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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: EGR1..3.p2

Z-value: 1.998

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_+_46524901	5.583		EPAS1	endothelial PAS domain protein 1
chr13_-_72440557	5.159		DACH1	dachshund homolog 1 (Drosophila)
chr5_+_56111379	4.785		MAP3K1	mitogen-activated protein kinase kinase kinase 1
chr12_+_57482886	4.774		NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr2_+_191513832	4.554	NM_005966	NAB1	NGFI-A binding protein 1 (EGR1 binding protein 1)
chr7_-_32931409	4.332	NM_015483	KBTBD2	kelch repeat and BTB (POZ) domain containing 2
chr4_-_102267952	4.324		PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme
chr6_+_84743250	4.319	NM_138409	MRAP2	melanocortin 2 receptor accessory protein 2
chr1_+_65991390	4.268		LEPR	leptin receptor
chr12_+_57482674	3.713	NM_005967	NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr12_+_57482922	3.530		NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr7_+_65338343	3.516		VKORC1L1	vitamin K epoxide reductase complex, subunit 1-like 1
chr1_+_65991357	3.477	NM_001198687 NM_001198688 NM_001198689	LEPR	leptin receptor
chr13_-_77460432	3.475	NM_138444	KCTD12	potassium channel tetramerisation domain containing 12
chr7_-_32931363	3.348		KBTBD2	kelch repeat and BTB (POZ) domain containing 2
chr1_+_35258598	3.271	NM_002060	GJA4	gap junction protein, alpha 4, 37kDa
chr4_-_25864430	3.159	NM_015187	SEL1L3	sel-1 suppressor of lin-12-like 3 (C. elegans)
chr9_+_115513050	3.060	NM_001012994	SNX30	sorting nexin family member 30
chr21_-_35987144	3.054	NM_004414	RCAN1	regulator of calcineurin 1
chr11_+_125034558	3.053	NM_022062	PKNOX2	PBX/knotted 1 homeobox 2
chr4_-_102268626	3.002	NM_000944 NM_001130691 NM_001130692	PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme
chr3_-_171177851	2.972	NM_001161560 NM_001161561 NM_001161562 NM_001161563 NM_001161564 NM_001161565 NM_001161566 NM_015028	TNIK	TRAF2 and NCK interacting kinase
chr7_-_82073020	2.874	NM_000722	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr7_+_94023872	2.868	NM_000089	COL1A2	collagen, type I, alpha 2
chr12_+_79258517	2.828		SYT1	synaptotagmin I
chr12_+_79258588	2.773		SYT1	synaptotagmin I
chr4_+_1005609	2.769	NM_001004356 NM_001004358	FGFRL1	fibroblast growth factor receptor-like 1
chr14_-_105635114	2.733	NM_002226 NM_145159	JAG2	jagged 2
chr7_+_65338349	2.728		VKORC1L1	vitamin K epoxide reductase complex, subunit 1-like 1
chr20_-_62462568	2.656		ZBTB46	zinc finger and BTB domain containing 46
chr4_-_102268333	2.632		PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme
chr3_+_20081853	2.631		KAT2B	K(lysine) acetyltransferase 2B
chr1_+_212459169	2.622		PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha
chr1_+_212459262	2.622		PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha
chr7_-_32931189	2.582		KBTBD2	kelch repeat and BTB (POZ) domain containing 2
chr22_+_51113069	2.558	NM_001080420	SHANK3	SH3 and multiple ankyrin repeat domains 3
chr2_+_12856813	2.554	NM_021643	TRIB2	tribbles homolog 2 (Drosophila)
chr4_+_134073180	2.546		PCDH10	protocadherin 10
chr1_-_22263676	2.522	NM_005529	HSPG2	heparan sulfate proteoglycan 2
chr6_-_110500803	2.482		WASF1	WAS protein family, member 1
chr13_+_20532881	2.380		ZMYM2	zinc finger, MYM-type 2
chr15_-_69113213	2.359		ANP32A	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr11_+_125034604	2.326		PKNOX2	PBX/knotted 1 homeobox 2
chr15_-_69113089	2.294		ANP32A	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr1_+_78354199	2.287	NM_001172309 NM_144573	NEXN	nexilin (F actin binding protein)
