Motif ID: HOX{A5,B5}.p2

Z-value: 1.276


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
HOXA5 3202 homeobox A5
HOXB5 3215 homeobox B5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HOXA5chr7_-_27183225-0.481.4e-02Click!
HOXB5chr17_-_46671043-0.481.6e-02Click!


Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_17958773 4.091 JAK3
Janus kinase 3
chr4_-_76944585 4.062 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr22_-_36556781 3.517 NM_145640
APOL3
apolipoprotein L, 3
chr19_+_8117645 3.143 NM_001201359
NM_005624
CCL25

chemokine (C-C motif) ligand 25

chr3_-_127541160 2.920 NM_007283
MGLL
monoglyceride lipase
chr12_+_56075329 2.410 NM_152637
METTL7B
methyltransferase like 7B
chr6_-_29527477 2.168 UBD
ubiquitin D
chr16_-_84651639 2.154 NM_021149
COTL1
coactosin-like 1 (Dictyostelium)
chr16_+_86544104 2.077 NM_001451
FOXF1
forkhead box F1
chr7_-_47622127 1.970 TNS3
tensin 3
chr6_+_31543340 1.846 NM_000594
TNF
tumor necrosis factor
chr1_+_205236591 1.845 TMCC2
transmembrane and coiled-coil domain family 2
chr1_-_12677347 1.794 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr6_+_31554975 1.722 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr11_+_20070609 1.698 NAV2
neuron navigator 2
chr12_+_56075418 1.667 METTL7B
methyltransferase like 7B
chr12_+_54955226 1.631 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr2_+_152214105 1.613 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr6_+_36644236 1.605 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr19_+_57106622 1.574 NM_021216
ZNF71
zinc finger protein 71
chr7_+_5322553 1.533 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr5_+_17217474 1.438 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr20_-_1638359 1.392 NM_001039508
NM_018556
NM_080816
SIRPG


signal-regulatory protein gamma


chr5_-_35938736 1.382 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr4_-_114900802 1.367 NM_024590
ARSJ
arylsulfatase family, member J
chr6_+_31588524 1.291 PRRC2A
proline-rich coiled-coil 2A
chr22_-_41682169 1.200 RANGAP1
Ran GTPase activating protein 1
chr15_+_75074714 1.181 CSK
c-src tyrosine kinase
chr3_+_23244703 1.146 NM_152653
UBE2E2
ubiquitin-conjugating enzyme E2E 2
chr11_-_62472901 1.128


chr9_+_35673852 1.126 NM_001216
CA9
carbonic anhydrase IX
chr19_-_17958814 1.104 NM_000215
JAK3
Janus kinase 3
chr14_-_24020766 1.103 NM_033400
ZFHX2
zinc finger homeobox 2
chr16_+_57662301 1.100 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr19_-_50432952 1.087 NM_016553
NUP62
nucleoporin 62kDa
chr12_-_323255 1.068 NM_001122848
NM_001206931
SLC6A12

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

chr1_+_28585959 1.055 NM_031459
SESN2
sestrin 2
chrM_+_12283 1.043


chr7_-_47621741 1.022 NM_022748
TNS3
tensin 3
chr2_+_234296799 1.007 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr1_+_24645811 1.002 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr1_-_155948934 1.000 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr3_-_164914448 0.999 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr9_+_35732629 0.995 CREB3
cAMP responsive element binding protein 3
chr1_+_155579978 0.994 NM_018116
MSTO1
misato homolog 1 (Drosophila)
chr19_+_8117887 0.984 CCL25
chemokine (C-C motif) ligand 25
chr11_-_57089670 0.971 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr1_-_120935893 0.949 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr5_-_35048239 0.920 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr10_+_114136014 0.910 ACSL5
acyl-CoA synthetase long-chain family member 5
chr9_+_140500148 0.908 ARRDC1
arrestin domain containing 1
chr12_+_108909049 0.903 NM_007076
FICD
FIC domain containing
chr20_-_45087914 0.893 ZNF663
zinc finger protein 663
chrY_-_1281526 0.888 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chrX_-_1331526 0.888 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr12_-_4488707 0.885 NM_020638
FGF23
fibroblast growth factor 23
chr6_-_29527701 0.885 NM_006398
UBD
ubiquitin D
chr5_+_133842276 0.874


