• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: ESR1.p2

Z-value: 1.153

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr4_+_156588811	4.333	NM_001130684	GUCY1A3	guanylate cyclase 1, soluble, alpha 3
chr19_+_676346	3.901	NM_005860	FSTL3	follistatin-like 3 (secreted glycoprotein)
chr22_-_19929447	3.013		TXNRD2	thioredoxin reductase 2
chr4_+_156587861	2.913	NM_000856 NM_001130682 NM_001130686 NM_001130687 NM_001130683 NM_001130685	GUCY1A3	guanylate cyclase 1, soluble, alpha 3
chr22_-_19929333	2.593	NM_006440	TXNRD2	thioredoxin reductase 2
chr22_-_19929250	2.262		TXNRD2	thioredoxin reductase 2
chr14_-_55369163	2.151	NM_000161 NM_001024024 NM_001024070 NM_001024071	GCH1	GTP cyclohydrolase 1
chr6_-_154831788	1.886		CNKSR3	CNKSR family member 3
chr6_-_154831652	1.868		CNKSR3	CNKSR family member 3
chr6_-_154831704	1.861	NM_173515	CNKSR3	CNKSR family member 3
chr4_+_4861371	1.723	NM_002448	MSX1	msh homeobox 1
chr1_-_209979388	1.672	NM_001206696 NM_006147	IRF6	interferon regulatory factor 6
chr22_-_43116796	1.650	NM_017436	A4GALT	alpha 1,4-galactosyltransferase
chr5_-_1112106	1.483	NM_006598	SLC12A7	solute carrier family 12 (potassium/chloride transporters), member 7
chr20_-_23030141	1.409	NM_000361	THBD	thrombomodulin
chr1_+_77748286	1.403	NM_012093	AK5	adenylate kinase 5
chr8_+_98881277	1.316	NM_002380 NM_030583	MATN2	matrilin 2
chr5_+_139028483	1.282		CXXC5	CXXC finger protein 5
chr13_-_103451271	1.280	NM_024089	KDELC1	KDEL (Lys-Asp-Glu-Leu) containing 1
chr2_+_85360373	1.278	NM_031283	TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)
chr19_+_45251933	1.170	NM_005178	BCL3	B-cell CLL/lymphoma 3
chr14_+_65007163	1.069	NM_021979	HSPA2	heat shock 70kDa protein 2
chr15_-_52587851	0.993	NM_018728	MYO5C	myosin VC
chr1_+_100818052	0.992		CDC14A	CDC14 cell division cycle 14 homolog A (S. cerevisiae)
chr21_-_45660841	0.984		ICOSLG	inducible T-cell co-stimulator ligand
chr9_-_16870664	0.981		BNC2	basonuclin 2
chr19_+_42829760	0.979	NM_001410	MEGF8	multiple EGF-like-domains 8
chr6_+_142622797	0.960	NM_001032394 NM_001032395 NM_020455 NM_198569	GPR126	G protein-coupled receptor 126
chr14_+_65007418	0.957		HSPA2	heat shock 70kDa protein 2
chr8_-_101322245	0.930	NM_183419	RNF19A	ring finger protein 19A
chr1_+_77747727	0.918		AK5	adenylate kinase 5
chr21_+_46293925	0.915
chr6_-_10419786	0.901	NM_001042425	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_65991390	0.883		LEPR	leptin receptor
chr8_-_101322180	0.872		RNF19A	ring finger protein 19A
chr20_-_61569227	0.870		DIDO1	death inducer-obliterator 1
chr7_-_11871735	0.868	NM_015204	THSD7A	thrombospondin, type I, domain containing 7A
chr18_+_77724575	0.851	NM_001136180	HSBP1L1	heat shock factor binding protein 1-like 1
chr11_+_111473099	0.835	NM_015191	SIK2	salt-inducible kinase 2
chr9_-_14313509	0.828		NFIB	nuclear factor I/B
chr14_-_51134862	0.822		SAV1	salvador homolog 1 (Drosophila)
chr21_-_45660699	0.817	NM_015259	ICOSLG	inducible T-cell co-stimulator ligand
chr3_+_52489617	0.800		NISCH	nischarin
chr1_-_95007139	0.800	NM_001178096 NM_001993	F3	coagulation factor III (thromboplastin, tissue factor)
chr1_+_100818007	0.794	NM_003672 NM_033312 NM_033313	CDC14A	CDC14 cell division cycle 14 homolog A (S. cerevisiae)
chr4_-_89080010	0.790	NM_004827	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2
chr15_-_64126081	0.786		HERC1	hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr20_-_62462568	0.781		ZBTB46	zinc finger and BTB domain containing 46
