Motif ID: HNF4A_NR2F1,2.p2

Z-value: 2.391


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NR2F2chr15_+_96875793-0.811.1e-06Click!
NR2F1chr5_+_92920592-0.491.3e-02Click!
HNF4Achr20_+_43029936-0.222.9e-01Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_29527477 17.098 UBD
ubiquitin D
chr5_+_131409484 12.178 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr6_-_31550065 10.309 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr6_-_29527701 8.840 NM_006398
UBD
ubiquitin D
chr19_+_10197023 8.168 C19orf66
chromosome 19 open reading frame 66
chr2_+_219433517 6.678 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr16_+_56685810 6.295 NM_005947
MT1B
metallothionein 1B
chr4_-_76944585 6.147 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr3_+_9691198 6.127 MTMR14
myotubularin related protein 14
chr19_-_4342718 5.410 STAP2
signal transducing adaptor family member 2
chr11_-_102668822 5.346 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr11_+_35160385 5.207 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
NM_001202555
NM_001202556
NM_001202557
CD44







CD44 molecule (Indian blood group)







chr19_+_10196972 5.079 C19orf66
chromosome 19 open reading frame 66
chr5_+_96211643 5.058 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr11_-_102668892 5.015 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr6_+_29691116 4.887 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chr1_+_113217039 4.817 NM_001130079
NM_020963
MOV10

Mov10, Moloney leukemia virus 10, homolog (mouse)

chr16_+_57653909 4.526 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr19_+_45394642 4.502 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr9_-_95896498 4.437 NM_004148
NINJ1
ninjurin 1
chr1_-_41328002 4.252 NM_133467
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr12_-_57504088 3.990 NM_001178079
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr19_-_633563 3.974 NM_005035
POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr19_-_633526 3.921 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr3_+_9691184 3.870 MTMR14
myotubularin related protein 14
chr16_+_3115312 3.847 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr19_+_45394522 3.664 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr10_+_114133838 3.580 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_111743261 3.554 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr2_-_208031570 3.547 KLF7
Kruppel-like factor 7 (ubiquitous)
chr2_+_26568900 3.519 NM_033505
EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr7_-_139763520 3.510 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr15_+_89182038 3.490 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_+_113217278 3.487 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr12_+_132413776 3.480 NM_001002019
NM_025215
PUS1

pseudouridylate synthase 1

chr19_-_633474 3.457 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr19_-_50432672 3.456 IL4I1
interleukin 4 induced 1
chr6_-_31926628 3.436 NM_002904
RDBP
RD RNA binding protein
chr2_+_219433302 3.401 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr2_+_102979096 3.377 NM_003855
IL18R1
interleukin 18 receptor 1
chr5_+_96212167 3.375 ERAP2
endoplasmic reticulum aminopeptidase 2
chr2_+_27719702 3.362 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr6_-_44233244 3.329 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr14_-_69259654 3.315 ZFP36L1
zinc finger protein 36, C3H type-like 1
chr11_+_69455837 3.303 NM_053056
CCND1
cyclin D1
chr11_+_63974144 3.282 NM_031471
NM_178443
FERMT3

fermitin family member 3

chr16_-_87970107 3.247 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr19_-_50432647 3.238 IL4I1
interleukin 4 induced 1
chr17_+_25958245 3.236 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_+_65613211 3.155 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr15_-_64338519 3.131 NM_014326
DAPK2
death-associated protein kinase 2
chr6_+_29691203 3.127 HLA-F
major histocompatibility complex, class I, F
chr12_+_113344738 3.073 NM_001032409
NM_002534
NM_016816
OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr10_+_114133775 3.064 ACSL5
acyl-CoA synthetase long-chain family member 5
chr8_-_119964059 3.053 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr16_+_57673206 3.015 NM_001145774
GPR56
G protein-coupled receptor 56
chr22_+_41697452 2.966 NM_017590
ZC3H7B
zinc finger CCCH-type containing 7B
chr19_+_18496966 2.951 NM_004864
GDF15
growth differentiation factor 15
chr17_-_3819959 2.884 NM_002558
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr17_-_3819692 2.882 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr19_+_45504686 2.860 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr12_+_132414240 2.852


chr12_+_132414041 2.844 PUS1
pseudouridylate synthase 1
chr15_+_67418053 2.771 NM_001145102
SMAD3
SMAD family member 3
chr19_+_18303989 2.733 NM_032683
MPV17L2
MPV17 mitochondrial membrane protein-like 2
chr16_-_4466607 2.733 CORO7
coronin 7
chr1_+_113217466 2.727 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr1_-_32264215 2.726 SPOCD1
SPOC domain containing 1
chr1_-_32281577 2.717 NM_144569
SPOCD1
SPOC domain containing 1
chr1_+_113217491 2.684 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr16_+_56598960 2.662 NM_032935
MT4
metallothionein 4
chr10_-_79789290 2.660 NM_007055
POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr12_-_322612 2.646 NM_003044
NM_001122847
SLC6A12

