Motif ID: EVI1.p2

Z-value: 1.557


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
EVI1 2122 ecotropic viral integration site 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
MECOMchr3_-_168864066-0.471.9e-02Click!


Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_+_43710190 7.433 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr2_+_102979096 6.338 NM_003855
IL18R1
interleukin 18 receptor 1
chr4_-_76944585 4.738 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr15_+_67418053 4.451 NM_001145102
SMAD3
SMAD family member 3
chr8_+_17396285 4.261 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr6_-_154831704 4.101 NM_173515
CNKSR3
CNKSR family member 3
chr6_-_154831788 3.999 CNKSR3
CNKSR family member 3
chr5_+_125695787 3.884 NM_001146319
GRAMD3
GRAM domain containing 3
chr6_+_126240369 3.867 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr6_-_154831652 3.737 CNKSR3
CNKSR family member 3
chr14_-_76447445 3.700 TGFB3
transforming growth factor, beta 3
chr8_-_6420454 3.471 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr1_+_212738675 3.255 NM_001030287
ATF3
activating transcription factor 3
chr15_-_55562483 3.193 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr8_+_90770201 3.140 RIPK2
receptor-interacting serine-threonine kinase 2
chr12_-_9913415 3.100 NM_001781
CD69
CD69 molecule
chr13_+_97928196 2.868 MBNL2
muscleblind-like 2 (Drosophila)
chr1_+_101185195 2.757 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr18_+_61554938 2.700 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr8_-_101315457 2.666 NM_015435
RNF19A
ring finger protein 19A
chr9_-_107690526 2.527 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr1_-_33338081 2.486 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr8_+_97505876 2.228 NM_002998
SDC2
syndecan 2
chr9_+_82187469 2.204 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr10_-_45474210 2.195 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr8_+_90769974 2.175 NM_003821
RIPK2
receptor-interacting serine-threonine kinase 2
chr9_+_74920329 2.109


chr9_+_118916069 2.081 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr8_+_97505895 2.068 SDC2
syndecan 2
chr8_+_86099909 2.067 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr8_+_17354562 1.999 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr9_-_139292888 1.957 NM_003086
SNAPC4
small nuclear RNA activating complex, polypeptide 4, 190kDa
chr14_+_55221505 1.900 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chrX_+_15525430 1.871 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr5_-_138862342 1.841 NM_198282
TMEM173
transmembrane protein 173
chr16_+_50731049 1.799 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr22_-_36562224 1.768 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr3_-_27498244 1.748 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr5_+_140739589 1.730 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr12_-_49259549 1.622 NM_014470
RND1
Rho family GTPase 1
chr1_-_204459445 1.584 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr15_-_80263460 1.582 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr2_+_169929009 1.557 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr19_-_47735858 1.515 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr6_+_26383323 1.512 NM_001197238
NM_001197239
NM_001197240
NM_006995
NM_181531
NM_001197237
BTN2A2





butyrophilin, subfamily 2, member A2





chrX_+_101502093 1.512 NM_022053
NM_001099686
NXF2
NXF2B
nuclear RNA export factor 2
nuclear RNA export factor 2B
chr1_+_50569581 1.457 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_-_158637060 1.429 NM_001199380
RNF145
ring finger protein 145
chr1_-_173020011 1.425 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr6_-_30652434 1.423 PPP1R18
protein phosphatase 1, regulatory subunit 18
chrX_-_101694848 1.419 NM_022053
NM_001099686
NXF2
NXF2B
nuclear RNA export factor 2
nuclear RNA export factor 2B
chr12_+_26205490 1.381 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr8_-_38008332 1.378 NM_000349
STAR
steroidogenic acute regulatory protein
chr1_-_182357757 1.336 GLUL
glutamate-ammonia ligase
chr2_-_231989755 1.312 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr4_-_122148620 1.303 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr19_+_36726883 1.279 ZNF146
zinc finger protein 146
chr11_+_114166534 1.267 NM_006169
NNMT
nicotinamide N-methyltransferase
chr1_-_182357871 1.252 GLUL
glutamate-ammonia ligase
chr11_-_47510518 1.237 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr4_-_7436614 1.223 NM_001085382
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr18_+_55714457 1.222 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_+_35426709 1.210 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr10_-_29754478 1.206 SVIL
supervillin
chrX_-_134953898 1.187 NM_001007551
NM_001172288
CT45A5