chr7_-_82072804	2.277		CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr2_-_190445466	2.274		SLC40A1	solute carrier family 40 (iron-regulated transporter), member 1
chr2_+_46524448	2.213	NM_001430	EPAS1	endothelial PAS domain protein 1
chr12_+_79258448	2.186	NM_005639	SYT1	synaptotagmin I
chr16_+_29817810	2.186	NM_001042539 NM_002383	MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)
chr4_-_90758126	2.184	NM_001146054 NM_007308 NM_000345	SNCA	synuclein, alpha (non A4 component of amyloid precursor)
chr9_-_14313899	2.178		NFIB	nuclear factor I/B
chr12_-_96793797	2.143		CDK17	cyclin-dependent kinase 17
chr5_-_81046943	2.126	NM_012446	SSBP2	single-stranded DNA binding protein 2
chr20_+_42543417	2.120	NM_001098797	TOX2	TOX high mobility group box family member 2
chr11_-_33891485	2.117	NM_001142315	LMO2	LIM domain only 2 (rhombotin-like 1)
chr20_+_34742656	2.103	NM_012156	EPB41L1	erythrocyte membrane protein band 4.1-like 1
chr21_-_47648685	2.100		LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr18_-_48723689	2.073		MEX3C	mex-3 homolog C (C. elegans)
chr10_+_94608224	2.066	NM_019053	EXOC6	exocyst complex component 6
chr17_+_65822206	2.062		BPTF	bromodomain PHD finger transcription factor
chr12_+_79258794	2.060		SYT1	synaptotagmin I
chr15_+_76135992	2.055		UBE2Q2	ubiquitin-conjugating enzyme E2Q family member 2
chr9_-_13279562	2.037		MPDZ	multiple PDZ domain protein
chr1_+_65886315	1.987	NM_001003679 NM_001003680 NM_002303 NM_001198681	LEPR LEPROT	leptin receptor leptin receptor overlapping transcript
chr1_+_77747602	1.964	NM_174858	AK5	adenylate kinase 5
chr14_-_105634708	1.957		JAG2	jagged 2
chr14_+_53019865	1.950	NM_001099652	GPR137C	G protein-coupled receptor 137C
chr3_+_37903643	1.938	NM_001008392 NM_005808	CTDSPL	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr17_+_65822242	1.918		BPTF	bromodomain PHD finger transcription factor
chr10_-_21805715	1.901		C10orf140	chromosome 10 open reading frame 140
chr2_+_159313466	1.895	NM_001005476 NM_003628	PKP4	plakophilin 4
chr10_-_131762017	1.882	NM_001005463	EBF3	early B-cell factor 3
chr9_+_139606916	1.850	NM_152421	FAM69B	family with sequence similarity 69, member B
chr2_+_48757292	1.821	NM_001198595 NM_006873	STON1	stonin 1
chr7_+_65338161	1.816	NM_173517	VKORC1L1	vitamin K epoxide reductase complex, subunit 1-like 1
chr9_-_14314036	1.815	NM_001190737 NM_005596	NFIB	nuclear factor I/B
chr17_+_60705051	1.813		MRC2	mannose receptor, C type 2
chr20_-_62680880	1.811	NM_018419	SOX18	SRY (sex determining region Y)-box 18
chr14_-_51135021	1.780	NM_021818	SAV1	salvador homolog 1 (Drosophila)
chr3_-_15900928	1.736	NM_015199	ANKRD28	ankyrin repeat domain 28
chr17_+_60705042	1.729		MRC2	mannose receptor, C type 2
chr2_+_181845368	1.727		UBE2E3	ubiquitin-conjugating enzyme E2E 3
chr4_+_38665587	1.722	NM_016531	KLF3	Kruppel-like factor 3 (basic)
chrX_-_117250624	1.696	NM_001168302 NM_001168303	KLHL13	kelch-like 13 (Drosophila)
chr2_-_190445521	1.687	NM_014585	SLC40A1	solute carrier family 40 (iron-regulated transporter), member 1
chr17_+_65821625	1.660	NM_004459 NM_182641	BPTF	bromodomain PHD finger transcription factor
chr18_-_53255734	1.659	NM_001083962 NM_001243230 NM_003199	TCF4	transcription factor 4
chr16_-_19896105	1.656	NM_016235	GPRC5B	G protein-coupled receptor, family C, group 5, member B
chr7_-_156685621	1.648		LMBR1	limb region 1 homolog (mouse)
chr22_+_19701968	1.637	NM_002688	SEPT5	septin 5
chr2_+_203241044	1.634	NM_001204	BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr1_-_51425795	1.630		FAF1	Fas (TNFRSF6) associated factor 1
chr2_-_165477986	1.613		GRB14	growth factor receptor-bound protein 14
