Motif ID: EWSR1-FLI1.p2

Z-value: 0.626


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
FLI1chr11_+_128563772-0.164.5e-01Click!
EWSR1chr22_+_296639970.029.3e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_43374487 2.222 NM_022358
 KCNK15
potassium channel, subfamily K, member 15
chr3_-_164914448 0.878 NM_014926
 SLITRK3
SLIT and NTRK-like family, member 3
chrX_+_1401570 0.665 NM_001161530
NM_172247
 CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr13_-_33780142 0.663 NM_001243474
NM_052851
 STARD13

StAR-related lipid transfer (START) domain containing 13

chrY_+_1351570 0.659 NM_001161530
NM_172247
 CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr1_+_167599329 0.657 NM_052862
 RCSD1
RCSD domain containing 1
chr6_+_36916038 0.591 NM_001199159
 PI16
peptidase inhibitor 16
chr6_-_134496833 0.557 SGK1
serum/glucocorticoid regulated kinase 1
chr6_-_134497069 0.557 NM_001143678
 SGK1
serum/glucocorticoid regulated kinase 1
chr2_+_167744996 0.550 NM_001079810
NM_001199143
NM_152381
 XIRP2


xin actin-binding repeat containing 2


chr18_+_43405544 0.541 NM_213602
 SIGLEC15
sialic acid binding Ig-like lectin 15
chr2_+_113816214 0.486 NM_173170
 IL36RN
interleukin 36 receptor antagonist
chr5_-_137089434 0.482 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr19_-_17958773 0.423 JAK3
Janus kinase 3
chr5_+_35856990 0.357 NM_002185
 IL7R
interleukin 7 receptor
chr19_-_6591012 0.341 CD70
CD70 molecule
chr1_-_31230594 0.339 LAPTM5
lysosomal protein transmembrane 5
chr2_-_99917638 0.324 NM_174898
 LYG1
lysozyme G-like 1
chr1_-_31230673 0.318 NM_006762
 LAPTM5
lysosomal protein transmembrane 5
chr12_-_117175634 0.316 NM_024738
 C12orf49
chromosome 12 open reading frame 49

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
3.30 2.16e-02 GO:0051130 positive regulation of cellular component organization
3.17 2.15e-02 GO:0045597 positive regulation of cell differentiation
3.05 2.79e-03 GO:0051094 positive regulation of developmental process
2.80 2.74e-02 GO:0048812 neuron projection morphogenesis
2.71 1.91e-02 GO:0032990 cell part morphogenesis
2.66 3.86e-02 GO:0031175 neuron projection development
2.63 4.56e-02 GO:0000904 cell morphogenesis involved in differentiation
2.51 2.90e-02 GO:0000902 cell morphogenesis
2.48 2.49e-02 GO:0032989 cellular component morphogenesis
2.30 1.68e-02 GO:0048584 positive regulation of response to stimulus
1.94 7.51e-03 GO:0009653 anatomical structure morphogenesis
1.80 1.09e-02 GO:0048583 regulation of response to stimulus
1.71 5.05e-03 GO:0048522 positive regulation of cellular process
1.68 3.58e-03 GO:0048518 positive regulation of biological process
1.49 3.01e-02 GO:0023052 signaling

Gene overrepresentation in compartment category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
3.82 1.66e-02 GO:0043025 neuronal cell body
3.71 2.20e-02 GO:0044297 cell body
2.29 3.11e-02 GO:0030054 cell junction

Nothing significant found in function category.