cancer/testis antigen family 45, member A5

chr14_-_35344852 1.168 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr1_+_152881022 1.154 NM_005547
IVL
involucrin
chr3_-_138478184 1.137 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr9_+_111624545 1.136 NM_006687
ACTL7A
actin-like 7A
chr13_+_97928414 1.132 MBNL2
muscleblind-like 2 (Drosophila)
chr5_+_140797243 1.121 NM_018927
PCDHGB7
protocadherin gamma subfamily B, 7
chr3_-_71353910 1.110 NM_001244812
FOXP1
forkhead box P1
chr9_+_82186846 1.104 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr3_+_121774208 1.094 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr14_+_65007163 1.093 NM_021979
HSPA2
heat shock 70kDa protein 2
chr9_+_71944240 1.075 NM_004816
FAM189A2
family with sequence similarity 189, member A2
chr1_+_154293568 1.073 NM_080429
AQP10
aquaporin 10
chr4_-_139163222 1.062 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr5_-_147162251 1.059 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr7_+_44240638 1.049 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr7_+_44240555 1.045 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr3_-_187454247 1.030 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr12_-_51422012 1.028 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr11_+_114167197 1.024 NNMT
nicotinamide N-methyltransferase
chr17_+_18625335 1.016 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr12_-_57504935 1.015 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr18_-_44561967 1.005 NM_016427
TCEB3B
transcription elongation factor B polypeptide 3B (elongin A2)
chr1_-_180991979 1.000 STX6
syntaxin 6
chr2_+_103035148 0.998 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr6_+_26440699 0.987 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr11_+_114167168 0.986 NNMT
nicotinamide N-methyltransferase
chr21_+_30400229 0.983 USP16
ubiquitin specific peptidase 16
chr4_-_76598558 0.977 G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr7_+_44240606 0.966 YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr1_-_208084432 0.942 NM_001025109
NM_001773
CD34

CD34 molecule

chr1_+_170904611 0.942 NM_001163629
NM_025063
C1orf129

chromosome 1 open reading frame 129

chr1_+_47901688 0.939 NM_004474
FOXD2
forkhead box D2
chr17_-_8424217 0.933 MYH10
myosin, heavy chain 10, non-muscle
chr9_+_34652125 0.913 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr6_+_26458152 0.908 NM_001197234
NM_007049
NM_078476
NM_001197233
BTN2A1



butyrophilin, subfamily 2, member A1



chr22_-_19512859 0.893 NM_001130861
NM_003277
CLDN5

claudin 5

chr14_+_64680858 0.883 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr5_+_113769226 0.878 NM_170775
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr7_+_28338939 0.868 NM_182899
CREB5
cAMP responsive element binding protein 5
chr1_-_226926875 0.867 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr5_-_147162175 0.861 JAKMIP2
janus kinase and microtubule interacting protein 2
chr7_-_93189121 0.860 NM_001164738
CALCR
calcitonin receptor
chr2_-_145277879 0.852 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr3_-_194188967 0.849 NM_024524
ATP13A3
ATPase type 13A3
chr15_+_85666291 0.848 PDE8A
phosphodiesterase 8A
chr4_-_159094163 0.820 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr6_+_144612872 0.816 NM_007124
UTRN
utrophin
chr6_+_31514627 0.810 NM_001144962
NM_001144963
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr1_+_117544371 0.806 NM_004258
CD101
CD101 molecule
chr19_+_10781648 0.793 ILF3
interleukin enhancer binding factor 3, 90kDa
chr3_+_97158453 0.790 NM_173655
EPHA6
EPH receptor A6
chr5_-_158634641 0.777 NM_001199382
RNF145
ring finger protein 145
chr1_-_24434927 0.773 MYOM3
myomesin family, member 3
chr6_+_31515352 0.757 NM_001144961
NM_005007
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr1_+_205236591 0.752 TMCC2
transmembrane and coiled-coil domain family 2
chr15_-_37391596 0.749 NM_172316
MEIS2
Meis homeobox 2
chr17_+_32582295 0.744 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr13_+_97794050 0.740 MBNL2
muscleblind-like 2 (Drosophila)
chr19_+_50030874 0.731 NM_020650
RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr4_-_76598563 0.729 G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr5_-_146460991 0.728 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr1_+_160160284 0.724 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_-_180992044 0.720 NM_005819
STX6
syntaxin 6
chr22_-_31688329 0.695 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr2_+_189839132 0.690 COL3A1
collagen, type III, alpha 1
chr3_+_132316080 0.684 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr12_+_20848288 0.683 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr19_+_50031232 0.683 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr3_+_184033936 0.682 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr2_-_165551178 0.678 COBLL1
COBL-like 1
chr6_+_31515391 0.675 NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr12_-_54758228 0.671 NM_020370
GPR84
G protein-coupled receptor 84
chr3_-_150966901 0.667 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr1_-_173174611 0.666 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr14_-_75330535 0.663 NM_001080408
NM_001243007
PROX2

prospero homeobox 2

chr15_+_59903980 0.661 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr19_-_3969734 0.660 NM_001348
DAPK3
death-associated protein kinase 3
chr3_-_145968819 0.656 PLSCR4
phospholipid scramblase 4
chr7_+_44240569 0.653 NM_006555
YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr11_-_104769396 0.651 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr3_+_85775631 0.648 NM_153184
CADM2
cell adhesion molecule 2
chr12_-_105322056 0.639 NM_032148
SLC41A2
solute carrier family 41, member 2
chr20_+_43343523 0.637 WISP2
WNT1 inducible signaling pathway protein 2
chr2_+_169923531 0.635 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr8_+_123794043 0.634 ZHX2
zinc fingers and homeoboxes 2
chr3_-_150996153 0.630 NM_014879
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr1_+_86934525 0.627 NM_001285
CLCA1
chloride channel accessory 1
chr15_+_44719765 0.623 CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr2_+_36923832 0.620 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr1_-_247242111 0.613 NM_001204220
NM_033213
ZNF670-ZNF695
ZNF670

