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Motif ID: EN1,2.p2

Z-value: 0.904

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr12_-_105322056	6.743	NM_032148	SLC41A2	solute carrier family 41, member 2
chr21_+_43710190	4.571		ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1
chr1_+_101185195	3.040	NM_001078 NM_001199834 NM_080682	VCAM1	vascular cell adhesion molecule 1
chr2_+_103035148	2.942	NM_003853	IL18RAP	interleukin 18 receptor accessory protein
chr1_-_173020011	2.837	NM_005092	TNFSF18	tumor necrosis factor (ligand) superfamily, member 18
chr15_-_80263460	2.720	NM_001114735 NM_004049	BCL2A1	BCL2-related protein A1
chr9_+_33026482	2.485		DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1
chr16_+_57050985	2.301	NM_032206	NLRC5	NLR family, CARD domain containing 5
chr9_+_74920329	2.157
chr11_-_51412447	1.776	NM_001005272	OR4A5	olfactory receptor, family 4, subfamily A, member 5
chr11_-_64647136	1.559		EHD1	EH-domain containing 1
chr6_+_14117857	1.503	NM_001040280 NM_004233	CD83	CD83 molecule
chr17_-_63009302	1.417		GNA13	guanine nucleotide binding protein (G protein), alpha 13
chr17_-_40264687	1.351	NM_024119	DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58
chr4_+_89299874	1.322	NM_001165136 NM_017912	HERC6	hect domain and RLD 6
chr12_+_113344811	1.307		OAS1	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr6_-_43595046	1.286		GTPBP2	GTP binding protein 2
chr4_-_7436614	1.240	NM_001085382	PSAPL1	prosaposin-like 1 (gene/pseudogene)
chr10_+_114154522	1.162		ACSL5	acyl-CoA synthetase long-chain family member 5
chr6_-_43595079	1.152		GTPBP2	GTP binding protein 2
chr15_-_55563091	1.088	NM_183236	RAB27A	RAB27A, member RAS oncogene family
chr7_-_115670774	1.078		TFEC	transcription factor EC
chr7_+_28452143	1.065	NM_182898	CREB5	cAMP responsive element binding protein 5
chr4_+_70916158	1.045	NM_002159	HTN1	histatin 1
chr6_-_30652434	1.000		PPP1R18	protein phosphatase 1, regulatory subunit 18
chr5_-_169816637	0.988	NM_004137	KCNMB1	potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr1_+_113236679	0.987		MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)
chr14_+_93799564	0.969	NM_020818	UNC79	unc-79 homolog (C. elegans)
chr17_+_56232493	0.933	NM_012374	OR4D1	olfactory receptor, family 4, subfamily D, member 1
chr10_+_75673346	0.920		PLAU	plasminogen activator, urokinase
chr9_-_123688352	0.900		TRAF1	TNF receptor-associated factor 1
chr8_+_7738908	0.877	NM_018661	DEFB103B	defensin, beta 103B
chr1_+_86934525	0.869	NM_001285	CLCA1	chloride channel accessory 1
chrX_+_9431314	0.859	NM_001139466 NM_001139467 NM_001139468	TBL1X	transducin (beta)-like 1X-linked
chr1_-_33338081	0.834	NM_001171941	FNDC5	fibronectin type III domain containing 5
chr5_+_125695787	0.824	NM_001146319	GRAMD3	GRAM domain containing 3
chr4_+_103422479	0.821	NM_001165412 NM_003998	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr1_-_159684274	0.818	NM_000567	CRP	C-reactive protein, pentraxin-related
chr6_-_114384008	0.807	NM_153612	HS3ST5	heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr16_+_50731049	0.790	NM_022162	NOD2	nucleotide-binding oligomerization domain containing 2
chr4_-_76928601	0.787	NM_002416	CXCL9	chemokine (C-X-C motif) ligand 9
chr2_+_69201704	0.780	NM_019617	GKN1	gastrokine 1
chr2_-_145277879	0.777	NM_001171653 NM_014795	ZEB2	zinc finger E-box binding homeobox 2
chr3_+_140770742	0.769	NM_080862	SPSB4	splA/ryanodine receptor domain and SOCS box containing 4
