Motif ID: GLI1..3.p2

Z-value: 0.917


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
GLI1chr12_+_57853917-0.311.3e-01Click!
GLI3chr7_-_42276617-0.019.7e-01Click!
GLI2chr2_+_1215548660.009.8e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_72380107 1.920 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr6_-_32821592 1.173 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr15_+_67430358 1.112 NM_001145103
SMAD3
SMAD family member 3
chr6_-_32821412 1.056 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_205782135 1.028 NM_173854
SLC41A1
solute carrier family 41, member 1
chr10_-_90712510 0.996 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr19_+_676346 0.993 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr16_+_30675777 0.861 NM_001105079
FBRS
fibrosin
chr5_+_113769226 0.840 NM_170775
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr8_+_31497267 0.815 NM_013962
NRG1
neuregulin 1
chr11_+_19734821 0.799 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr2_-_7005764 0.794 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr1_+_183155393 0.767 LAMC2
laminin, gamma 2
chr7_-_92465929 0.705 NM_001145306
CDK6
cyclin-dependent kinase 6
chr3_-_45267068 0.703 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr5_-_150460599 0.690 NM_001252385
NM_001252386
NM_001252393
NM_006058
TNIP1



TNFAIP3 interacting protein 1



chr5_-_131826426 0.690 NM_002198
IRF1
interferon regulatory factor 1
chr22_-_41842432 0.680 TOB2
transducer of ERBB2, 2
chr5_+_113698015 0.678 NM_021614
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr17_+_80192774 0.668 NM_001206951
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr5_-_150460550 0.655 TNIP1
TNFAIP3 interacting protein 1
chr1_-_32264215 0.645 SPOCD1
SPOC domain containing 1
chr5_-_95297597 0.627 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chr22_-_19512001 0.627 CLDN5
claudin 5
chr16_+_86544104 0.610 NM_001451
FOXF1
forkhead box F1
chr1_+_183155361 0.601 LAMC2
laminin, gamma 2
chr17_+_40439564 0.597 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr17_-_53499055 0.560 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr4_+_74735107 0.559 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr1_+_183155173 0.557 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr20_+_62328002 0.557 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr12_+_102271349 0.557 DRAM1
DNA-damage regulated autophagy modulator 1
chr15_-_77712436 0.554 NM_024776
PEAK1
NKF3 kinase family member
chr3_-_107809754 0.549 NM_001777
NM_198793
CD47

CD47 molecule

chr17_+_80193649 0.542 NM_001206952
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr11_+_9779832 0.534 LOC283104
uncharacterized LOC283104
chr7_+_143079354 0.512 ZYX
zyxin
chr5_-_142783975 0.509 NM_001018076
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr7_+_150068252 0.502 NM_014374
REPIN1
replication initiator 1
chr5_+_113698304 0.483 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr16_+_27325269 0.483 IL4R
interleukin 4 receptor
chr1_+_2518071 0.482 NM_001195736
NM_001195737
NM_001195738
NM_001195740
NM_001195741
NM_152371
FAM213B





family with sequence similarity 213, member B





chr16_+_31044849 0.480 STX4
syntaxin 4
chr22_-_19511777 0.479 CLDN5
claudin 5
chr5_-_121412805 0.476 NM_001178102
LOX
lysyl oxidase
chr19_+_45251933 0.473 NM_005178
BCL3
B-cell CLL/lymphoma 3
chr3_+_67048726 0.471 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr20_+_62328068 0.468 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr19_+_3539154 0.468 NM_001135580
C19orf71
chromosome 19 open reading frame 71
chr10_+_104503724 0.461 NM_001083913
C10orf26
chromosome 10 open reading frame 26
chr17_-_17399494 0.458 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr1_+_2518464 0.450 FAM213B
family with sequence similarity 213, member B
chr1_-_45308603 0.449 NM_001166292
NM_003738
PTCH2

patched 2

chr9_-_123676849 0.448 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr1_-_32281577 0.441 NM_144569
SPOCD1
SPOC domain containing 1
chr1_+_9352955 0.428 SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr20_+_6748744 0.427 NM_001200
BMP2
bone morphogenetic protein 2
chr2_+_109745996 0.426 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr10_+_104154228 0.422 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr7_-_108096693 0.412 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr6_-_29600668 0.412 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr17_+_39261640 0.410 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr8_+_32405727 0.409 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr6_+_83072922 0.407 NM_006670
TPBG
trophoblast glycoprotein
chr22_-_50893728 0.406 SBF1
SET binding factor 1
chr17_-_41623652 0.404 NM_001079675
ETV4
ets variant 4
chr8_+_120428551 0.402 NM_002514
NOV
nephroblastoma overexpressed gene
chr6_-_29600959 0.401 NM_001470
NM_021904
GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr11_-_65430427 0.400 NM_001145138
NM_001243984
NM_001243985
NM_021975
RELA