chr18_+_77160243	1.603	NM_172387 NM_172389	NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr15_-_82338459	1.600		MEX3B	mex-3 homolog B (C. elegans)
chr6_-_13711643	1.597	NM_005493	RANBP9	RAN binding protein 9
chr7_+_116502529	1.589	NM_006136	CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2
chrX_+_117861523	1.577	NM_001560	IL13RA1	interleukin 13 receptor, alpha 1
chr1_-_51425740	1.567		FAF1	Fas (TNFRSF6) associated factor 1
chr19_-_18392436	1.566		JUND	jun D proto-oncogene
chr18_-_22932109	1.554	NM_015461	ZNF521	zinc finger protein 521
chr4_+_1006251	1.551	NM_021923	FGFRL1	fibroblast growth factor receptor-like 1
chr1_+_12040475	1.541		MFN2	mitofusin 2
chr6_-_16761600	1.534	NM_000332 NM_001128164	ATXN1	ataxin 1
chr4_-_55991746	1.529	NM_002253	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)
chr10_+_112631675	1.514		PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)
chr19_-_14629227	1.506		DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1
chr18_-_22931970	1.501		ZNF521	zinc finger protein 521
chr19_+_2476122	1.499	NM_015675	GADD45B	growth arrest and DNA-damage-inducible, beta
chr5_-_81046858	1.499		SSBP2	single-stranded DNA binding protein 2
chr19_+_35760002	1.497		USF2	upstream transcription factor 2, c-fos interacting
chr7_-_86688944	1.486	NM_001142749	KIAA1324L	KIAA1324-like
chr3_+_134514044	1.486	NM_004441	EPHB1	EPH receptor B1
chr20_+_10015696	1.480	NM_022096 NM_198798	ANKRD5	ankyrin repeat domain 5
chr21_+_46494433	1.477	NM_001112 NM_001160230 NM_015833 NM_015834	ADARB1	adenosine deaminase, RNA-specific, B1
chr7_+_106685007	1.477	NM_002736	PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta
chr12_+_6875468	1.473	NM_002824	PTMS	parathymosin
chr13_-_110438896	1.471	NM_003749	IRS2	insulin receptor substrate 2
chr13_-_99738639	1.455	NM_001130049 NM_015296	DOCK9	dedicator of cytokinesis 9
chr17_-_57184116	1.450		TRIM37	tripartite motif containing 37
chr2_-_99347430	1.447		MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr6_-_110501164	1.446	NM_001024934 NM_001024935 NM_001024936 NM_003931	WASF1	WAS protein family, member 1
chr15_-_82338348	1.438	NM_032246	MEX3B	mex-3 homolog B (C. elegans)
chr7_-_74867340	1.435	NM_001145064	GTF2IP1 GATSL2	general transcription factor IIi, pseudogene 1 GATS protein-like 2
chr15_-_69113255	1.433	NM_006305	ANP32A	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr4_+_41362750	1.430	NM_001112717 NM_001112718 NM_014988	LIMCH1	LIM and calponin homology domains 1
chr11_-_10315680	1.425	NM_030962	SBF2	SET binding factor 2
chr6_-_111136330	1.421		CDK19	cyclin-dependent kinase 19
chr13_+_20532906	1.412	NM_001190965	ZMYM2	zinc finger, MYM-type 2
chr3_+_58223415	1.410		ABHD6	abhydrolase domain containing 6
chr1_+_212458867	1.389	NM_006243	PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha
chr10_+_131265500	1.386		MGMT	O-6-methylguanine-DNA methyltransferase
chr11_-_2906960	1.383	NM_000076 NM_001122630 NM_001122631	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr8_+_144816287	1.382		LOC100128338	uncharacterized LOC100128338
chr2_-_178129858	1.379	NM_006164	NFE2L2	nuclear factor (erythroid-derived 2)-like 2
chr8_+_120220554	1.378	NM_052886	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)
chr10_-_125851850	1.378	NM_014863 NM_015892	CHST15	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr10_+_131265453	1.371	NM_002412	MGMT	O-6-methylguanine-DNA methyltransferase
chr3_+_32280211	1.369		CMTM8	CKLF-like MARVEL transmembrane domain containing 8
chr6_-_13711484	1.366		RANBP9	RAN binding protein 9
chr8_-_127570465	1.359		FAM84B	family with sequence similarity 84, member B
