Motif ID: HIC1.p2

Z-value: 2.566


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HIC1chr17_+_1958354,
chr17_+_1959512		-0.281.7e-01Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_33891485 9.766 NM_001142315
 LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33891258 9.289 LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_61547625 8.852 NM_001134673
NM_005595
 NFIA

nuclear factor I/A

chr1_-_92351613 8.576 NM_001195683
NM_003243
 TGFBR3

transforming growth factor, beta receptor III

chr2_+_7057471 7.971 NM_014746
 RNF144A
ring finger protein 144A
chr20_-_62462568 7.937 ZBTB46
zinc finger and BTB domain containing 46
chr11_-_33891361 7.900 NM_001142316
 LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_-_92351476 7.809 TGFBR3
transforming growth factor, beta receptor III
chr11_-_33890931 7.705 LMO2
LIM domain only 2 (rhombotin-like 1)
chr2_-_99347430 6.555 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr20_-_62680880 6.316 NM_018419
 SOX18
SRY (sex determining region Y)-box 18
chr14_-_105635114 5.733 NM_002226
NM_145159
 JAG2

jagged 2

chr9_-_111775721 5.639 NM_003798
 CTNNAL1
catenin (cadherin-associated protein), alpha-like 1
chr7_-_132261268 5.570 NM_001105543
NM_020911
 PLXNA4

plexin A4

chr7_-_11871735 5.570 NM_015204
 THSD7A
thrombospondin, type I, domain containing 7A
chr14_-_105634708 5.363 JAG2
jagged 2
chr11_+_94822937 5.314 NM_015036
 ENDOD1
endonuclease domain containing 1
chr8_+_27491384 5.094 SCARA3
scavenger receptor class A, member 3
chr20_-_23030141 5.034 NM_000361
 THBD
thrombomodulin
chr8_-_48650683 4.986 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 55 entries
enrichment   p-value GO term description
1.93 4.49e-03 GO:0040029 regulation of gene expression, epigenetic
1.59 2.27e-03 GO:0016567 protein ubiquitination
1.56 3.33e-03 GO:0032446 protein modification by small protein conjugation
1.47 3.47e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.45 3.93e-02 GO:0070647 protein modification by small protein conjugation or removal
1.38 3.01e-03 GO:0010629 negative regulation of gene expression
1.38 1.70e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.37 1.71e-02 GO:0051253 negative regulation of RNA metabolic process
1.37 1.83e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.36 4.96e-02 GO:0007417 central nervous system development
1.35 1.92e-09 GO:0007399 nervous system development
1.35 4.03e-03 GO:0009890 negative regulation of biosynthetic process
1.34 1.09e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.34 1.16e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.34 3.26e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.34 3.30e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.33 1.70e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.32 8.02e-04 GO:0048468 cell development
1.32 1.23e-03 GO:0022008 neurogenesis
1.31 7.52e-04 GO:0006793 phosphorus metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
1.68 4.03e-03 GO:0005912 adherens junction
1.64 4.36e-03 GO:0070161 anchoring junction
1.47 4.71e-02 GO:0016323 basolateral plasma membrane
1.37 5.83e-04 GO:0044431 Golgi apparatus part
1.37 7.34e-03 GO:0000139 Golgi membrane
1.29 3.77e-04 GO:0005794 Golgi apparatus
1.19 5.50e-04 GO:0031090 organelle membrane
1.19 1.04e-02 GO:0012505 endomembrane system
1.16 7.79e-13 GO:0044444 cytoplasmic part
1.15 1.97e-21 GO:0005737 cytoplasm
1.12 1.36e-13 GO:0043231 intracellular membrane-bounded organelle
1.12 1.45e-13 GO:0043227 membrane-bounded organelle
1.11 1.83e-24 GO:0005622 intracellular
1.11 2.06e-23 GO:0044424 intracellular part
1.11 9.06e-15 GO:0043229 intracellular organelle
1.11 1.18e-14 GO:0043226 organelle
1.10 4.27e-04 GO:0005634 nucleus
1.10 3.29e-03 GO:0044446 intracellular organelle part
1.09 8.97e-03 GO:0044422 organelle part
1.04 2.67e-06 GO:0044464 cell part

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
1.56 7.86e-05 GO:0003779 actin binding
1.53 8.53e-04 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.53 3.42e-03 GO:0016881 acid-amino acid ligase activity
1.52 1.40e-07 GO:0008092 cytoskeletal protein binding
1.51 2.61e-03 GO:0008134 transcription factor binding
1.51 3.43e-02 GO:0004842 ubiquitin-protein ligase activity
1.50 3.26e-02 GO:0019787 small conjugating protein ligase activity
1.20 4.70e-03 GO:0016740 transferase activity
1.15 2.02e-02 GO:0000166 nucleotide binding
1.14 4.15e-07 GO:0003824 catalytic activity
1.14 2.00e-04 GO:0043167 ion binding
1.14 2.34e-04 GO:0043169 cation binding
1.14 3.29e-04 GO:0046872 metal ion binding
1.12 5.06e-10 GO:0005515 protein binding
1.08 1.25e-12 GO:0005488 binding