Motif ID: ETS1,2.p2

Z-value: 0.768


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ETS1chr11_-_1283920610.386.4e-02Click!
ETS2chr21_+_401778470.252.3e-01Click!


Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_169703178 1.545 NM_000450
 SELE
selectin E
chr11_-_46722139 1.452 ARHGAP1
Rho GTPase activating protein 1
chr11_-_46722160 1.311 ARHGAP1
Rho GTPase activating protein 1
chr17_+_32582295 0.917 NM_002982
 CCL2
chemokine (C-C motif) ligand 2
chr1_-_160313056 0.895 COPA
coatomer protein complex, subunit alpha
chr21_+_26934440 0.797 MIR155HG
MIR155 host gene (non-protein coding)
chr19_+_39899749 0.781


chr16_+_29674564 0.771 SPN
sialophorin
chr1_-_160312959 0.736


chr5_-_131826426 0.685 NM_002198
 IRF1
interferon regulatory factor 1
chr5_+_118604417 0.674 NM_001077654
 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr7_+_150148078 0.668 GIMAP8
GTPase, IMAP family member 8
chr10_+_49892860 0.662 WDFY4
WDFY family member 4
chr4_-_74964836 0.654 CXCL2
chemokine (C-X-C motif) ligand 2
chr5_+_56111379 0.646 MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr19_+_42387249 0.638 NM_004706
NM_198977
 ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1

chr6_-_10412606 0.621 NM_001032280
 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr9_-_123688352 0.601 TRAF1
TNF receptor-associated factor 1
chr19_+_42387307 0.579 ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr14_+_103592663 0.576 NM_006291
 TNFAIP2
tumor necrosis factor, alpha-induced protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 54 entries
enrichment   p-value GO term description
2.01 3.55e-02 GO:0007265 Ras protein signal transduction
1.93 6.17e-04 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
1.93 6.17e-04 GO:0000398 nuclear mRNA splicing, via spliceosome
1.88 1.70e-03 GO:0000375 RNA splicing, via transesterification reactions
1.73 1.98e-02 GO:0030168 platelet activation
1.63 3.63e-05 GO:0001775 cell activation
1.58 1.34e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.52 1.79e-02 GO:0002684 positive regulation of immune system process
1.51 1.03e-02 GO:0007599 hemostasis
1.50 1.07e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.50 1.28e-02 GO:0007596 blood coagulation
1.50 1.28e-02 GO:0050817 coagulation
1.49 3.25e-02 GO:0045859 regulation of protein kinase activity
1.48 5.60e-03 GO:0042060 wound healing
1.44 5.13e-03 GO:0043085 positive regulation of catalytic activity
1.44 4.65e-02 GO:0050878 regulation of body fluid levels
1.41 9.44e-03 GO:0006955 immune response
1.41 1.06e-02 GO:0006468 protein phosphorylation
1.41 1.61e-02 GO:0002682 regulation of immune system process
1.41 4.75e-02 GO:0007167 enzyme linked receptor protein signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
2.77 1.71e-02 GO:0032587 ruffle membrane
1.72 2.65e-02 GO:0031252 cell leading edge
1.25 1.36e-04 GO:0005829 cytosol
1.21 3.91e-02 GO:0031981 nuclear lumen
1.19 1.63e-02 GO:0031974 membrane-enclosed lumen
1.19 3.56e-02 GO:0044428 nuclear part
1.18 3.25e-02 GO:0043233 organelle lumen
1.13 3.66e-09 GO:0005737 cytoplasm
1.13 3.53e-05 GO:0044444 cytoplasmic part
1.12 3.00e-03 GO:0044422 organelle part
1.12 5.68e-03 GO:0044446 intracellular organelle part
1.08 5.82e-08 GO:0005622 intracellular
1.08 7.27e-08 GO:0044424 intracellular part
1.08 6.36e-03 GO:0043227 membrane-bounded organelle
1.08 1.01e-02 GO:0043231 intracellular membrane-bounded organelle
1.07 9.77e-03 GO:0043226 organelle
1.07 1.25e-02 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
1.52 1.50e-02 GO:0000988 protein binding transcription factor activity
1.52 1.50e-02 GO:0000989 transcription factor binding transcription factor activity
1.51 4.65e-03 GO:0019904 protein domain specific binding
1.51 2.34e-02 GO:0003712 transcription cofactor activity
1.44 1.29e-03 GO:0046983 protein dimerization activity
1.37 9.89e-03 GO:0042802 identical protein binding
1.20 1.04e-18 GO:0005515 protein binding
1.06 6.08e-05 GO:0005488 binding