Motif ID: GTF2A1,2.p2

Z-value: 1.359


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
GTF2A2chr15_-_59949536-0.433.0e-02Click!
GTF2A1chr14_-_816875740.125.6e-01Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_203274646 2.794 NM_006763
BTG2
BTG family, member 2
chr1_-_169703178 2.380 NM_000450
SELE
selectin E
chr21_-_28217692 2.326 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr15_-_62457481 2.032 NM_001007595
C2CD4B
C2 calcium-dependent domain containing 4B
chr4_-_74904329 1.611 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr2_+_28616346 1.574 FOSL2
FOS-like antigen 2
chr2_+_28615771 1.489 NM_005253
FOSL2
FOS-like antigen 2
chr2_+_28615695 1.465 FOSL2
FOS-like antigen 2
chr7_-_41742666 1.450 NM_002192
INHBA
inhibin, beta A
chr11_+_5653484 1.412 NM_130390
TRIM34
tripartite motif containing 34
chr21_-_28217272 1.390 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr5_+_156696351 1.344 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr13_-_72440143 1.322 DACH1
dachshund homolog 1 (Drosophila)
chr2_+_28616360 1.224 FOSL2
FOS-like antigen 2
chr19_+_56153417 1.174 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr1_+_84768333 1.171 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr13_-_72440557 1.167 DACH1
dachshund homolog 1 (Drosophila)
chr4_+_41614911 1.159 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr1_+_181057835 1.123 IER5
immediate early response 5
chr4_+_41614725 1.114 LIMCH1
LIM and calponin homology domains 1
chr15_+_67000929 1.092 NM_001142861
SMAD6
SMAD family member 6
chr19_-_45909566 1.061 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr14_+_39735871 1.036 CTAGE5
CTAGE family, member 5
chr14_+_75745480 1.009 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr3_+_50304989 0.965 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr17_-_26697224 0.964 VTN
vitronectin
chr1_-_221915458 0.946 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr4_+_41614933 0.940 LIMCH1
LIM and calponin homology domains 1
chr3_+_100328432 0.936 NM_032787
GPR128
G protein-coupled receptor 128
chr19_-_18654376 0.918 NM_012181
FKBP8
FK506 binding protein 8, 38kDa
chr21_-_35987144 0.908 NM_004414
RCAN1
regulator of calcineurin 1
chr21_+_26934440 0.901 MIR155HG
MIR155 host gene (non-protein coding)
chr19_-_18654280 0.899 FKBP8
FK506 binding protein 8, 38kDa
chr1_+_181057637 0.898 NM_016545
IER5
immediate early response 5
chr1_+_163038564 0.879 NM_005613
RGS4
regulator of G-protein signaling 4
chr1_+_163038934 0.839 NM_001113381
RGS4
regulator of G-protein signaling 4
chr3_+_46448678 0.824 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr1_-_27339448 0.814 FAM46B
family with sequence similarity 46, member B
chr2_+_28615668 0.812 FOSL2
FOS-like antigen 2
chr14_+_56584854 0.805 NM_021255
PELI2
pellino homolog 2 (Drosophila)
chr22_+_31487315 0.799 SMTN
smoothelin
chr12_-_76425207 0.794 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr4_-_186697065 0.790 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr9_-_35732115 0.761 TLN1
talin 1
chr17_+_80193649 0.757 NM_001206952
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr17_-_26697310 0.756 VTN
vitronectin
chr19_+_42388445 0.753 NM_199002
ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr17_-_1248346 0.741 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr18_-_18691615 0.735 ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chr1_+_164818083 0.731 PBX1
pre-B-cell leukemia homeobox 1
chr12_-_46766563 0.729 NM_018976
SLC38A2
solute carrier family 38, member 2
chrX_+_50653734 0.721 NM_005448
BMP15
bone morphogenetic protein 15
chr4_+_41700736 0.719 LIMCH1
LIM and calponin homology domains 1
chr12_-_322612 0.718 NM_003044
NM_001122847
SLC6A12

