Motif ID: ATF5_CREB3.p2

Z-value: 1.947


Transcription factors associated with ATF5_CREB3.p2:

Gene SymbolEntrez IDGene Name
ATF5 22809 activating transcription factor 5
CREB3 10488 cAMP responsive element binding protein 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ATF5chr19_+_504319580.554.1e-03Click!
CREB3chr9_+_357326290.527.7e-03Click!


Activity profile for motif ATF5_CREB3.p2.

activity profile for motif ATF5_CREB3.p2


Sorted Z-values histogram for motif ATF5_CREB3.p2

Sorted Z-values for motif ATF5_CREB3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF5_CREB3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_28448970 6.181 LOC401317
uncharacterized LOC401317
chr5_-_95297597 5.291 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr5_-_95297424 5.139 ELL2
elongation factor, RNA polymerase II, 2
chr10_+_104154228 5.118 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr8_+_23386386 4.867 SLC25A37
solute carrier family 25, member 37
chr8_+_90770201 4.792 RIPK2
receptor-interacting serine-threonine kinase 2
chr8_-_48650683 4.462 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr8_+_90769974 4.338 NM_003821
RIPK2
receptor-interacting serine-threonine kinase 2
chr6_+_138188352 4.140 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr19_+_45504686 4.127 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr9_-_123688352 4.095 TRAF1
TNF receptor-associated factor 1
chr15_+_62359175 3.918 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr5_+_113698304 3.869 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr19_-_44100127 3.833 NM_001007561
IRGQ
immunity-related GTPase family, Q
chr2_+_28615771 3.752 NM_005253
FOSL2
FOS-like antigen 2
chr11_+_73087670 3.661 NM_032871
RELT
RELT tumor necrosis factor receptor
chr11_+_73087396 3.517 NM_152222
RELT
RELT tumor necrosis factor receptor
chr8_-_48650703 3.437 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr8_+_23386468 3.328 SLC25A37
solute carrier family 25, member 37
chr11_-_126138789 3.170 SRPR
signal recognition particle receptor (docking protein)
chr6_-_90062450 3.139 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr19_+_1941184 3.066 CSNK1G2
casein kinase 1, gamma 2
chr2_+_231577536 3.016 NM_016289
CAB39
calcium binding protein 39
chr10_+_104155431 3.008 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr8_+_23386362 2.967 NM_016612
SLC25A37
solute carrier family 25, member 37
chr1_+_212782103 2.928 ATF3
activating transcription factor 3
chr14_-_55369163 2.912 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr1_+_212781969 2.877 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr10_+_112257624 2.820 NM_004419
DUSP5
dual specificity phosphatase 5
chr4_+_103422553 2.805 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr12_+_100660846 2.801 SCYL2
SCY1-like 2 (S. cerevisiae)
chr4_+_103422479 2.789 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr4_+_103422822 2.762 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr17_-_17399494 2.751 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr9_+_102584136 2.734 NM_006981
NM_173199
NM_173200
NR4A3


nuclear receptor subfamily 4, group A, member 3


chr4_+_103422730 2.724 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr8_+_86089618 2.722 NM_001083588
NM_001951
E2F5

E2F transcription factor 5, p130-binding

chr1_+_218518675 2.722 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr6_-_90062439 2.714 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr12_+_100661158 2.709 SCYL2
SCY1-like 2 (S. cerevisiae)
chr6_-_90062289 2.662 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr20_+_33146500 2.642 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr1_-_160313056 2.630 COPA
coatomer protein complex, subunit alpha
chr10_+_23983674 2.585 NM_001098500
KIAA1217
KIAA1217
chr2_+_28615695 2.551 FOSL2
FOS-like antigen 2
chr8_+_86089641 2.505


chr18_+_57567191 2.499 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr7_+_5632435 2.473 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr6_-_29595746 2.470 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr20_+_33292117 2.408 NM_021202
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr17_-_4642638 2.407 CXCL16
chemokine (C-X-C motif) ligand 16
chrX_-_83757398 2.394 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr1_-_160312959 2.386


chr7_+_5632453 2.342 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr6_+_30295007 2.318 NM_172016
TRIM39
tripartite motif containing 39
chr6_-_90062349 2.308 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr2_+_231577624 2.304 CAB39
calcium binding protein 39
chr2_+_219745243 2.299 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr6_-_37225360 2.286 NM_145316
TMEM217
transmembrane protein 217
chr10_+_6186878 2.277 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr21_-_43430448 2.263 NM_001098402
NM_001098403
NM_020727
ZNF295


