Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 1.707


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HOXB7chr17_-_466879250.817.9e-07Click!
HOXA7chr7_-_271961630.681.8e-04Click!
HOXB6chr17_-_46682333-0.358.6e-02Click!
HOXA6chr7_-_271873670.331.0e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_14086901 31.534 NFIB
nuclear factor I/B
chr1_+_61869699 20.504 NFIA
nuclear factor I/A
chr1_+_84630575 16.138 NM_001242860
NM_001242861
 PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr1_+_84630014 13.228 NM_001242857
NM_001242858
NM_001242859
 PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr5_-_88119604 13.158 NM_001193348
NM_001193349
 MEF2C

myocyte enhancer factor 2C

chr4_+_41614725 12.921 LIMCH1
LIM and calponin homology domains 1
chr4_+_41614911 12.479 NM_001112719
NM_001112720
 LIMCH1

LIM and calponin homology domains 1

chr4_+_41614933 12.047 LIMCH1
LIM and calponin homology domains 1
chr5_-_88199868 11.429 NM_001131005
NM_001193347
 MEF2C

myocyte enhancer factor 2C

chr4_-_186877869 9.282 NM_021069
 SORBS2
sorbin and SH3 domain containing 2
chr4_+_41700736 8.931 LIMCH1
LIM and calponin homology domains 1
chr3_-_64211111 8.079 NM_198859
 PRICKLE2
prickle homolog 2 (Drosophila)
chr1_+_84630374 7.782 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_-_27183225 7.186 NM_019102
 HOXA5
homeobox A5
chr8_-_93107442 7.175 NM_001198629
NM_001198630
NM_001198632
NM_175635
 RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr1_+_61547388 6.550 NM_001145512
 NFIA
nuclear factor I/A
chr14_-_54423448 6.538 NM_001202
NM_130850
 BMP4

bone morphogenetic protein 4

chr18_-_53089722 6.461 NM_001243233
 TCF4
transcription factor 4
chr1_+_100111430 6.451 NM_017734
 PALMD
palmdelphin
chr4_-_186733372 6.374 NM_003603
NM_001145670
 SORBS2

sorbin and SH3 domain containing 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 76 entries
enrichment   p-value GO term description
2.78 4.10e-02 GO:0045639 positive regulation of myeloid cell differentiation
2.41 3.55e-03 GO:0048706 embryonic skeletal system development
2.32 9.09e-03 GO:0045637 regulation of myeloid cell differentiation
1.99 2.26e-03 GO:0009952 anterior/posterior pattern formation
1.94 5.29e-05 GO:0003002 regionalization
1.81 3.65e-05 GO:0001501 skeletal system development
1.75 3.11e-05 GO:0009792 embryo development ending in birth or egg hatching
1.75 3.42e-05 GO:0043009 chordate embryonic development
1.67 2.24e-03 GO:0007389 pattern specification process
1.65 6.50e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.60 6.54e-04 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.58 1.65e-05 GO:0045893 positive regulation of transcription, DNA-dependent
1.58 2.09e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.58 2.17e-04 GO:0051253 negative regulation of RNA metabolic process
1.57 1.12e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
1.57 3.28e-02 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.56 1.33e-05 GO:0010628 positive regulation of gene expression
1.54 5.27e-07 GO:0009891 positive regulation of biosynthetic process
1.54 6.53e-07 GO:0031328 positive regulation of cellular biosynthetic process
1.53 2.66e-02 GO:0032583 regulation of gene-specific transcription

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
1.99 1.58e-02 GO:0030055 cell-substrate junction
1.77 4.80e-02 GO:0005912 adherens junction
1.75 3.29e-02 GO:0070161 anchoring junction
1.66 1.36e-02 GO:0016323 basolateral plasma membrane
1.48 4.08e-02 GO:0009986 cell surface
1.46 1.12e-03 GO:0030054 cell junction
1.23 9.54e-04 GO:0044459 plasma membrane part
1.11 2.00e-02 GO:0005634 nucleus
1.05 1.87e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.54 5.36e-06 GO:0043565 sequence-specific DNA binding
1.52 2.08e-02 GO:0003712 transcription cofactor activity
1.51 2.32e-02 GO:0000988 protein binding transcription factor activity
1.51 2.32e-02 GO:0000989 transcription factor binding transcription factor activity
1.48 2.14e-07 GO:0001071 nucleic acid binding transcription factor activity
1.48 2.14e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.46 6.88e-04 GO:0005509 calcium ion binding
1.39 9.59e-05 GO:0030528 transcription regulator activity
1.31 2.18e-02 GO:0005102 receptor binding
1.12 6.00e-06 GO:0005515 protein binding
1.05 3.04e-02 GO:0005488 binding