Motif ID: CRX.p2

Z-value: 0.918


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
CRXchr19_+_48325098-0.125.8e-01Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_102668892 1.648 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr4_+_81106423 1.309 NM_020226
PRDM8
PR domain containing 8
chr17_-_34207308 0.993 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr13_-_33760215 0.965 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr12_+_7942025 0.957 NANOG
Nanog homeobox
chr12_+_6881669 0.890 NM_002286
LAG3
lymphocyte-activation gene 3
chrM_-_9203 0.867


chr1_+_31883020 0.856 NM_001199037
SERINC2
serine incorporator 2
chr6_-_134496833 0.844 SGK1
serum/glucocorticoid regulated kinase 1
chr6_-_11779279 0.780 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr2_-_202563353 0.713 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr7_-_115670828 0.712 NM_001018058
NM_012252
TFEC

transcription factor EC

chrM_+_9217 0.687


chr9_-_35111534 0.678 FAM214B
family with sequence similarity 214, member B
chrM_+_8857 0.671


chrX_+_69454504 0.667 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr6_-_132967141 0.642 NM_138327
TAAR1
trace amine associated receptor 1
chr16_-_48266181 0.621 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr7_-_115670774 0.614 TFEC
transcription factor EC
chr1_+_79086087 0.604 NM_006820
IFI44L
interferon-induced protein 44-like
chr15_-_90222572 0.577 NM_001145311
NM_002666
PLIN1

perilipin 1

chr11_-_1629614 0.567 NM_001012708
KRTAP5-3
keratin associated protein 5-3
chr12_-_56236614 0.565 NM_002429
MMP19
matrix metallopeptidase 19
chr17_-_39280377 0.553 NM_031854
KRTAP4-12
keratin associated protein 4-12
chr7_+_99425635 0.537 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr20_+_9288446 0.524 NM_000933
PLCB4
phospholipase C, beta 4
chrX_-_110655384 0.520 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr10_+_114154522 0.505 ACSL5
acyl-CoA synthetase long-chain family member 5
chr5_+_135364583 0.493 NM_000358
TGFBI
transforming growth factor, beta-induced, 68kDa
chr17_-_39334439 0.492 NM_033062
KRTAP4-2
keratin associated protein 4-2
chrX_+_102585113 0.491 NM_152278
TCEAL7
transcription elongation factor A (SII)-like 7
chr2_-_26101301 0.491 NM_018263
ASXL2
additional sex combs like 2 (Drosophila)
chr6_+_32407618 0.482 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chrM_+_9182 0.478


chr9_-_74675498 0.468 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr13_-_34250899 0.461 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr20_+_20037289 0.460 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chr14_-_61748510 0.455 NM_001017970
TMEM30B
transmembrane protein 30B
chr9_+_12693385 0.443 NM_000550
TYRP1
tyrosinase-related protein 1
chr5_+_131409484 0.439 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr1_+_179560747 0.436 NM_001199091
NM_001199085
NM_173533
TDRD5


tudor domain containing 5


chr11_+_61717355 0.432 NM_001139443
NM_004183
BEST1

bestrophin 1

chr6_-_24877453 0.430 NM_015864
FAM65B
family with sequence similarity 65, member B
chr11_+_5410606 0.424 NM_001004756
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr8_+_32579350 0.421 NM_001159996
NRG1
neuregulin 1
chr15_-_40633122 0.420 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr21_-_31869427 0.420 NM_181610
KRTAP19-4
keratin associated protein 19-4
chr15_-_99789585 0.419 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr12_-_21487831 0.414 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr18_+_29769986 0.413 NM_005925
MEP1B
meprin A, beta
chr19_+_45174723 0.408 NM_001127893
NM_020219
CEACAM19

carcinoembryonic antigen-related cell adhesion molecule 19

chr3_+_160394946 0.391 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr4_-_76957139 0.383 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr3_+_97868169 0.380 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chrX_-_70331297 0.375 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr20_-_49253425 0.375 NM_080829
FAM65C
family with sequence similarity 65, member C
chr20_-_62611308 0.367 SAMD10
sterile alpha motif domain containing 10
chr3_+_50306578 0.367 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr11_+_69467210 0.364 CCND1
cyclin D1
chr3_+_50306305 0.360 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr1_-_168513201 0.358 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr4_+_106631966 0.358 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr1_-_173174611 0.351 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr1_+_20396652 0.349 NM_000929
PLA2G5
phospholipase A2, group V
chr1_+_155006281 0.349 NM_001143687
NM_152494
DCST1