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

chr17_+_32597239 0.711 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr14_+_56585147 0.707 PELI2
pellino homolog 2 (Drosophila)
chr1_-_221915393 0.682 DUSP10
dual specificity phosphatase 10
chr19_+_39833096 0.680 SAMD4B
sterile alpha motif domain containing 4B
chr13_+_100633977 0.665 NM_007129
ZIC2
Zic family member 2
chr17_+_40610897 0.654 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr4_-_149363498 0.654 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr8_+_40010986 0.652 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr12_-_46766019 0.649 SLC38A2
solute carrier family 38, member 2
chr19_-_13213973 0.638 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr1_-_153067000 0.637 NM_001024209
SPRR2E
small proline-rich protein 2E
chr19_+_13263890 0.622 IER2
immediate early response 2
chr19_-_44031310 0.616 NM_014297
ETHE1
ethylmalonic encephalopathy 1
chr12_-_8088629 0.615 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr4_-_38666429 0.614 FLJ13197
uncharacterized FLJ13197
chr1_-_221915426 0.614 DUSP10
dual specificity phosphatase 10
chrX_-_43832920 0.611 NM_000266
NDP
Norrie disease (pseudoglioma)
chr17_-_26697293 0.610 VTN
vitronectin
chr20_-_56285576 0.591 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr1_-_16482426 0.589 NM_004431
EPHA2
EPH receptor A2
chr6_+_36644236 0.571 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr17_-_27916620 0.570 GIT1
G protein-coupled receptor kinase interacting ArfGAP 1
chr17_+_40610940 0.569 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr17_+_40610875 0.568 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr19_+_49403567 0.568 NUCB1
nucleobindin 1
chr2_-_96781887 0.567 NM_000682
ADRA2B
adrenergic, alpha-2B-, receptor
chr18_-_22932109 0.559 NM_015461
ZNF521
zinc finger protein 521
chr19_+_10222196 0.558 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr16_+_30662188 0.556 NM_024031
PRR14
proline rich 14
chr6_-_31865439 0.554 EHMT2
euchromatic histone-lysine N-methyltransferase 2
chr9_+_131191206 0.553 CERCAM
cerebral endothelial cell adhesion molecule
chr19_+_49403306 0.552 NM_006184
NUCB1
nucleobindin 1
chr5_+_60933635 0.550 NM_173667
C5orf64
chromosome 5 open reading frame 64
chr2_-_237172987 0.549 NM_212556
ASB18
ankyrin repeat and SOCS box containing 18
chr8_+_128748476 0.549 MYC
v-myc myelocytomatosis viral oncogene homolog (avian)
chr7_+_100770378 0.543 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr15_-_65067696 0.542 NM_194272
RBPMS2
RNA binding protein with multiple splicing 2
chr18_-_22931970 0.534 ZNF521
zinc finger protein 521
chr3_+_194406614 0.534 NM_153690
FAM43A
family with sequence similarity 43, member A
chr17_+_48133357 0.527 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr17_+_80009775 0.525 GPS1
G protein pathway suppressor 1
chr9_+_131644368 0.525 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chr17_+_32582295 0.520 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr11_+_64107687 0.519 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr16_+_31366519 0.518 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr6_-_32143886 0.507 AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chrX_-_24045302 0.506 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr19_+_12902295 0.505 NM_002229
JUNB
jun B proto-oncogene
chr17_+_80009739 0.503 NM_004127
NM_212492
GPS1

G protein pathway suppressor 1

chr16_+_691901 0.500 FAM195A
family with sequence similarity 195, member A
chr12_-_52761254 0.498 NM_002283
KRT85
keratin 85
chr17_+_48133331 0.497 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr5_-_81046943 0.497 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr19_-_54692132 0.496 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr3_-_18480203 0.489 NM_001131010
SATB1
SATB homeobox 1
chr16_+_30007562 0.485 INO80E
INO80 complex subunit E
chr6_-_111888520 0.482 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr22_+_29702950 0.477 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr12_+_109577201 0.477 NM_001093
ACACB
acetyl-CoA carboxylase beta
chr7_-_75443026 0.476 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr1_+_161087861 0.470 NM_001185092
NM_005600
NM_001185093
NM_001185094
NIT1



