Motif ID: HNF1A.p2

Z-value: 0.864


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HNF1Achr12_+_1214165480.368.1e-02Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_43029973 1.659 HNF4A
hepatocyte nuclear factor 4, alpha
chr22_+_32439103 1.348 SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr22_+_32439211 1.343 SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr13_+_97874704 1.060 MBNL2
muscleblind-like 2 (Drosophila)
chr16_-_66952729 1.050 NM_001204744
NM_001204745
NM_001204746
NM_004062
CDH16



cadherin 16, KSP-cadherin



chr2_+_152214105 1.044 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr6_+_29274402 0.885 NM_030946
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr15_+_67418053 0.877 NM_001145102
SMAD3
SMAD family member 3
chr22_+_32439250 0.800 SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr9_+_82186846 0.673 NM_007005
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_+_48688356 0.662 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr22_-_38506532 0.660 BAIAP2L2
BAI1-associated protein 2-like 2
chr14_+_55168831 0.649 SAMD4A
sterile alpha motif domain containing 4A
chr16_-_69385656 0.640 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr4_+_74347461 0.629 NM_001133
AFM
afamin
chr19_+_799281 0.625 PTBP1
polypyrimidine tract binding protein 1
chr14_+_95027760 0.619 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr3_-_161089747 0.619 NM_001040100
SPTSSB
serine palmitoyltransferase, small subunit B
chr14_+_68168602 0.612 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr1_+_119911395 0.599 NM_001005783
NM_016527
HAO2

hydroxyacid oxidase 2 (long chain)

chr16_-_55909208 0.576 NM_001143685
NM_145024
CES5A

carboxylesterase 5A

chr8_-_17555158 0.572 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr17_+_73642645 0.552 NM_001162997
C17orf110
chromosome 17 open reading frame 110
chr11_-_26743545 0.549 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr6_+_31623668 0.541 NM_019101
APOM
apolipoprotein M
chr4_+_3443659 0.526 HGFAC
HGF activator
chr4_+_3443691 0.524 NM_001528
HGFAC
HGF activator
chr11_-_121986800 0.515 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr16_+_89696674 0.508 DPEP1
dipeptidase 1 (renal)
chr11_-_62783281 0.506 NM_001184732
NM_001184733
NM_001184736
NM_004254
SLC22A8



solute carrier family 22 (organic anion transporter), member 8



chr2_-_228244005 0.502 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr6_+_31623688 0.491 APOM
apolipoprotein M
chr4_+_155484131 0.488 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr6_+_126070724 0.484 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr1_+_17906941 0.484 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr11_-_64825992 0.477 NM_005468
NAALADL1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr20_+_42984338 0.461 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr6_+_155411422 0.461 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chrX_+_70435048 0.456 NM_001097642
GJB1
gap junction protein, beta 1, 32kDa
chr8_+_76320106 0.439 HNF4G
hepatocyte nuclear factor 4, gamma
chr4_-_110723127 0.431 CFI
complement factor I
chr8_-_6420454 0.430 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr7_-_92777657 0.419 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr11_+_46740769 0.418 F2
coagulation factor II (thrombin)
chr1_-_159684274 0.415 NM_000567
CRP
C-reactive protein, pentraxin-related
chr1_+_211519705 0.412 NM_145759
TRAF5
TNF receptor-associated factor 5
chr1_-_206288646 0.411 NM_001007544
C1orf186
chromosome 1 open reading frame 186
chr17_+_4692226 0.408 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chrX_+_36065052 0.400 NM_173695
CXorf59
chromosome X open reading frame 59
chr2_+_27719702 0.399 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr8_+_21911062 0.392 NM_001114137
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr7_-_108142934 0.391 PNPLA8
patatin-like phospholipase domain containing 8
chr11_+_46740736 0.388 NM_000506
F2
coagulation factor II (thrombin)
chrX_-_105282714 0.388 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr4_+_57036360 0.387 NM_020722
KIAA1211
KIAA1211
chr9_-_21305311 0.372 NM_002169
IFNA5
interferon, alpha 5
chr3_+_141043054 0.371 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr14_-_94759556 0.369 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759360 0.353 NM_016186
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr16_+_31404596 0.352 NM_005353
ITGAD
integrin, alpha D
chr4_-_110723334 0.351 NM_000204
CFI
complement factor I
chr10_+_5136613 0.351 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr4_-_69817478 0.347 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr4_-_101439071 0.347 NM_001159694
NM_016242
EMCN

