Motif ID: CREB1.p2

Z-value: 1.440


Transcription factors associated with CREB1.p2:

Gene SymbolEntrez IDGene Name
CREB1 1385 cAMP responsive element binding protein 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
CREB1chr2_+_208394823-0.645.5e-04Click!


Activity profile for motif CREB1.p2.

activity profile for motif CREB1.p2


Sorted Z-values histogram for motif CREB1.p2

Sorted Z-values for motif CREB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CREB1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_58515408 2.784 NM_001190827
NM_022106
 C20orf177

chromosome 20 open reading frame 177

chr3_+_170075449 2.269 NM_001145098
NM_005414
 SKIL

SKI-like oncogene

chr4_-_89618928 2.233 NM_153757
 NAP1L5
nucleosome assembly protein 1-like 5
chr10_-_93392857 2.120 NM_005398
 PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr9_-_125027017 2.040 RBM18
RNA binding motif protein 18
chr13_-_80912971 2.039 SPRY2
sprouty homolog 2 (Drosophila)
chr16_-_88772732 1.967 NM_001171815
 RNF166
ring finger protein 166
chr16_-_88772807 1.889 NM_178841
 RNF166
ring finger protein 166
chr9_-_125027080 1.861 NM_033117
 RBM18
RNA binding motif protein 18
chr11_+_69455938 1.749 CCND1
cyclin D1
chr19_+_54058493 1.715 NM_001079907
 ZNF331
zinc finger protein 331
chr3_+_170075494 1.646 SKIL
SKI-like oncogene
chr11_-_119252267 1.599 USP2
ubiquitin specific peptidase 2
chr12_-_10766130 1.589 NM_018048
 MAGOHB
mago-nashi homolog B (Drosophila)
chr10_-_99094427 1.544 NM_012083
 FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr14_+_68086570 1.543 NM_001172
 ARG2
arginase, type II
chr19_+_38810540 1.486 KCNK6
potassium channel, subfamily K, member 6
chr12_-_123380628 1.481 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr3_+_16306666 1.478 NM_138381
 OXNAD1
oxidoreductase NAD-binding domain containing 1
chr19_-_46088084 1.464 NM_001017989
NM_025136
 OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
2.88 7.90e-03 GO:0065004 protein-DNA complex assembly
2.72 2.10e-02 GO:0071824 protein-DNA complex subunit organization
2.28 9.86e-12 GO:0006396 RNA processing
2.26 3.76e-02 GO:0034470 ncRNA processing
2.15 5.94e-05 GO:0006397 mRNA processing
2.15 1.65e-03 GO:0008380 RNA splicing
2.03 4.49e-02 GO:0034660 ncRNA metabolic process
1.90 3.39e-04 GO:0016071 mRNA metabolic process
1.73 3.40e-02 GO:0044265 cellular macromolecule catabolic process
1.69 2.34e-02 GO:0051276 chromosome organization
1.65 6.18e-13 GO:0090304 nucleic acid metabolic process
1.63 1.62e-09 GO:0010467 gene expression
1.63 6.97e-09 GO:0016070 RNA metabolic process
1.53 4.87e-11 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.51 2.98e-02 GO:0007049 cell cycle
1.48 7.61e-11 GO:0034641 cellular nitrogen compound metabolic process
1.48 4.40e-04 GO:0006996 organelle organization
1.46 1.73e-10 GO:0006807 nitrogen compound metabolic process
1.43 4.80e-14 GO:0044260 cellular macromolecule metabolic process
1.43 4.53e-02 GO:0033036 macromolecule localization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
2.57 2.91e-03 GO:0005681 spliceosomal complex
1.87 1.36e-04 GO:0030529 ribonucleoprotein complex
1.83 5.33e-04 GO:0005730 nucleolus
1.69 1.03e-15 GO:0044428 nuclear part
1.69 8.85e-13 GO:0031981 nuclear lumen
1.67 3.01e-08 GO:0005654 nucleoplasm
1.59 6.28e-12 GO:0070013 intracellular organelle lumen
1.56 6.29e-11 GO:0043233 organelle lumen
1.54 1.26e-10 GO:0031974 membrane-enclosed lumen
1.44 3.50e-03 GO:0005739 mitochondrion
1.36 7.52e-15 GO:0044446 intracellular organelle part
1.35 8.00e-15 GO:0044422 organelle part
1.34 1.81e-13 GO:0005634 nucleus
1.32 1.06e-02 GO:0005829 cytosol
1.31 2.38e-05 GO:0032991 macromolecular complex
1.29 5.70e-24 GO:0043231 intracellular membrane-bounded organelle
1.29 8.70e-24 GO:0043227 membrane-bounded organelle
1.27 2.38e-09 GO:0044444 cytoplasmic part
1.25 4.71e-02 GO:0043228 non-membrane-bounded organelle
1.25 4.71e-02 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
13.26 2.04e-02 GO:0004305 ethanolamine kinase activity
4.42 1.98e-03 GO:0019783 small conjugating protein-specific protease activity
4.17 2.13e-02 GO:0004843 ubiquitin-specific protease activity
3.94 3.79e-02 GO:0003954 NADH dehydrogenase activity
3.94 3.79e-02 GO:0008137 NADH dehydrogenase (ubiquinone) activity
3.94 3.79e-02 GO:0050136 NADH dehydrogenase (quinone) activity
3.76 8.35e-04 GO:0004221 ubiquitin thiolesterase activity
2.84 2.86e-02 GO:0016790 thiolester hydrolase activity
1.79 2.16e-06 GO:0003723 RNA binding
1.39 3.09e-03 GO:0016740 transferase activity
1.37 3.54e-02 GO:0005524 ATP binding
1.35 7.97e-04 GO:0000166 nucleotide binding
1.32 2.04e-05 GO:0003676 nucleic acid binding
1.32 4.75e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.23 2.77e-05 GO:0003824 catalytic activity
1.16 4.58e-04 GO:0005515 protein binding
1.09 3.08e-04 GO:0005488 binding