Motif ID: IKZF1.p2

Z-value: 1.399


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
IKZF1chr7_+_503442550.654.1e-04Click!


Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_49259549 8.147 NM_014470
RND1
Rho family GTPase 1
chr19_+_10381763 8.054 ICAM1
intercellular adhesion molecule 1
chr1_+_101185195 7.936 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr19_+_10381516 6.650 NM_000201
ICAM1
intercellular adhesion molecule 1
chr16_-_11680146 6.596 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr15_+_67418053 5.019 NM_001145102
SMAD3
SMAD family member 3
chr15_+_67358194 4.294 NM_005902
SMAD3
SMAD family member 3
chr4_-_74864296 4.237 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr1_-_120612175 4.227 NOTCH2
notch 2
chr1_-_120612019 4.160 NOTCH2
notch 2
chr1_-_120612260 4.132 NOTCH2
notch 2
chr6_-_32821592 4.096 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_169703178 3.918 NM_000450
SELE
selectin E
chr6_-_32821743 3.898 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_120612301 3.892 NM_001200001
NM_024408
NOTCH2

notch 2

chr15_+_67358161 3.858 SMAD3
SMAD family member 3
chr1_+_206643786 3.640 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr1_+_145209067 3.602 NM_203458
NOTCH2NL
notch 2 N-terminal like
chr17_+_40440481 3.392 STAT5A
signal transducer and activator of transcription 5A
chr6_-_32821412 3.181 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_+_206643585 2.987 NM_001193321
NM_001193322
NM_014002
IKBKE


inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon


chr3_+_53195214 2.916 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr1_+_209848659 2.904 NM_015714
G0S2
G0/G1switch 2
chr5_+_125758818 2.748 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr21_+_27012067 2.680 JAM2
junctional adhesion molecule 2
chr1_+_206643830 2.675 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr4_-_120549115 2.673 NM_033437
PDE5A
phosphodiesterase 5A, cGMP-specific
chr21_+_27011766 2.641 JAM2
junctional adhesion molecule 2
chr5_-_35938736 2.600 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr21_+_37507209 2.573 NM_001236
CBR3
carbonyl reductase 3
chr19_+_496453 2.472 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr5_+_125759076 2.397 GRAMD3
GRAM domain containing 3
chr6_-_33168448 2.328 RXRB
retinoid X receptor, beta
chr6_+_126070895 2.320 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr12_-_322612 2.266 NM_003044
NM_001122847
SLC6A12

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

chr1_-_209825797 2.233 NM_000228
LAMB3
laminin, beta 3
chr1_+_183155173 2.114 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr10_+_104155431 2.083 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr19_+_19322763 2.080 NM_004386
NCAN
neurocan
chr12_+_52626953 2.071 NM_005556
KRT7
keratin 7
chr3_-_127541160 2.057 NM_007283
MGLL
monoglyceride lipase
chr1_-_95007139 1.962 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr16_+_23690234 1.895 PLK1
polo-like kinase 1
chr9_+_115913266 1.841 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr1_-_51787881 1.829 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr12_+_52627007 1.817 KRT7
keratin 7
chr1_-_209825673 1.814 NM_001127641
LAMB3
laminin, beta 3
chr5_-_131563481 1.806 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr9_+_115913227 1.801 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr2_+_97202463 1.780 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr8_+_90769974 1.746 NM_003821
RIPK2
receptor-interacting serine-threonine kinase 2
chr21_-_37914897 1.739 NM_001146078
CLDN14
claudin 14
chr5_-_16936290 1.732 MYO10
myosin X
chr6_+_18155535 1.730 NM_153042
KDM1B
lysine (K)-specific demethylase 1B
chr22_-_19512859 1.722 NM_001130861
NM_003277
CLDN5

claudin 5

chr8_-_23261632 1.722 LOXL2
lysyl oxidase-like 2
chr22_+_37309618 1.702 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr9_-_21994379 1.662 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr14_+_55221505 1.616 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr4_-_74904329 1.616 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr4_-_122085475 1.603 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr15_+_66679107 1.601 NM_002755
MAP2K1
mitogen-activated protein kinase kinase 1
chr21_+_27012045 1.600 JAM2
junctional adhesion molecule 2
chr16_+_23690212 1.598 PLK1
polo-like kinase 1
chr3_-_127541975 1.550 NM_001003794
MGLL
monoglyceride lipase
chr14_+_103589711 1.522 TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr8_+_145065366 1.507 GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr19_+_45582469 1.495 NM_001007270
NM_001007269
NM_024707
GEMIN7


gem (nuclear organelle) associated protein 7


chr9_-_21994329 1.484 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr3_-_107809754 1.476 NM_001777
NM_198793
CD47