chr22_-_50746000 0.868 NM_012401
PLXNB2
plexin B2
chr19_-_47922339 0.861 MEIS3
Meis homeobox 3
chr1_+_24645914 0.855 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr19_-_50400131 0.845 NM_152899
IL4I1
interleukin 4 induced 1
chr6_-_29595746 0.842 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr16_-_1821709 0.834 NM_002513
NME3
non-metastatic cells 3, protein expressed in
chr11_-_35440514 0.826 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr17_+_7338761 0.817 NM_178518
TMEM102
transmembrane protein 102
chr17_+_25958245 0.816 LGALS9
lectin, galactoside-binding, soluble, 9
chr16_+_3115641 0.814 NM_001012632
NM_001012636
IL32

interleukin 32

chr19_-_42348507 0.807 NM_173506
LYPD4
LY6/PLAUR domain containing 4
chr16_-_84651519 0.795 COTL1
coactosin-like 1 (Dictyostelium)
chr17_+_6659155 0.792 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr1_+_4714668 0.790 AJAP1
adherens junctions associated protein 1
chrX_+_48368063 0.766 NM_203474
NM_203475
PORCN

porcupine homolog (Drosophila)

chr1_+_198608244 0.760 PTPRC
protein tyrosine phosphatase, receptor type, C
chr5_+_304290 0.747 NM_001242412
NM_020731
AHRR

aryl-hydrocarbon receptor repressor

chr12_-_6798419 0.746 ZNF384
zinc finger protein 384
chr2_-_113542970 0.741 NM_000575
IL1A
interleukin 1, alpha
chr21_+_43710190 0.735 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr1_+_79086087 0.734 NM_006820
IFI44L
interferon-induced protein 44-like
chr10_+_114135937 0.729 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_10419786 0.727 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr14_-_107218786 0.722 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr19_+_51152634 0.720 NM_001195076
C19orf81
chromosome 19 open reading frame 81
chr3_-_195538699 0.718 NM_004532
NM_018406
NM_138297
MUC4


mucin 4, cell surface associated


chr17_+_53828413 0.715 PCTP
phosphatidylcholine transfer protein
chr5_-_159546389 0.714 NM_001130864
NM_052927
PWWP2A

PWWP domain containing 2A

chrX_-_52386995 0.712 NM_130777
XAGE2
X antigen family, member 2
chr9_+_140500136 0.709 ARRDC1
arrestin domain containing 1
chr17_+_53828339 0.708 NM_021213
PCTP
phosphatidylcholine transfer protein
chrX_+_52112077 0.708 NM_130777
XAGE2
X antigen family, member 2
chr19_-_14064192 0.704 NM_001146254
NM_001146255
PODNL1

podocan-like 1

chr10_+_91152321 0.702 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr15_+_90544608 0.699 NM_198526
ZNF710
zinc finger protein 710
chr17_-_46894380 0.687 NM_001130918
TTLL6
tubulin tyrosine ligase-like family, member 6
chr11_+_65292526 0.684 NM_001048218
NM_020680
SCYL1

SCY1-like 1 (S. cerevisiae)

chr4_-_122148620 0.683 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr7_-_104567089 0.682 LOC723809
uncharacterized LOC723809
chr10_+_75673346 0.679 PLAU
plasminogen activator, urokinase
chr3_-_121379757 0.675 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr16_-_1821503 0.673 NME3
non-metastatic cells 3, protein expressed in
chr17_-_74483806 0.673 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr3_+_72937168 0.673 NM_001080393
GXYLT2
glucoside xylosyltransferase 2
chr6_+_36916038 0.672 NM_001199159
PI16
peptidase inhibitor 16
chr5_+_149569519 0.671 NM_014228
SLC6A7
solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
chr9_-_112970412 0.670 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr2_-_85637473 0.669 CAPG
capping protein (actin filament), gelsolin-like
chr2_+_102770401 0.661 NM_000877
IL1R1
interleukin 1 receptor, type I
chr1_+_10490774 0.649 NM_001243768
APITD1-CORT
APITD1-CORT readthrough
chr1_-_155177685 0.649 NM_001252607
NM_001252608
NM_007112
THBS3


thrombospondin 3


chr16_-_28634873 0.643 NM_177536
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr20_+_25176333 0.642 NM_001114089
NM_001247
ENTPD6

ectonucleoside triphosphate diphosphohydrolase 6 (putative)

chr8_+_54764367 0.637 NM_170587
RGS20
regulator of G-protein signaling 20
chr13_-_46679143 0.632 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr17_+_7284292 0.631 NM_001251902
NM_003985
TNK1

tyrosine kinase, non-receptor, 1

chr1_-_26644755 0.627 NM_145345
UBXN11
UBX domain protein 11
chr17_-_40337384 0.623 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr1_-_89488412 0.621 NM_018284
GBP3
guanylate binding protein 3
chr9_+_42717233 0.615 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr22_-_36635552 0.612 APOL2
apolipoprotein L, 2
chr10_+_114135965 0.608 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_-_97563830 0.599 NM_016490
FAM178B
family with sequence similarity 178, member B
chr20_+_18488167 0.589 NM_006363
NM_032985
NM_032986
NM_001172746
SEC23B