zinc finger protein 295


chr17_+_40985412 2.244 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr12_-_58165877 2.243 NM_005371
NM_023033
METTL1

methyltransferase like 1

chr9_-_140082983 2.238 ANAPC2
anaphase promoting complex subunit 2
chr10_+_6244839 2.235 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr8_+_17104384 2.224 NM_001145152
NM_152415
VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr6_-_90062610 2.203 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr13_-_21635703 2.201 NM_014572
LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr3_-_187463474 2.191 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr10_+_103911932 2.182 NM_004741
NOLC1
nucleolar and coiled-body phosphoprotein 1
chr1_-_47184790 2.176


chr16_-_75498497 2.165 TMEM170A
transmembrane protein 170A
chr10_+_6186903 2.160 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr13_-_21635629 2.159 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr16_+_31044414 2.134 STX4
syntaxin 4
chr11_-_1593149 2.131 NM_004420
DUSP8
dual specificity phosphatase 8
chr6_-_137540544 2.115 IFNGR1
interferon gamma receptor 1
chr11_-_67276101 2.109 NM_005851
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr19_+_49375679 2.098 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr6_+_30294620 2.098 NM_021253
TRIM39
tripartite motif containing 39
chr21_-_35899046 2.097 NM_203418
RCAN1
regulator of calcineurin 1
chr20_+_18488167 2.093 NM_006363
NM_032985
NM_032986
NM_001172746
SEC23B



Sec23 homolog B (S. cerevisiae)



chr17_-_76836852 2.087 NM_025090
USP36
ubiquitin specific peptidase 36
chr19_+_1941157 2.082 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr19_+_49375677 2.064 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr7_+_44646197 2.052 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr3_-_187463227 2.050 BCL6
B-cell CLL/lymphoma 6
chr1_+_12040475 2.050 MFN2
mitofusin 2
chr7_+_44646189 2.048 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr1_+_37940074 2.037 NM_025079
ZC3H12A
zinc finger CCCH-type containing 12A
chr19_+_49375638 2.031 NM_014330
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr7_+_44646168 2.020 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr11_-_126138698 1.963 SRPR
signal recognition particle receptor (docking protein)
chr10_+_6186758 1.958 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr19_+_50979788 1.952 C19orf63
chromosome 19 open reading frame 63
chr11_+_111473099 1.946 NM_015191
SIK2
salt-inducible kinase 2
chr11_-_126138824 1.945 NM_001177842
NM_003139
SRPR

signal recognition particle receptor (docking protein)

chr3_+_133293256 1.940 NM_001134423
CDV3
CDV3 homolog (mouse)
chr19_-_18392436 1.932 JUND
jun D proto-oncogene
chr17_+_8339135 1.929 NM_001025579
NM_030808
NDEL1

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

chr3_+_127771342 1.915


chr3_+_127771307 1.912 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr20_+_18488548 1.890 NM_001172745
SEC23B
Sec23 homolog B (S. cerevisiae)
chr2_-_60780767 1.878 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr5_-_132299248 1.867 AFF4
AF4/FMR2 family, member 4
chr3_+_133292404 1.861 NM_001134422
NM_017548
CDV3

CDV3 homolog (mouse)

chr8_+_123794043 1.851 ZHX2
zinc fingers and homeoboxes 2
chr20_+_18488525 1.840 SEC23B
Sec23 homolog B (S. cerevisiae)
chr2_-_28113954 1.837 LOC100302650
uncharacterized LOC100302650
chr2_+_28615668 1.821 FOSL2
FOS-like antigen 2
chr8_+_123793894 1.820 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr8_+_123793988 1.818 ZHX2
zinc fingers and homeoboxes 2
chr19_+_16187047 1.802 NM_003290
TPM4
tropomyosin 4
chr6_-_137540551 1.798 NM_000416
IFNGR1
interferon gamma receptor 1
chr17_-_36981552 1.796 NM_017748
CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chr3_+_133292557 1.795 CDV3
CDV3 homolog (mouse)
chr1_-_150552077 1.778 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr19_+_16187266 1.773 TPM4
tropomyosin 4
chr3_-_119182423 1.766 NM_018266
TMEM39A
transmembrane protein 39A
chr17_+_40985444 1.766 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr16_+_31044849 1.761 STX4
syntaxin 4
chrX_+_48398162 1.760 TBC1D25
TBC1 domain family, member 25
chr11_+_66610882 1.759 NM_001032279
NM_005133
RCE1