DC-STAMP domain containing 1

chr12_+_7941994 0.346 NM_024865
NANOG
Nanog homeobox
chr11_-_102668822 0.344 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr12_+_131438451 0.339 NM_198827
GPR133
G protein-coupled receptor 133
chr6_+_7107799 0.337 NM_001168344
RREB1
ras responsive element binding protein 1
chr2_-_26101329 0.336 ASXL2
additional sex combs like 2 (Drosophila)
chr7_-_138363789 0.335 NM_001139456
SVOPL
SVOP-like
chr14_+_74035762 0.335 NM_006821
ACOT2
acyl-CoA thioesterase 2
chr18_+_616671 0.332 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr10_+_124670216 0.331 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr8_+_79428335 0.330 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr5_-_95768660 0.330 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr4_-_190948396 0.330 NM_001199232
NM_001005217
LOC100288255
FRG2
FSHD region gene 2-like
FSHD region gene 2
chr1_-_156786500 0.329 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr17_-_39092714 0.329 KRT23
keratin 23 (histone deacetylase inducible)
chr11_-_102651321 0.328 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr1_-_27998700 0.326 IFI6
interferon, alpha-inducible protein 6
chr12_-_4488707 0.324 NM_020638
FGF23
fibroblast growth factor 23
chr9_+_125132823 0.319 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr8_-_87755880 0.317 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr19_-_633526 0.316 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr19_-_55668956 0.312 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr2_-_100758970 0.310 NM_002285
AFF3
AF4/FMR2 family, member 3
chr12_-_52761254 0.309 NM_002283
KRT85
keratin 85
chr3_-_47621729 0.308 NM_001206942
NM_001206945
CSPG5

chondroitin sulfate proteoglycan 5 (neuroglycan C)

chrX_+_64708614 0.303 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chr7_-_138482848 0.295 NM_020632
NM_130840
ATP6V0A4

ATPase, H+ transporting, lysosomal V0 subunit a4

chr6_+_43543877 0.294 NM_006502
POLH
polymerase (DNA directed), eta
chr3_-_147123306 0.293 NM_001168379
ZIC4
Zic family member 4
chr10_-_62149487 0.292 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_-_7818488 0.292 NM_153444
OR5P2
olfactory receptor, family 5, subfamily P, member 2
chr17_+_68100994 0.285 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr9_+_80911990 0.285 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr11_+_60467046 0.279 NM_031457
MS4A8B
membrane-spanning 4-domains, subfamily A, member 8B
chr14_-_61748193 0.278


chr4_-_87028805 0.278 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr5_-_169724614 0.277 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr20_-_44538654 0.276 PLTP
phospholipid transfer protein
chr6_+_43543921 0.276 POLH
polymerase (DNA directed), eta
chr11_+_118175294 0.275 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr15_-_31393906 0.273 NM_001252024
NM_001252030
NM_002420
TRPM1


transient receptor potential cation channel, subfamily M, member 1


chr11_-_116663106 0.273 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr12_+_7341758 0.272 NM_001131026
PEX5
peroxisomal biogenesis factor 5
chr6_-_111894897 0.272 NM_001164282
TRAF3IP2
TRAF3 interacting protein 2
chr18_+_8717368 0.271 NM_015210
CCDC165
coiled-coil domain containing 165
chr2_-_163099877 0.270 NM_004460
FAP
fibroblast activation protein, alpha
chr1_-_149908721 0.270 MTMR11
myotubularin related protein 11
chr12_-_2027802 0.266 NM_172364
CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr17_-_7590731 0.265 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chrM_+_9725 0.264


chr12_-_8088629 0.263 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr3_-_15563160 0.262 NM_005677
NM_080539
COLQ

collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

chr2_-_31030271 0.262 NM_144575
CAPN13
calpain 13
chr1_-_149908759 0.259 NM_001145862
MTMR11
myotubularin related protein 11
chr14_+_23842017 0.259 NM_172314
NM_022789
IL25

interleukin 25

chr12_-_11175169 0.253 NM_176888
TAS2R19
taste receptor, type 2, member 19
chr21_-_35884503 0.253 KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr19_+_51645556 0.253 NM_014385
NM_016543
SIGLEC7

sialic acid binding Ig-like lectin 7

chr1_-_153067000 0.252 NM_001024209
SPRR2E
small proline-rich protein 2E
chr3_+_149192367 0.252 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr12_-_16758312 0.251 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_+_26400503 0.251 NM_001199837
SNX10
sorting nexin 10
chr1_+_158979681 0.251 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr9_-_114090712 0.250 NM_205859
OR2K2
olfactory receptor, family 2, subfamily K, member 2
chr1_+_18957499 0.250 NM_001135254
NM_002584
NM_013945
PAX7


paired box 7


chr1_-_160617042 0.249 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr11_-_36619776 0.249 NM_000536
NM_001243785
NM_001243786
RAG2


recombination activating gene 2


chr12_-_16757944 0.249 LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_-_111435604 0.248 NM_004336
BUB1
budding uninhibited by benzimidazoles 1 homolog (yeast)
chr4_-_40936640 0.244 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chrX_-_11284094 0.241 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr17_+_7210929 0.239 EIF5A
eukaryotic translation initiation factor 5A
chr14_+_88852065 0.237 SPATA7
spermatogenesis associated 7
chr8_+_86376130 0.237 NM_000067
CA2
carbonic anhydrase II
chr22_+_22676814 0.235