endomucin

chr10_+_5136556 0.340 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr14_-_94759594 0.335 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr22_+_45098046 0.332 NM_181333
PRR5
proline rich 5 (renal)
chr10_+_5136589 0.329 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr22_+_32439018 0.325 NM_000343
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr10_+_45406629 0.320 NM_001123376
TMEM72
transmembrane protein 72
chr4_-_70080448 0.317 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr11_-_8739398 0.308 ST5
suppression of tumorigenicity 5
chr16_-_3085541 0.305 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr20_-_17641122 0.301 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr19_-_58864820 0.296 NM_130786
A1BG
alpha-1-B glycoprotein
chrX_-_15683153 0.296 NM_020665
TMEM27
transmembrane protein 27
chr6_+_54173202 0.294 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr10_-_70066594 0.291 PBLD
phenazine biosynthesis-like protein domain containing
chr19_+_41509825 0.288 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr15_+_58430394 0.286 NM_020980
AQP9
aquaporin 9
chr11_-_62911692 0.282 NM_001136506
SLC22A24
solute carrier family 22, member 24
chr14_-_94855120 0.276 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_-_121602030 0.272 MCMBP
minichromosome maintenance complex binding protein
chr21_-_19775958 0.270 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr1_-_204183036 0.270 NM_198447
GOLT1A
golgi transport 1A
chr7_+_120629444 0.266 NM_001105533
C7orf58
chromosome 7 open reading frame 58
chr4_+_187187117 0.262 NM_000128
F11
coagulation factor XI
chr12_+_54410893 0.257 HOXC5
HOXC6
homeobox C5
homeobox C6
chr11_+_114167168 0.253 NNMT
nicotinamide N-methyltransferase
chr7_+_139528951 0.239 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr12_-_102874158 0.238 IGF1
insulin-like growth factor 1 (somatomedin C)
chr10_+_115312777 0.238 NM_004132
HABP2
hyaluronan binding protein 2
chr20_+_43030005 0.235 HNF4A
hepatocyte nuclear factor 4, alpha
chr12_-_102874299 0.234 IGF1
insulin-like growth factor 1 (somatomedin C)
chr22_-_43355886 0.227 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr5_-_111093792 0.226 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr10_+_101542554 0.225 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr10_-_101690655 0.223 DNMBP
dynamin binding protein
chr3_-_157221362 0.222 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chrX_+_2958274 0.220 NM_001201538
ARSF
arylsulfatase F
chr14_+_55221505 0.219 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr1_+_15764934 0.213 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr5_-_147211235 0.212 NM_003122
SPINK1
serine peptidase inhibitor, Kazal type 1
chr17_-_8424217 0.212 MYH10
myosin, heavy chain 10, non-muscle
chr5_+_156607847 0.210 NM_005546
ITK
IL2-inducible T-cell kinase
chr20_+_2944918 0.208 PTPRA
protein tyrosine phosphatase, receptor type, A
chr11_-_47447915 0.208 NM_002804
PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr6_-_29644930 0.205 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chrX_+_135251454 0.204 NM_001159704
FHL1
four and a half LIM domains 1
chr10_+_101542460 0.203 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr14_-_92333856 0.202 NM_001128596
TC2N
tandem C2 domains, nuclear
chr7_+_45927958 0.198 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr5_-_111093251 0.185 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr11_+_64323089 0.182 NM_018484
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chrX_+_70435087 0.179 GJB1
gap junction protein, beta 1, 32kDa
chr19_-_33360641 0.177 NM_001126335
NM_001243036
NM_014270
SLC7A9


solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9


chr12_-_102874373 0.176 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr14_+_65171243 0.175 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_-_117695408 0.174 NM_001680
FXYD2
FXYD domain containing ion transport regulator 2
chr3_-_71353910 0.173 NM_001244812
FOXP1
forkhead box P1
chr12_+_9980076 0.169 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr6_-_24383519 0.167 NM_001195610
DCDC2
doublecortin domain containing 2
chr21_-_43346780 0.165 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr19_-_48389514 0.163 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr12_-_18243052 0.159 NM_024730
RERGL
RERG/RAS-like
chr14_-_57960432 0.157 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr13_-_41593405 0.156 ELF1
E74-like factor 1 (ets domain transcription factor)
chr5_-_147211141 0.155 SPINK1
serine peptidase inhibitor, Kazal type 1
chr12_-_71551564 0.150 TSPAN8
tetraspanin 8
chr19_+_15052298 0.148 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr21_-_36231794 0.148 RUNX1
runt-related transcription factor 1
chr13_-_41593491 0.148 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_-_39443326 0.147 NM_148169
FBXO17
F-box protein 17
chr6_+_167704802 0.146 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr5_-_138718941 0.146 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr17_-_64225496 0.145 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chrX_-_15332680 0.144 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr19_+_11909360 0.143 NM_152356
ZNF491
zinc finger protein 491
chr11_+_561449 0.140 NM_001143994
NM_003475
RASSF7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr4_-_102268626 0.139 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr12_-_8693391 0.138 NM_014358
CLEC4E
C-type lectin domain family 4, member E
chr2_-_88427535 0.137 NM_001443
FABP1
fatty acid binding protein 1, liver
chr20_+_62371109 0.137 NM_020062
SLC2A4RG
SLC2A4 regulator
chr12_-_102874340 0.136 IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_-_159093523 0.133 FAM198B
family with sequence similarity 198, member B
chr11_+_114167197 0.132 NNMT
nicotinamide N-methyltransferase
chr12_-_22089627 0.131 NM_005691
NM_020297
ABCC9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

chr2_+_29038862 0.131 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr6_-_29455678 0.130 NM_052967
MAS1L
MAS1 oncogene-like
chr5_+_88185090 0.129


chr14_+_78870092 0.126 NM_004796
NRXN3
neurexin 3
chr2_+_103035148 0.126 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr2_-_162931051 0.125 NM_001935
DPP4
dipeptidyl-peptidase 4
chr22_+_45098091 0.125 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr1_-_43424324 0.125 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr16_+_81272293 0.125 NM_017429
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr5_-_138719018 0.124 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr4_+_71494460 0.124 NM_031889
ENAM
enamelin
chr7_-_156801980 0.122 NM_001165255
MNX1
motor neuron and pancreas homeobox 1
chr1_+_104159953 0.122 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr3_-_141719188 0.121 NM_001178140
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_-_102874321 0.121 IGF1
insulin-like growth factor 1 (somatomedin C)
chr19_-_43098980 0.120 NM_001816
CEACAM8
carcinoembryonic antigen-related cell adhesion molecule 8
chr2_-_102003923 0.120 NM_153836
CREG2
cellular repressor of E1A-stimulated genes 2
chr2_+_182850550 0.120 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr10_+_69869249 0.120 NM_032578
MYPN
myopalladin
chr12_-_24102563 0.116 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr10_+_135340865 0.115 NM_000773
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr1_-_1711453 0.115 NM_001198994
NADK
NAD kinase
chr3_+_97158453 0.113 NM_173655
EPHA6
EPH receptor A6
chr12_-_22487566 0.109 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr5_+_140529619 0.109 NM_018939
PCDHB6
protocadherin beta 6
chr15_+_24920540 0.109 NM_018958
C15orf2
chromosome 15 open reading frame 2
chrX_+_36254050 0.107 NM_001098843
CXorf30
chromosome X open reading frame 30
chr22_+_22697538 0.107