chr4_+_156587861	1.358	NM_000856 NM_001130682 NM_001130686 NM_001130687 NM_001130683 NM_001130685	GUCY1A3	guanylate cyclase 1, soluble, alpha 3
chr20_-_39317875	1.356	NM_005461	MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr19_-_41859519	1.355		TGFB1	transforming growth factor, beta 1
chr9_-_15510899	1.348	NM_001128217 NM_033222	PSIP1	PC4 and SFRS1 interacting protein 1
chr8_-_125384916	1.342	NM_194291	TMEM65	transmembrane protein 65
chr1_-_55352920	1.340	NM_014762	DHCR24	24-dehydrocholesterol reductase
chr12_-_109125254	1.336		CORO1C	coronin, actin binding protein, 1C
chr12_+_6875686	1.333		PTMS	parathymosin
chr17_-_76921076	1.333		TIMP2	TIMP metallopeptidase inhibitor 2
chr18_+_12948004	1.328		SEH1L	SEH1-like (S. cerevisiae)
chr17_-_62914902	1.315	NM_199340	LRRC37A3	leucine rich repeat containing 37, member A3
chr1_-_55352818	1.296		DHCR24	24-dehydrocholesterol reductase
chr17_+_60704747	1.284	NM_006039	MRC2	mannose receptor, C type 2
chr21_-_27542919	1.271		APP	amyloid beta (A4) precursor protein
chr2_+_181845088	1.268	NM_182678 NM_006357	UBE2E3	ubiquitin-conjugating enzyme E2E 3
chr12_-_109125275	1.267		CORO1C	coronin, actin binding protein, 1C
chr2_+_191745546	1.262	NM_014905	GLS	glutaminase
chr19_-_54693453	1.256		MBOAT7	membrane bound O-acyltransferase domain containing 7
chr2_+_159313407	1.253		PKP4	plakophilin 4
chr21_-_40032563	1.252	NM_001243428	ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr9_-_135230340	1.247		SETX	senataxin
chrX_+_107069459	1.247		MID2	midline 2
chrX_+_107069502	1.245		MID2	midline 2
chr2_+_191745791	1.242		GLS	glutaminase
chr21_+_27107731	1.237		GABPA	GA binding protein transcription factor, alpha subunit 60kDa
chr6_-_13711952	1.236		RANBP9	RAN binding protein 9
chr18_-_48723105	1.230		MEX3C	mex-3 homolog C (C. elegans)
chr4_+_108745718	1.230	NM_001136258	SGMS2	sphingomyelin synthase 2
chr9_+_131314669	1.228	NM_001130438 NM_001195532 NM_003127	SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
chr12_+_51158242	1.226		ATF1	activating transcription factor 1
chr1_-_226374400	1.223		ACBD3	acyl-CoA binding domain containing 3
chr2_+_132285469	1.220	NM_138770	CCDC74A	coiled-coil domain containing 74A
chr17_-_79008372	1.211		FLJ90757	uncharacterized LOC440465
chr9_+_2015218	1.203	NM_003070 NM_139045	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr13_-_114898013	1.200		RASA3	RAS p21 protein activator 3
chr6_+_111135823	1.188		AMD1	adenosylmethionine decarboxylase 1
chr4_-_77134948	1.186		SCARB2	scavenger receptor class B, member 2
chr10_+_112631552	1.183	NM_001199492 NM_014456 NM_145341	PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)
chr1_-_51425918	1.182	NM_007051	FAF1	Fas (TNFRSF6) associated factor 1
chrX_-_128657453	1.174	NM_003069 NM_139035	SMARCA1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr2_-_27485774	1.172	NM_003459	SLC30A3	solute carrier family 30 (zinc transporter), member 3
chr13_-_22033477	1.171
chr19_-_14201230	1.168	NM_138352	SAMD1	sterile alpha motif domain containing 1
chr2_-_130902568	1.167	NM_207310	CCDC74B	coiled-coil domain containing 74B
chr14_-_99947080	1.166		SETD3	SET domain containing 3
chr14_-_51134862	1.162		SAV1	salvador homolog 1 (Drosophila)
chr1_+_24104906	1.161		PITHD1	PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
chr10_+_69644341	1.159	NM_012238	SIRT1	sirtuin 1
chr1_-_33168356	1.153	NM_001161708 NM_030786	SYNC	syncoilin, intermediate filament protein
chr6_-_84418705	1.152	NM_001242792	SNAP91	synaptosomal-associated protein, 91kDa homolog (mouse)
chr9_+_123963728	1.151		GSN	gelsolin
