Motif ID: GLI1..3.p2

Z-value: 0.917


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
GLI1chr12_+_57853917-0.311.3e-01Click!
GLI3chr7_-_42276617-0.019.7e-01Click!
GLI2chr2_+_1215548660.009.8e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_72380107 1.920 NM_001146209
 PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr6_-_32821592 1.173 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr15_+_67430358 1.112 NM_001145103
 SMAD3
SMAD family member 3
chr6_-_32821412 1.056 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_205782135 1.028 NM_173854
 SLC41A1
solute carrier family 41, member 1
chr10_-_90712510 0.996 NM_001613
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr19_+_676346 0.993 NM_005860
 FSTL3
follistatin-like 3 (secreted glycoprotein)
chr16_+_30675777 0.861 NM_001105079
 FBRS
fibrosin
chr5_+_113769226 0.840 NM_170775
 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr8_+_31497267 0.815 NM_013962
 NRG1
neuregulin 1
chr11_+_19734821 0.799 NM_001244963
NM_145117
NM_182964
 NAV2


neuron navigator 2


chr2_-_7005764 0.794 NM_207315
 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr1_+_183155393 0.767 LAMC2
laminin, gamma 2
chr7_-_92465929 0.705 NM_001145306
 CDK6
cyclin-dependent kinase 6
chr3_-_45267068 0.703 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr5_-_150460599 0.690 NM_001252385
NM_001252386
NM_001252393
NM_006058
 TNIP1



TNFAIP3 interacting protein 1



chr5_-_131826426 0.690 NM_002198
 IRF1
interferon regulatory factor 1
chr22_-_41842432 0.680 TOB2
transducer of ERBB2, 2
chr5_+_113698015 0.678 NM_021614
 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr17_+_80192774 0.668 NM_001206951
 SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
1.73 9.69e-03 GO:0045597 positive regulation of cell differentiation
1.58 2.62e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.50 9.94e-03 GO:0045595 regulation of cell differentiation
1.48 2.01e-02 GO:0010628 positive regulation of gene expression
1.47 3.42e-02 GO:0051254 positive regulation of RNA metabolic process
1.46 1.86e-03 GO:0050793 regulation of developmental process
1.44 1.78e-02 GO:0048584 positive regulation of response to stimulus
1.41 4.06e-03 GO:0010646 regulation of cell communication
1.38 6.42e-04 GO:0009966 regulation of signal transduction
1.37 1.39e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.36 2.08e-05 GO:0048583 regulation of response to stimulus
1.34 1.12e-03 GO:0023051 regulation of signaling
1.34 2.01e-02 GO:0009893 positive regulation of metabolic process
1.34 3.77e-02 GO:0031325 positive regulation of cellular metabolic process
1.29 2.83e-05 GO:0048518 positive regulation of biological process
1.27 8.26e-03 GO:0048869 cellular developmental process
1.26 1.57e-03 GO:0048522 positive regulation of cellular process
1.26 2.69e-02 GO:0030154 cell differentiation
1.10 4.15e-02 GO:0065007 biological regulation
1.09 7.73e-05 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.28 3.77e-02 GO:0005654 nucleoplasm
1.11 3.32e-04 GO:0005737 cytoplasm
1.08 2.79e-06 GO:0005622 intracellular
1.08 1.02e-05 GO:0044424 intracellular part
1.08 3.79e-02 GO:0043227 membrane-bounded organelle
1.07 3.22e-02 GO:0043226 organelle
1.07 4.63e-02 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.73 5.78e-03 GO:0008134 transcription factor binding
1.68 2.01e-02 GO:0005083 small GTPase regulator activity
1.48 3.68e-03 GO:0043565 sequence-specific DNA binding
1.20 9.50e-13 GO:0005515 protein binding
1.08 1.97e-06 GO:0005488 binding