chr1_+_171154387	0.748	NM_001460	FMO2	flavin containing monooxygenase 2 (non-functional)
chr7_-_115670828	0.730	NM_001018058 NM_012252	TFEC	transcription factor EC
chr12_+_75874512	0.717	NM_006851	GLIPR1	GLI pathogenesis-related 1
chr12_+_113344738	0.701	NM_001032409 NM_002534 NM_016816	OAS1	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr2_-_163008913	0.685	NM_002054	GCG	glucagon
chr19_-_56249739	0.674	NM_176820	NLRP9	NLR family, pyrin domain containing 9
chr16_+_4674819	0.671	NM_001142289 NM_001142290 NM_001142291 NM_015246	MGRN1	mahogunin, ring finger 1
chr1_-_154578775	0.666	NM_001193495	ADAR	adenosine deaminase, RNA-specific
chr4_-_122137781	0.665	NM_001128843	TNIP3	TNFAIP3 interacting protein 3
chr12_-_49999259	0.648	NM_032130	FAM186B	family with sequence similarity 186, member B
chr12_-_57504088	0.639	NM_001178079	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced
chr6_-_33282006	0.635	NM_003190 NM_172208 NM_172209	TAPBP	TAP binding protein (tapasin)
chr15_+_97326629	0.633	NM_173499	SPATA8	spermatogenesis associated 8
chr3_-_27498244	0.625	NM_003615	SLC4A7	solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr17_+_32646058	0.624	NM_005623	CCL8	chemokine (C-C motif) ligand 8
chr21_+_34697197	0.621	NM_000629	IFNAR1	interferon (alpha, beta and omega) receptor 1
chr15_-_74659926	0.619	NM_000781	CYP11A1	cytochrome P450, family 11, subfamily A, polypeptide 1
chr6_+_30294224	0.613
chr9_-_134585107	0.612	NM_198679	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1
chr22_+_36044412	0.610	NM_030641	APOL6	apolipoprotein L, 6
chr8_-_122653493	0.600	NM_005328	HAS2	hyaluronan synthase 2
chr1_-_27732069	0.597		WASF2	WAS protein family, member 2
chr9_-_19786886	0.596	NM_001193288 NM_020344	SLC24A2	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr3_-_71592707	0.586	NM_001244816	FOXP1	forkhead box P1
chr1_-_204459445	0.580	NM_002646	PIK3C2B	phosphoinositide-3-kinase, class 2, beta polypeptide
chr7_-_107880492	0.575	NM_001037132	NRCAM	neuronal cell adhesion molecule
chr8_+_11141983	0.569	NM_015458	MTMR9	myotubularin related protein 9
chr12_+_7942025	0.567		NANOG	Nanog homeobox
chr10_+_114133838	0.562	NM_203379	ACSL5	acyl-CoA synthetase long-chain family member 5
chr14_+_23305792	0.562	NM_004995	MMP14	matrix metallopeptidase 14 (membrane-inserted)
chr11_+_20070609	0.557		NAV2	neuron navigator 2
chr17_-_4643162	0.549	NM_001100812 NM_022059	CXCL16	chemokine (C-X-C motif) ligand 16
chr2_+_102953716	0.543	NM_003856	IL1RL1	interleukin 1 receptor-like 1
chr16_+_31085751	0.539		ZNF646	zinc finger protein 646
chr16_-_20364029	0.530	NM_001008389 NM_003361	UMOD	uromodulin
chr6_+_32811895	0.529
chr2_-_209054772	0.528	NM_001099334	C2orf80	chromosome 2 open reading frame 80
chr8_-_87755880	0.526	NM_019098	CNGB3	cyclic nucleotide gated channel beta 3
chr17_+_39261640	0.524	NM_001146041	KRTAP4-9	keratin associated protein 4-9
chr17_+_77030471	0.523	NM_198593	C1QTNF1	C1q and tumor necrosis factor related protein 1
chrX_+_65235279	0.517
chr13_+_97874540	0.516	NM_144778 NM_207304	MBNL2	muscleblind-like 2 (Drosophila)
chr14_-_100841656	0.513		WARS	tryptophanyl-tRNA synthetase
chr16_-_71748697	0.512	NM_015020	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2
chr5_+_125758818	0.512	NM_001146320 NM_001146321 NM_023927	GRAMD3	GRAM domain containing 3
chrX_+_41548225	0.509	NM_001097579 NM_005300	GPR34	G protein-coupled receptor 34