RCE1 homolog, prenyl protein protease (S. cerevisiae)

chr7_+_155089614 1.756 INSIG1
insulin induced gene 1
chr20_-_10654429 1.745 NM_000214
JAG1
jagged 1
chr7_+_6144504 1.744 NM_032172
USP42
ubiquitin specific peptidase 42
chr19_+_50979656 1.744 NM_175063
NM_206538
C19orf63

chromosome 19 open reading frame 63

chr12_+_121647936 1.740 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr1_-_32110464 1.732 PEF1
penta-EF-hand domain containing 1
chr19_+_16187306 1.725 TPM4
tropomyosin 4
chr3_-_150480887 1.718 SIAH2
seven in absentia homolog 2 (Drosophila)
chr9_-_130477918 1.717 NM_001002913
PTRH1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr3_-_107809754 1.714 NM_001777
NM_198793
CD47

CD47 molecule

chr12_+_121647850 1.708 P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr16_+_31044881 1.707 NM_004604
STX4
syntaxin 4
chr3_-_195808980 1.702 TFRC
transferrin receptor (p90, CD71)
chr9_-_140083010 1.686 ANAPC2
anaphase promoting complex subunit 2
chr15_+_66679107 1.675 NM_002755
MAP2K1
mitogen-activated protein kinase kinase 1
chr17_-_76836608 1.674 USP36
ubiquitin specific peptidase 36
chr6_+_55039070 1.674 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr12_+_121647659 1.658 NM_002560
P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr17_+_40985434 1.650 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr1_-_16482426 1.636 NM_004431
EPHA2
EPH receptor A2
chr20_+_37101457 1.634 NM_020336
RALGAPB
Ral GTPase activating protein, beta subunit (non-catalytic)
chr18_+_23806385 1.633 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr3_+_42190736 1.623 TRAK1
trafficking protein, kinesin binding 1
chr6_+_43445304 1.622 TJAP1
tight junction associated protein 1 (peripheral)
chr12_-_89920038 1.620 NM_001199781
NM_001199782
NM_172240
POC1B-GALNT4

POC1B
POC1B-GALNT4 readthrough

POC1 centriolar protein homolog B (Chlamydomonas)
chr15_+_52311432 1.597 MAPK6
mitogen-activated protein kinase 6
chr2_+_208394823 1.594 CREB1
cAMP responsive element binding protein 1
chr3_-_150480917 1.585 SIAH2
seven in absentia homolog 2 (Drosophila)
chr4_-_76598558 1.573 G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr15_+_52311438 1.570 MAPK6
mitogen-activated protein kinase 6
chr3_+_113465901 1.565 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr19_-_18392413 1.565 NM_005354
JUND
jun D proto-oncogene
chr2_+_208394756 1.561 CREB1
cAMP responsive element binding protein 1
chr17_+_40985425 1.560 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr12_-_14956315 1.555 WBP11
WW domain binding protein 11
chr8_+_59465783 1.552 SDCBP
syndecan binding protein (syntenin)
chr1_-_150601911 1.532 ENSA
endosulfine alpha
chr17_-_1619473 1.524 MIR22HG
MIR22 host gene (non-protein coding)
chr16_-_75498582 1.511 NM_145254
TMEM170A
transmembrane protein 170A
chr17_+_26662547 1.507 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr2_+_74757243 1.507 HTRA2
HtrA serine peptidase 2
chr17_+_39845126 1.502 NM_005801
EIF1
eukaryotic translation initiation factor 1
chr14_+_50087400 1.481 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr1_-_150602047 1.479 ENSA
endosulfine alpha
chr2_+_10184371 1.477 NM_001177718
KLF11
Kruppel-like factor 11
chr11_-_126138778 1.470 SRPR
signal recognition particle receptor (docking protein)
chr15_+_52311408 1.470 NM_002748
MAPK6
mitogen-activated protein kinase 6
chr7_+_44646220 1.453 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr6_+_64282449 1.440 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr19_-_18392048 1.437 JUND
jun D proto-oncogene
chr17_+_57642885 1.430 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr12_-_129308293 1.426 NM_145648
SLC15A4
solute carrier family 15, member 4
chr14_-_76448091 1.420 NM_003239
TGFB3
transforming growth factor, beta 3
chr12_+_110011499 1.420 NM_000431
NM_001114185
MVK