chr14_+_96505566	0.777	NM_001252507	C14orf132	chromosome 14 open reading frame 132
chr19_+_54371150	0.777		MYADM	myeloid-associated differentiation marker
chr17_-_57184116	0.773		TRIM37	tripartite motif containing 37
chr17_-_27224569	0.771		FLOT2	flotillin 2
chr6_-_137540504	0.769		IFNGR1	interferon gamma receptor 1
chr6_-_137540435	0.763		IFNGR1	interferon gamma receptor 1
chr1_+_65991357	0.759	NM_001198687 NM_001198688 NM_001198689	LEPR	leptin receptor
chr2_-_208489972	0.759	NM_001127395	METTL21A	methyltransferase like 21A
chr1_+_77747602	0.741	NM_174858	AK5	adenylate kinase 5
chr1_+_62660473	0.731	NM_001164835 NM_019079	L1TD1	LINE-1 type transposase domain containing 1
chr12_+_57482886	0.727		NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr6_-_137540551	0.709	NM_000416	IFNGR1	interferon gamma receptor 1
chr6_-_137540544	0.700		IFNGR1	interferon gamma receptor 1
chr13_+_21277481	0.692	NM_138284	IL17D	interleukin 17D
chr11_+_73087670	0.681	NM_032871	RELT	RELT tumor necrosis factor receptor
chr11_+_68079999	0.680	NM_002335	LRP5	low density lipoprotein receptor-related protein 5
chrX_-_150067062	0.672		CD99L2	CD99 molecule-like 2
chr1_-_92351613	0.664	NM_001195683 NM_003243	TGFBR3	transforming growth factor, beta receptor III
chr6_-_47277354	0.661		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr12_+_57482922	0.659		NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr11_+_64001974	0.658	NM_001243733 NM_003377	VEGFB	vascular endothelial growth factor B
chr22_+_19929262	0.654	NM_000754	COMT	catechol-O-methyltransferase
chr5_+_179247841	0.650	NM_003900	SQSTM1	sequestosome 1
chr14_+_100438095	0.645		EVL	Enah/Vasp-like
chr1_-_150241210	0.645		APH1A	anterior pharynx defective 1 homolog A (C. elegans)
chrX_-_150067127	0.644	NM_001184808 NM_001242614 NM_031462 NM_134445 NM_134446	CD99L2	CD99 molecule-like 2
chr9_-_140082983	0.643		ANAPC2	anaphase promoting complex subunit 2
chr22_+_19929310	0.643		COMT	catechol-O-methyltransferase
chr9_-_74383301	0.641	NM_001135820 NM_013390	TMEM2	transmembrane protein 2
chr4_-_25864430	0.640	NM_015187	SEL1L3	sel-1 suppressor of lin-12-like 3 (C. elegans)
chr1_-_33336289	0.639	NM_001171940 NM_153756	FNDC5	fibronectin type III domain containing 5
chr22_+_33197678	0.637		TIMP3	TIMP metallopeptidase inhibitor 3
chr22_+_44319685	0.637		PNPLA3	patatin-like phospholipase domain containing 3
chr9_+_5450455	0.636	NM_014143	CD274	CD274 molecule
chr21_-_27945267	0.634	NM_052954	CYYR1	cysteine/tyrosine-rich 1
chr11_-_33891258	0.628		LMO2	LIM domain only 2 (rhombotin-like 1)
chr22_+_33197744	0.626		TIMP3	TIMP metallopeptidase inhibitor 3
chr22_+_44319618	0.622	NM_025225	PNPLA3	patatin-like phospholipase domain containing 3
chr22_+_44319674	0.620		PNPLA3	patatin-like phospholipase domain containing 3
chr20_+_48429249	0.619	NM_015266	SLC9A8	solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr7_+_30960914	0.611	NM_001185060 NM_001185061 NM_001185062	AQP1	aquaporin 1 (Colton blood group)
chr11_-_2162340	0.611	NM_001127598	IGF2	insulin-like growth factor 2 (somatomedin A)
chr3_-_46505077	0.606	NM_001199149	LTF	lactotransferrin
chr2_+_234263141	0.602	NM_152879	DGKD	diacylglycerol kinase, delta 130kDa
chr1_-_92351476	0.599		TGFBR3	transforming growth factor, beta receptor III
chr20_+_62694456	0.592		TCEA2	transcription elongation factor A (SII), 2
chr9_-_16870719	0.592	NM_017637	BNC2	basonuclin 2
chr19_-_36705982	0.591	NM_001042474	ZNF565	zinc finger protein 565
