Motif ID: E2F1..5.p2

Z-value: 2.979


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
E2F2chr1_-_23857711-0.611.3e-03Click!
E2F1chr20_-_322741540.423.7e-02Click!
E2F4chr16_+_67226098,
chr16_+_67226027
-0.367.4e-02Click!
E2F5chr8_+_86099909-0.271.8e-01Click!
E2F3chr6_+_20404033-0.135.4e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_131762017 21.081 NM_001005463
EBF3
early B-cell factor 3
chr19_+_4909447 10.940 NM_001048201
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chr11_-_33890931 7.921 LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33891361 6.662 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33891258 6.049 LMO2
LIM domain only 2 (rhombotin-like 1)
chr8_-_124408458 5.681 ATAD2
ATPase family, AAA domain containing 2
chrX_+_101967290 5.672 GPRASP2
G protein-coupled receptor associated sorting protein 2
chr11_-_19262424 5.609 NM_024680
E2F8
E2F transcription factor 8
chr8_-_124408688 5.434 NM_014109
ATAD2
ATPase family, AAA domain containing 2
chr8_-_124408665 5.284 ATAD2
ATPase family, AAA domain containing 2
chr20_-_5100443 5.256 NM_182649
PCNA
proliferating cell nuclear antigen
chr3_-_148804122 5.159 NM_003071
NM_139048
HLTF

helicase-like transcription factor

chrX_-_62974942 4.631 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chrX_-_62974341 4.580 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr9_-_99180661 4.482 NM_153695
ZNF367
zinc finger protein 367
chr1_+_61547625 4.388 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr10_+_8096633 4.366 NM_001002295
NM_002051
GATA3

GATA binding protein 3

chr2_+_16080639 4.283 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr19_+_4910339 4.273 NM_013282
UHRF1
ubiquitin-like with PHD and ring finger domains 1
chrX_-_62974987 4.246 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 135 entries
enrichment   p-value GO term description
11.09 8.27e-07 GO:0071897 DNA biosynthetic process
10.35 1.09e-03 GO:0002566 somatic diversification of immune receptors via somatic mutation
10.35 1.09e-03 GO:0016446 somatic hypermutation of immunoglobulin genes
9.98 1.13e-02 GO:0000731 DNA synthesis involved in DNA repair
9.98 1.13e-02 GO:0007064 mitotic sister chromatid cohesion
7.39 3.60e-04 GO:0007062 sister chromatid cohesion
7.32 9.57e-05 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
7.32 9.57e-05 GO:0006298 mismatch repair
7.26 2.55e-05 GO:0006270 DNA-dependent DNA replication initiation
6.65 6.52e-06 GO:0006271 DNA strand elongation involved in DNA replication
6.34 2.35e-03 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
6.34 2.35e-03 GO:0016444 somatic cell DNA recombination
6.26 3.40e-02 GO:0016447 somatic recombination of immunoglobulin gene segments
6.21 2.05e-05 GO:0022616 DNA strand elongation
5.86 1.79e-03 GO:0002200 somatic diversification of immune receptors
5.44 3.91e-02 GO:0016445 somatic diversification of immunoglobulins
4.88 1.54e-02 GO:0007131 reciprocal meiotic recombination
4.75 3.88e-08 GO:0006261 DNA-dependent DNA replication
4.54 9.43e-04 GO:0000819 sister chromatid segregation
4.54 2.26e-03 GO:0000070 mitotic sister chromatid segregation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 45 entries
enrichment   p-value GO term description
10.35 1.78e-04 GO:0035098 ESC/E(Z) complex
9.98 1.85e-03 GO:0042555 MCM complex
8.87 1.59e-04 GO:0032300 mismatch repair complex
6.30 1.46e-03 GO:0031519 PcG protein complex
3.96 2.42e-02 GO:0005657 replication fork
3.77 5.14e-04 GO:0000123 histone acetyltransferase complex
3.63 2.87e-02 GO:0000792 heterochromatin
3.26 4.78e-02 GO:0034708 methyltransferase complex
3.26 4.78e-02 GO:0035097 histone methyltransferase complex
3.08 3.33e-03 GO:0000790 nuclear chromatin
3.01 1.71e-10 GO:0000785 chromatin
2.94 2.50e-03 GO:0032993 protein-DNA complex
2.92 1.24e-08 GO:0000228 nuclear chromosome
2.74 1.53e-05 GO:0044454 nuclear chromosome part
2.72 1.98e-19 GO:0005694 chromosome
2.64 1.24e-14 GO:0044427 chromosomal part
2.49 5.34e-03 GO:0000793 condensed chromosome
2.44 7.91e-03 GO:0000775 chromosome, centromeric region
2.25 1.12e-03 GO:0005813 centrosome
2.25 1.12e-03 GO:0016604 nuclear body

Gene overrepresentation in function category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
13.31 1.91e-02 GO:0032138 single base insertion or deletion binding
11.09 8.04e-03 GO:0032135 DNA insertion or deletion binding
9.51 2.64e-02 GO:0032404 mismatch repair complex binding
8.56 6.32e-05 GO:0030983 mismatched DNA binding
5.63 6.67e-04 GO:0003887 DNA-directed DNA polymerase activity
5.51 2.88e-04 GO:0034061 DNA polymerase activity
3.60 2.21e-02 GO:0003684 damaged DNA binding
3.27 3.66e-02 GO:0003697 single-stranded DNA binding
3.06 1.58e-02 GO:0042393 histone binding
2.58 7.22e-05 GO:0003682 chromatin binding
2.47 1.32e-02 GO:0003690 double-stranded DNA binding
2.45 5.66e-04 GO:0043566 structure-specific DNA binding
1.94 1.48e-03 GO:0003712 transcription cofactor activity
1.93 1.60e-03 GO:0000988 protein binding transcription factor activity
1.93 1.60e-03 GO:0000989 transcription factor binding transcription factor activity
1.60 6.59e-13 GO:0003677 DNA binding
1.56 8.89e-03 GO:0003723 RNA binding
1.56 1.86e-02 GO:0019899 enzyme binding
1.55 1.64e-17 GO:0003676 nucleic acid binding
1.23 1.89e-09 GO:0005515 protein binding