Sec23 homolog B (S. cerevisiae)



chr2_-_85637486 0.586 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr17_+_25958257 0.585 LGALS9
lectin, galactoside-binding, soluble, 9
chr17_+_53828440 0.583 NM_001102402
PCTP
phosphatidylcholine transfer protein
chr6_+_29913400 0.581


chr12_-_6798528 0.579 NM_133476
ZNF384
zinc finger protein 384
chr9_+_103191795 0.575 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr6_-_24877453 0.573 NM_015864
FAM65B
family with sequence similarity 65, member B
chr1_+_209848659 0.572 NM_015714
G0S2
G0/G1switch 2
chr17_+_25958151 0.571 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr12_-_53614121 0.569 NM_001042728
NM_001243732
RARG

retinoic acid receptor, gamma

chr3_-_46068978 0.564 NM_001024644
NM_005283
XCR1

chemokine (C motif) receptor 1

chr1_-_28503454 0.556 NM_000952
NM_001164723
PTAFR

platelet-activating factor receptor

chr4_-_185747051 0.552 ACSL1
acyl-CoA synthetase long-chain family member 1
chr6_+_31553955 0.551 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr1_-_184723952 0.549 EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr11_+_36317724 0.544 NM_001160167
PRR5L
proline rich 5 like
chr1_+_158259558 0.541 NM_001765
CD1C
CD1c molecule
chr1_+_203444882 0.532 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chrX_-_119249774 0.530 NM_139282
RHOXF1
Rhox homeobox family, member 1
chr9_-_70178814 0.529 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr10_+_122216465 0.514 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr7_-_107880492 0.513 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr20_+_3190055 0.511 NM_033453
NM_181493
ITPA

inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

chr15_+_59359061 0.510 RNF111
ring finger protein 111
chr1_+_159409511 0.509 NM_012351
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr11_+_57435458 0.509 NM_015457
ZDHHC5
zinc finger, DHHC-type containing 5
chr9_-_70429730 0.505 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr19_+_46498338 0.505 NM_001080402
CCDC61
coiled-coil domain containing 61
chr2_-_88427535 0.503 NM_001443
FABP1
fatty acid binding protein 1, liver
chrX_+_8432870 0.502 NM_001001888
VCX3B
VCX3A
variable charge, X-linked 3B
variable charge, X-linked 3A
chr19_-_10491172 0.497 TYK2
tyrosine kinase 2
chr5_+_179247841 0.497 NM_003900
SQSTM1
sequestosome 1
chr1_-_89591685 0.494 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr1_+_111413820 0.492 NM_001040033
CD53
CD53 molecule
chr1_+_203444955 0.488 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr21_+_45725058 0.488 PFKL
phosphofructokinase, liver
chr12_+_54519836 0.487 LOC400043
uncharacterized LOC400043
chr19_-_42636559 0.485 NM_001207025
NM_001207026
NM_001247994
NM_002698
POU2F2



POU class 2 homeobox 2



chr19_+_46498695 0.484 CCDC61
coiled-coil domain containing 61
chr18_+_74961925 0.482 NM_001480
GALR1
galanin receptor 1
chr16_-_2031359 0.481 NM_144603
NOXO1
NADPH oxidase organizer 1
chr18_+_77441429 0.478 NM_001202504
CTDP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr19_+_50354417 0.478 PTOV1
prostate tumor overexpressed 1
chr2_+_17721806 0.477 NM_003385
VSNL1
visinin-like 1
chr12_+_6881669 0.475 NM_002286
LAG3
lymphocyte-activation gene 3
chr11_+_74862031 0.469 NM_001145212
NM_007256
SLCO2B1

