Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 1.432


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
FOSL1chr11_-_656678580.783.7e-06Click!
JUNBchr19_+_129022950.359.1e-02Click!
JUNDchr19_-_183924130.331.0e-01Click!
FOSchr14_+_75745480-0.321.2e-01Click!
FOSBchr19_+_45971249-0.096.8e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_74606222 20.501 NM_000584
IL8
interleukin 8
chr1_-_169703178 19.131 NM_000450
SELE
selectin E
chr1_-_95007139 13.642 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr9_-_123688352 13.039 TRAF1
TNF receptor-associated factor 1
chr15_+_89182038 11.597 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_+_183155393 11.447 LAMC2
laminin, gamma 2
chr21_+_26934440 10.483 MIR155HG
MIR155 host gene (non-protein coding)
chr1_+_183155173 8.749 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr12_-_49259549 8.246 NM_014470
RND1
Rho family GTPase 1
chr1_-_153521717 8.181 NM_002960
S100A3
S100 calcium binding protein A3
chr1_+_183155361 7.660 LAMC2
laminin, gamma 2
chr2_+_152214105 7.633 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr11_-_8739398 7.574 ST5
suppression of tumorigenicity 5
chr6_+_138188352 7.197 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr17_+_21191347 6.627 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr11_-_102668892 5.526 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr11_-_102668822 5.507 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr18_+_61554938 5.434 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr4_-_76957139 5.282 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr3_+_11178778 4.803 NM_001098213
HRH1
histamine receptor H1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.61 1.11e-02 GO:0009611 response to wounding
1.51 3.71e-02 GO:0051246 regulation of protein metabolic process
1.36 4.52e-03 GO:0048522 positive regulation of cellular process
1.36 4.58e-03 GO:0006950 response to stress
1.34 3.21e-03 GO:0048518 positive regulation of biological process
1.31 3.53e-04 GO:0023052 signaling
1.31 8.99e-04 GO:0007165 signal transduction
1.28 8.25e-04 GO:0051716 cellular response to stimulus
1.22 8.87e-06 GO:0050794 regulation of cellular process
1.20 6.28e-05 GO:0050789 regulation of biological process
1.18 7.47e-05 GO:0065007 biological regulation
1.18 2.77e-02 GO:0050896 response to stimulus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
1.48 4.00e-02 GO:0005102 receptor binding
1.19 2.91e-05 GO:0005515 protein binding
1.09 6.18e-03 GO:0005488 binding