Motif ID: EN1,2.p2

Z-value: 0.904


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
EN2chr7_+_1552507050.174.1e-01Click!
EN1chr2_-_119605758-0.067.8e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_105322056 6.743 NM_032148
 SLC41A2
solute carrier family 41, member 2
chr21_+_43710190 4.571 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr1_+_101185195 3.040 NM_001078
NM_001199834
NM_080682
 VCAM1


vascular cell adhesion molecule 1


chr2_+_103035148 2.942 NM_003853
 IL18RAP
interleukin 18 receptor accessory protein
chr1_-_173020011 2.837 NM_005092
 TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr15_-_80263460 2.720 NM_001114735
NM_004049
 BCL2A1

BCL2-related protein A1

chr9_+_33026482 2.485 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr16_+_57050985 2.301 NM_032206
 NLRC5
NLR family, CARD domain containing 5
chr9_+_74920329 2.157


chr11_-_51412447 1.776 NM_001005272
 OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr11_-_64647136 1.559 EHD1
EH-domain containing 1
chr6_+_14117857 1.503 NM_001040280
NM_004233
 CD83

CD83 molecule

chr17_-_63009302 1.417 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr17_-_40264687 1.351 NM_024119
 DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr4_+_89299874 1.322 NM_001165136
NM_017912
 HERC6

hect domain and RLD 6

chr12_+_113344811 1.307 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr6_-_43595046 1.286 GTPBP2
GTP binding protein 2
chr4_-_7436614 1.240 NM_001085382
 PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr10_+_114154522 1.162 ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_43595079 1.152 GTPBP2
GTP binding protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
2.00 3.26e-02 GO:0045087 innate immune response
1.96 5.91e-06 GO:0006955 immune response
1.94 5.82e-03 GO:0030001 metal ion transport
1.83 1.15e-04 GO:0006952 defense response
1.78 3.73e-02 GO:0006812 cation transport
1.75 5.44e-04 GO:0006811 ion transport
1.52 1.98e-02 GO:0002376 immune system process
1.19 9.20e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.75 1.87e-04 GO:0005615 extracellular space
1.74 6.35e-06 GO:0044421 extracellular region part
1.69 1.81e-06 GO:0005887 integral to plasma membrane
1.67 2.88e-06 GO:0031226 intrinsic to plasma membrane
1.63 4.69e-10 GO:0005576 extracellular region
1.54 9.12e-08 GO:0044459 plasma membrane part
1.35 1.27e-07 GO:0005886 plasma membrane
1.34 1.83e-07 GO:0071944 cell periphery
1.18 1.73e-02 GO:0031224 intrinsic to membrane
1.17 8.60e-03 GO:0044425 membrane part

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
13.04 3.75e-02 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
13.04 3.75e-02 GO:0001012 RNA polymerase II regulatory region DNA binding
8.89 1.04e-02 GO:0030553 cGMP binding
8.15 1.96e-02 GO:0019002 GMP binding
3.90 4.43e-02 GO:0008009 chemokine activity
2.44 4.90e-02 GO:0008509 anion transmembrane transporter activity
2.04 6.13e-04 GO:0015267 channel activity
2.04 6.61e-04 GO:0022803 passive transmembrane transporter activity
2.02 1.34e-03 GO:0022838 substrate-specific channel activity
2.01 1.99e-03 GO:0005216 ion channel activity
1.80 4.11e-06 GO:0022857 transmembrane transporter activity
1.74 1.06e-04 GO:0022891 substrate-specific transmembrane transporter activity
1.71 2.06e-03 GO:0015075 ion transmembrane transporter activity
1.67 1.69e-04 GO:0022892 substrate-specific transporter activity
1.62 8.02e-05 GO:0005215 transporter activity
1.56 7.82e-03 GO:0005102 receptor binding