Motif ID: HNF4A_NR2F1,2.p2

Z-value: 2.391


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NR2F2chr15_+_96875793-0.811.1e-06Click!
NR2F1chr5_+_92920592-0.491.3e-02Click!
HNF4Achr20_+_43029936-0.222.9e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_29527477 17.098 UBD
ubiquitin D
chr5_+_131409484 12.178 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr6_-_31550065 10.309 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr6_-_29527701 8.840 NM_006398
UBD
ubiquitin D
chr19_+_10197023 8.168 C19orf66
chromosome 19 open reading frame 66
chr2_+_219433517 6.678 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr16_+_56685810 6.295 NM_005947
MT1B
metallothionein 1B
chr4_-_76944585 6.147 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr3_+_9691198 6.127 MTMR14
myotubularin related protein 14
chr19_-_4342718 5.410 STAP2
signal transducing adaptor family member 2
chr11_-_102668822 5.346 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr11_+_35160385 5.207 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
NM_001202555
NM_001202556
NM_001202557
CD44







CD44 molecule (Indian blood group)







chr19_+_10196972 5.079 C19orf66
chromosome 19 open reading frame 66
chr5_+_96211643 5.058 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr11_-_102668892 5.015 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr6_+_29691116 4.887 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chr1_+_113217039 4.817 NM_001130079
NM_020963
MOV10

Mov10, Moloney leukemia virus 10, homolog (mouse)

chr16_+_57653909 4.526 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr19_+_45394642 4.502 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr9_-_95896498 4.437 NM_004148
NINJ1
ninjurin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.25 3.35e-02 GO:0048583 regulation of response to stimulus
1.19 2.13e-02 GO:0006810 transport
1.19 3.88e-02 GO:0051234 establishment of localization
1.07 1.18e-03 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
1.46 5.16e-05 GO:0005626 insoluble fraction
1.44 3.00e-04 GO:0005624 membrane fraction
1.42 1.47e-05 GO:0000267 cell fraction
1.29 9.54e-04 GO:0012505 endomembrane system
1.23 2.38e-03 GO:0044459 plasma membrane part
1.10 3.83e-02 GO:0044444 cytoplasmic part
1.09 1.98e-03 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
4.00 3.31e-02 GO:0051537 2 iron, 2 sulfur cluster binding
1.11 1.45e-03 GO:0005515 protein binding
1.05 2.56e-02 GO:0005488 binding