v-rel reticuloendotheliosis viral oncogene homolog A (avian)



chr19_-_10679328 0.396 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr16_+_31044881 0.393 NM_004604
STX4
syntaxin 4
chrX_+_153409724 0.393 NM_020061
OPN1LW
opsin 1 (cone pigments), long-wave-sensitive
chr11_+_576482 0.387 NM_020901
PHRF1
PHD and ring finger domains 1
chr6_+_83073501 0.384 TPBG
trophoblast glycoprotein
chr4_-_5021095 0.380 NM_018659
CYTL1
cytokine-like 1
chr6_-_29600859 0.380 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr10_-_62332666 0.376 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr1_+_11724148 0.371 NM_018438
FBXO6
F-box protein 6
chr1_-_12677347 0.367 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr20_+_44746889 0.367 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr1_-_40105341 0.366 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr20_-_44540685 0.366 PLTP
phospholipid transfer protein
chr16_+_30676098 0.363 FBRS
fibrosin
chr11_-_3078596 0.358 NM_001014437
NM_001194997
NM_001751
NM_139273
CARS



cysteinyl-tRNA synthetase



chr10_+_105156382 0.358 NM_014976
PDCD11
programmed cell death 11
chr4_+_8200918 0.354 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr22_+_31742739 0.352 FLJ20464
uncharacterized protein FLJ20464
chr5_-_95297424 0.348 ELL2
elongation factor, RNA polymerase II, 2
chr20_+_814355 0.348 NM_001042353
FAM110A
family with sequence similarity 110, member A
chr8_+_90914095 0.341 NM_004337
OSGIN2
oxidative stress induced growth inhibitor family member 2
chr16_+_55689899 0.340 SLC6A2
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
chr1_+_184356364 0.338 C1orf21
chromosome 1 open reading frame 21
chr7_-_92463211 0.331 NM_001259
CDK6
cyclin-dependent kinase 6
chr16_+_86612114 0.327 NM_005250
FOXL1
forkhead box L1
chr11_-_65430214 0.326 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr7_+_100770378 0.325 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr5_-_1112106 0.324 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr10_+_103892786 0.319 NM_015062
PPRC1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr12_-_125473618 0.318 NM_032656
DHX37
DEAH (Asp-Glu-Ala-His) box polypeptide 37
chr1_+_150122095 0.317 NM_016274
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr16_-_67881360 0.316 NM_025082
CENPT
centromere protein T
chr17_+_7388080 0.316


chr16_-_2059795 0.315 ZNF598
zinc finger protein 598
chr17_-_15244898 0.315 NM_031898
TEKT3
tektin 3
chr6_-_44233499 0.314 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr14_-_52535945 0.313 NM_007361
NID2
nidogen 2 (osteonidogen)
chr22_+_39436608 0.313 NM_001006666
NM_145298
APOBEC3F

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

chr16_+_31483066 0.313 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr17_+_56232493 0.312 NM_012374
OR4D1
olfactory receptor, family 4, subfamily D, member 1
chr19_+_14544100 0.311 NM_002741
PKN1
protein kinase N1
chr16_-_84220570 0.309 NM_001243156
NM_001243157
NM_001243158
NM_001243159
NM_001243160
NM_005679
NM_139353
TAF1C






TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa






chrX_-_153744372 0.309 NM_001171132
NM_001171133
NM_001171134
NM_021806
FAM3A



family with sequence similarity 3, member A



chr3_+_10206562 0.309 NM_001570
IRAK2
interleukin-1 receptor-associated kinase 2
chr11_+_45825873 0.307 SLC35C1
solute carrier family 35, member C1
chr5_-_58571916 0.307 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_80548666 0.306 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr12_-_45269953 0.306 NELL2
NEL-like 2 (chicken)
chr1_+_220701523 0.305 MARK1
MAP/microtubule affinity-regulating kinase 1
chr22_-_24640850 0.302 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr8_+_90914761 0.299 NM_001126111
OSGIN2
oxidative stress induced growth inhibitor family member 2
chr11_+_118307072 0.298 NM_001197104
NM_005933
MLL