chr7_+_141695678	0.507	NM_004668	MGAM	maltase-glucoamylase (alpha-glucosidase)
chr16_+_58010338	0.500	NM_199046 NM_199456	TEPP	testis, prostate and placenta expressed
chr6_-_32811773	0.498	NM_148919	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr12_-_57504935	0.498		STAT6	signal transducer and activator of transcription 6, interleukin-4 induced
chr20_-_47894570	0.497		ZNFX1	zinc finger, NFX1-type containing 1
chr12_+_93096618	0.497	NM_001037671 NM_001178097	C12orf74	chromosome 12 open reading frame 74
chr14_+_24774429	0.493
chr10_+_114133775	0.492		ACSL5	acyl-CoA synthetase long-chain family member 5
chr6_-_101329006	0.488		ASCC3	activating signal cointegrator 1 complex subunit 3
chr16_+_31085722	0.481	NM_014699	ZNF646	zinc finger protein 646
chr5_-_24645084	0.481	NM_006727	CDH10	cadherin 10, type 2 (T2-cadherin)
chr10_-_27443138	0.479		YME1L1	YME1-like 1 (S. cerevisiae)
chrX_+_128913897	0.479		SASH3	SAM and SH3 domain containing 3
chr6_+_83072922	0.476	NM_006670	TPBG	trophoblast glycoprotein
chr6_+_106546736	0.475	NM_182907	PRDM1	PR domain containing 1, with ZNF domain
chrX_+_48336379	0.472	NM_177434	FTSJ1	FtsJ homolog 1 (E. coli)
chrX_-_75004979	0.471	NM_138703	MAGEE2	melanoma antigen family E, 2
chr21_+_34697277	0.467		IFNAR1	interferon (alpha, beta and omega) receptor 1
chr4_-_146095891	0.462	NM_017493	OTUD4	OTU domain containing 4
chr3_+_42201658	0.459	NM_014965	TRAK1	trafficking protein, kinesin binding 1
chr3_-_187452669	0.450	NM_001134738	BCL6	B-cell CLL/lymphoma 6
chr6_-_119470336	0.447	NM_001100411	FAM184A	family with sequence similarity 184, member A
chr7_+_107110501	0.446	NM_005295	GPR22	G protein-coupled receptor 22
chr12_-_11548485	0.442	NM_006248	PRB1 PRB2	proline-rich protein BstNI subfamily 1 proline-rich protein BstNI subfamily 2
chr22_-_36562224	0.442	NM_145641 NM_145642	APOL3	apolipoprotein L, 3
chr1_-_247921707	0.436	NM_012353	OR1C1	olfactory receptor, family 1, subfamily C, member 1
chr14_+_95027760	0.431	NM_006215	SERPINA4	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr21_-_19775958	0.431	NM_002772	TMPRSS15	transmembrane protease, serine 15
chr17_+_45810609	0.431	NM_013351	TBX21	T-box 21
chr17_-_32483550	0.420	NM_001094	ACCN1	amiloride-sensitive cation channel 1, neuronal
chr15_+_71433787	0.413	NM_024817	THSD4	thrombospondin, type I, domain containing 4
chr4_-_40516567	0.413		RBM47	RNA binding motif protein 47
chr4_-_48136245	0.411	NM_003328	TXK	TXK tyrosine kinase
chr4_+_89299980	0.407		HERC6	hect domain and RLD 6
chr3_-_71180061	0.400	NM_001244815	FOXP1	forkhead box P1
chr12_+_121570630	0.398	NM_002562	P2RX7	purinergic receptor P2X, ligand-gated ion channel, 7
chr12_+_57881853	0.398		MARS	methionyl-tRNA synthetase
chr3_+_127641901	0.397	NM_207335	KBTBD12	kelch repeat and BTB (POZ) domain containing 12
chr6_+_31913852	0.397		CFB	complement factor B
chr17_+_39240412	0.396	NM_033061	KRTAP4-7	keratin associated protein 4-7
chr15_+_74287148	0.393		PML	promyelocytic leukemia
chr12_+_100041527	0.392	NM_153364	FAM71C	family with sequence similarity 71, member C
chr8_+_11142314	0.391		MTMR9	myotubularin related protein 9
chr11_+_124095343	0.391	NM_001007249	OR8G2	olfactory receptor, family 8, subfamily G, member 2
chr11_-_9225780	0.390		DENND5A	DENN/MADD domain containing 5A
chr5_+_126859157	0.390		PRRC1	proline-rich coiled-coil 1
chr6_+_31583766	0.388	NM_032955	AIF1	allograft inflammatory factor 1
