Motif ID: BACH2.p2

Z-value: 0.637


Transcription factors associated with BACH2.p2:

Gene SymbolEntrez IDGene Name
BACH2 60468 BTB and CNC homology 1, basic leucine zipper transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
BACH2chr6_-_91006580-0.193.6e-01Click!


Activity profile for motif BACH2.p2.

activity profile for motif BACH2.p2


Sorted Z-values histogram for motif BACH2.p2

Sorted Z-values for motif BACH2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of BACH2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_102668892 3.283 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr11_-_102668822 3.238 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr12_+_56075329 2.401 NM_152637
METTL7B
methyltransferase like 7B
chr15_+_89182038 2.347 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr9_-_123688352 2.235 TRAF1
TNF receptor-associated factor 1
chr1_-_153521717 2.037 NM_002960
S100A3
S100 calcium binding protein A3
chr5_+_35856990 1.809 NM_002185
IL7R
interleukin 7 receptor
chr12_+_56075418 1.763 METTL7B
methyltransferase like 7B
chr1_-_209824641 1.743 NM_001017402
LAMB3
laminin, beta 3
chr15_-_80263460 1.558 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chrX_-_154563735 1.552 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_183155393 1.514 LAMC2
laminin, gamma 2
chr16_+_57662301 1.454 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr1_+_183155361 1.259 LAMC2
laminin, gamma 2
chr11_-_8739398 1.175 ST5
suppression of tumorigenicity 5
chr10_-_6019454 1.163 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr1_+_156084458 1.124 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr11_+_12308446 1.092 NM_032867
MICALCL
MICAL C-terminal like
chr4_-_122085475 0.991 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr10_-_31288420 0.958 NM_001143769
ZNF438
zinc finger protein 438
chr6_-_134496833 0.954 SGK1
serum/glucocorticoid regulated kinase 1
chr7_-_115670774 0.932 TFEC
transcription factor EC
chr17_+_79650961 0.931 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr4_+_74606222 0.898 NM_000584
IL8
interleukin 8
chr1_+_183155173 0.895 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr17_+_79651072 0.895 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr19_+_38794800 0.859 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr12_+_7023490 0.854 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr17_+_79651035 0.852 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr19_-_44174497 0.841 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr21_-_36421630 0.839 RUNX1
runt-related transcription factor 1
chr10_-_6019880 0.809 NM_001243539
IL15RA
interleukin 15 receptor, alpha
chr11_-_65667809 0.808 FOSL1
FOS-like antigen 1
chr17_+_79651042 0.806 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr11_-_2950593 0.743 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr11_-_65667858 0.743 FOSL1
FOS-like antigen 1
chr2_-_85641128 0.740 CAPG
capping protein (actin filament), gelsolin-like
chr1_-_6662681 0.725 KLHL21
kelch-like 21 (Drosophila)
chr7_-_1498961 0.723 MICALL2
MICAL-like 2
chr3_+_154797644 0.714 NM_007287
MME
membrane metallo-endopeptidase
chr1_+_205198058 0.712 NM_001242925
TMCC2
transmembrane and coiled-coil domain family 2
chr1_+_156084541 0.672 LMNA
lamin A/C
chr11_-_65430427 0.658 NM_001145138
NM_001243984
NM_001243985
NM_021975
RELA



v-rel reticuloendotheliosis viral oncogene homolog A (avian)



chr1_-_6662898 0.655 NM_014851
KLHL21
kelch-like 21 (Drosophila)
chr16_+_57050985 0.636 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr22_+_22723972 0.588


chr19_-_44174271 0.578 PLAUR
plasminogen activator, urokinase receptor
chr10_-_129691047 0.570


chr16_+_56642477 0.547 NM_005953
MT2A
metallothionein 2A
chr22_+_20861884 0.542 NM_001003891
NM_015889
MED15

mediator complex subunit 15

chr6_-_84140854 0.535 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr6_+_43597278 0.532 NM_001003690
MAD2L1BP
MAD2L1 binding protein
chr18_+_55888838 0.530 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr22_+_20861875 0.528 MED15
mediator complex subunit 15
chr22_+_20861886 0.528 MED15
mediator complex subunit 15
chr11_+_18415917 0.524 NM_001135239
NM_001165415
NM_001165416
NM_005566
LDHA



lactate dehydrogenase A



chr18_+_55888750 0.521 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr7_-_115670828 0.521 NM_001018058
NM_012252
TFEC

transcription factor EC

chr16_+_30077120 0.519 ALDOA
aldolase A, fructose-bisphosphate
chr18_+_55888799 0.518 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr16_+_30076993 0.508 NM_001243177
NM_184041
ALDOA