chrX_-_128657440	1.145		SMARCA1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr19_+_41107220	1.145	NM_001042545	LTBP4	latent transforming growth factor beta binding protein 4
chr17_+_81037504	1.145	NM_001004431	METRNL	meteorin, glial cell differentiation regulator-like
chr12_-_58240446	1.145		CTDSP2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr8_-_127570710	1.141	NM_174911	FAM84B	family with sequence similarity 84, member B
chr3_+_50192420	1.139		SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr6_-_111136407	1.134	NM_015076	CDK19	cyclin-dependent kinase 19

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.12	5.41e-20	GO:0009987	cellular process
1.21	7.05e-20	GO:0050794	regulation of cellular process
1.19	4.01e-19	GO:0050789	regulation of biological process
1.18	9.03e-18	GO:0065007	biological regulation
1.19	8.23e-14	GO:0044237	cellular metabolic process
1.42	9.10e-14	GO:0006464	protein modification process
1.24	1.51e-13	GO:0044260	cellular macromolecule metabolic process
1.40	1.85e-13	GO:0043412	macromolecule modification
1.35	1.58e-12	GO:0048519	negative regulation of biological process
1.36	1.16e-11	GO:0048523	negative regulation of cellular process
1.27	1.18e-11	GO:0060255	regulation of macromolecule metabolic process
1.25	2.19e-11	GO:0032502	developmental process
1.24	2.50e-11	GO:0019222	regulation of metabolic process
1.25	8.12e-11	GO:0031323	regulation of cellular metabolic process
1.54	8.65e-11	GO:0006357	regulation of transcription from RNA polymerase II promoter
1.42	1.56e-10	GO:0007399	nervous system development
1.25	3.01e-10	GO:0080090	regulation of primary metabolic process
1.25	3.98e-10	GO:0007275	multicellular organismal development
1.39	4.22e-10	GO:0023051	regulation of signaling
1.15	6.00e-10	GO:0008152	metabolic process
1.19	1.07e-09	GO:0043170	macromolecule metabolic process
1.28	1.43e-09	GO:0048731	system development
1.26	1.50e-09	GO:0048856	anatomical structure development
1.32	1.66e-09	GO:0051252	regulation of RNA metabolic process
1.29	2.25e-09	GO:0010468	regulation of gene expression
1.30	2.52e-09	GO:0044267	cellular protein metabolic process
1.28	3.44e-09	GO:0009889	regulation of biosynthetic process
1.16	4.87e-09	GO:0044238	primary metabolic process
1.28	5.29e-09	GO:0031326	regulation of cellular biosynthetic process
1.27	1.62e-08	GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.24	2.96e-08	GO:0016043	cellular component organization
1.29	2.98e-08	GO:2000112	regulation of cellular macromolecule biosynthetic process
1.39	4.03e-08	GO:0009966	regulation of signal transduction
1.52	4.46e-08	GO:0051128	regulation of cellular component organization
1.30	4.58e-08	GO:0006355	regulation of transcription, DNA-dependent
1.28	4.59e-08	GO:0048522	positive regulation of cellular process
1.22	4.91e-08	GO:0023052	signaling
1.28	5.52e-08	GO:0010556	regulation of macromolecule biosynthetic process
1.47	2.61e-07	GO:0050793	regulation of developmental process
1.26	2.75e-07	GO:0071842	cellular component organization at cellular level
1.36	3.05e-07	GO:0009653	anatomical structure morphogenesis
1.30	4.25e-07	GO:0030154	cell differentiation
1.29	4.59e-07	GO:0048869	cellular developmental process
1.25	5.19e-07	GO:0051171	regulation of nitrogen compound metabolic process
1.22	7.79e-07	GO:0007165	signal transduction
1.42	9.13e-07	GO:0010646	regulation of cell communication
1.51	9.14e-07	GO:0006468	protein phosphorylation
1.21	1.37e-06	GO:0071840	cellular component organization or biogenesis
1.39	1.89e-06	GO:0031325	positive regulation of cellular metabolic process
1.24	1.99e-06	GO:0048518	positive regulation of biological process
1.45	2.19e-06	GO:0022008	neurogenesis