chr10_+_112257624	0.588	NM_004419	DUSP5	dual specificity phosphatase 5
chr19_-_2236246	0.586	NM_018049	PLEKHJ1	pleckstrin homology domain containing, family J member 1
chr2_-_178129858	0.585	NM_006164	NFE2L2	nuclear factor (erythroid-derived 2)-like 2
chr2_+_234263153	0.583		DGKD	diacylglycerol kinase, delta 130kDa
chr2_-_288181	0.578	NM_001002919	FAM150B	family with sequence similarity 150, member B
chr8_-_17658385	0.576	NM_001001924 NM_001001925	MTUS1	microtubule associated tumor suppressor 1
chr9_-_140083034	0.574	NM_013366	ANAPC2	anaphase promoting complex subunit 2
chr6_-_47277246	0.573		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr18_+_55711890	0.560		NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chr14_-_100841656	0.559		WARS	tryptophanyl-tRNA synthetase
chr11_-_119211034	0.559		MFRP	membrane frizzled-related protein
chr14_+_105992930	0.558	NM_025268	TMEM121	transmembrane protein 121
chr17_-_27224708	0.552	NM_004475	FLOT2	flotillin 2
chr19_-_19052032	0.547	NM_004838	HOMER3	homer homolog 3 (Drosophila)
chr22_-_29138397	0.543		CHEK2	checkpoint kinase 2
chrX_+_117861523	0.540	NM_001560	IL13RA1	interleukin 13 receptor, alpha 1
chr21_+_43639930	0.538	NM_207174	ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1
chr11_-_63381485	0.534		PLA2G16	phospholipase A2, group XVI
chr9_-_22009270	0.534	NM_004936 NM_078487	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr11_-_116968986	0.532	NM_025164	SIK3	SIK family kinase 3
chr6_-_159240398	0.531		EZR	ezrin
chr2_-_180129245	0.530	NM_178123	SESTD1	SEC14 and spectrin domains 1
chr19_-_36705556	0.526	NM_152477	ZNF565	zinc finger protein 565
chr10_+_115438934	0.525	NM_033340	CASP7	caspase 7, apoptosis-related cysteine peptidase
chr11_-_63381840	0.520		PLA2G16	phospholipase A2, group XVI
chr1_+_16083132	0.520		FBLIM1	filamin binding LIM protein 1
chr20_+_48429375	0.519		SLC9A8	solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr6_+_12012723	0.517	NM_002114	HIVEP1	human immunodeficiency virus type I enhancer binding protein 1
chr19_-_3047632	0.512	NM_001144761	TLE2	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr22_-_19166276	0.511		SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr14_+_55738871	0.511	NM_152231	FBXO34	F-box protein 34
chr2_-_175869910	0.507	NM_001822 NM_001025201	CHN1	chimerin (chimaerin) 1
chr2_+_173600595	0.504		RAPGEF4	Rap guanine nucleotide exchange factor (GEF) 4
chr17_-_18266691	0.504	NM_004169 NM_148918	SHMT1	serine hydroxymethyltransferase 1 (soluble)
chr2_+_173600634	0.501		RAPGEF4	Rap guanine nucleotide exchange factor (GEF) 4
chr1_-_59042827	0.500		TACSTD2	tumor-associated calcium signal transducer 2
chrX_+_103357106	0.499	NM_001143978	ZCCHC18	zinc finger, CCHC domain containing 18
chr11_-_33890931	0.498		LMO2	LIM domain only 2 (rhombotin-like 1)
chr11_-_63381907	0.498	NM_007069	PLA2G16	phospholipase A2, group XVI
chr11_+_76571966	0.496		ACER3	alkaline ceramidase 3
chr11_-_63381940	0.496	NM_001128203	PLA2G16	phospholipase A2, group XVI
chr14_+_104605441	0.490		KIF26A	kinesin family member 26A
chr11_-_74022609	0.484	NM_182904	P4HA3	prolyl 4-hydroxylase, alpha polypeptide III
chr2_+_173600519	0.483	NM_007023	RAPGEF4	Rap guanine nucleotide exchange factor (GEF) 4
chr5_-_81046858	0.482		SSBP2	single-stranded DNA binding protein 2
chr5_+_179247903	0.477		SQSTM1	sequestosome 1
chrX_-_118827116	0.472		SEPT6	septin 6
chr7_+_101460881	0.470	NM_181552	CUX1	cut-like homeobox 1