aldolase A, fructose-bisphosphate

chr1_+_156084565 0.503 LMNA
lamin A/C
chr6_-_84140651 0.502 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr22_+_20861964 0.499 MED15
mediator complex subunit 15
chr21_+_43619798 0.498 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr9_+_103191795 0.496 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr2_+_231191877 0.487 NM_138402
SP140L
SP140 nuclear body protein-like
chr19_+_41725135 0.477 AXL
AXL receptor tyrosine kinase
chr10_+_104155431 0.473 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr17_-_56595192 0.471 NM_004687
MTMR4
myotubularin related protein 4
chr16_+_30077146 0.467 ALDOA
aldolase A, fructose-bisphosphate
chr6_-_138428477 0.466 NM_022121
PERP
PERP, TP53 apoptosis effector
chr22_+_20861898 0.465 MED15
mediator complex subunit 15
chr7_+_143078457 0.463 ZYX
zyxin
chr1_+_156084579 0.460 LMNA
lamin A/C
chr1_+_17866276 0.454 NM_018125
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr11_-_65667860 0.448 NM_005438
FOSL1
FOS-like antigen 1
chr7_+_143078447 0.447 ZYX
zyxin
chr19_+_41725131 0.446 AXL
AXL receptor tyrosine kinase
chr22_+_39378404 0.441 NM_004900
APOBEC3D
APOBEC3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
chr1_+_40627066 0.437 RLF
rearranged L-myc fusion
chr7_+_143078444 0.434 ZYX
zyxin
chr18_+_61637262 0.434 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr10_-_129691202 0.432 NM_152311
CLRN3
clarin 3
chr1_-_89591685 0.432 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr7_+_143078395 0.431 ZYX
zyxin
chr10_-_95170 0.425 NM_177987
TUBB8
tubulin, beta 8 class VIII
chr17_+_74381419 0.419 SPHK1
sphingosine kinase 1
chr6_-_84140758 0.418 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr3_+_48507209 0.417 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr19_-_46285645 0.411 DMPK
dystrophia myotonica-protein kinase
chr6_-_84140744 0.411 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr2_-_85641153 0.406 CAPG
capping protein (actin filament), gelsolin-like
chr7_+_143078399 0.400 ZYX
zyxin
chr21_+_30517897 0.394 C21orf7
chromosome 21 open reading frame 7
chr3_+_48507621 0.393 TREX1
three prime repair exonuclease 1
chr1_+_36554452 0.390 NM_017825
ADPRHL2
ADP-ribosylhydrolase like 2
chr8_-_30515665 0.389 NM_002095
GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr17_+_74381186 0.389 NM_001142602
SPHK1
sphingosine kinase 1
chr20_-_52199635 0.387 NM_006526
ZNF217
zinc finger protein 217
chr6_-_134497069 0.381 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr17_+_73717515 0.380 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr1_+_40627055 0.376 RLF
rearranged L-myc fusion
chr22_-_39151979 0.373 SUN2
Sad1 and UNC84 domain containing 2
chrX_-_129244422 0.372 ELF4
E74-like factor 4 (ets domain transcription factor)
chrX_-_48937560 0.369 NM_001029896
WDR45
WD repeat domain 45
chr19_+_58695199 0.366 ZNF274
zinc finger protein 274
chr7_+_143078358 0.362 NM_001010972
NM_003461
ZYX

zyxin

chrX_-_48937457 0.360 WDR45
WD repeat domain 45
chr10_+_134901408 0.360 NM_001083909
GPR123
G protein-coupled receptor 123
chr1_-_27816676 0.355 NM_001201404
NM_006990
WASF2

WAS protein family, member 2

chr12_-_51403028 0.352 NM_001174130
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr1_-_27816542 0.350 WASF2
WAS protein family, member 2
chr1_+_36621457 0.347 MAP7D1
MAP7 domain containing 1
chrX_-_129244471 0.345 NM_001421
ELF4
E74-like factor 4 (ets domain transcription factor)
chr22_-_39152008 0.344 NM_001199579
NM_015374
SUN2

Sad1 and UNC84 domain containing 2

chr1_+_36621751 0.341 NM_018067
MAP7D1
MAP7 domain containing 1
chr18_-_25756946 0.337 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr1_-_109969044 0.335 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr1_+_155853546 0.334 SYT11
synaptotagmin XI
chr22_-_39151457 0.333 NM_001199580
SUN2
Sad1 and UNC84 domain containing 2
chr1_-_27816667 0.330 WASF2
WAS protein family, member 2
chr5_+_70944968 0.328 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr17_+_18380097 0.327 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr16_-_1429612 0.327 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr19_-_43969723 0.323 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr2_-_73316782 0.323 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr3_+_11178778 0.321 NM_001098213
HRH1
histamine receptor H1
chr1_-_109968951 0.315 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr22_-_30642683 0.315 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr16_+_67311412 0.310 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr7_+_143058794 0.309 ZYX
zyxin
chr12_-_56236614 0.308 NM_002429
MMP19
matrix metallopeptidase 19
chr17_+_21187967 0.305 NM_145109
MAP2K3
mitogen-activated protein kinase kinase 3
chr3_-_151034514 0.303 NM_023915
GPR87
G protein-coupled receptor 87
chr6_+_29910308 0.302 HLA-A
major histocompatibility complex, class I, A
chr1_+_244515936 0.300 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr16_+_56685810 0.296 NM_005947
MT1B
metallothionein 1B
chr6_-_35888816 0.295 SRPK1
SRSF protein kinase 1
chr17_-_55980749 0.292 NM_017949
CUEDC1
CUE domain containing 1
chr1_-_109969058 0.291 NM_001199772
NM_002790
NM_001199773
NM_001199774
PSMA5