1.49	2.98e-06	GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.39	3.19e-06	GO:0010604	positive regulation of macromolecule metabolic process
1.42	3.23e-06	GO:0006793	phosphorus metabolic process
1.42	3.23e-06	GO:0006796	phosphate metabolic process
1.18	3.91e-06	GO:0051716	cellular response to stimulus
1.36	3.92e-06	GO:0051239	regulation of multicellular organismal process
1.49	3.99e-06	GO:0016192	vesicle-mediated transport
1.52	4.07e-06	GO:0051254	positive regulation of RNA metabolic process
1.54	4.21e-06	GO:0045893	positive regulation of transcription, DNA-dependent
1.53	4.39e-06	GO:0007167	enzyme linked receptor protein signaling pathway
1.22	5.32e-06	GO:0019538	protein metabolic process
1.72	7.76e-06	GO:0018193	peptidyl-amino acid modification
1.47	8.87e-06	GO:0051173	positive regulation of nitrogen compound metabolic process
1.51	9.40e-06	GO:0010628	positive regulation of gene expression
1.47	1.23e-05	GO:2000026	regulation of multicellular organismal development
1.53	1.29e-05	GO:0010629	negative regulation of gene expression
1.36	1.33e-05	GO:0009893	positive regulation of metabolic process
1.50	1.62e-05	GO:0045595	regulation of cell differentiation
1.47	1.67e-05	GO:0010557	positive regulation of macromolecule biosynthetic process
1.44	1.69e-05	GO:0048699	generation of neurons
1.35	1.88e-05	GO:0051641	cellular localization
1.23	2.38e-05	GO:0071841	cellular component organization or biogenesis at cellular level
1.43	2.57e-05	GO:0009891	positive regulation of biosynthetic process
1.87	2.71e-05	GO:0048011	nerve growth factor receptor signaling pathway
1.37	3.24e-05	GO:0051649	establishment of localization in cell
1.43	4.17e-05	GO:0016310	phosphorylation
1.43	4.17e-05	GO:0031328	positive regulation of cellular biosynthetic process
1.56	4.26e-05	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
1.53	7.05e-05	GO:0051253	negative regulation of RNA metabolic process
1.32	1.10e-04	GO:0035556	intracellular signal transduction
1.42	1.63e-04	GO:0046907	intracellular transport
1.40	1.70e-04	GO:0006351	transcription, DNA-dependent
1.52	1.78e-04	GO:0045892	negative regulation of transcription, DNA-dependent
1.46	1.84e-04	GO:0031327	negative regulation of cellular biosynthetic process
1.45	1.91e-04	GO:0009890	negative regulation of biosynthetic process
1.69	2.15e-04	GO:0022603	regulation of anatomical structure morphogenesis
1.37	3.00e-04	GO:0009892	negative regulation of metabolic process
1.47	3.70e-04	GO:0045934	negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.38	3.79e-04	GO:0048468	cell development
1.57	4.66e-04	GO:0007409	axonogenesis
1.25	4.87e-04	GO:0048583	regulation of response to stimulus
1.46	5.27e-04	GO:0051172	negative regulation of nitrogen compound metabolic process
1.60	8.06e-04	GO:0016568	chromatin modification
1.27	8.78e-04	GO:0006996	organelle organization
1.36	8.88e-04	GO:0032774	RNA biosynthetic process
1.54	9.70e-04	GO:0032583	regulation of gene-specific transcription
1.50	1.18e-03	GO:0000904	cell morphogenesis involved in differentiation
1.20	1.42e-03	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.44	1.45e-03	GO:2000113	negative regulation of cellular macromolecule biosynthetic process
1.56	1.46e-03	GO:0000122	negative regulation of transcription from RNA polymerase II promoter
1.43	1.53e-03	GO:0010558	negative regulation of macromolecule biosynthetic process
1.36	1.70e-03	GO:0010605	negative regulation of macromolecule metabolic process
1.51	1.75e-03	GO:0072358	cardiovascular system development
1.51	1.75e-03	GO:0072359	circulatory system development
1.50	1.85e-03	GO:0031175	neuron projection development