chr15_+_85923739 0.106 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr16_-_57836380 0.104 NM_001130100
NM_005550
KIFC3

kinesin family member C3

chr1_-_114429996 0.104 BCL2L15
BCL2-like 15
chr19_-_48389571 0.101 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chrX_+_16668280 0.101 NM_004057
S100G
S100 calcium binding protein G
chr2_+_177016112 0.100 NM_014621
HOXD4
homeobox D4
chr6_+_167536240 0.098 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr6_-_31681845 0.096


chr20_+_42187705 0.094 SGK2
serum/glucocorticoid regulated kinase 2
chr15_-_44969085 0.091 NM_001145112
PATL2
protein associated with topoisomerase II homolog 2 (yeast)
chr5_-_111091947 0.091 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr6_+_106534210 0.090 PRDM1
PR domain containing 1, with ZNF domain
chrX_-_65835845 0.089 NM_001242310
EDA2R
ectodysplasin A2 receptor
chr11_-_67450536 0.088 RPL37
ribosomal protein L37
chr8_-_95220769 0.087 NM_004063
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr7_+_94292737 0.087 PEG10
paternally expressed 10
chr7_+_143701021 0.087 NM_001005281
OR6B1
olfactory receptor, family 6, subfamily B, member 1
chr17_+_3377346 0.086 NM_001128085
ASPA
aspartoacylase
chr19_+_45417576 0.085 APOC1
apolipoprotein C-I
chr6_+_161123224 0.085 NM_000301
NM_001168338
PLG

plasminogen

chr2_-_216003068 0.084 NM_173076
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr8_-_18541441 0.083 PSD3
pleckstrin and Sec7 domain containing 3
chr6_+_126070813 0.083 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chrY_+_1351570 0.083 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr3_-_164796275 0.082 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.99 6.66e-03 GO:0071702 organic substance transport
53.44 7.63e-03 GO:0034392 negative regulation of smooth muscle cell apoptosis
9.59 8.23e-03 GO:0030193 regulation of blood coagulation
4.82 9.17e-03 GO:0006805 xenobiotic metabolic process
4.82 9.17e-03 GO:0071466 cellular response to xenobiotic stimulus
4.79 9.91e-03 GO:0009410 response to xenobiotic stimulus
11.45 1.29e-02 GO:0030195 negative regulation of blood coagulation
8.91 1.38e-02 GO:0050818 regulation of coagulation
11.06 1.61e-02 GO:0050819 negative regulation of coagulation
2.17 3.22e-02 GO:0009611 response to wounding
2.50 3.31e-02 GO:0042060 wound healing
7.80 3.41e-02 GO:0061041 regulation of wound healing

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.51 1.17e-04 GO:0005615 extracellular space
2.21 4.56e-04 GO:0044421 extracellular region part
1.74 2.09e-03 GO:0005576 extracellular region
3.80 2.24e-03 GO:0045177 apical part of cell
4.14 3.52e-03 GO:0016324 apical plasma membrane
7.96 5.07e-03 GO:0031093 platelet alpha granule lumen
7.80 5.84e-03 GO:0034774 secretory granule lumen
7.48 7.67e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
1.65 8.31e-03 GO:0044459 plasma membrane part
7.20 9.95e-03 GO:0031983 vesicle lumen
6.57 1.82e-02 GO:0031091 platelet alpha granule
7.13 3.66e-02 GO:0005903 brush border

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.83 2.39e-02 GO:0022804 active transmembrane transporter activity
15.27 3.10e-02 GO:0005355 glucose transmembrane transporter activity
14.25 4.16e-02 GO:0008514 organic anion transmembrane transporter activity
7.29 4.76e-02 GO:0043498 cell surface binding