nitrilase 1



chr3_-_127309495 0.469 NM_001136053
NM_001142646
TPRA1

transmembrane protein, adipocyte asscociated 1

chr16_+_30007502 0.467 NM_173618
INO80E
INO80 complex subunit E
chr3_-_74570262 0.465 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chrX_+_149009940 0.461 NM_001166400
NM_001166401
NM_005364
MAGEA8


melanoma antigen family A, 8


chr3_-_127309313 0.461 TPRA1
transmembrane protein, adipocyte asscociated 1
chr3_+_43020758 0.460 NM_001129908
FAM198A
family with sequence similarity 198, member A
chr9_+_131644427 0.459 LRRC8A
leucine rich repeat containing 8 family, member A
chr5_-_171881355 0.458 SH3PXD2B
SH3 and PX domains 2B
chr11_+_59522905 0.453 STX3
syntaxin 3
chr17_-_80009237 0.451 RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr22_+_24129143 0.450 NM_001007468
NM_003073
SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

chr13_+_53035227 0.450 CKAP2
cytoskeleton associated protein 2
chr19_+_49403605 0.447 NUCB1
nucleobindin 1
chr1_+_32538497 0.440 NM_018056
TMEM39B
transmembrane protein 39B
chr22_-_42343079 0.439 NM_001002876
NM_024053
CENPM

centromere protein M

chr3_+_133494275 0.438 TF
transferrin
chr4_-_186733372 0.437 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chrX_-_154033729 0.436 NM_001166460
NM_001166461
NM_001166462
NM_002436
MPP1



membrane protein, palmitoylated 1, 55kDa



chr6_-_32143899 0.434 NM_006411
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr5_+_156820161 0.429 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr5_+_180794268 0.428 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr3_+_49711816 0.427 APEH
N-acylaminoacyl-peptide hydrolase
chr7_-_6010313 0.426 NM_173565
NM_001099697
RSPH10B
RSPH10B2
radial spoke head 10 homolog B (Chlamydomonas)
radial spoke head 10 homolog B2 (Chlamydomonas)
chr5_-_111312522 0.426 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr17_+_40610857 0.424 NM_001130020
NM_001130021
NM_005177
ATP6V0A1


ATPase, H+ transporting, lysosomal V0 subunit a1


chr19_+_2476122 0.424 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr16_+_21245015 0.422 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr8_-_144810691 0.420 FAM83H
family with sequence similarity 83, member H
chr17_+_7255427 0.418 KCTD11
potassium channel tetramerisation domain containing 11
chr12_+_56618104 0.418 NM_024068
OBFC2B
oligonucleotide/oligosaccharide-binding fold containing 2B
chr12_+_48516428 0.417 NM_001166687
NM_001166688
PFKM

phosphofructokinase, muscle

chr13_+_100634257 0.416 ZIC2
Zic family member 2
chrX_-_154033696 0.414 MPP1
membrane protein, palmitoylated 1, 55kDa
chr11_+_59522801 0.411 STX3
syntaxin 3
chrX_-_154033647 0.410 MPP1
membrane protein, palmitoylated 1, 55kDa
chr12_+_13349601 0.407 NM_001423
EMP1
epithelial membrane protein 1
chr6_-_31865455 0.406 NM_006709
NM_025256
EHMT2

euchromatic histone-lysine N-methyltransferase 2

chr3_+_50654589 0.404 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr1_+_78470593 0.402 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr7_+_6793739 0.402 NM_173565
NM_001099697
RSPH10B
RSPH10B2
radial spoke head 10 homolog B (Chlamydomonas)
radial spoke head 10 homolog B2 (Chlamydomonas)
chr5_-_177423242 0.400 NM_006261
PROP1
PROP paired-like homeobox 1
chr20_+_3776905 0.400 CDC25B
cell division cycle 25 homolog B (S. pombe)
chr16_+_691827 0.397 NM_138418
FAM195A
family with sequence similarity 195, member A
chr17_+_17206626 0.397 NM_020201
NT5M
5',3'-nucleotidase, mitochondrial
chr16_-_49860917 0.396 NM_015069
ZNF423
zinc finger protein 423
chr5_-_135701163 0.394 NM_001167576
NM_001167577
NM_020389
TRPC7