chr21_-_47648685	0.469		LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr1_+_25944610	0.467		MAN1C1	mannosidase, alpha, class 1C, member 1
chr12_+_57482674	0.464	NM_005967	NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr19_+_39899749	0.461
chr1_-_226374400	0.459		ACBD3	acyl-CoA binding domain containing 3
chr12_-_109251333	0.459	NM_001161330 NM_018984	SSH1	slingshot homolog 1 (Drosophila)
chr22_-_19166133	0.458		SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr5_-_180076599	0.454		FLT4	fms-related tyrosine kinase 4
chr5_+_1008900	0.453	NM_033120	NKD2	naked cuticle homolog 2 (Drosophila)
chr22_-_19166296	0.450	NM_005984	SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr3_-_50374795	0.450		RASSF1	Ras association (RalGDS/AF-6) domain family member 1
chr5_+_179247911	0.449		SQSTM1	sequestosome 1
chr7_+_44143945	0.446	NM_001129	AEBP1	AE binding protein 1
chr9_-_140083010	0.442		ANAPC2	anaphase promoting complex subunit 2
chr3_-_50374875	0.442	NM_170713	RASSF1	Ras association (RalGDS/AF-6) domain family member 1
chr7_-_91764036	0.439	NM_001146152	CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1
chr20_-_25038501	0.436	NM_001252675 NM_001252677 NM_032501	ACSS1	acyl-CoA synthetase short-chain family member 1
chr1_-_231004050	0.435		C1orf198	chromosome 1 open reading frame 198
chr5_+_179248089	0.434		SQSTM1	sequestosome 1
chr12_+_82752275	0.433	NM_032230	C12orf26	chromosome 12 open reading frame 26
chr5_-_180076616	0.433	NM_002020 NM_182925	FLT4	fms-related tyrosine kinase 4
chr21_-_35987144	0.432	NM_004414	RCAN1	regulator of calcineurin 1
chr20_+_62372436	0.432		SLC2A4RG	SLC2A4 regulator
chr3_+_53195214	0.431	NM_006254 NM_212539	PRKCD	protein kinase C, delta
chr8_+_28559143	0.427	NM_001440	EXTL3	exostoses (multiple)-like 3
chr3_-_50374749	0.426		RASSF1	Ras association (RalGDS/AF-6) domain family member 1
chr3_+_195384918	0.424		SDHAP1 SDHAP2	succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1 succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
chrX_+_152240726	0.419	NM_001170944 NM_001242319 NM_032882	PNMA6C PNMA6D PNMA6A	paraneoplastic antigen like 6C paraneoplastic antigen like 6D paraneoplastic antigen like 6A
chr19_-_11373117	0.419	NM_020812	DOCK6	dedicator of cytokinesis 6
chr7_-_75368276	0.419	NM_001243198 NM_005338	HIP1	huntingtin interacting protein 1
chr14_+_105941061	0.418	NM_001312	CRIP2	cysteine-rich protein 2
chr15_-_65067696	0.416	NM_194272	RBPMS2	RNA binding protein with multiple splicing 2
chr19_+_50016490	0.413		FCGRT	Fc fragment of IgG, receptor, transporter, alpha
chr12_-_58240746	0.411	NM_005730	CTDSP2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr19_-_7293876	0.410	NM_000208 NM_001079817	INSR	insulin receptor
chr13_+_44453968	0.409	NM_153218	LACC1	laccase (multicopper oxidoreductase) domain containing 1
chr19_+_54371125	0.408	NM_001020819 NM_138373	MYADM	myeloid-associated differentiation marker
chr19_+_1407750	0.407		DAZAP1	DAZ associated protein 1
chr15_+_67358194	0.407	NM_005902	SMAD3	SMAD family member 3
chr19_+_51152634	0.405	NM_001195076	C19orf81	chromosome 19 open reading frame 81
chr2_-_204399906	0.405	NM_203365 NM_213589	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr9_+_139972195	0.399		UAP1L1	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr7_-_33148897	0.399	NM_203288	RP9	retinitis pigmentosa 9 (autosomal dominant)
chr22_-_38794853	0.398		LOC400927	TPTE and PTEN homologous inositol lipid phosphatase pseudogene
