Motif ID: FOX{D1,D2}.p2

Z-value: 2.310


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
FOXD1 2297 forkhead box D1
FOXD2 2306 forkhead box D2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
FOXD2chr1_+_47901688-0.376.8e-02Click!
FOXD1chr5_-_72744351-0.252.3e-01Click!


Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_84630575 20.920 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr1_+_84630374 13.554 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_+_41700736 12.932 LIMCH1
LIM and calponin homology domains 1
chr1_+_84630014 12.233 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr2_+_12856813 9.024 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr18_-_22930826 7.786


chr2_+_132480063 7.620 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr14_-_91526912 7.524 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr10_+_63808968 7.468 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr4_-_141075232 7.378 NM_018717
MAML3
mastermind-like 3 (Drosophila)
chr1_-_92351476 7.159 TGFBR3
transforming growth factor, beta receptor III
chr1_-_92351613 7.107 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr2_-_165424993 6.925 GRB14
growth factor receptor-bound protein 14
chr17_+_58755158 6.914 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr7_+_150688143 6.613 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr9_+_6215785 6.592 NM_001199640
NM_001199641
NM_033439
IL33


interleukin 33


chr8_-_28243941 6.582 NM_018660
ZNF395
zinc finger protein 395
chr12_-_9268440 5.975 A2M
alpha-2-macroglobulin
chr12_-_9268513 5.866 A2M
alpha-2-macroglobulin
chrX_-_135863502 5.836 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr5_+_68800003 5.636 NM_001205255
OCLN
occludin
chr4_+_140587086 5.626 MGST2
microsomal glutathione S-transferase 2
chr6_+_74405856 5.601 CD109
CD109 molecule
chr14_+_24867926 5.515 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr7_+_134832765 5.408 NM_018295
TMEM140
transmembrane protein 140
chr2_-_191878883 5.392 STAT1
signal transducer and activator of transcription 1, 91kDa
chr14_+_56584854 5.289 NM_021255
PELI2
pellino homolog 2 (Drosophila)
chr14_+_56585147 5.238 PELI2
pellino homolog 2 (Drosophila)
chr2_-_191878908 5.203 STAT1
signal transducer and activator of transcription 1, 91kDa
chr12_-_9268522 5.200 NM_000014
A2M
alpha-2-macroglobulin
chr3_-_168865521 5.155 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr18_-_500583 5.089 NM_130386
COLEC12
collectin sub-family member 12
chr4_+_140586921 5.061 NM_001204366
NM_001204367
NM_001204368
NM_002413
MGST2



microsomal glutathione S-transferase 2



chr15_-_70994608 4.970 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr3_-_93692898 4.920 NM_000313
PROS1
protein S (alpha)
chr12_+_13349720 4.904 EMP1
epithelial membrane protein 1
chr3_-_15839674 4.900 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr9_-_94124194 4.826 NM_001698
AUH
AU RNA binding protein/enoyl-CoA hydratase
chr2_-_191878882 4.826 STAT1
signal transducer and activator of transcription 1, 91kDa
chr3_-_93692592 4.825 PROS1
protein S (alpha)
chr2_-_191878924 4.793 NM_007315
NM_139266
STAT1

signal transducer and activator of transcription 1, 91kDa

chr12_+_13349601 4.723 NM_001423
EMP1
epithelial membrane protein 1
chr12_-_9268475 4.685 A2M
alpha-2-macroglobulin
chr10_+_82173574 4.646 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr11_-_71752099 4.576 NUMA1
nuclear mitotic apparatus protein 1
chr6_-_42016383 4.554 CCND3
cyclin D3
chr17_-_66951381 4.420 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_-_64211111 4.419 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr1_+_185703470 4.374 NM_031935
HMCN1
hemicentin 1
chr2_+_189157551 4.322 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr6_-_42016609 4.302 NM_001136017
NM_001136126
CCND3

cyclin D3

chr9_-_94124149 4.261 AUH
AU RNA binding protein/enoyl-CoA hydratase
chr14_-_74551073 4.173 ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr6_+_74405505 4.158 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr18_-_53303129 4.144 NM_001243226
TCF4
transcription factor 4
chr5_+_68788118 4.140 NM_002538
OCLN
occludin
chr16_-_30107492 4.100 NM_031477
NM_001145524
YPEL3

yippee-like 3 (Drosophila)

chr14_-_74551159 4.055 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr1_+_61547388 3.884 NM_001145512
NFIA
nuclear factor I/A
chr8_-_93115453 3.877 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr6_+_74405764 3.873 CD109
CD109 molecule
chr17_+_9745847 3.802 GLP2R
glucagon-like peptide 2 receptor
chr20_-_45976626 3.763 ZMYND8
zinc finger, MYND-type containing 8
chr18_-_53071225 3.730 NM_001243232
TCF4
transcription factor 4
chr12_-_29936685 3.713 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr10_-_45474210 3.708 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr5_+_78531848 3.702 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chr7_+_89843133 3.639 NM_001040666
STEAP2
STEAP family member 2, metalloreductase
chr1_+_87794576 3.630 LMO4
LIM domain only 4
chr12_+_48499655 3.590 NM_001166686
PFKM
phosphofructokinase, muscle
chr10_+_35426709 3.533 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr14_-_23288912 3.504 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr9_-_98269480 3.432 NM_001083607
PTCH1
patched 1
chr18_-_53257033 3.366 NM_001243227
NM_001243228
TCF4