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

chrX_-_136113832 0.297 NM_054021
GPR101
G protein-coupled receptor 101
chr3_-_38691118 0.297 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr22_+_31478845 0.296 NM_001207017
SMTN
smoothelin
chr6_-_167040700 0.295 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr12_+_112563293 0.295 NM_001143906
NM_006700
TRAFD1

TRAF-type zinc finger domain containing 1

chr17_-_48262900 0.294 COL1A1
collagen, type I, alpha 1
chr19_+_12902295 0.292 NM_002229
JUNB
jun B proto-oncogene
chr8_-_101322180 0.292 RNF19A
ring finger protein 19A
chr1_-_32264271 0.288 SPOCD1
SPOC domain containing 1
chr6_-_138428477 0.288 NM_022121
PERP
PERP, TP53 apoptosis effector
chr3_-_164914448 0.287 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chrX_-_48814853 0.287 NM_001136157
NM_001136158
NM_017602
OTUD5


OTU domain containing 5


chr14_-_52535765 0.286 NID2
nidogen 2 (osteonidogen)
chr9_-_34048887 0.285 NM_018449
UBAP2
ubiquitin associated protein 2
chr19_-_47249629 0.285 STRN4
striatin, calmodulin binding protein 4
chr14_+_21525980 0.285 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr9_-_123342258 0.285 NM_001011649
NM_018249
CDK5RAP2

CDK5 regulatory subunit associated protein 2

chr19_+_14544216 0.285 PKN1
protein kinase N1
chr8_+_123793988 0.284 ZHX2
zinc fingers and homeoboxes 2
chr1_-_41328002 0.283 NM_133467
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr11_-_64646053 0.283 NM_006795
EHD1
EH-domain containing 1
chr9_+_35673852 0.283 NM_001216
CA9
carbonic anhydrase IX
chr19_-_47249708 0.283 NM_001039877
NM_013403
STRN4

striatin, calmodulin binding protein 4

chr4_+_4861371 0.281 NM_002448
MSX1
msh homeobox 1
chr4_+_8582216 0.281 NM_080819
GPR78
G protein-coupled receptor 78
chr19_-_47249682 0.281 STRN4
striatin, calmodulin binding protein 4
chr5_+_52776408 0.279 FST
follistatin
chrX_-_63450486 0.279 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr12_-_6798419 0.279 ZNF384
zinc finger protein 384
chr14_-_24898730 0.279 NM_001039771
CBLN3
cerebellin 3 precursor
chr21_-_47604340 0.276 C21orf56
chromosome 21 open reading frame 56
chrX_+_19362010 0.275 NM_000284
NM_001173454
NM_001173455
NM_001173456
PDHA1



pyruvate dehydrogenase (lipoamide) alpha 1



chr7_-_2354010 0.273 SNX8
sorting nexin 8
chr16_-_4465876 0.273 CORO7
coronin 7
chr11_-_414975 0.273 NM_001135054
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr1_-_40105296 0.272 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr21_+_45161343 0.271 PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr19_+_8117645 0.269 NM_001201359
NM_005624
CCL25

chemokine (C-C motif) ligand 25

chr12_-_122985471 0.266 NM_017612
ZCCHC8
zinc finger, CCHC domain containing 8
chr1_+_156123321 0.265 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr1_-_212873197 0.265 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr8_+_21881587 0.264 NPM2
nucleophosmin/nucleoplasmin 2
chr1_-_153935950 0.264 SLC39A1
solute carrier family 39 (zinc transporter), member 1
chr19_-_13947101 0.264 LOC284454
uncharacterized LOC284454
chr12_+_102271082 0.262 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr5_+_179234002 0.261 NM_001142299
SQSTM1
sequestosome 1
chr11_-_125933186 0.260 NM_001243597
NM_016952
CDON

