Motif ID: FOXP3.p2

Z-value: 0.645


Transcription factors associated with FOXP3.p2:

Gene SymbolEntrez IDGene Name
FOXP3 50943 forkhead box P3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
FOXP3chrX_-_49121171-0.252.3e-01Click!


Activity profile for motif FOXP3.p2.

activity profile for motif FOXP3.p2


Sorted Z-values histogram for motif FOXP3.p2

Sorted Z-values for motif FOXP3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXP3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_152214105 2.338 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr11_-_8892909 1.772 ST5
suppression of tumorigenicity 5
chr17_+_6659155 1.497 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr8_+_54764367 1.433 NM_170587
RGS20
regulator of G-protein signaling 20
chr17_+_6659356 1.162 XAF1
XIAP associated factor 1
chr22_+_21128378 1.032 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr1_-_150738292 1.021 NM_001199739
NM_004079
CTSS

cathepsin S

chr11_-_51412447 0.948 NM_001005272
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr3_-_57312979 0.899 NM_130387
ASB14
ankyrin repeat and SOCS box containing 14
chr12_+_102271349 0.865 DRAM1
DNA-damage regulated autophagy modulator 1
chr6_-_11779279 0.843 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr8_+_120079423 0.819 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr9_-_34381497 0.800 NM_001252195
NM_147168
NM_147169
C9orf24


chromosome 9 open reading frame 24


chr7_-_107880492 0.783 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr11_-_72380107 0.727 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr1_-_153044083 0.723 NM_001017418
SPRR2B
small proline-rich protein 2B
chr1_+_15990300 0.721


chr1_-_150738232 0.707 CTSS
cathepsin S
chr15_+_45021319 0.672 TRIM69
tripartite motif containing 69
chr15_-_80263460 0.663 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr2_+_231281470 0.635 NM_001206704
SP100
SP100 nuclear antigen
chr5_-_59783885 0.587 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_+_132036276 0.566 ACPP
acid phosphatase, prostate
chr19_-_17958773 0.558 JAK3
Janus kinase 3
chr21_+_43710190 0.546 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr7_-_92747317 0.542 NM_001193307
NM_017654
SAMD9

sterile alpha motif domain containing 9

chr10_+_114135013 0.539 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_103035148 0.533 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr17_+_51900238 0.532 NM_032559
KIF2B
kinesin family member 2B
chr16_-_55989942 0.515 NM_001190158
CES5A
carboxylesterase 5A
chrX_+_8432870 0.501 NM_001001888
VCX3B
VCX3A
variable charge, X-linked 3B
variable charge, X-linked 3A
chr17_-_39306053 0.469 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr11_+_124824076 0.460 CCDC15
coiled-coil domain containing 15
chr4_-_123377471 0.429 NM_000586
IL2
interleukin 2
chr5_-_126366439 0.420 NM_178450
MARCH3
membrane-associated ring finger (C3HC4) 3
chr1_-_16539103 0.407 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr7_-_92747269 0.400 SAMD9
sterile alpha motif domain containing 9
chr15_+_85666291 0.391 PDE8A
phosphodiesterase 8A
chr13_+_108955763 0.390


chr12_+_100867739 0.384 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr4_+_70146216 0.360 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr11_+_63974144 0.358 NM_031471
NM_178443
FERMT3

fermitin family member 3

chrX_-_8139307 0.354 NM_016378
VCX2
variable charge, X-linked 2
chr9_+_132962871 0.353 NM_001128826
NCS1
neuronal calcium sensor 1
chr10_+_91092238 0.350 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr5_+_34687663 0.346 NM_001145523
RAI14
retinoic acid induced 14
chr11_-_85437457 0.342 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr8_+_132991171 0.341 EFR3A
EFR3 homolog A (S. cerevisiae)
chr6_-_25874439 0.340 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr3_+_130569368 0.330 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr7_+_134576187 0.316 CALD1
caldesmon 1
chr1_-_151804225 0.311 NM_005060
RORC
RAR-related orphan receptor C
chr3_-_196911001 0.311 NM_001204387
NM_001204388
DLG1