mevalonate kinase

chr19_+_17666502 1.418 NM_024656
GLT25D1
glycosyltransferase 25 domain containing 1
chr3_-_39195101 1.416 NM_033027
CSRNP1
cysteine-serine-rich nuclear protein 1
chr5_-_132298973 1.415 AFF4
AF4/FMR2 family, member 4
chr17_+_40985416 1.412 NM_005789
NM_176863
PSME3

proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)

chr11_-_126138756 1.378 SRPR
signal recognition particle receptor (docking protein)
chr6_+_43211221 1.370 NM_032538
TTBK1
tau tubulin kinase 1
chr11_+_6502607 1.370 NM_012192
FXC1
fracture callus 1 homolog (rat)
chr4_+_56261763 1.366


chr3_-_71632741 1.365 NM_001244808
NM_001012505
NM_001244810
NM_032682
FOXP1



forkhead box P1



chr2_-_64881040 1.364 NM_014755
SERTAD2
SERTA domain containing 2
chr7_+_38217919 1.364 STARD3NL
STARD3 N-terminal like
chr2_+_30454396 1.356 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr17_+_7210841 1.349 NM_001970
EIF5A
eukaryotic translation initiation factor 5A
chr1_-_65432203 1.339 JAK1
Janus kinase 1
chr8_-_104427319 1.339 SLC25A32
solute carrier family 25, member 32
chr3_+_186739643 1.335 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr19_+_16187315 1.332 TPM4
tropomyosin 4
chr13_-_30169795 1.331 NM_003045
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr20_+_32399046 1.326 NM_176812
CHMP4B
charged multivesicular body protein 4B
chr7_+_6144589 1.321 USP42
ubiquitin specific peptidase 42
chr6_-_38607589 1.319 BTBD9
BTB (POZ) domain containing 9
chr4_-_111544206 1.317 NM_000325
PITX2
paired-like homeodomain 2
chr1_-_169703178 1.317 NM_000450
SELE
selectin E