Cdon homolog (mouse)

chr19_-_39108534 0.259 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr2_+_68694669 0.259 NM_173545
APLF
aprataxin and PNKP like factor
chr14_-_52535711 0.259 NID2
nidogen 2 (osteonidogen)
chr16_+_89778242 0.258 LOC100128881
uncharacterized LOC100128881
chr19_+_11039419 0.258 NM_138358
C19orf52
chromosome 19 open reading frame 52
chr10_+_124134093 0.257 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr10_-_121632265 0.256 NM_024834
MCMBP
minichromosome maintenance complex binding protein
chr4_-_120548329 0.256 NM_033430
PDE5A
phosphodiesterase 5A, cGMP-specific
chr21_+_45736351 0.256 PFKL
phosphofructokinase, liver
chr14_-_52535737 0.254 NID2
nidogen 2 (osteonidogen)
chr1_-_151798552 0.254 NM_001001523
RORC
RAR-related orphan receptor C
chr4_-_146100793 0.254 NM_001102653
OTUD4
OTU domain containing 4
chr20_-_44538654 0.253 PLTP
phospholipid transfer protein
chr10_+_99498233 0.253 NM_001002261
ZFYVE27
zinc finger, FYVE domain containing 27
chr8_-_63951609 0.253 NM_003878
GGH
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
chr5_-_148758787 0.252 NM_014443
IL17B
interleukin 17B
chr14_+_96152753 0.252 NM_004918
TCL1B
T-cell leukemia/lymphoma 1B
chr14_+_96342728 0.251 LOC100507043
uncharacterized LOC100507043
chr17_+_7531275 0.251 SHBG
sex hormone-binding globulin
chr1_+_19969722 0.249 NM_182744
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr7_-_97501737 0.248 NM_001178075
NM_001178076
NM_001673
NM_183356
ASNS



asparagine synthetase (glutamine-hydrolyzing)



chr12_+_54891539 0.248 NCKAP1L
NCK-associated protein 1-like
chr10_+_82214066 0.247 TSPAN14
tetraspanin 14
chr12_-_45270071 0.247 NELL2
NEL-like 2 (chicken)
chr10_+_106113513 0.246 NM_001008723
CCDC147
coiled-coil domain containing 147
chr16_+_56691854 0.246 NM_005949
MT1F
metallothionein 1F
chr1_+_9352931 0.246 NM_025106
SPSB1
splA/ryanodine receptor domain and SOCS box containing 1
chr21_-_47604300 0.246 C21orf56
chromosome 21 open reading frame 56
chr16_+_28834407 0.244 NM_007245
NM_145714
NM_148414
NM_148415
NM_148416
ATXN2L




ataxin 2-like




chr14_+_105780903 0.244 PACS2
phosphofurin acidic cluster sorting protein 2
chr1_+_101361589 0.244 NM_001144884
NM_133496
SLC30A7

solute carrier family 30 (zinc transporter), member 7

chr19_-_45926819 0.243 NM_202001
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.36 2.08e-05 GO:0048583 regulation of response to stimulus
1.29 2.83e-05 GO:0048518 positive regulation of biological process
1.09 7.73e-05 GO:0009987 cellular process
1.38 6.42e-04 GO:0009966 regulation of signal transduction
1.34 1.12e-03 GO:0023051 regulation of signaling
1.26 1.57e-03 GO:0048522 positive regulation of cellular process
1.46 1.86e-03 GO:0050793 regulation of developmental process
1.41 4.06e-03 GO:0010646 regulation of cell communication
1.27 8.26e-03 GO:0048869 cellular developmental process
1.73 9.69e-03 GO:0045597 positive regulation of cell differentiation
1.50 9.94e-03 GO:0045595 regulation of cell differentiation
1.37 1.39e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.44 1.78e-02 GO:0048584 positive regulation of response to stimulus
1.48 2.01e-02 GO:0010628 positive regulation of gene expression
1.34 2.01e-02 GO:0009893 positive regulation of metabolic process
1.58 2.62e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.26 2.69e-02 GO:0030154 cell differentiation
1.47 3.42e-02 GO:0051254 positive regulation of RNA metabolic process
1.34 3.77e-02 GO:0031325 positive regulation of cellular metabolic process
1.10 4.15e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 2.79e-06 GO:0005622 intracellular
1.08 1.02e-05 GO:0044424 intracellular part
1.11 3.32e-04 GO:0005737 cytoplasm
1.07 3.22e-02 GO:0043226 organelle
1.28 3.77e-02 GO:0005654 nucleoplasm
1.08 3.79e-02 GO:0043227 membrane-bounded organelle
1.07 4.63e-02 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.20 9.50e-13 GO:0005515 protein binding
1.08 1.97e-06 GO:0005488 binding
1.48 3.68e-03 GO:0043565 sequence-specific DNA binding
1.73 5.78e-03 GO:0008134 transcription factor binding
1.68 2.01e-02 GO:0005083 small GTPase regulator activity