Motif ID: HIF1A.p2

Z-value: 1.860


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HIF1Achr14_+_62162042,
chr14_+_62164339		-0.311.3e-01Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_7005764 7.819 NM_207315
 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr1_+_65613211 7.163 NM_203464
NM_001005353
 AK4

adenylate kinase 4

chr1_+_65613971 7.094 AK4
adenylate kinase 4
chr3_-_127541160 5.334 NM_007283
 MGLL
monoglyceride lipase
chr3_-_127541975 5.267 NM_001003794
 MGLL
monoglyceride lipase
chr8_+_17354562 5.033 NM_001008539
 SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr17_-_74497406 4.963 NM_024599
 RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr1_+_65613771 4.674 NM_013410
 AK4
adenylate kinase 4
chr8_+_31497267 4.173 NM_013962
 NRG1
neuregulin 1
chr3_-_145879222 4.145 NM_000935
NM_182943
 PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr7_+_55086922 3.948 EGFR
epidermal growth factor receptor
chr10_-_6019454 3.946 NM_002189
NM_172200
 IL15RA

interleukin 15 receptor, alpha

chr11_+_18416111 3.808 LDHA
lactate dehydrogenase A
chr11_+_18416106 3.747 LDHA
lactate dehydrogenase A
chr11_+_18415917 3.399 NM_001135239
NM_001165415
NM_001165416
NM_005566
 LDHA



lactate dehydrogenase A



chr13_-_44361032 3.356 NM_001242863
NM_017993
 ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr3_-_145878936 3.250 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr5_-_131563481 3.149 NM_001017974
NM_001142598
NM_001142599
 P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr7_-_77045706 3.093 NM_017439
 PION
pigeon homolog (Drosophila)
chr12_+_107349673 2.662 C12orf23
chromosome 12 open reading frame 23

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
2.34 3.44e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.32 4.07e-02 GO:0022604 regulation of cell morphogenesis
2.05 2.19e-02 GO:0071843 cellular component biogenesis at cellular level
2.05 3.45e-02 GO:0022613 ribonucleoprotein complex biogenesis
1.79 1.63e-02 GO:0044419 interspecies interaction between organisms
1.57 3.44e-04 GO:0010605 negative regulation of macromolecule metabolic process
1.54 2.44e-03 GO:0045184 establishment of protein localization
1.50 1.03e-03 GO:0008104 protein localization
1.50 7.89e-03 GO:0031324 negative regulation of cellular metabolic process
1.50 1.33e-02 GO:0015031 protein transport
1.49 1.29e-03 GO:0051649 establishment of localization in cell
1.48 9.04e-03 GO:0009892 negative regulation of metabolic process
1.46 8.57e-04 GO:0051641 cellular localization
1.44 3.54e-02 GO:0032268 regulation of cellular protein metabolic process
1.42 3.76e-03 GO:0033036 macromolecule localization
1.36 1.44e-04 GO:0048523 negative regulation of cellular process
1.35 1.03e-02 GO:0016070 RNA metabolic process
1.33 3.21e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.32 1.23e-03 GO:0048519 negative regulation of biological process
1.31 4.78e-05 GO:0051234 establishment of localization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
2.92 6.23e-03 GO:0031256 leading edge membrane
2.43 3.16e-02 GO:0001726 ruffle
2.20 6.85e-04 GO:0031252 cell leading edge
2.16 1.41e-02 GO:0031965 nuclear membrane
1.93 5.32e-03 GO:0005635 nuclear envelope
1.81 1.30e-05 GO:0005730 nucleolus
1.41 3.71e-07 GO:0005829 cytosol
1.35 4.79e-04 GO:0031981 nuclear lumen
1.34 3.75e-03 GO:0012505 endomembrane system
1.33 1.14e-04 GO:0044428 nuclear part
1.30 1.05e-03 GO:0070013 intracellular organelle lumen
1.29 1.93e-03 GO:0043233 organelle lumen
1.29 3.44e-03 GO:0031090 organelle membrane
1.28 1.91e-03 GO:0031974 membrane-enclosed lumen
1.25 7.23e-10 GO:0005634 nucleus
1.21 5.73e-08 GO:0044444 cytoplasmic part
1.20 4.74e-14 GO:0043227 membrane-bounded organelle
1.20 4.92e-14 GO:0043231 intracellular membrane-bounded organelle
1.19 2.58e-05 GO:0044446 intracellular organelle part
1.19 4.65e-05 GO:0044422 organelle part

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.65 1.31e-02 GO:0019904 protein domain specific binding
1.49 4.98e-03 GO:0003723 RNA binding
1.44 5.46e-03 GO:0030528 transcription regulator activity
1.34 4.60e-05 GO:0000166 nucleotide binding
1.29 1.50e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.29 1.67e-02 GO:0032553 ribonucleotide binding
1.29 1.67e-02 GO:0032555 purine ribonucleotide binding
1.29 1.75e-02 GO:0017076 purine nucleotide binding
1.26 1.39e-04 GO:0003676 nucleic acid binding
1.22 1.16e-11 GO:0005515 protein binding
1.10 5.51e-08 GO:0005488 binding