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

chr6_-_82461857 2.636 FAM46A
family with sequence similarity 46, member A
chr1_+_113217574 2.608 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr2_+_74757243 2.599 HTRA2
HtrA serine peptidase 2
chr17_+_25958151 2.569 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr17_+_25958192 2.567 LGALS9
lectin, galactoside-binding, soluble, 9
chr2_-_100758970 2.495 NM_002285
AFF3
AF4/FMR2 family, member 3
chr19_-_4338750 2.494 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr2_-_7005764 2.476 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr1_-_41328019 2.448 CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr12_+_132413743 2.440 NM_001002020
PUS1
pseudouridylate synthase 1
chr1_+_203097427 2.440 ADORA1
adenosine A1 receptor
chr15_+_45021319 2.440 TRIM69
tripartite motif containing 69
chr7_+_86273867 2.433 GRM3
glutamate receptor, metabotropic 3
chr14_-_24777064 2.412


chr1_-_32264271 2.380 SPOCD1
SPOC domain containing 1
chr9_-_100881462 2.342 NM_014788
NM_033219
NM_033220
TRIM14


tripartite motif containing 14


chr10_+_102732285 2.336 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr16_+_4714709 2.334 MGRN1
mahogunin, ring finger 1
chr19_-_17958773 2.327 JAK3
Janus kinase 3
chr9_-_123689172 2.304 NM_005658
TRAF1
TNF receptor-associated factor 1
chr7_-_115608366 2.296 NM_001244583
TFEC
transcription factor EC
chr1_-_161102457 2.294 NM_001039711
NM_032998
DEDD

death effector domain containing

chr19_+_45394459 2.275 NM_001128916
NM_001128917
NM_006114
TOMM40


translocase of outer mitochondrial membrane 40 homolog (yeast)


chr11_+_35160832 2.268 CD44
CD44 molecule (Indian blood group)
chr1_+_101185195 2.245 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr18_-_71959109 2.231 NM_001190807
NM_001914
NM_148923
CYB5A


cytochrome b5 type A (microsomal)


chr18_+_21719025 2.223 CABYR
calcium binding tyrosine-(Y)-phosphorylation regulated
chr10_+_91092238 2.213 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr9_-_117568292 2.204 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr6_-_134498973 2.194 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr19_+_45394569 2.184 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr16_+_21245015 2.172 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr14_+_103592663 2.157 NM_006291
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr6_-_31324955 2.138 HLA-B
major histocompatibility complex, class I, B
chr8_+_145065366 2.125 GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr16_-_4466595 2.113 CORO7
coronin 7
chr6_-_143266283 2.092 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr4_+_100495972 2.088 MTTP
microsomal triglyceride transfer protein
chr21_+_45345278 2.083 NM_001037553
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr6_+_138188352 2.080 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr12_+_113344811 2.070 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr6_-_31324898 2.054 HLA-B
major histocompatibility complex, class I, B
chr10_-_79789164 2.052 POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr7_+_143079354 2.023 ZYX
zyxin
chr19_+_10362886 2.003 MRPL4
mitochondrial ribosomal protein L4
chr19_+_36239261 2.001 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr6_+_30227335 1.996 HLA-L
major histocompatibility complex, class I, L, pseudogene
chr1_-_161102367 1.995 DEDD
death effector domain containing
chr15_+_74165967 1.978 NM_153356
TBC1D21
TBC1 domain family, member 21
chr3_-_189840225 1.956 NM_001134418
LEPREL1
leprecan-like 1
chr19_-_50400131 1.953 NM_152899
IL4I1
interleukin 4 induced 1
chr7_+_143079925 1.940 ZYX
zyxin
chr19_+_36239445 1.938 LIN37
lin-37 homolog (C. elegans)
chr19_-_1174257 1.938 SBNO2
strawberry notch homolog 2 (Drosophila)
chr19_-_51017124 1.923 NM_001114598
ASPDH
aspartate dehydrogenase domain containing
chr19_-_1174263 1.919 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr17_+_79651042 1.917 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr22_-_50963961 1.917 NM_001169111
NM_005138
SCO2

SCO cytochrome oxidase deficient homolog 2 (yeast)

chr12_+_27485767 1.911 NM_001248002
NM_001248003
NM_001248004
NM_001248005
NM_020183
ARNTL2




aryl hydrocarbon receptor nuclear translocator-like 2




chr5_-_58295758 1.906 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_113465101 1.902 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr17_+_40439564 1.897 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr9_-_117554809 1.884 NM_001204344
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr10_+_60028885 1.883 NM_018464
CISD1
CDGSH iron sulfur domain 1
chr12_-_51419923 1.882 NM_001174129
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr7_-_93189121 1.842 NM_001164738
CALCR
calcitonin receptor
chr6_-_31324975 1.838 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr11_-_117747331 1.819 FXYD6
FXYD domain containing ion transport regulator 6
chr19_-_15391261 1.812 NM_014299
NM_058243
BRD4