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 5.17e-16 GO:0044260 cellular macromolecule metabolic process
1.28 2.75e-14 GO:0044237 cellular metabolic process
1.49 1.07e-13 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.31 3.56e-12 GO:0043170 macromolecule metabolic process
1.14 7.58e-12 GO:0009987 cellular process
1.60 1.48e-11 GO:0016070 RNA metabolic process
1.41 2.52e-11 GO:0034641 cellular nitrogen compound metabolic process
1.56 8.79e-11 GO:0010467 gene expression
1.24 1.62e-10 GO:0044238 primary metabolic process
1.38 5.29e-10 GO:0006807 nitrogen compound metabolic process
1.48 6.04e-10 GO:0090304 nucleic acid metabolic process
1.82 7.43e-10 GO:0006351 transcription, DNA-dependent
1.87 7.74e-10 GO:0046907 intracellular transport
1.21 6.41e-09 GO:0008152 metabolic process
1.63 1.26e-08 GO:0051641 cellular localization
1.33 2.40e-08 GO:0031323 regulation of cellular metabolic process
1.62 4.22e-07 GO:0051649 establishment of localization in cell
1.66 5.99e-07 GO:0032774 RNA biosynthetic process
1.48 9.29e-07 GO:0034645 cellular macromolecule biosynthetic process
1.29 9.87e-07 GO:0019222 regulation of metabolic process
1.48 1.04e-06 GO:0009059 macromolecule biosynthetic process
1.36 1.39e-06 GO:0009889 regulation of biosynthetic process
1.30 1.89e-06 GO:0080090 regulation of primary metabolic process
1.36 1.97e-06 GO:0031326 regulation of cellular biosynthetic process
1.31 3.32e-06 GO:0060255 regulation of macromolecule metabolic process
1.37 7.77e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.34 8.39e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.36 1.10e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.51 1.56e-05 GO:0033036 macromolecule localization
1.37 1.57e-05 GO:0051252 regulation of RNA metabolic process
1.17 4.86e-05 GO:0050794 regulation of cellular process
1.55 5.31e-05 GO:0008104 protein localization
1.67 5.83e-05 GO:0016192 vesicle-mediated transport
1.33 7.64e-05 GO:0010468 regulation of gene expression
1.33 8.54e-05 GO:0044267 cellular protein metabolic process
1.61 8.94e-05 GO:0045184 establishment of protein localization
1.16 9.03e-05 GO:0050789 regulation of biological process
1.32 1.06e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
4.86 1.55e-04 GO:0006984 ER-nucleus signaling pathway
1.60 1.78e-04 GO:0015031 protein transport
1.77 1.84e-04 GO:0016071 mRNA metabolic process
1.50 2.00e-04 GO:0010604 positive regulation of macromolecule metabolic process
1.31 2.76e-04 GO:0048518 positive regulation of biological process
1.35 2.79e-04 GO:0006355 regulation of transcription, DNA-dependent
1.14 3.12e-04 GO:0065007 biological regulation
2.54 3.42e-04 GO:0006184 GTP catabolic process
2.11 3.48e-04 GO:0009166 nucleotide catabolic process
1.47 4.43e-04 GO:0009893 positive regulation of metabolic process
1.32 4.50e-04 GO:0048522 positive regulation of cellular process
2.04 6.68e-04 GO:0034655 nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
2.04 6.68e-04 GO:0034656 nucleobase, nucleoside and nucleotide catabolic process
1.47 7.89e-04 GO:0031325 positive regulation of cellular metabolic process
2.15 9.49e-04 GO:0009261 ribonucleotide catabolic process
2.17 1.01e-03 GO:0009203 ribonucleoside triphosphate catabolic process
2.17 1.01e-03 GO:0009207 purine ribonucleoside triphosphate catabolic process
2.09 1.16e-03 GO:0072523 purine-containing compound catabolic process
2.16 1.17e-03 GO:0009146 purine nucleoside triphosphate catabolic process
2.10 1.26e-03 GO:0006195 purine nucleotide catabolic process
1.98 1.48e-03 GO:0006366 transcription from RNA polymerase II promoter
2.13 1.81e-03 GO:0009143 nucleoside triphosphate catabolic process
2.13 1.81e-03 GO:0009154 purine ribonucleotide catabolic process
2.38 1.84e-03 GO:0046039 GTP metabolic process
1.45 2.82e-03 GO:0044248 cellular catabolic process
2.61 2.96e-03 GO:0016197 endosome transport
1.60 5.76e-03 GO:0051254 positive regulation of RNA metabolic process
1.34 5.91e-03 GO:0006464 protein modification process
1.29 6.63e-03 GO:0044249 cellular biosynthetic process
1.89 6.83e-03 GO:0044270 cellular nitrogen compound catabolic process
3.09 8.58e-03 GO:0031124 mRNA 3'-end processing
1.88 9.52e-03 GO:0046700 heterocycle catabolic process
2.36 9.55e-03 GO:0048193 Golgi vesicle transport
1.47 1.07e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.76 1.27e-02 GO:0006397 mRNA processing
1.27 1.30e-02 GO:0009058 biosynthetic process
1.83 1.30e-02 GO:0009259 ribonucleotide metabolic process
1.32 1.45e-02 GO:0043412 macromolecule modification
2.06 1.63e-02 GO:0000375 RNA splicing, via transesterification reactions
2.03 1.95e-02 GO:0033365 protein localization to organelle
2.07 2.03e-02 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.07 2.03e-02 GO:0000398 nuclear mRNA splicing, via spliceosome
1.57 2.09e-02 GO:0006396 RNA processing
1.64 2.40e-02 GO:0034613 cellular protein localization
1.55 2.71e-02 GO:0010628 positive regulation of gene expression
4.86 2.74e-02 GO:0048199 vesicle targeting, to, from or within Golgi
4.45 2.82e-02 GO:0006901 vesicle coating
1.63 3.04e-02 GO:0070727 cellular macromolecule localization
1.84 3.17e-02 GO:0009205 purine ribonucleoside triphosphate metabolic process
3.83 3.35e-02 GO:0034976 response to endoplasmic reticulum stress
1.84 3.53e-02 GO:0009199 ribonucleoside triphosphate metabolic process
1.80 3.77e-02 GO:0009150 purine ribonucleotide metabolic process
1.23 4.18e-02 GO:0019538 protein metabolic process
1.82 4.35e-02 GO:0009144 purine nucleoside triphosphate metabolic process
2.72 4.43e-02 GO:0031123 RNA 3'-end processing
2.89 4.48e-02 GO:0006986 response to unfolded protein
4.28 4.56e-02 GO:0006900 membrane budding
1.56 4.58e-02 GO:0045893 positive regulation of transcription, DNA-dependent

