Motif ID: ESR1.p2

Z-value: 1.153


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ESR1chr6_+_152128453-0.183.8e-01Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_156588811 4.333 NM_001130684
 GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr19_+_676346 3.901 NM_005860
 FSTL3
follistatin-like 3 (secreted glycoprotein)
chr22_-_19929447 3.013 TXNRD2
thioredoxin reductase 2
chr4_+_156587861 2.913 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
 GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr22_-_19929333 2.593 NM_006440
 TXNRD2
thioredoxin reductase 2
chr22_-_19929250 2.262 TXNRD2
thioredoxin reductase 2
chr14_-_55369163 2.151 NM_000161
NM_001024024
NM_001024070
NM_001024071
 GCH1



GTP cyclohydrolase 1



chr6_-_154831788 1.886 CNKSR3
CNKSR family member 3
chr6_-_154831652 1.868 CNKSR3
CNKSR family member 3
chr6_-_154831704 1.861 NM_173515
 CNKSR3
CNKSR family member 3
chr4_+_4861371 1.723 NM_002448
 MSX1
msh homeobox 1
chr1_-_209979388 1.672 NM_001206696
NM_006147
 IRF6

interferon regulatory factor 6

chr22_-_43116796 1.650 NM_017436
 A4GALT
alpha 1,4-galactosyltransferase
chr5_-_1112106 1.483 NM_006598
 SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr20_-_23030141 1.409 NM_000361
 THBD
thrombomodulin
chr1_+_77748286 1.403 NM_012093
 AK5
adenylate kinase 5
chr8_+_98881277 1.316 NM_002380
NM_030583
 MATN2

matrilin 2

chr5_+_139028483 1.282 CXXC5
CXXC finger protein 5
chr13_-_103451271 1.280 NM_024089
 KDELC1
KDEL (Lys-Asp-Glu-Leu) containing 1
chr2_+_85360373 1.278 NM_031283
 TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
1.91 4.59e-02 GO:0030029 actin filament-based process
1.70 4.81e-02 GO:0045859 regulation of protein kinase activity
1.59 5.39e-03 GO:0031399 regulation of protein modification process
1.58 8.70e-07 GO:0009966 regulation of signal transduction
1.56 7.14e-04 GO:0032268 regulation of cellular protein metabolic process
1.56 3.12e-02 GO:0006468 protein phosphorylation
1.55 5.24e-04 GO:0051246 regulation of protein metabolic process
1.52 1.44e-06 GO:0023051 regulation of signaling
1.51 3.03e-02 GO:0008219 cell death
1.51 3.78e-02 GO:0016265 death
1.48 6.10e-04 GO:0035556 intracellular signal transduction
1.45 1.40e-02 GO:0050790 regulation of catalytic activity
1.39 1.03e-03 GO:0048583 regulation of response to stimulus
1.38 3.57e-02 GO:0065009 regulation of molecular function
1.33 5.96e-03 GO:0048523 negative regulation of cellular process
1.31 1.15e-02 GO:0048519 negative regulation of biological process
1.30 6.66e-06 GO:0023052 signaling
1.30 6.18e-05 GO:0007165 signal transduction
1.26 1.94e-02 GO:0019538 protein metabolic process
1.24 6.22e-04 GO:0051716 cellular response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
1.84 1.53e-02 GO:0015629 actin cytoskeleton
1.49 2.14e-03 GO:0005794 Golgi apparatus
1.34 1.16e-02 GO:0012505 endomembrane system
1.27 3.01e-02 GO:0031090 organelle membrane
1.22 3.60e-07 GO:0044444 cytoplasmic part
1.20 8.38e-11 GO:0005737 cytoplasm
1.18 4.83e-04 GO:0044446 intracellular organelle part
1.17 1.11e-03 GO:0044422 organelle part
1.12 3.07e-09 GO:0005622 intracellular
1.12 1.98e-08 GO:0044424 intracellular part
1.12 4.23e-04 GO:0043231 intracellular membrane-bounded organelle
1.12 5.25e-04 GO:0043227 membrane-bounded organelle
1.11 2.36e-04 GO:0043229 intracellular organelle
1.11 3.49e-04 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.66 4.35e-02 GO:0004674 protein serine/threonine kinase activity
1.56 3.05e-02 GO:0004672 protein kinase activity
1.54 1.19e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.52 1.87e-02 GO:0019899 enzyme binding
1.51 1.63e-02 GO:0016301 kinase activity
1.23 9.72e-12 GO:0005515 protein binding
1.12 7.98e-09 GO:0005488 binding