transient receptor potential cation channel, subfamily C, member 7


chr20_-_56284945 0.393 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr7_-_99698916 0.390 MCM7
minichromosome maintenance complex component 7
chr19_+_45458646 0.390 CLPTM1
cleft lip and palate associated transmembrane protein 1
chr12_-_53893195 0.389 NM_001193511
NM_006301
MAP3K12

mitogen-activated protein kinase kinase kinase 12

chr3_+_50654558 0.388 NM_001243925
NM_004635
MAPKAPK3

mitogen-activated protein kinase-activated protein kinase 3

chrX_+_149531439 0.387 NM_001177465
MAMLD1
mastermind-like domain containing 1
chr13_+_111855406 0.384 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_-_156265457 0.381 C1orf85
chromosome 1 open reading frame 85
chr17_-_73893016 0.380 NM_173547
TRIM65
tripartite motif containing 65
chr19_+_35773409 0.380 NM_021175
HAMP
hepcidin antimicrobial peptide
chr1_+_156084565 0.379 LMNA
lamin A/C
chr1_+_84630014 0.379 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr19_+_45458598 0.378 NM_001294
CLPTM1
cleft lip and palate associated transmembrane protein 1
chr19_-_47975244 0.378 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr7_-_99699030 0.378 MCM7
minichromosome maintenance complex component 7
chr19_+_2222415 0.378 DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr1_+_156084541 0.374 LMNA
lamin A/C
chr7_-_99698993 0.374 MCM7
minichromosome maintenance complex component 7
chr2_+_56411123 0.373 NM_001080433
CCDC85A
coiled-coil domain containing 85A
chr19_-_58090254 0.373 ZNF416
zinc finger protein 416
chr4_-_113206883 0.373 NM_052864
TIFA
TRAF-interacting protein with forkhead-associated domain
chr16_+_23690212 0.371 PLK1
polo-like kinase 1
chr20_+_42544781 0.371 NM_001098796
NM_032883
TOX2

TOX high mobility group box family member 2

chr3_-_50358855 0.370 HYAL2
hyaluronoglucosaminidase 2
chr11_+_60989820 0.370 NM_001079808
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr12_+_56618150 0.370 OBFC2B
oligonucleotide/oligosaccharide-binding fold containing 2B
chr6_-_32143795 0.370 AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr2_-_74607425 0.367 NM_001135040
NM_001190837
NM_004082
DCTN1


dynactin 1


chr11_-_61129352 0.366 CYBASC3
cytochrome b, ascorbate dependent 3
chr11_+_60970983 0.365 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr17_+_40610899 0.365 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr19_-_47975074 0.363 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr2_-_113542970 0.362 NM_000575
IL1A
interleukin 1, alpha
chr11_-_113577023 0.360 NM_030770
TMPRSS5
transmembrane protease, serine 5
chr20_-_43977023 0.360 NM_002999
SDC4
syndecan 4
chr6_-_24877453 0.359 NM_015864
FAM65B
family with sequence similarity 65, member B
chr1_-_156265395 0.358 NM_144580
C1orf85
chromosome 1 open reading frame 85
chr1_+_156084579 0.353 LMNA
lamin A/C
chr9_+_12693385 0.352 NM_000550
TYRP1
tyrosinase-related protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 1.03e-04 GO:0065007 biological regulation
1.10 2.92e-04 GO:0009987 cellular process
1.24 2.03e-03 GO:0023052 signaling
1.30 4.61e-03 GO:0006950 response to stress
1.14 5.10e-03 GO:0050789 regulation of biological process
1.21 6.58e-03 GO:0051716 cellular response to stimulus
1.49 3.08e-02 GO:0009611 response to wounding
1.32 4.12e-02 GO:0048583 regulation of response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.44 5.71e-03 GO:0044421 extracellular region part
1.27 3.13e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 1.48e-07 GO:0005515 protein binding
1.07 1.40e-02 GO:0005488 binding