solute carrier organic anion transporter family, member 2B1

chr17_-_39023461 0.467 NM_000223
KRT12
keratin 12
chr12_-_6484557 0.467 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr17_+_32646058 0.465 NM_005623
CCL8
chemokine (C-C motif) ligand 8
chrX_+_47077426 0.464 NM_033018
CDK16
cyclin-dependent kinase 16
chr1_-_170043608 0.462 NM_001204514
NM_001204516
NM_014970
KIFAP3


kinesin-associated protein 3


chr20_+_53092131 0.460 NM_018431
DOK5
docking protein 5
chr7_-_99381703 0.460 NM_001202855
NM_017460
CYP3A4

cytochrome P450, family 3, subfamily A, polypeptide 4

chr17_+_78161598 0.459 NM_052819
CARD14
caspase recruitment domain family, member 14
chr7_+_143078358 0.454 NM_001010972
NM_003461
ZYX

zyxin

chr3_+_130612806 0.454 NM_001199179
NM_001001485
NM_001199183
NM_001199184
NM_001199185
NM_014382
NM_001001486
NM_001001487
ATP2C1







ATPase, Ca++ transporting, type 2C, member 1







chr16_+_50775960 0.453 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr21_-_45660699 0.452 NM_015259
ICOSLG
inducible T-cell co-stimulator ligand
chr6_+_36646455 0.448 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr11_-_8954534 0.445 NM_020643
C11orf16
chromosome 11 open reading frame 16
chr5_+_179248089 0.444 SQSTM1
sequestosome 1
chr20_-_23807297 0.443 NM_001322
CST2
cystatin SA
chr6_-_31981049 0.443 NM_032470
TNXB
tenascin XB
chr9_+_140500054 0.437 NM_152285
ARRDC1
arrestin domain containing 1
chr7_-_97501424 0.434 NM_001178077
NM_133436
ASNS

asparagine synthetase (glutamine-hydrolyzing)

chr6_+_31588460 0.432 PRRC2A
proline-rich coiled-coil 2A
chr3_+_39509069 0.432 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr15_+_89631625 0.431 ABHD2
abhydrolase domain containing 2
chr11_+_47430045 0.428 NM_001128225
NM_152264
SLC39A13

solute carrier family 39 (zinc transporter), member 13

chr19_+_19322763 0.422 NM_004386
NCAN
neurocan
chr19_-_10491212 0.420 NM_003331
TYK2
tyrosine kinase 2
chr14_-_23834417 0.418 EFS
embryonal Fyn-associated substrate
chr22_-_18507151 0.417 NM_001122731
NM_001136004
NM_015241
MICAL3


microtubule associated monoxygenase, calponin and LIM domain containing 3


chr15_-_75017710 0.415 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr17_+_6659356 0.414 XAF1
XIAP associated factor 1
chr4_-_80994309 0.414 NM_001145794
NM_058172
ANTXR2

anthrax toxin receptor 2

chr4_-_48014960 0.413 NM_000087
CNGA1
cyclic nucleotide gated channel alpha 1
chr11_+_71259465 0.406 NM_005553
KRTAP5-9
keratin associated protein 5-9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
14.99 4.11e-05 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
13.32 1.76e-04 GO:0048880 sensory system development
13.32 1.76e-04 GO:0048892 lateral line nerve development
13.32 1.76e-04 GO:0048895 lateral line nerve glial cell differentiation
13.32 1.76e-04 GO:0048925 lateral line system development
13.32 1.76e-04 GO:0048937 lateral line nerve glial cell development
13.32 1.76e-04 GO:0050935 iridophore differentiation
9.14 1.40e-03 GO:0048485 sympathetic nervous system development
10.90 1.45e-03 GO:0060600 dichotomous subdivision of an epithelial terminal unit
1.18 2.55e-03 GO:0065007 biological regulation
9.99 3.30e-03 GO:0048846 axon extension involved in axon guidance
9.99 3.30e-03 GO:0090184 positive regulation of kidney development
1.18 6.77e-03 GO:0050789 regulation of biological process
7.99 2.30e-02 GO:0030513 positive regulation of BMP signaling pathway
7.99 2.30e-02 GO:0048484 enteric nervous system development
6.53 3.23e-02 GO:0030318 melanocyte differentiation
6.53 3.23e-02 GO:0050931 pigment cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 1.36e-02 GO:0044459 plasma membrane part
2.22 3.25e-02 GO:0034702 ion channel complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.05 7.52e-03 GO:0008301 DNA bending activity
3.00 2.56e-02 GO:0016566 specific transcriptional repressor activity