ZNF670-ZNF695 readthrough
zinc finger protein 670

chr4_+_108814419 0.612 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr22_-_30960875 0.610 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr15_-_40401041 0.610 NM_001003940
BMF
Bcl2 modifying factor
chr15_+_34261088 0.608 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chr15_+_44719831 0.608 CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr6_+_123100860 0.608 FABP7
fatty acid binding protein 7, brain
chr15_-_37391893 0.606 MEIS2
Meis homeobox 2
chrX_+_72667089 0.602 NM_005193
CDX4
caudal type homeobox 4
chr11_-_114430579 0.598 NM_152315
FAM55A
family with sequence similarity 55, member A
chr22_-_27013959 0.594 NM_001887
CRYBB1
crystallin, beta B1
chr1_+_32666201 0.592 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr10_-_75335415 0.592 NM_152586
USP54
ubiquitin specific peptidase 54
chr5_-_35048239 0.591 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr3_-_112359277 0.589 CCDC80
coiled-coil domain containing 80
chr4_-_159093717 0.586 NM_016613
FAM198B
family with sequence similarity 198, member B
chr3_-_71179736 0.585 FOXP1
forkhead box P1
chr17_-_56494930 0.584 NM_017763
RNF43
ring finger protein 43
chr12_-_57505176 0.582 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chr17_+_19990334 0.578 NM_001033553
NM_152904
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr15_-_50411405 0.577 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chrX_-_83757398 0.575 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr22_-_27014037 0.573 CRYBB1
crystallin, beta B1
chr14_-_61748510 0.570 NM_001017970
TMEM30B
transmembrane protein 30B
chr5_+_56509900 0.569 NM_001127236
GPBP1
GC-rich promoter binding protein 1
chr4_+_77953942 0.567 SEPT11
septin 11
chr19_+_44084758 0.567 LOC390940
uncharacterized protein ENSP00000244321
chr3_-_71542628 0.564 FOXP1
forkhead box P1
chr16_-_48644087 0.562 NM_153029
N4BP1
NEDD4 binding protein 1
chr12_+_21168629 0.558 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr1_+_209859524 0.550 NM_001206741
NM_181755
HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr5_-_16738346 0.544 MYO10
myosin X
chr8_+_134203281 0.543 NM_001204869
NM_001204870
NM_003882
NM_080838
WISP1



WNT1 inducible signaling pathway protein 1



chr8_-_27115935 0.541 STMN4
stathmin-like 4
chr5_+_166711842 0.538 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr7_+_134576187 0.534 CALD1
caldesmon 1
chr5_+_55147206 0.530 NM_001242637
NM_001242638
NM_139017
IL31RA


interleukin 31 receptor A


chr21_-_37948866 0.530 NM_001146077
CLDN14
claudin 14
chr18_-_29340698 0.528 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chr5_+_118965253 0.521 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr8_+_23427477 0.520 SLC25A37
solute carrier family 25, member 37
chr12_-_57505121 0.517 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr2_+_36923902 0.516 VIT
vitrin
chrX_-_102531673 0.515 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr2_-_224467049 0.514 SCG2
secretogranin II
chr5_-_96149804 0.511 NM_001198541
ERAP1
endoplasmic reticulum aminopeptidase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.35 1.44e-04 GO:0007165 signal transduction
1.32 2.72e-04 GO:0023052 signaling
1.72 1.15e-03 GO:0009611 response to wounding
1.16 2.83e-03 GO:0065007 biological regulation
2.01 3.28e-03 GO:0050776 regulation of immune response
1.78 4.90e-03 GO:0002682 regulation of immune system process
1.44 8.84e-03 GO:0007166 cell surface receptor linked signaling pathway
2.35 9.17e-03 GO:0002694 regulation of leukocyte activation
1.26 9.99e-03 GO:0051716 cellular response to stimulus
1.16 1.68e-02 GO:0050789 regulation of biological process
1.19 1.82e-02 GO:0050896 response to stimulus
8.12 1.85e-02 GO:0046640 regulation of alpha-beta T cell proliferation
2.26 2.13e-02 GO:0050865 regulation of cell activation
1.20 3.25e-02 GO:0032501 multicellular organismal process
1.86 3.59e-02 GO:0009628 response to abiotic stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.52 1.25e-06 GO:0005576 extracellular region
1.30 1.76e-05 GO:0071944 cell periphery
1.29 4.24e-05 GO:0005886 plasma membrane
1.41 2.28e-04 GO:0044459 plasma membrane part
1.64 4.95e-03 GO:0005615 extracellular space
1.54 5.41e-03 GO:0044421 extracellular region part
1.13 1.85e-02 GO:0016020 membrane
1.15 4.53e-02 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.15 5.13e-04 GO:0022804 active transmembrane transporter activity
2.43 3.71e-02 GO:0030414 peptidase inhibitor activity
12.99 3.81e-02 GO:0000099 sulfur amino acid transmembrane transporter activity
12.99 3.81e-02 GO:0015184 L-cystine transmembrane transporter activity