discs, large homolog 1 (Drosophila)

chr6_+_31730772 0.305 NM_001039651
C6orf26
chromosome 6 open reading frame 26
chr20_+_29956420 0.304 NM_054112
DEFB118
defensin, beta 118
chr2_+_143635194 0.291 NM_001032998
NM_001199241
NM_003937
KYNU


kynureninase


chr18_+_77441429 0.287 NM_001202504
CTDP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr8_-_37727937 0.284 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr1_-_153348057 0.277 NM_005621
S100A12
S100 calcium binding protein A12
chr18_+_32173281 0.267 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr5_+_140743755 0.263 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr3_-_58563070 0.250 FAM107A
family with sequence similarity 107, member A
chr3_-_157213138 0.249 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr10_-_118680978 0.246 KIAA1598
KIAA1598
chr2_-_21225640 0.242 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_+_46646199 0.241 TSPAN1
tetraspanin 1
chr5_-_135290521 0.238 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr9_+_103191795 0.236 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr19_+_52266640 0.235 NM_001462
FPR2
formyl peptide receptor 2
chr17_+_60447578 0.235 NM_001144933
EFCAB3
EF-hand calcium binding domain 3
chr1_-_207095198 0.234 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr2_+_102770401 0.224 NM_000877
IL1R1
interleukin 1 receptor, type I
chr12_+_100897137 0.217 NM_001206992
NM_001206993
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr7_+_28475233 0.213 NM_004904
CREB5
cAMP responsive element binding protein 5
chr10_-_91102430 0.211 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr1_-_160549226 0.210 CD84
CD84 molecule
chr9_+_12693385 0.208 NM_000550
TYRP1
tyrosinase-related protein 1
chrX_-_83757398 0.206 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr1_+_2938045 0.205 NM_080431
ACTRT2
actin-related protein T2
chr10_-_72545110 0.204 NM_152710
C10orf27
chromosome 10 open reading frame 27
chr6_-_30640781 0.203 NM_001164239
NM_003587
DHX16

DEAH (Asp-Glu-Ala-His) box polypeptide 16

chr12_+_56075418 0.201 METTL7B
methyltransferase like 7B
chr18_+_13825542 0.200 NM_005913
MC5R
melanocortin 5 receptor
chr1_-_146082632 0.196 NM_183372
NBPF11
NBPF24
neuroblastoma breakpoint family, member 11
neuroblastoma breakpoint family, member 24
chr5_+_54320083 0.195 NM_002104
GZMK
granzyme K (granzyme 3; tryptase II)
chr1_-_89591685 0.194 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr7_-_142659397 0.193 KEL
Kell blood group, metallo-endopeptidase
chr17_+_41052813 0.191 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr2_+_191002485 0.191 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr6_-_167797917 0.188 NM_004610
TCP10
t-complex 10 homolog (mouse)
chr6_-_32497925 0.183 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr2_+_166152282 0.183 NM_001040143
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr17_-_29641068 0.182 EVI2B
ecotropic viral integration site 2B
chr11_+_71900601 0.181 NM_016724
NM_016725
FOLR1

folate receptor 1 (adult)

chr17_-_67240955 0.181 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr11_-_36531767 0.179 NM_004620
NM_145803
TRAF6

TNF receptor-associated factor 6

chr5_+_137419580 0.179 NM_058244
WNT8A
wingless-type MMTV integration site family, member 8A
chr17_+_39405938 0.176 NM_033191
KRTAP9-4
keratin associated protein 9-4
chr7_+_143701021 0.175 NM_001005281
OR6B1
olfactory receptor, family 6, subfamily B, member 1
chr12_+_100867550 0.175 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr5_+_149887673 0.169 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr2_-_49381555 0.167 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr6_-_38563763 0.166 NM_001172418
NM_152733
BTBD9