1.53	2.04e-03	GO:0048667	cell morphogenesis involved in neuron differentiation
1.45	2.21e-03	GO:0009887	organ morphogenesis
1.41	2.69e-03	GO:0009790	embryo development
1.51	3.06e-03	GO:0048812	neuron projection morphogenesis
1.50	3.09e-03	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
2.74	3.22e-03	GO:0045995	regulation of embryonic development
1.94	3.24e-03	GO:0016055	Wnt receptor signaling pathway
1.65	3.45e-03	GO:0032446	protein modification by small protein conjugation
1.23	4.72e-03	GO:0048513	organ development
1.64	4.86e-03	GO:0035295	tube development
1.61	4.99e-03	GO:0032870	cellular response to hormone stimulus
1.47	5.14e-03	GO:0032990	cell part morphogenesis
1.62	5.85e-03	GO:0001944	vasculature development
1.43	7.02e-03	GO:0000902	cell morphogenesis
1.48	7.18e-03	GO:0006325	chromatin organization
1.23	7.83e-03	GO:0007166	cell surface receptor linked signaling pathway
1.34	8.93e-03	GO:0031324	negative regulation of cellular metabolic process
1.46	8.98e-03	GO:0048858	cell projection morphogenesis
1.57	9.29e-03	GO:0007411	axon guidance
1.56	1.08e-02	GO:0071495	cellular response to endogenous stimulus
1.38	1.34e-02	GO:0019220	regulation of phosphate metabolic process
1.38	1.34e-02	GO:0051174	regulation of phosphorus metabolic process
1.94	1.40e-02	GO:0043254	regulation of protein complex assembly
1.48	1.40e-02	GO:0051094	positive regulation of developmental process
1.56	1.50e-02	GO:0033043	regulation of organelle organization
1.57	1.53e-02	GO:0060284	regulation of cell development
1.31	1.60e-02	GO:0032879	regulation of localization
1.40	1.61e-02	GO:0032989	cellular component morphogenesis
1.62	1.87e-02	GO:0016567	protein ubiquitination
1.39	2.38e-02	GO:0030030	cell projection organization
1.89	2.59e-02	GO:0010769	regulation of cell morphogenesis involved in differentiation
1.63	3.07e-02	GO:0050767	regulation of neurogenesis
1.15	3.11e-02	GO:0006807	nitrogen compound metabolic process
1.53	3.11e-02	GO:0070647	protein modification by small protein conjugation or removal
1.46	3.25e-02	GO:0023057	negative regulation of signaling
1.39	3.29e-02	GO:0009725	response to hormone stimulus
1.87	3.31e-02	GO:0022604	regulation of cell morphogenesis
1.48	3.44e-02	GO:0009968	negative regulation of signal transduction
1.86	3.59e-02	GO:0001503	ossification
1.46	3.68e-02	GO:0010648	negative regulation of cell communication
1.16	3.82e-02	GO:0034641	cellular nitrogen compound metabolic process
1.66	4.05e-02	GO:0006916	anti-apoptosis
1.68	4.64e-02	GO:0044087	regulation of cellular component biogenesis

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.15	3.84e-36	GO:0044424	intracellular part
1.15	1.22e-35	GO:0005622	intracellular
1.17	2.35e-29	GO:0043226	organelle
1.17	5.86e-29	GO:0043229	intracellular organelle
1.17	5.86e-24	GO:0043227	membrane-bounded organelle
1.17	9.88e-24	GO:0043231	intracellular membrane-bounded organelle
1.17	9.91e-21	GO:0005737	cytoplasm
1.20	1.10e-14	GO:0005634	nucleus
1.18	8.86e-13	GO:0044444	cytoplasmic part
1.19	3.72e-12	GO:0044446	intracellular organelle part
1.05	1.45e-11	GO:0044464	cell part
1.05	1.57e-11	GO:0005623	cell
1.18	2.81e-11	GO:0044422	organelle part
1.33	5.18e-06	GO:0005654	nucleoplasm
1.30	5.42e-06	GO:0012505	endomembrane system
1.26	5.97e-06	GO:0005829	cytosol
1.25	8.27e-06	GO:0044428	nuclear part
1.42	1.49e-05	GO:0031982	vesicle
1.99	2.05e-05	GO:0005912	adherens junction
1.41	4.82e-05	GO:0031410	cytoplasmic vesicle
1.82	6.32e-05	GO:0030135	coated vesicle
1.89	8.27e-05	GO:0070161	anchoring junction
1.22	8.43e-05	GO:0031974	membrane-enclosed lumen
1.21	1.78e-04	GO:0043233	organelle lumen
1.88	1.87e-04	GO:0030136	clathrin-coated vesicle