chr5_-_137071703 0.235 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr19_-_633563 0.234 NM_005035
POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr12_-_23737507 0.234 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr10_-_14372807 0.233 NM_018027
FRMD4A
FERM domain containing 4A
chr13_-_33780142 0.232 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr4_+_25658085 0.232 NM_001177999
SLC34A2
solute carrier family 34 (sodium phosphate), member 2
chr4_+_100432160 0.231 NM_032149
C4orf17
chromosome 4 open reading frame 17
chr14_-_73360792 0.231 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chrX_-_24690740 0.231 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr5_-_83680590 0.230 NM_005711
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr12_+_6949374 0.230 NM_002075
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr14_-_71001731 0.230 NM_003814
ADAM20
ADAM metallopeptidase domain 20
chr16_-_69385656 0.229 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr17_-_39254374 0.229 NM_031960
KRTAP4-8
keratin associated protein 4-8
chr3_+_88188261 0.227 NM_018293
ZNF654
zinc finger protein 654
chr12_-_53242716 0.227 NM_173352
KRT78
keratin 78
chr4_+_106067031 0.226 NM_017628
TET2
tet methylcytosine dioxygenase 2
chr1_+_150459913 0.224 NM_025150
TARS2
threonyl-tRNA synthetase 2, mitochondrial (putative)
chr20_+_2903852 0.224 NM_080841
PTPRA
protein tyrosine phosphatase, receptor type, A
chr6_-_42690308 0.223 NM_000322
PRPH2
peripherin 2 (retinal degeneration, slow)
chr1_-_161601752 0.223 NM_000570
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr5_-_58652671 0.222 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr16_+_67311412 0.221 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr2_-_37374948 0.221 NM_001135652
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr1_-_39347258 0.221 NM_030772
GJA9-MYCBP
GJA9
GJA9-MYCBP readthrough
gap junction protein, alpha 9, 59kDa
chr7_+_141463896 0.220 NM_016943
TAS2R3
taste receptor, type 2, member 3
chr16_+_81272293 0.220 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr6_-_52109226 0.219 NM_052872
IL17F
interleukin 17F
chr1_+_150459873 0.219 TARS2
threonyl-tRNA synthetase 2, mitochondrial (putative)
chr3_-_58563490 0.218 NM_001076778
NM_007177
FAM107A

family with sequence similarity 107, member A

chr3_+_148447966 0.217 NM_032049
AGTR1
angiotensin II receptor, type 1
chr3_-_12941547 0.217 IQSEC1
IQ motif and Sec7 domain 1
chr6_+_52284948 0.217 NM_018100
EFHC1
EF-hand domain (C-terminal) containing 1
chr6_+_31554475 0.216 NM_205837
LST1
leukocyte specific transcript 1
chr10_+_91152321 0.215 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr3_-_19975671 0.215 NM_144715
EFHB
EF-hand domain family, member B
chr3_+_51989329 0.215 NM_080865
GPR62
G protein-coupled receptor 62
chr1_-_47655723 0.214 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr12_-_11244828 0.214 NM_176884
TAS2R43
TAS2R31
taste receptor, type 2, member 43
taste receptor, type 2, member 31
chr12_+_49524648 0.213


chr15_-_72501017 0.213 PKM2
pyruvate kinase, muscle
chr12_-_53189780 0.212 NM_057088
KRT3
keratin 3
chr17_+_41158741 0.211 NM_005533
IFI35
interferon-induced protein 35
chr17_+_3118911 0.211 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr6_+_147527102 0.210 STXBP5
syntaxin binding protein 5 (tomosyn)
chr6_-_80247103 0.210 NM_001122769
NM_181714
LCA5

Leber congenital amaurosis 5

chr8_-_42234562 0.210 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr19_-_39235113 0.210 NM_144691
CAPN12
calpain 12
chr20_+_31805118 0.209 NM_001042439
NM_178466
BPIFA3

BPI fold containing family A, member 3

chr2_+_3705785 0.209 NM_018436
ALLC
allantoicase
chr8_-_7220489 0.208 NM_001164457
ZNF705G
zinc finger protein 705G
chr1_-_158656487 0.208 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr20_-_20036685 0.208 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr17_+_38465422 0.208 NM_000964
RARA
retinoic acid receptor, alpha
chr11_+_7618416 0.207 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr19_+_54415990 0.206 NM_031896
CACNG7
calcium channel, voltage-dependent, gamma subunit 7
chr12_-_111358353 0.206 NM_000432
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr12_+_20848288 0.206 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr12_+_29376596 0.206 NM_018099
FAR2
fatty acyl CoA reductase 2
chr6_-_35480635 0.205 NM_003322
TULP1
tubby like protein 1
chr1_+_202509241 0.205 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory subunit 12B

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.53 1.10e-03 GO:0002376 immune system process
1.63 1.04e-02 GO:0006955 immune response
2.04 1.21e-02 GO:0050778 positive regulation of immune response
1.57 2.91e-02 GO:0006952 defense response
1.79 2.99e-02 GO:0002684 positive regulation of immune system process
1.77 4.01e-02 GO:0050776 regulation of immune response
10.49 4.78e-02 GO:0007210 serotonin receptor signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 8.56e-04 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.08 4.15e-02 GO:0005125 cytokine activity