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 4.70e-28 GO:0044424 intracellular part
1.18 1.88e-26 GO:0005622 intracellular
1.26 2.75e-26 GO:0043227 membrane-bounded organelle
1.26 5.12e-26 GO:0043231 intracellular membrane-bounded organelle
1.23 3.08e-25 GO:0043226 organelle
1.23 3.92e-25 GO:0043229 intracellular organelle
1.23 2.91e-17 GO:0005737 cytoplasm
1.31 7.41e-16 GO:0005634 nucleus
1.29 6.57e-14 GO:0044446 intracellular organelle part
1.29 1.15e-13 GO:0044422 organelle part
1.24 7.63e-11 GO:0044444 cytoplasmic part
1.48 7.06e-09 GO:0031981 nuclear lumen
1.43 1.24e-08 GO:0044428 nuclear part
1.38 2.67e-07 GO:0031974 membrane-enclosed lumen
1.39 3.86e-07 GO:0070013 intracellular organelle lumen
1.38 5.95e-07 GO:0043233 organelle lumen
1.50 1.90e-06 GO:0005654 nucleoplasm
1.38 4.72e-06 GO:0005829 cytosol
1.52 6.83e-05 GO:0005794 Golgi apparatus
1.05 9.72e-05 GO:0044464 cell part
1.05 1.01e-04 GO:0005623 cell
1.23 4.33e-04 GO:0032991 macromolecular complex
1.74 4.66e-04 GO:0005768 endosome
1.31 5.40e-04 GO:0031090 organelle membrane
1.24 1.98e-03 GO:0043234 protein complex
2.02 4.32e-03 GO:0030135 coated vesicle
1.53 5.39e-03 GO:0015630 microtubule cytoskeleton
1.33 5.51e-03 GO:0012505 endomembrane system
1.24 7.76e-03 GO:0043228 non-membrane-bounded organelle
1.24 7.76e-03 GO:0043232 intracellular non-membrane-bounded organelle
3.06 8.31e-03 GO:0005798 Golgi-associated vesicle
3.49 8.52e-03 GO:0030120 vesicle coat
1.46 1.11e-02 GO:0031982 vesicle
1.47 1.12e-02 GO:0031410 cytoplasmic vesicle
1.38 1.55e-02 GO:0005783 endoplasmic reticulum
3.64 2.04e-02 GO:0030660 Golgi-associated vesicle membrane
1.46 2.05e-02 GO:0031988 membrane-bounded vesicle
1.53 2.06e-02 GO:0044431 Golgi apparatus part
1.57 2.37e-02 GO:0005730 nucleolus
1.46 2.46e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.46 2.77e-02 GO:0044451 nucleoplasm part
2.33 2.89e-02 GO:0030133 transport vesicle
2.19 3.46e-02 GO:0016607 nuclear speck
2.20 4.28e-02 GO:0030662 coated vesicle membrane
2.92 4.75e-02 GO:0030658 transport vesicle membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.27 1.76e-19 GO:0005515 protein binding
1.13 1.22e-14 GO:0005488 binding
1.44 7.37e-10 GO:0000166 nucleotide binding
1.66 4.06e-08 GO:0001071 nucleic acid binding transcription factor activity
1.66 4.06e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.45 8.76e-08 GO:0032553 ribonucleotide binding
1.45 8.76e-08 GO:0032555 purine ribonucleotide binding
1.45 1.10e-07 GO:0035639 purine ribonucleoside triphosphate binding
1.44 1.58e-07 GO:0017076 purine nucleotide binding
1.31 2.35e-07 GO:0003676 nucleic acid binding
2.31 1.22e-05 GO:0003924 GTPase activity
1.64 1.46e-05 GO:0016462 pyrophosphatase activity
1.63 1.85e-05 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.62 2.35e-05 GO:0016817 hydrolase activity, acting on acid anhydrides
1.63 3.51e-05 GO:0017111 nucleoside-triphosphatase activity
1.60 4.03e-05 GO:0003723 RNA binding
1.60 4.89e-04 GO:0043565 sequence-specific DNA binding
1.80 1.52e-03 GO:0005525 GTP binding
1.77 2.22e-03 GO:0019001 guanyl nucleotide binding
1.77 2.22e-03 GO:0032561 guanyl ribonucleotide binding
1.35 2.62e-03 GO:0032559 adenyl ribonucleotide binding
1.35 3.05e-03 GO:0005524 ATP binding
1.35 3.78e-03 GO:0030554 adenyl nucleotide binding
1.27 6.54e-03 GO:0003677 DNA binding