2.20	1.93e-04	GO:0016585	chromatin remodeling complex
1.24	2.40e-04	GO:0031981	nuclear lumen
1.21	2.43e-04	GO:0070013	intracellular organelle lumen
1.18	3.12e-04	GO:0043234	protein complex
1.39	3.25e-04	GO:0031988	membrane-bounded vesicle
2.56	5.01e-04	GO:0035770	RNA granule
1.56	5.63e-04	GO:0048471	perinuclear region of cytoplasm
1.42	7.90e-04	GO:0044431	Golgi apparatus part
1.38	8.09e-04	GO:0016023	cytoplasmic membrane-bounded vesicle
1.41	1.30e-03	GO:0030054	cell junction
1.75	1.99e-03	GO:0031252	cell leading edge
1.31	2.14e-03	GO:0005794	Golgi apparatus
1.48	3.45e-03	GO:0045202	synapse
1.35	3.92e-03	GO:0044451	nucleoplasm part
1.43	4.72e-03	GO:0000139	Golgi membrane
1.32	4.82e-03	GO:0042995	cell projection
1.23	5.90e-03	GO:0005856	cytoskeleton
1.19	6.08e-03	GO:0031090	organelle membrane
1.46	9.07e-03	GO:0043005	neuron projection
1.59	1.41e-02	GO:0016323	basolateral plasma membrane
1.15	2.16e-02	GO:0043228	non-membrane-bounded organelle
1.15	2.16e-02	GO:0043232	intracellular non-membrane-bounded organelle
1.62	2.33e-02	GO:0005911	cell-cell junction
2.73	2.38e-02	GO:0000932	cytoplasmic mRNA processing body
2.50	2.40e-02	GO:0000118	histone deacetylase complex
1.87	2.42e-02	GO:0005924	cell-substrate adherens junction
1.86	4.29e-02	GO:0005925	focal adhesion

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.22	1.32e-27	GO:0005515	protein binding
1.12	3.60e-25	GO:0005488	binding
1.44	8.15e-08	GO:0001071	nucleic acid binding transcription factor activity
1.44	8.15e-08	GO:0003700	sequence-specific DNA binding transcription factor activity
1.77	1.40e-06	GO:0008134	transcription factor binding
1.40	1.86e-06	GO:0030528	transcription regulator activity
1.24	4.34e-06	GO:0003677	DNA binding
1.43	2.58e-05	GO:0019899	enzyme binding
1.22	7.78e-05	GO:0000166	nucleotide binding
1.16	1.04e-04	GO:0046872	metal ion binding
1.45	1.31e-04	GO:0004672	protein kinase activity
1.54	1.42e-04	GO:0019904	protein domain specific binding
1.15	2.32e-04	GO:0043167	ion binding
1.15	2.40e-04	GO:0043169	cation binding
1.41	4.57e-04	GO:0043565	sequence-specific DNA binding
1.50	8.33e-04	GO:0004674	protein serine/threonine kinase activity
1.16	8.88e-04	GO:0003676	nucleic acid binding
1.21	2.21e-03	GO:0008270	zinc ion binding
1.39	2.31e-03	GO:0046983	protein dimerization activity
1.74	3.07e-03	GO:0003682	chromatin binding
1.35	3.68e-03	GO:0016301	kinase activity
1.36	4.42e-03	GO:0016773	phosphotransferase activity, alcohol group as acceptor
1.55	5.18e-03	GO:0016564	transcription repressor activity
1.21	5.96e-03	GO:0017076	purine nucleotide binding
1.40	9.19e-03	GO:0008092	cytoskeletal protein binding
1.20	1.31e-02	GO:0032553	ribonucleotide binding
1.20	1.31e-02	GO:0032555	purine ribonucleotide binding
1.51	1.65e-02	GO:0016563	transcription activator activity
1.22	2.03e-02	GO:0030554	adenyl nucleotide binding
1.71	2.15e-02	GO:0000287	magnesium ion binding
1.20	2.15e-02	GO:0035639	purine ribonucleoside triphosphate binding
1.46	2.35e-02	GO:0000988	protein binding transcription factor activity
1.46	2.35e-02	GO:0000989	transcription factor binding transcription factor activity
1.56	2.81e-02	GO:0003702	RNA polymerase II transcription factor activity
1.64	2.89e-02	GO:0010843	promoter binding
1.62	2.93e-02	GO:0000975	regulatory region DNA binding
1.62	2.93e-02	GO:0001067	regulatory region nucleic acid binding
1.62	2.93e-02	GO:0044212	transcription regulatory region DNA binding
1.17	3.49e-02	GO:0046914	transition metal ion binding
1.45	3.50e-02	GO:0003712	transcription cofactor activity
1.50	4.27e-02	GO:0016879	ligase activity, forming carbon-nitrogen bonds
1.40	4.87e-02	GO:0030695	GTPase regulator activity