Motif ID: GTF2I.p2

Z-value: 1.999


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
GTF2Ichr7_+_740720380.792.7e-06Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_16900348 22.598 NM_001130834
NM_001290
 LDB2

LIM domain binding 2

chr4_-_16900028 21.863 LDB2
LIM domain binding 2
chr4_-_16900256 20.907 LDB2
LIM domain binding 2
chr14_-_54423448 9.659 NM_001202
NM_130850
 BMP4

bone morphogenetic protein 4

chr8_-_22549901 8.660 NM_001199880
 EGR3
early growth response 3
chr13_-_72441312 8.592 NM_004392
NM_080759
NM_080760
 DACH1


dachshund homolog 1 (Drosophila)


chr18_-_22930826 7.792


chr11_+_125034558 7.104 NM_022062
 PKNOX2
PBX/knotted 1 homeobox 2
chr7_+_30951414 6.944 NM_198098
 AQP1
aquaporin 1 (Colton blood group)
chr5_-_81046858 6.212 SSBP2
single-stranded DNA binding protein 2
chr8_-_22550057 6.195 NM_001199881
 EGR3
early growth response 3
chr11_+_125034604 6.158 PKNOX2
PBX/knotted 1 homeobox 2
chr13_+_58205943 6.020 PCDH17
protocadherin 17
chr13_+_58205788 5.795 NM_001040429
 PCDH17
protocadherin 17
chr14_-_54421269 5.573 NM_130851
 BMP4
bone morphogenetic protein 4
chr5_-_81046943 5.493 NM_012446
 SSBP2
single-stranded DNA binding protein 2
chr4_-_102268626 5.243 NM_000944
NM_001130691
NM_001130692
 PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr1_+_164528586 5.202 NM_001204961
NM_001204963
NM_002585
 PBX1


pre-B-cell leukemia homeobox 1


chr9_+_133971862 5.184 NM_001185095
NM_001185096
NM_031426
 AIF1L


allograft inflammatory factor 1-like


chr11_-_33890931 5.089 LMO2
LIM domain only 2 (rhombotin-like 1)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 117 entries
enrichment   p-value GO term description
2.36 3.83e-02 GO:0060443 mammary gland morphogenesis
1.85 1.47e-02 GO:0030879 mammary gland development
1.58 7.83e-03 GO:0048732 gland development
1.54 3.50e-03 GO:0003002 regionalization
1.51 1.57e-02 GO:0051129 negative regulation of cellular component organization
1.45 1.21e-03 GO:0016568 chromatin modification
1.42 6.12e-04 GO:0007268 synaptic transmission
1.39 9.35e-04 GO:0019226 transmission of nerve impulse
1.39 9.35e-04 GO:0035637 multicellular organismal signaling
1.39 2.09e-03 GO:0006325 chromatin organization
1.37 1.96e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.37 4.35e-03 GO:0031175 neuron projection development
1.36 8.59e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.36 3.26e-03 GO:0010942 positive regulation of cell death
1.35 7.06e-04 GO:0009725 response to hormone stimulus
1.35 2.47e-03 GO:0050878 regulation of body fluid levels
1.35 3.92e-03 GO:0051253 negative regulation of RNA metabolic process
1.34 2.91e-06 GO:0022008 neurogenesis
1.34 1.41e-05 GO:0048699 generation of neurons
1.34 7.15e-04 GO:0009719 response to endogenous stimulus

Gene overrepresentation in compartment category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
1.52 1.13e-02 GO:0030424 axon
1.46 2.05e-05 GO:0043005 neuron projection
1.41 3.10e-04 GO:0045202 synapse
1.40 3.24e-02 GO:0012506 vesicle membrane
1.39 2.07e-02 GO:0044456 synapse part
1.35 2.35e-02 GO:0048471 perinuclear region of cytoplasm
1.29 1.00e-02 GO:0044431 Golgi apparatus part
1.28 2.72e-04 GO:0042995 cell projection
1.27 1.55e-03 GO:0031410 cytoplasmic vesicle
1.27 2.08e-03 GO:0031982 vesicle
1.27 3.72e-03 GO:0031988 membrane-bounded vesicle
1.27 5.02e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.25 4.80e-04 GO:0005794 Golgi apparatus
1.19 1.07e-02 GO:0005654 nucleoplasm
1.17 4.74e-04 GO:0005829 cytosol
1.16 4.76e-02 GO:0012505 endomembrane system
1.15 2.11e-02 GO:0031981 nuclear lumen
1.13 3.07e-02 GO:0044459 plasma membrane part
1.11 4.37e-02 GO:0043234 protein complex
1.09 2.53e-08 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
2.07 4.20e-02 GO:0019888 protein phosphatase regulator activity
1.67 4.83e-02 GO:0005057 receptor signaling protein activity
1.59 8.83e-04 GO:0003682 chromatin binding
1.44 1.56e-04 GO:0003712 transcription cofactor activity
1.44 1.91e-04 GO:0000988 protein binding transcription factor activity
1.44 1.91e-04 GO:0000989 transcription factor binding transcription factor activity
1.40 3.27e-04 GO:0019904 protein domain specific binding
1.35 1.84e-05 GO:0043565 sequence-specific DNA binding
1.33 3.96e-05 GO:0019899 enzyme binding
1.32 7.00e-07 GO:0001071 nucleic acid binding transcription factor activity
1.32 7.00e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.29 3.07e-02 GO:0008092 cytoskeletal protein binding
1.28 2.52e-02 GO:0004672 protein kinase activity
1.26 1.06e-02 GO:0042802 identical protein binding
1.24 2.24e-03 GO:0030528 transcription regulator activity
1.23 1.62e-02 GO:0030234 enzyme regulator activity
1.15 9.04e-20 GO:0005515 protein binding
1.07 6.55e-14 GO:0005488 binding