chr1_+_207925409	0.398		CD46	CD46 molecule, complement regulatory protein
chr2_+_201983419	0.397		CFLAR	CASP8 and FADD-like apoptosis regulator
chr4_+_120133729	0.394
chr7_-_91763775	0.394		CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1
chr2_-_101767714	0.393	NM_001102426	TBC1D8	TBC1 domain family, member 8 (with GRAM domain)
chr21_-_46237978	0.391		SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr11_+_109964086	0.391	NM_033390	ZC3H12C	zinc finger CCCH-type containing 12C
chr2_+_39893021	0.391	NM_152390	TMEM178	transmembrane protein 178
chr3_-_66550844	0.390	NM_015541	LRIG1	leucine-rich repeats and immunoglobulin-like domains 1
chr8_+_28559010	0.389		EXTL3	exostoses (multiple)-like 3
chr9_+_97488993	0.388		C9orf3	chromosome 9 open reading frame 3
chr5_+_179234002	0.388	NM_001142299	SQSTM1	sequestosome 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.58	8.70e-07	GO:0009966	regulation of signal transduction
1.20	1.40e-06	GO:0050794	regulation of cellular process
1.52	1.44e-06	GO:0023051	regulation of signaling
1.12	3.75e-06	GO:0009987	cellular process
1.30	6.66e-06	GO:0023052	signaling
1.18	1.44e-05	GO:0008152	metabolic process
1.17	4.95e-05	GO:0050789	regulation of biological process
1.30	6.18e-05	GO:0007165	signal transduction
1.16	1.78e-04	GO:0065007	biological regulation
1.55	5.24e-04	GO:0051246	regulation of protein metabolic process
1.48	6.10e-04	GO:0035556	intracellular signal transduction
1.24	6.22e-04	GO:0051716	cellular response to stimulus
1.56	7.14e-04	GO:0032268	regulation of cellular protein metabolic process
1.39	1.03e-03	GO:0048583	regulation of response to stimulus
1.17	4.17e-03	GO:0044238	primary metabolic process
1.59	5.39e-03	GO:0031399	regulation of protein modification process
1.33	5.96e-03	GO:0048523	negative regulation of cellular process
1.16	9.47e-03	GO:0044237	cellular metabolic process
1.31	1.15e-02	GO:0048519	negative regulation of biological process
1.45	1.40e-02	GO:0050790	regulation of catalytic activity
1.26	1.94e-02	GO:0019538	protein metabolic process
1.51	3.03e-02	GO:0008219	cell death
1.56	3.12e-02	GO:0006468	protein phosphorylation
1.38	3.57e-02	GO:0065009	regulation of molecular function
1.51	3.78e-02	GO:0016265	death
1.91	4.59e-02	GO:0030029	actin filament-based process
1.70	4.81e-02	GO:0045859	regulation of protein kinase activity

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.20	8.38e-11	GO:0005737	cytoplasm
1.12	3.07e-09	GO:0005622	intracellular
1.12	1.98e-08	GO:0044424	intracellular part
1.22	3.60e-07	GO:0044444	cytoplasmic part
1.11	2.36e-04	GO:0043229	intracellular organelle
1.11	3.49e-04	GO:0043226	organelle
1.12	4.23e-04	GO:0043231	intracellular membrane-bounded organelle
1.18	4.83e-04	GO:0044446	intracellular organelle part
1.12	5.25e-04	GO:0043227	membrane-bounded organelle
1.17	1.11e-03	GO:0044422	organelle part
1.49	2.14e-03	GO:0005794	Golgi apparatus
1.34	1.16e-02	GO:0012505	endomembrane system
1.84	1.53e-02	GO:0015629	actin cytoskeleton
1.27	3.01e-02	GO:0031090	organelle membrane

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.23	9.72e-12	GO:0005515	protein binding
1.12	7.98e-09	GO:0005488	binding
1.54	1.19e-02	GO:0016773	phosphotransferase activity, alcohol group as acceptor
1.51	1.63e-02	GO:0016301	kinase activity
1.52	1.87e-02	GO:0019899	enzyme binding
1.56	3.05e-02	GO:0004672	protein kinase activity
1.66	4.35e-02	GO:0004674	protein serine/threonine kinase activity