BTB (POZ) domain containing 9

chr3_-_167191808 0.162 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr6_+_43457214 0.161 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)
chr3_-_121264780 0.160 NM_199420
POLQ
polymerase (DNA directed), theta
chr12_-_8219001 0.158 C3AR1
complement component 3a receptor 1
chr6_+_116782555 0.157 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr5_-_131879172 0.157 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr8_-_90996785 0.156 NBN
nibrin
chr17_-_29641094 0.155 NM_006495
EVI2B
ecotropic viral integration site 2B
chr12_-_91505541 0.155 NM_002345
LUM
lumican
chr4_+_88896801 0.154 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr1_-_150669499 0.152 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr9_-_19786886 0.151 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr6_+_158733691 0.150 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr4_-_7436614 0.149 NM_001085382
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr2_-_190044330 0.146 NM_000393
COL5A2
collagen, type V, alpha 2
chr7_-_121944485 0.142 NM_001024613
NM_001160264
FEZF1

FEZ family zinc finger 1

chr1_-_100643770 0.141 NM_144620
LRRC39
leucine rich repeat containing 39
chr13_+_23755059 0.140 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr6_+_29079586 0.140 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr10_+_124151818 0.139 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr14_+_37131116 0.138 PAX9
paired box 9
chr7_-_142659412 0.138 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr12_+_109967734 0.137 UBE3B
ubiquitin protein ligase E3B
chr1_-_152552962 0.136 NM_032563
LCE3D
late cornified envelope 3D
chr2_+_198570027 0.136 NM_138395
MARS2
methionyl-tRNA synthetase 2, mitochondrial
chr20_+_24929904 0.135 CST7
cystatin F (leukocystatin)
chr17_-_2996289 0.135 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr16_+_31085722 0.132 NM_014699
ZNF646
zinc finger protein 646
chr2_+_29038862 0.132 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr18_+_72167021 0.131 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr6_+_144185572 0.130 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chr3_+_149192479 0.130 TM4SF4
transmembrane 4 L six family member 4
chr16_-_12897632 0.129 CPPED1
calcineurin-like phosphoesterase domain containing 1
chr16_-_71748697 0.129 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr20_+_24929862 0.126 NM_003650
CST7
cystatin F (leukocystatin)
chr18_+_72166822 0.125 NM_001168499
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr17_+_28268622 0.125 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr6_+_83072922 0.125 NM_006670
TPBG
trophoblast glycoprotein
chr9_+_96846710 0.124 NM_001253829
NM_152422
PTPDC1

protein tyrosine phosphatase domain containing 1

chr7_+_134576150 0.122 NM_033139
NM_033140
CALD1

caldesmon 1

chr16_+_29831714 0.122 NM_005115
NM_017458
MVP

major vault protein

chr5_+_67586466 0.121 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr22_+_18043147 0.120 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr11_+_71900958 0.120 NM_000802
FOLR1
folate receptor 1 (adult)
chr10_+_118305427 0.120 NM_000936
PNLIP
pancreatic lipase
chr11_-_7847518 0.118 NM_153445
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr16_+_31085751 0.118 ZNF646
zinc finger protein 646
chrX_+_103031797 0.117 PLP1
proteolipid protein 1
chr4_+_71062241 0.117 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr16_-_12897693 0.116 NM_001099455
NM_018340
CPPED1

calcineurin-like phosphoesterase domain containing 1

chrX_-_52386995 0.115 NM_130777
XAGE2
X antigen family, member 2
chr20_-_7921068 0.115 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr17_-_8274852 0.113 NM_213597
KRBA2
KRAB-A domain containing 2
chr11_-_57158103 0.113 NM_001243245
NM_002728
PRG2

