Motif ID: EGR1..3.p2

Z-value: 1.998


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
EGR3chr8_-_225507080.359.0e-02Click!
EGR2chr10_-_64578926,
chr10_-_64576074,
chr10_-_64576123
0.252.3e-01Click!
EGR1chr5_+_1378011780.193.7e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_46524901 5.583 EPAS1
endothelial PAS domain protein 1
chr13_-_72440557 5.159 DACH1
dachshund homolog 1 (Drosophila)
chr5_+_56111379 4.785 MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr12_+_57482886 4.774 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr2_+_191513832 4.554 NM_005966
NAB1
NGFI-A binding protein 1 (EGR1 binding protein 1)
chr7_-_32931409 4.332 NM_015483
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr4_-_102267952 4.324 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr6_+_84743250 4.319 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr1_+_65991390 4.268 LEPR
leptin receptor
chr12_+_57482674 3.713 NM_005967
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr12_+_57482922 3.530 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr7_+_65338343 3.516 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr1_+_65991357 3.477 NM_001198687
NM_001198688
NM_001198689
LEPR


leptin receptor


chr13_-_77460432 3.475 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr7_-_32931363 3.348 KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr1_+_35258598 3.271 NM_002060
GJA4
gap junction protein, alpha 4, 37kDa
chr4_-_25864430 3.159 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr9_+_115513050 3.060 NM_001012994
SNX30
sorting nexin family member 30
chr21_-_35987144 3.054 NM_004414
RCAN1
regulator of calcineurin 1
chr11_+_125034558 3.053 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 149 entries
enrichment   p-value GO term description
2.74 3.22e-03 GO:0045995 regulation of embryonic development
1.94 3.24e-03 GO:0016055 Wnt receptor signaling pathway
1.94 1.40e-02 GO:0043254 regulation of protein complex assembly
1.89 2.59e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.87 2.71e-05 GO:0048011 nerve growth factor receptor signaling pathway
1.87 3.31e-02 GO:0022604 regulation of cell morphogenesis
1.86 3.59e-02 GO:0001503 ossification
1.72 7.76e-06 GO:0018193 peptidyl-amino acid modification
1.69 2.15e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.68 4.64e-02 GO:0044087 regulation of cellular component biogenesis
1.66 4.05e-02 GO:0006916 anti-apoptosis
1.65 3.45e-03 GO:0032446 protein modification by small protein conjugation
1.64 4.86e-03 GO:0035295 tube development
1.63 3.07e-02 GO:0050767 regulation of neurogenesis
1.62 5.85e-03 GO:0001944 vasculature development
1.62 1.87e-02 GO:0016567 protein ubiquitination
1.61 4.99e-03 GO:0032870 cellular response to hormone stimulus
1.60 8.06e-04 GO:0016568 chromatin modification
1.57 4.66e-04 GO:0007409 axonogenesis
1.57 9.29e-03 GO:0007411 axon guidance

Gene overrepresentation in compartment category:

Showing 1 to 20 of 52 entries
enrichment   p-value GO term description
2.73 2.38e-02 GO:0000932 cytoplasmic mRNA processing body
2.56 5.01e-04 GO:0035770 RNA granule
2.50 2.40e-02 GO:0000118 histone deacetylase complex
2.20 1.93e-04 GO:0016585 chromatin remodeling complex
1.99 2.05e-05 GO:0005912 adherens junction
1.89 8.27e-05 GO:0070161 anchoring junction
1.88 1.87e-04 GO:0030136 clathrin-coated vesicle
1.87 2.42e-02 GO:0005924 cell-substrate adherens junction
1.86 4.29e-02 GO:0005925 focal adhesion
1.82 6.32e-05 GO:0030135 coated vesicle
1.75 1.99e-03 GO:0031252 cell leading edge
1.62 2.33e-02 GO:0005911 cell-cell junction
1.59 1.41e-02 GO:0016323 basolateral plasma membrane
1.56 5.63e-04 GO:0048471 perinuclear region of cytoplasm
1.48 3.45e-03 GO:0045202 synapse
1.46 9.07e-03 GO:0043005 neuron projection
1.43 4.72e-03 GO:0000139 Golgi membrane
1.42 1.49e-05 GO:0031982 vesicle
1.42 7.90e-04 GO:0044431 Golgi apparatus part
1.41 4.82e-05 GO:0031410 cytoplasmic vesicle

Gene overrepresentation in function category:

Showing 1 to 20 of 42 entries
enrichment   p-value GO term description
1.77 1.40e-06 GO:0008134 transcription factor binding
1.74 3.07e-03 GO:0003682 chromatin binding
1.71 2.15e-02 GO:0000287 magnesium ion binding
1.64 2.89e-02 GO:0010843 promoter binding
1.62 2.93e-02 GO:0000975 regulatory region DNA binding
1.62 2.93e-02 GO:0001067 regulatory region nucleic acid binding
1.62 2.93e-02 GO:0044212 transcription regulatory region DNA binding
1.56 2.81e-02 GO:0003702 RNA polymerase II transcription factor activity
1.55 5.18e-03 GO:0016564 transcription repressor activity
1.54 1.42e-04 GO:0019904 protein domain specific binding
1.51 1.65e-02 GO:0016563 transcription activator activity
1.50 8.33e-04 GO:0004674 protein serine/threonine kinase activity
1.50 4.27e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.46 2.35e-02 GO:0000988 protein binding transcription factor activity
1.46 2.35e-02 GO:0000989 transcription factor binding transcription factor activity
1.45 1.31e-04 GO:0004672 protein kinase activity
1.45 3.50e-02 GO:0003712 transcription cofactor activity
1.44 8.15e-08 GO:0001071 nucleic acid binding transcription factor activity
1.44 8.15e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.43 2.58e-05 GO:0019899 enzyme binding