chr17_-_29624249	0.387	NM_002544	OMG	oligodendrocyte myelin glycoprotein
chr3_-_189840225	0.384	NM_001134418	LEPREL1	leprecan-like 1
chr9_+_116207010	0.384	NM_144488	RGS3	regulator of G-protein signaling 3
chr16_+_4674829	0.383		MGRN1	mahogunin, ring finger 1
chr11_-_49003246	0.381	NM_001206625	LOC120824	tripartite motif-containing protein ENSP00000309378-like
chr5_+_140529619	0.380	NM_018939	PCDHB6	protocadherin beta 6
chr12_-_323255	0.380	NM_001122848 NM_001206931	SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr2_-_88427535	0.380	NM_001443	FABP1	fatty acid binding protein 1, liver
chr9_-_117568292	0.379	NM_005118	TNFSF15	tumor necrosis factor (ligand) superfamily, member 15
chrX_+_50653734	0.378	NM_005448	BMP15	bone morphogenetic protein 15
chr4_-_120549115	0.376	NM_033437	PDE5A	phosphodiesterase 5A, cGMP-specific
chr7_+_28530747	0.376		CREB5	cAMP responsive element binding protein 5
chr6_+_41303527	0.374	NM_001199509 NM_001199510 NM_004828	NCR2	natural cytotoxicity triggering receptor 2
chr1_+_36554452	0.371	NM_017825	ADPRHL2	ADP-ribosylhydrolase like 2
chr12_-_13103317	0.370	NM_018654	GPRC5D	G protein-coupled receptor, family C, group 5, member D
chr10_-_73976025	0.369	NM_001198799 NM_001198800	ASCC1	activating signal cointegrator 1 complex subunit 1
chr4_+_72102249	0.368		SLC4A4	solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr18_-_40857245	0.366	NM_020783	SYT4	synaptotagmin IV
chr1_-_47082529	0.365	NM_201403	MOB3C	MOB kinase activator 3C
chr18_+_43306917	0.364	NM_001146037	SLC14A1	solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr18_-_58040000	0.361	NM_005912	MC4R	melanocortin 4 receptor
chr1_+_160765927	0.359	NM_001033667 NM_002348	LY9	lymphocyte antigen 9
chr6_-_32812409	0.358		PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr16_+_24788568	0.357		TNRC6A	trinucleotide repeat containing 6A
chr10_+_118380451	0.357	NM_005396	PNLIPRP2	pancreatic lipase-related protein 2
chr5_-_35938736	0.357	NM_001042625 NM_144647	CAPSL	calcyphosine-like
chr16_-_1821503	0.354		NME3	non-metastatic cells 3, protein expressed in
chr20_-_47894591	0.350	NM_021035	ZNFX1	zinc finger, NFX1-type containing 1
chr19_+_41594367	0.349	NM_000766	CYP2A13	cytochrome P450, family 2, subfamily A, polypeptide 13
chr10_-_62149487	0.346	NM_020987	ANK3	ankyrin 3, node of Ranvier (ankyrin G)
chr4_+_71091787	0.345	NM_152997	C4orf7	chromosome 4 open reading frame 7
chr9_+_135457974	0.343	NM_020064	BARHL1	BarH-like homeobox 1
chr9_-_34381497	0.342	NM_001252195 NM_147168 NM_147169	C9orf24	chromosome 9 open reading frame 24
chr11_-_10673832	0.341	NM_001098579	MRVI1	murine retrovirus integration site 1 homolog
chr4_+_71200670	0.339	NM_033122	CABS1	calcium-binding protein, spermatid-specific 1
chr6_-_76782204	0.338	NM_001563	IMPG1	interphotoreceptor matrix proteoglycan 1
chr10_-_75335415	0.336	NM_152586	USP54	ubiquitin specific peptidase 54
chr4_+_78432905	0.332	NM_006419	CXCL13	chemokine (C-X-C motif) ligand 13
chr5_-_141993691	0.331	NM_033137	FGF1	fibroblast growth factor 1 (acidic)
chrX_+_103031797	0.329		PLP1	proteolipid protein 1
chr17_-_64225496	0.329	NM_000042	APOH	apolipoprotein H (beta-2-glycoprotein I)
chr12_-_121736110	0.328	NM_006549 NM_153499 NM_153500 NM_172214 NM_172215 NM_172216	CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta
chr6_+_30227335	0.324		HLA-L	major histocompatibility complex, class I, L, pseudogene