transcription factor 4

chr8_-_127570710 3.358 NM_174911
FAM84B
family with sequence similarity 84, member B
chr12_+_96588254 3.318 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr16_-_86542463 3.315 LOC400550
uncharacterized LOC400550
chr19_+_18111923 3.310 NM_001025604
ARRDC2
arrestin domain containing 2
chr12_-_71031174 3.294 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr17_-_67138013 3.259 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr1_+_33722158 3.259 NM_152493
ZNF362
zinc finger protein 362
chr15_-_52970808 3.200 NM_019600
FAM214A
family with sequence similarity 214, member A
chr2_+_65283485 3.157 NM_015147
CEP68
centrosomal protein 68kDa
chr11_-_17191287 3.091 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr22_-_17747520 3.010 CECR3
cat eye syndrome chromosome region, candidate 3 (non-protein coding)
chr12_+_96588000 2.995 NM_005230
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr1_+_61542928 2.994 NM_001145511
NFIA
nuclear factor I/A
chr12_-_76425375 2.915 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr5_-_111091947 2.884 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr15_+_25281105 2.848 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr7_+_106809405 2.848 NM_001244262
NM_012257
HBP1

HMG-box transcription factor 1

chr2_-_165478357 2.843 NM_004490
GRB14
growth factor receptor-bound protein 14
chr14_+_65877309 2.840 NM_004480
NM_178155
NM_178156
FUT8


fucosyltransferase 8 (alpha (1,6) fucosyltransferase)


chr3_-_149421059 2.837 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr1_+_87797371 2.831 LMO4
LIM domain only 4
chr20_+_62887046 2.830 NM_001104925
NM_018257
PCMTD2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

chrX_-_10851808 2.815 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr1_+_196788860 2.779 NM_002113
CFHR1
complement factor H-related 1
chr4_+_134073180 2.710 PCDH10
protocadherin 10
chr7_-_27213873 2.694 NM_018951
HOXA10
homeobox A10
chr6_+_74405933 2.684 CD109
CD109 molecule
chr8_-_127570465 2.607 FAM84B
family with sequence similarity 84, member B
chr2_-_160472960 2.561 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr3_+_113616317 2.555 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr14_+_23067128 2.554 NM_022060
ABHD4
abhydrolase domain containing 4
chr2_-_208890207 2.530 NM_001080475
PLEKHM3
pleckstrin homology domain containing, family M, member 3
chr1_+_198125890 2.517 NM_133494
NEK7
NIMA (never in mitosis gene a)-related kinase 7
chrX_-_117119282 2.506 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr21_-_40033617 2.460 NM_001243432
NM_001136154
NM_004449
ERG


v-ets erythroblastosis virus E26 oncogene homolog (avian)


chr7_+_1577118 2.452 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chrX_-_63005212 2.388 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr6_+_74405909 2.375 CD109
CD109 molecule
chr3_+_23987514 2.349 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr8_-_93075190 2.305 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_-_192711923 2.299 NM_004657
SDPR
serum deprivation response
chr2_+_173686314 2.279 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_-_20812727 2.255 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr16_-_68033355 2.247 NM_022355
DPEP2
dipeptidase 2
chr11_+_844111 2.227 TSPAN4
tetraspanin 4
chr20_+_306205 2.212 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr4_-_152149042 2.203 NM_001243349
SH3D19
SH3 domain containing 19
chr1_+_229440128 2.193 NM_006542
SPHAR
S-phase response (cyclin related)
chr7_+_150147882 2.169 GIMAP8
GTPase, IMAP family member 8
chr8_+_70405080 2.148 SULF1
sulfatase 1
chr6_+_139094656 2.132 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr12_-_6054398 2.086 ANO2
anoctamin 2
chr2_-_68547018 2.069 NM_001111101
NM_015463
CNRIP1

cannabinoid receptor interacting protein 1

chr1_+_87794548 2.059 LMO4
LIM domain only 4
chr3_-_141868208 2.053 NM_001178138
NM_001178139
TFDP2

transcription factor Dp-2 (E2F dimerization partner 2)

