Motif ID: HAND1,2.p2

Z-value: 1.101


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HAND2chr4_-_1744513560.481.6e-02Click!
HAND1chr5_-_153857820-0.001.0e+00Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_228678556 3.203 NM_001130046
NM_004591
 CCL20

chemokine (C-C motif) ligand 20

chr19_-_17958773 3.106 JAK3
Janus kinase 3
chr1_-_120612019 3.047 NOTCH2
notch 2
chr5_-_150467220 3.028 NM_001252390
 TNIP1
TNFAIP3 interacting protein 1
chr22_-_36556781 2.958 NM_145640
 APOL3
apolipoprotein L, 3
chr5_-_150466696 2.710 NM_001252391
NM_001252392
 TNIP1

TNFAIP3 interacting protein 1

chr9_+_72658496 2.365 NM_153267
 MAMDC2
MAM domain containing 2
chr1_-_149908759 2.326 NM_001145862
 MTMR11
myotubularin related protein 11
chr1_-_149908721 1.964 MTMR11
myotubularin related protein 11
chr6_-_30652434 1.789 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr9_+_72658735 1.715 MAMDC2
MAM domain containing 2
chr21_+_27012045 1.581 JAM2
junctional adhesion molecule 2
chr1_-_156722023 1.500 NM_001126051
NM_001126050
 HDGF

hepatoma-derived growth factor

chr2_-_113542970 1.483 NM_000575
 IL1A
interleukin 1, alpha
chr17_+_77020278 1.360 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr3_-_123411185 1.301 MYLK
myosin light chain kinase
chrX_+_1455508 1.290 NM_002183
 IL3RA
interleukin 3 receptor, alpha (low affinity)
chrY_+_1405508 1.245 NM_002183
 IL3RA
interleukin 3 receptor, alpha (low affinity)
chr17_+_32582295 1.145 NM_002982
 CCL2
chemokine (C-C motif) ligand 2
chr12_+_27485767 1.101 NM_001248002
NM_001248003
NM_001248004
NM_001248005
NM_020183
 ARNTL2




aryl hydrocarbon receptor nuclear translocator-like 2





Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
9.03 4.54e-02 GO:0001516 prostaglandin biosynthetic process
9.03 4.54e-02 GO:0046457 prostanoid biosynthetic process
2.74 1.51e-02 GO:0006936 muscle contraction
2.73 6.93e-03 GO:0003012 muscle system process
2.21 3.96e-02 GO:0030029 actin filament-based process
1.67 6.05e-03 GO:0007154 cell communication

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.70 2.35e-03 GO:0005624 membrane fraction
1.69 2.07e-03 GO:0005626 insoluble fraction
1.67 1.38e-04 GO:0000267 cell fraction
1.63 2.03e-02 GO:0005615 extracellular space
1.62 1.89e-04 GO:0005887 integral to plasma membrane
1.60 7.70e-08 GO:0005576 extracellular region
1.59 4.55e-04 GO:0031226 intrinsic to plasma membrane
1.49 1.75e-05 GO:0044459 plasma membrane part
1.31 5.66e-05 GO:0071944 cell periphery
1.31 1.06e-04 GO:0005886 plasma membrane
1.15 2.87e-02 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
2.63 2.39e-02 GO:0004252 serine-type endopeptidase activity
2.38 2.76e-02 GO:0005529 sugar binding
2.13 6.59e-03 GO:0003779 actin binding
1.59 8.40e-03 GO:0005102 receptor binding