proteasome (prosome, macropain) subunit, alpha type, 5



chr21_+_42733916 0.290 NM_002463
LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr6_+_138483024 0.289 NM_020340
KIAA1244
KIAA1244
chr11_-_65430214 0.287 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr17_+_74380943 0.282 SPHK1
sphingosine kinase 1
chr2_+_69201704 0.278 NM_019617
GKN1
gastrokine 1
chr12_-_76478737 0.275 NM_004537
NM_139207
NAP1L1

nucleosome assembly protein 1-like 1

chr18_-_74207145 0.273 NM_014643
ZNF516
zinc finger protein 516
chr9_+_99691285 0.273 NM_001045477
NM_001170741
FAM22G

family with sequence similarity 22, member G

chr21_-_36421586 0.273 NM_001754
RUNX1
runt-related transcription factor 1
chr17_-_33390676 0.272 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chrX_-_129244652 0.272 NM_001127197
ELF4
E74-like factor 4 (ets domain transcription factor)
chr17_+_21188032 0.271 MAP2K3
mitogen-activated protein kinase kinase 3
chr1_+_40627031 0.271 NM_012421
RLF
rearranged L-myc fusion
chr1_-_45308603 0.271 NM_001166292
NM_003738
PTCH2

patched 2

chr10_-_35363167 0.266 NM_001198778
NM_001198779
CUL2

cullin 2

chr1_+_19638739 0.265 NM_001040125
NM_001040126
NM_017765
PQLC2


PQ loop repeat containing 2


chr14_-_24777064 0.265


chr6_-_119031230 0.263 NM_001178035
CEP85L
centrosomal protein 85kDa-like
chr12_+_64845839 0.262 NM_013254
TBK1
TANK-binding kinase 1
chr21_-_36421578 0.261 RUNX1
runt-related transcription factor 1
chr10_+_104154228 0.257 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr16_+_67312057 0.257 NM_001129727
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr17_+_60447578 0.257 NM_001144933
EFCAB3
EF-hand calcium binding domain 3
chr22_-_30942668 0.256 NM_001193336
SEC14L6
SEC14-like 6 (S. cerevisiae)
chr3_-_150480917 0.254 SIAH2
seven in absentia homolog 2 (Drosophila)
chr10_+_121410751 0.254 NM_004281
BAG3
BCL2-associated athanogene 3
chr6_-_74161824 0.252 MB21D1
Mab-21 domain containing 1
chr8_-_125579395 0.247 MTSS1
metastasis suppressor 1
chr7_-_150721551 0.247 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chrX_+_133371076 0.246 NM_001101357
CCDC160
coiled-coil domain containing 160
chr15_+_22892714 0.245 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr2_+_207630310 0.243 FASTKD2
FAST kinase domains 2
chr11_-_92931045 0.242 NM_152313
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr17_+_21191347 0.242 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr19_-_6591012 0.242 CD70
CD70 molecule
chr6_-_30654978 0.242 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr5_+_40841296 0.241 NM_032587
CARD6
caspase recruitment domain family, member 6
chr5_-_75919051 0.239 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr16_-_84538219 0.238 NM_020947
KIAA1609
KIAA1609
chr5_+_42756919 0.237 NM_001134848
CCDC152
coiled-coil domain containing 152
chr1_-_158656487 0.236 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr15_+_22892517 0.235 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr12_-_323255 0.234 NM_001122848
NM_001206931
SLC6A12

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

chr16_-_28607694 0.234 NM_177528
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr16_+_89988416 0.234 NM_001197181
TUBB3
tubulin, beta 3 class III
chr17_-_28257017 0.234 NM_033389
SSH2
slingshot homolog 2 (Drosophila)
chr15_+_22892683 0.232 NM_014608
CYFIP1
cytoplasmic FMR1 interacting protein 1
chr3_-_150480963 0.230 NM_005067
SIAH2
seven in absentia homolog 2 (Drosophila)
chr22_+_22676814 0.227


chr4_-_100356290 0.227 NM_001166504
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr1_+_15480213 0.226 NM_001136218
NM_018022
TMEM51

transmembrane protein 51

chr16_-_12010518 0.225 NM_001130007
GSPT1
G1 to S phase transition 1
chr3_+_184016985 0.225 NM_002808
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr1_+_223889253 0.224 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr12_-_58165877 0.223 NM_005371
NM_023033
METTL1

methyltransferase like 1

chr10_+_71075609 0.221 NM_033496
HK1
hexokinase 1
chr15_+_22892723 0.220 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr1_-_108231122 0.220 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr1_-_1149495 0.218 NM_003327
TNFRSF4
tumor necrosis factor receptor superfamily, member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.92 2.45e-02 GO:0006915 apoptosis
4.55 4.19e-02 GO:0033238 regulation of cellular amine metabolic process
5.00 4.21e-02 GO:0006521 regulation of cellular amino acid metabolic process
1.79 4.91e-02 GO:0008219 cell death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
5.46 1.46e-04 GO:0000502 proteasome complex

Nothing significant found in function category.