chr4_-_103682126 2.039 MANBA
mannosidase, beta A, lysosomal
chr2_-_188419185 2.016 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr2_+_179184970 2.002 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr12_-_71551564 1.996 TSPAN8
tetraspanin 8
chr7_+_77469446 1.959 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr16_+_55512801 1.952 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr3_-_125820390 1.937 NM_001164475
SLC41A3
solute carrier family 41, member 3
chr10_-_48416692 1.936 NM_016204
GDF2
growth differentiation factor 2
chr11_+_844062 1.930 NM_001025234
TSPAN4
tetraspanin 4
chr12_+_79439432 1.886 NM_001135806
SYT1
synaptotagmin I
chr2_-_188312872 1.881 NM_005795
CALCRL
calcitonin receptor-like
chr15_+_96869156 1.876 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr14_+_24584467 1.857 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr11_+_844445 1.857 NM_001025237
TSPAN4
tetraspanin 4
chr15_-_52483564 1.845 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr6_+_32121775 1.838 NM_001204103
NM_005155
PPT2-EGFL8
PPT2

PPT2-EGFL8 readthrough
palmitoyl-protein thioesterase 2

chr11_+_62104773 1.836 NM_001083926
NM_025080
ASRGL1

asparaginase like 1

chr1_+_196912910 1.829 NM_005666
CFHR2
complement factor H-related 2
chr14_+_24583905 1.823 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr7_+_116364175 1.811 MET
met proto-oncogene (hepatocyte growth factor receptor)
chr7_-_27183225 1.804 NM_019102
HOXA5
homeobox A5
chr7_+_91570150 1.804 NM_005751
NM_147185
AKAP9

A kinase (PRKA) anchor protein (yotiao) 9

chr10_+_63661012 1.802 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chrX_+_118108575 1.800 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr10_+_99400469 1.797 PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr12_+_6875686 1.793 PTMS
parathymosin
chr9_-_98269686 1.790 NM_001083606
PTCH1
patched 1
chr11_-_102826433 1.784 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr3_-_114343052 1.783 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr9_-_8733893 1.778 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr2_-_192711651 1.772 SDPR
serum deprivation response
chr10_+_94594469 1.769 NM_001013848
EXOC6
exocyst complex component 6
chr2_+_33661392 1.759 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr11_+_117049838 1.752 NM_001040455
SIDT2
SID1 transmembrane family, member 2
chrX_+_118108595 1.751 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr10_-_79628870 1.744 DLG5
discs, large homolog 5 (Drosophila)
chr5_-_42811959 1.742 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr2_-_26205327 1.732 KIF3C
kinesin family member 3C
chr2_-_152684933 1.731 ARL5A
ADP-ribosylation factor-like 5A
chr8_+_70405027 1.728 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr14_+_24583979 1.726 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr17_+_67410825 1.709 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr16_-_67184822 1.705 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr1_-_47695442 1.658 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr15_-_31283617 1.656 NM_017762
MTMR10
myotubularin related protein 10
chr11_+_71238312 1.648 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr7_+_150264457 1.648 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr3_-_124605840 1.644 ITGB5
integrin, beta 5
chr6_-_79944324 1.628 HMGN3
high mobility group nucleosomal binding domain 3
chr20_+_21106623 1.618 NM_001163022
NM_001163023
NM_018474
PLK1S1


polo-like kinase 1 substrate 1


chr6_+_89791510 1.614 PNRC1
proline-rich nuclear receptor coactivator 1
chr6_-_79944397 1.609 NM_001201362
NM_001201363
NM_004242
NM_138730
HMGN3



high mobility group nucleosomal binding domain 3



chr2_-_152684882 1.606 ARL5A
ADP-ribosylation factor-like 5A
chr2_-_170430312 1.604 NM_024622
FASTKD1
FAST kinase domains 1
chr14_+_24584009 1.603 DCAF11
DDB1 and CUL4 associated factor 11
chr16_-_28550227 1.572 NUPR1
nuclear protein, transcriptional regulator, 1
chr3_-_3221361 1.563 CRBN
cereblon
chr4_-_111119752 1.547 NM_001130721
NM_024090
ELOVL6

ELOVL fatty acid elongase 6

chr17_+_61086897 1.545 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr18_+_56530060 1.542 NM_018181
ZNF532
zinc finger protein 532
chr3_+_23986735 1.533 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr1_-_168106535 1.530 GPR161
G protein-coupled receptor 161
chr13_-_48987247 1.517 LPAR6
lysophosphatidic acid receptor 6
chr7_+_129007942 1.510 NM_001130723
AHCYL2
adenosylhomocysteinase-like 2
chr22_-_38902300 1.508 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr5_+_64920557 1.496 NM_001093755
NM_001093756
NM_001243737
NM_024941
C5orf44



chromosome 5 open reading frame 44



chrX_+_54834107 1.494 NM_177433
MAGED2
melanoma antigen family D, 2
chr17_-_80656461 1.491 NM_006822
RAB40B
RAB40B, member RAS oncogene family
chr2_+_191301020 1.490 MFSD6
major facilitator superfamily domain containing 6
chr3_+_122513965 1.489 DIRC2
disrupted in renal carcinoma 2
chr1_+_65730423 1.476 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.