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

chr22_-_37499456 0.113 NM_153609
TMPRSS6
transmembrane protease, serine 6
chr12_-_10588543 0.112 NM_002260
KLRC2
KLRC3
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 3
chrX_+_78003205 0.112 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr12_-_8218930 0.112 NM_004054
C3AR1
complement component 3a receptor 1
chr19_-_47291594 0.109 NM_005628
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr4_+_124317884 0.109 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chrX_+_52112077 0.109 NM_130777
XAGE2
X antigen family, member 2
chr17_-_39211462 0.107 NM_033032
KRTAP2-2
keratin associated protein 2-2
chr9_-_69202203 0.107 NM_001085476
FOXD4L6
forkhead box D4-like 6
chrX_-_52985628 0.106 NM_001099684
FAM156A
FAM156B
family with sequence similarity 156, member A
family with sequence similarity 156, member B
chr19_+_42724498 0.106 ZNF526
zinc finger protein 526
chr1_-_115238091 0.106 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr12_-_56359794 0.106 NM_001200053
NM_001200054
PMEL

premelanosome protein

chr11_-_5291372 0.106 NM_005330
HBE1
hemoglobin, epsilon 1
chr14_+_37131064 0.106 PAX9
paired box 9
chr1_+_174417211 0.105 NM_005684
GPR52
G protein-coupled receptor 52
chr1_-_247921707 0.104 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr14_+_21498344 0.103 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr4_+_88896838 0.103 SPP1
secreted phosphoprotein 1
chrX_+_102965836 0.102 NM_182541
TMEM31
transmembrane protein 31
chr8_+_32579350 0.102 NM_001159996
NRG1
neuregulin 1
chr17_+_7258454 0.102 NM_198154
TMEM95
transmembrane protein 95
chr1_+_67632168 0.100 NM_144701
IL23R
interleukin 23 receptor
chr11_+_124824012 0.100 NM_025004
CCDC15
coiled-coil domain containing 15
chr1_-_78444690 0.099 FUBP1
far upstream element (FUSE) binding protein 1
chr21_-_19775958 0.099 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr12_-_3982394 0.098 NM_020367
PARP11
poly (ADP-ribose) polymerase family, member 11
chr17_+_3118911 0.096 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr16_+_67312688 0.096 PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr11_+_5474637 0.095 NM_001004754
OR51I2
olfactory receptor, family 51, subfamily I, member 2
chr1_-_153029987 0.094 NM_005988
SPRR2A
small proline-rich protein 2A
chr4_-_69536314 0.094 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr6_-_11382501 0.093 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr18_-_74729049 0.091 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr16_-_69385656 0.091 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr6_-_136847078 0.091 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr4_+_88896899 0.091 SPP1
secreted phosphoprotein 1
chr16_+_30676098 0.090 FBRS
fibrosin
chr1_-_153321021 0.088 NM_020393
PGLYRP4
peptidoglycan recognition protein 4
chr4_-_164534656 0.087 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr6_+_88117689 0.087 NM_001031743
C6orf165
chromosome 6 open reading frame 165
chr3_+_42704598 0.087 ZBTB47
zinc finger and BTB domain containing 47
chr5_+_140566655 0.087 NM_019119
PCDHB9
protocadherin beta 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.51 1.04e-05 GO:0006952 defense response
2.55 2.22e-05 GO:0006955 immune response
2.10 6.73e-05 GO:0002376 immune system process
1.36 1.15e-04 GO:0050896 response to stimulus
2.82 6.81e-03 GO:0045087 innate immune response
5.50 4.74e-02 GO:0002703 regulation of leukocyte mediated immunity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.76 3.02e-05 GO:0005576 extracellular region
1.38 2.91e-03 GO:0005886 plasma membrane
1.37 3.78e-03 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.61 2.73e-02 GO:0004872 receptor activity
1.53 3.95e-02 GO:0004871 signal transducer activity
1.53 3.95e-02 GO:0060089 molecular transducer activity