1.98 1.63e-04 GO:0005730 nucleolus
1.93 1.68e-04 GO:0005694 chromosome
1.90 2.62e-03 GO:0044427 chromosomal part
1.73 6.70e-08 GO:0005654 nucleoplasm
1.71 6.38e-11 GO:0031981 nuclear lumen
1.68 2.31e-12 GO:0044428 nuclear part
1.61 2.34e-10 GO:0070013 intracellular organelle lumen
1.59 4.08e-10 GO:0031974 membrane-enclosed lumen
1.59 9.07e-10 GO:0043233 organelle lumen
1.41 5.66e-04 GO:0005829 cytosol
1.39 9.81e-15 GO:0005634 nucleus
1.38 6.96e-05 GO:0043228 non-membrane-bounded organelle
1.38 6.96e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.35 6.33e-12 GO:0044446 intracellular organelle part
1.34 1.79e-11 GO:0044422 organelle part
1.28 3.23e-18 GO:0043231 intracellular membrane-bounded organelle
1.28 4.52e-18 GO:0043227 membrane-bounded organelle
1.24 4.39e-17 GO:0043229 intracellular organelle
1.24 7.78e-17 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
10.01 2.36e-02 GO:0016944 RNA polymerase II transcription elongation factor activity
1.87 2.46e-06 GO:0003723 RNA binding
1.68 3.81e-03 GO:0017111 nucleoside-triphosphatase activity
1.66 4.23e-03 GO:0016462 pyrophosphatase activity
1.65 4.89e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.65 5.64e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.57 2.09e-05 GO:0005524 ATP binding
1.55 4.28e-05 GO:0030554 adenyl nucleotide binding
1.55 5.28e-05 GO:0032559 adenyl ribonucleotide binding
1.53 5.60e-06 GO:0035639 purine ribonucleoside triphosphate binding
1.50 1.56e-05 GO:0017076 purine nucleotide binding
1.50 1.77e-05 GO:0032553 ribonucleotide binding
1.50 1.77e-05 GO:0032555 purine ribonucleotide binding
1.49 9.99e-07 GO:0000166 nucleotide binding
1.37 5.94e-06 GO:0003676 nucleic acid binding
1.27 1.17e-10 GO:0005515 protein binding
1.18 3.51e-02 GO:0003824 catalytic activity
1.11 4.15e-05 GO:0005488 binding