bromodomain containing 4

chr1_-_109969058 1.803 NM_001199772
NM_002790
NM_001199773
NM_001199774
PSMA5



proteasome (prosome, macropain) subunit, alpha type, 5



chr19_-_1174201 1.787


chr8_+_145066886 1.785 GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr12_+_56075329 1.778 NM_152637
METTL7B
methyltransferase like 7B
chr2_+_120125141 1.773 NM_001079863
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr3_+_9691116 1.761 NM_001077525
NM_001077526
NM_022485
MTMR14


myotubularin related protein 14


chr3_-_79068542 1.738 NM_001145845
NM_133631
ROBO1

roundabout, axon guidance receptor, homolog 1 (Drosophila)

chr12_+_56075418 1.722 METTL7B
methyltransferase like 7B
chr17_-_45928530 1.716 SP6
Sp6 transcription factor
chr6_-_11779279 1.710 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr11_-_4414887 1.708 NM_003141
TRIM21
tripartite motif containing 21
chr12_-_323255 1.704 NM_001122848
NM_001206931
SLC6A12

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

chr12_+_124773709 1.696 NM_181709
FAM101A
family with sequence similarity 101, member A
chr15_-_100273540 1.692 LYSMD4
LysM, putative peptidoglycan-binding, domain containing 4
chr21_+_41029253 1.683 NM_006057
NM_033170
NM_033171
NM_033172
NM_033173
B3GALT5




UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5




chr14_-_24658010 1.682 NM_024658
IPO4
importin 4
chr12_-_54779482 1.671 ZNF385A
zinc finger protein 385A
chr17_-_34207308 1.671 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr2_+_228678556 1.665 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr21_+_43639202 1.662 NM_004915
NM_016818
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr6_-_109776832 1.658 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr19_-_51530781 1.650 NM_144947
KLK11
kallikrein-related peptidase 11
chr2_+_162016926 1.628 NM_001199135
TANK
TRAF family member-associated NFKB activator
chr2_+_120124828 1.625 NM_001178017
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chrX_+_38211735 1.617 NM_000531
OTC
ornithine carbamoyltransferase
chr12_+_21168629 1.616 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr11_+_35160666 1.607 CD44
CD44 molecule (Indian blood group)
chr12_-_57504935 1.593 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr11_-_65430214 1.588 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr19_+_10362912 1.581 MRPL4
mitochondrial ribosomal protein L4
chr19_+_35629727 1.578 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr11_-_64764388 1.575 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr11_+_18416111 1.571 LDHA
lactate dehydrogenase A
chr19_-_1111972 1.568 SBNO2
strawberry notch homolog 2 (Drosophila)
chr20_-_20693122 1.567 NM_020343
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr1_-_177939347 1.564 SEC16B
SEC16 homolog B (S. cerevisiae)
chr1_-_109969044 1.563 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr19_-_59069747 1.550 UBE2M
ubiquitin-conjugating enzyme E2M
chr4_-_7436614 1.546 NM_001085382
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr11_-_1593149 1.542 NM_004420
DUSP8
dual specificity phosphatase 8
chr3_+_154797435 1.538 NM_000902
MME
membrane metallo-endopeptidase
chr6_+_29913400 1.534


chr17_-_77005822 1.526 NM_001159772
NM_001159773
NM_138793
CANT1


calcium activated nucleotidase 1


chr1_-_109968951 1.526 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr4_-_139163222 1.524 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr11_+_18416106 1.508 LDHA
lactate dehydrogenase A
chr16_+_29471206 1.503 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr22_+_38453478 1.503 PICK1
protein interacting with PRKCA 1
chr8_+_32405727 1.482 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr6_+_31913852 1.479 CFB
complement factor B
chr11_+_124735281 1.478 NM_022370
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr22_+_31608284 1.474 LIMK2
LIM domain kinase 2
chr11_-_441956 1.471 ANO9
anoctamin 9
chr2_+_26568991 1.465 EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr20_-_48530275 1.463 NM_001135773
SPATA2
spermatogenesis associated 2
chr6_+_18155535 1.456 NM_153042
KDM1B
lysine (K)-specific demethylase 1B
chr7_-_143105897 1.454 NM_005232
EPHA1
EPH receptor A1
chr5_+_149887673 1.448 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.07 1.18e-03 GO:0009987 cellular process
1.19 2.13e-02 GO:0006810 transport
1.25 3.35e-02 GO:0048583 regulation of response to stimulus
1.19 3.88e-02 GO:0051234 establishment of localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 1.47e-05 GO:0000267 cell fraction
1.46 5.16e-05 GO:0005626 insoluble fraction
1.44 3.00e-04 GO:0005624 membrane fraction
1.29 9.54e-04 GO:0012505 endomembrane system
1.09 1.98e-03 GO:0005737 cytoplasm
1.23 2.38e-03 GO:0044459 plasma membrane part
1.10 3.83e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 1.45e-03 GO:0005515 protein binding
1.05 2.56e-02 GO:0005488 binding
4.00 3.31e-02 GO:0051537 2 iron, 2 sulfur cluster binding