chrX_+_128913881	0.323	NM_018990	SASH3	SAM and SH3 domain containing 3
chr11_+_60223281	0.323	NM_021950 NM_152866	MS4A1	membrane-spanning 4-domains, subfamily A, member 1
chr6_+_26368405	0.323	NM_001197246	BTN3A2	butyrophilin, subfamily 3, member A2
chrX_+_144908927	0.323	NM_004709	CXorf1	chromosome X open reading frame 1
chr9_+_116263706	0.322	NM_130795	RGS3	regulator of G-protein signaling 3
chr7_+_117864711	0.321	NM_019644	ANKRD7	ankyrin repeat domain 7
chr10_+_13142055	0.321	NM_001008211 NM_001008212 NM_001008213 NM_021980	OPTN	optineurin
chr14_+_65007163	0.320	NM_021979	HSPA2	heat shock 70kDa protein 2
chr11_+_124120422	0.320	NM_001002905	OR8G1	olfactory receptor, family 8, subfamily G, member 1
chr8_-_27115935	0.319		STMN4	stathmin-like 4
chr22_-_50523780	0.318	NM_139202	MLC1	megalencephalic leukoencephalopathy with subcortical cysts 1
chr10_-_92680784	0.316		ANKRD1	ankyrin repeat domain 1 (cardiac muscle)
chrX_+_103411235	0.316		FAM199X	family with sequence similarity 199, X-linked
chr1_+_47901688	0.316	NM_004474	FOXD2	forkhead box D2
chr22_+_23054862	0.311		IGLV3-21 IGLJ3 IGLC1	immunoglobulin lambda variable 3-21 immunoglobulin lambda joining 3 immunoglobulin lambda constant 1 (Mcg marker)
chr6_-_152702450	0.310		SYNE1	spectrin repeat containing, nuclear envelope 1
chr7_+_141463896	0.310	NM_016943	TAS2R3	taste receptor, type 2, member 3
chr13_+_97874704	0.309		MBNL2	muscleblind-like 2 (Drosophila)
chr2_-_163099877	0.309	NM_004460	FAP	fibroblast activation protein, alpha
chr12_-_7281374	0.308	NM_031491	RBP5	retinol binding protein 5, cellular

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.96	5.91e-06	GO:0006955	immune response
1.83	1.15e-04	GO:0006952	defense response
1.75	5.44e-04	GO:0006811	ion transport
1.94	5.82e-03	GO:0030001	metal ion transport
1.19	9.20e-03	GO:0050896	response to stimulus
1.52	1.98e-02	GO:0002376	immune system process
2.00	3.26e-02	GO:0045087	innate immune response
1.78	3.73e-02	GO:0006812	cation transport

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.63	4.69e-10	GO:0005576	extracellular region
1.54	9.12e-08	GO:0044459	plasma membrane part
1.35	1.27e-07	GO:0005886	plasma membrane
1.34	1.83e-07	GO:0071944	cell periphery
1.69	1.81e-06	GO:0005887	integral to plasma membrane
1.67	2.88e-06	GO:0031226	intrinsic to plasma membrane
1.74	6.35e-06	GO:0044421	extracellular region part
1.75	1.87e-04	GO:0005615	extracellular space
1.17	8.60e-03	GO:0044425	membrane part
1.18	1.73e-02	GO:0031224	intrinsic to membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.80	4.11e-06	GO:0022857	transmembrane transporter activity
1.62	8.02e-05	GO:0005215	transporter activity
1.74	1.06e-04	GO:0022891	substrate-specific transmembrane transporter activity
1.67	1.69e-04	GO:0022892	substrate-specific transporter activity
2.04	6.13e-04	GO:0015267	channel activity
2.04	6.61e-04	GO:0022803	passive transmembrane transporter activity
2.02	1.34e-03	GO:0022838	substrate-specific channel activity
2.01	1.99e-03	GO:0005216	ion channel activity
1.71	2.06e-03	GO:0015075	ion transmembrane transporter activity
1.56	7.82e-03	GO:0005102	receptor binding
8.89	1.04e-02	GO:0030553	cGMP binding
8.15	1.96e-02	GO:0019002	GMP binding
13.04	3.75e-02	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
13.04	3.75e-02	GO:0001012	RNA polymerase II regulatory region DNA binding
3.90	4.43e-02	GO:0008009	chemokine activity
2.44	4.90e-02	GO:0008509	anion transmembrane transporter activity