Motif ID: ATF5_CREB3.p2

Z-value: 1.947


Transcription factors associated with ATF5_CREB3.p2:

Gene SymbolEntrez IDGene Name
ATF5 22809 activating transcription factor 5
CREB3 10488 cAMP responsive element binding protein 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ATF5chr19_+_504319580.554.1e-03Click!
CREB3chr9_+_357326290.527.7e-03Click!


Activity profile for motif ATF5_CREB3.p2.

activity profile for motif ATF5_CREB3.p2


Sorted Z-values histogram for motif ATF5_CREB3.p2

Sorted Z-values for motif ATF5_CREB3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF5_CREB3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_28448970 6.181 LOC401317
uncharacterized LOC401317
chr5_-_95297597 5.291 NM_012081
 ELL2
elongation factor, RNA polymerase II, 2
chr5_-_95297424 5.139 ELL2
elongation factor, RNA polymerase II, 2
chr10_+_104154228 5.118 NM_001077493
NM_001077494
 NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr8_+_23386386 4.867 SLC25A37
solute carrier family 25, member 37
chr8_+_90770201 4.792 RIPK2
receptor-interacting serine-threonine kinase 2
chr8_-_48650683 4.462 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr8_+_90769974 4.338 NM_003821
 RIPK2
receptor-interacting serine-threonine kinase 2
chr6_+_138188352 4.140 NM_006290
 TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr19_+_45504686 4.127 NM_006509
 RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr9_-_123688352 4.095 TRAF1
TNF receptor-associated factor 1
chr15_+_62359175 3.918 NM_207322
 C2CD4A
C2 calcium-dependent domain containing 4A
chr5_+_113698304 3.869 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr19_-_44100127 3.833 NM_001007561
 IRGQ
immunity-related GTPase family, Q
chr2_+_28615771 3.752 NM_005253
 FOSL2
FOS-like antigen 2
chr11_+_73087670 3.661 NM_032871
 RELT
RELT tumor necrosis factor receptor
chr11_+_73087396 3.517 NM_152222
 RELT
RELT tumor necrosis factor receptor
chr8_-_48650703 3.437 NM_005195
 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr8_+_23386468 3.328 SLC25A37
solute carrier family 25, member 37
chr11_-_126138789 3.170 SRPR
signal recognition particle receptor (docking protein)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 96 entries
enrichment   p-value GO term description
4.86 1.55e-04 GO:0006984 ER-nucleus signaling pathway
4.86 2.74e-02 GO:0048199 vesicle targeting, to, from or within Golgi
4.45 2.82e-02 GO:0006901 vesicle coating
4.28 4.56e-02 GO:0006900 membrane budding
3.83 3.35e-02 GO:0034976 response to endoplasmic reticulum stress
3.09 8.58e-03 GO:0031124 mRNA 3'-end processing
2.89 4.48e-02 GO:0006986 response to unfolded protein
2.72 4.43e-02 GO:0031123 RNA 3'-end processing
2.61 2.96e-03 GO:0016197 endosome transport
2.54 3.42e-04 GO:0006184 GTP catabolic process
2.38 1.84e-03 GO:0046039 GTP metabolic process
2.36 9.55e-03 GO:0048193 Golgi vesicle transport
2.17 1.01e-03 GO:0009203 ribonucleoside triphosphate catabolic process
2.17 1.01e-03 GO:0009207 purine ribonucleoside triphosphate catabolic process
2.16 1.17e-03 GO:0009146 purine nucleoside triphosphate catabolic process
2.15 9.49e-04 GO:0009261 ribonucleotide catabolic process
2.13 1.81e-03 GO:0009143 nucleoside triphosphate catabolic process
2.13 1.81e-03 GO:0009154 purine ribonucleotide catabolic process
2.11 3.48e-04 GO:0009166 nucleotide catabolic process
2.10 1.26e-03 GO:0006195 purine nucleotide catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 45 entries
enrichment   p-value GO term description
3.64 2.04e-02 GO:0030660 Golgi-associated vesicle membrane
3.49 8.52e-03 GO:0030120 vesicle coat
3.06 8.31e-03 GO:0005798 Golgi-associated vesicle
2.92 4.75e-02 GO:0030658 transport vesicle membrane
2.33 2.89e-02 GO:0030133 transport vesicle
2.20 4.28e-02 GO:0030662 coated vesicle membrane
2.19 3.46e-02 GO:0016607 nuclear speck
2.02 4.32e-03 GO:0030135 coated vesicle
1.74 4.66e-04 GO:0005768 endosome
1.57 2.37e-02 GO:0005730 nucleolus
1.53 5.39e-03 GO:0015630 microtubule cytoskeleton
1.53 2.06e-02 GO:0044431 Golgi apparatus part
1.52 6.83e-05 GO:0005794 Golgi apparatus
1.50 1.90e-06 GO:0005654 nucleoplasm
1.48 7.06e-09 GO:0031981 nuclear lumen
1.47 1.12e-02 GO:0031410 cytoplasmic vesicle
1.46 1.11e-02 GO:0031982 vesicle
1.46 2.05e-02 GO:0031988 membrane-bounded vesicle
1.46 2.46e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.46 2.77e-02 GO:0044451 nucleoplasm part

Gene overrepresentation in function category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
2.31 1.22e-05 GO:0003924 GTPase activity
1.80 1.52e-03 GO:0005525 GTP binding
1.77 2.22e-03 GO:0019001 guanyl nucleotide binding
1.77 2.22e-03 GO:0032561 guanyl ribonucleotide binding
1.66 4.06e-08 GO:0001071 nucleic acid binding transcription factor activity
1.66 4.06e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.64 1.46e-05 GO:0016462 pyrophosphatase activity
1.63 1.85e-05 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.63 3.51e-05 GO:0017111 nucleoside-triphosphatase activity
1.62 2.35e-05 GO:0016817 hydrolase activity, acting on acid anhydrides
1.60 4.03e-05 GO:0003723 RNA binding
1.60 4.89e-04 GO:0043565 sequence-specific DNA binding
1.45 8.76e-08 GO:0032553 ribonucleotide binding
1.45 8.76e-08 GO:0032555 purine ribonucleotide binding
1.45 1.10e-07 GO:0035639 purine ribonucleoside triphosphate binding
1.44 7.37e-10 GO:0000166 nucleotide binding
1.44 1.58e-07 GO:0017076 purine nucleotide binding
1.35 2.62e-03 GO:0032559 adenyl ribonucleotide binding
1.35 3.05e-03 GO:0005524 ATP binding
1.35 3.78e-03 GO:0030554 adenyl nucleotide binding