CD47 molecule

chr18_+_55714457 1.461 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr15_+_66694216 1.461 MAP2K1
mitogen-activated protein kinase kinase 1
chr6_+_144471631 1.447 NM_003764
STX11
syntaxin 11
chr10_+_111767877 1.443 ADD3
adducin 3 (gamma)
chr6_+_36646455 1.441 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr11_-_72380107 1.436 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr10_+_96305521 1.412 NM_018063
HELLS
helicase, lymphoid-specific
chr6_+_126070738 1.408 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr16_+_50776012 1.402 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr8_-_23261626 1.397 LOXL2
lysyl oxidase-like 2
chr12_+_102271349 1.387 DRAM1
DNA-damage regulated autophagy modulator 1
chr2_+_150186498 1.387 NM_001195685
LYPD6
LY6/PLAUR domain containing 6
chr2_-_11810254 1.376 NM_012344
NTSR2
neurotensin receptor 2
chr15_+_71839540 1.369 THSD4
thrombospondin, type I, domain containing 4
chr1_+_165797060 1.367 UCK2
uridine-cytidine kinase 2
chr11_+_62649160 1.350 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr3_+_46448678 1.339 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr8_-_23261591 1.327 LOXL2
lysyl oxidase-like 2
chr9_-_136344182 1.316 NM_001145099
NM_017585
SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr4_+_140222668 1.310 NM_057175
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr9_-_123676849 1.310 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr7_-_99698916 1.297 MCM7
minichromosome maintenance complex component 7
chr9_-_21994414 1.286 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr13_+_25254548 1.262 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr5_+_14488523 1.258 TRIO
triple functional domain (PTPRF interacting)
chr16_+_56703725 1.254 NM_005951
MT1H
metallothionein 1H
chr21_-_45660699 1.247 NM_015259
ICOSLG
inducible T-cell co-stimulator ligand
chr8_-_125740650 1.229 NM_014751
MTSS1
metastasis suppressor 1
chr8_-_63951353 1.225 GGH
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
chr8_+_23386468 1.215 SLC25A37
solute carrier family 25, member 37
chr6_+_30227335 1.212 HLA-L
major histocompatibility complex, class I, L, pseudogene
chr9_+_100174369 1.205 TDRD7
tudor domain containing 7
chr13_-_102068705 1.199 NM_052867
NALCN
sodium leak channel, non-selective
chr1_-_935352 1.185 HES4
hairy and enhancer of split 4 (Drosophila)
chr19_-_10514242 1.181 NM_007065
CDC37
cell division cycle 37 homolog (S. cerevisiae)
chr9_+_103189494 1.171 NM_001198807
NM_080655
NM_001198805
C9orf30


chromosome 9 open reading frame 30


chr15_-_72522062 1.161 NM_001206799
PKM2
pyruvate kinase, muscle
chr8_-_63951609 1.158 NM_003878
GGH
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
chr1_-_184943673 1.157 NM_052966
FAM129A
family with sequence similarity 129, member A
chr14_+_96671015 1.154 NM_000623
BDKRB2
bradykinin receptor B2
chr15_-_23086290 1.148 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr21_+_25801042 1.148 FLJ42200
FLJ42200 protein
chr8_+_126442557 1.136 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr21_-_37852387 1.133 NM_001146079
NM_144492
CLDN14

claudin 14

chr17_+_40439564 1.129 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr12_-_51422012 1.127 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr16_+_56659679 1.113 MT1E
metallothionein 1E
chr15_-_62457481 1.106 NM_001007595
C2CD4B
C2 calcium-dependent domain containing 4B
chr1_+_205197031 1.102 NM_014858
TMCC2
transmembrane and coiled-coil domain family 2
chr16_+_23690160 1.095 PLK1
polo-like kinase 1
chr8_-_12612968 1.094 NM_152271
LONRF1
LON peptidase N-terminal domain and ring finger 1
chr11_+_102217915 1.093 BIRC2
baculoviral IAP repeat containing 2
chr6_-_32160289 1.086 GPSM3
G-protein signaling modulator 3
chr17_+_46184910 1.085 NM_152244
NM_013323
SNX11

sorting nexin 11

chr12_-_89919182 1.083 NM_001199777
POC1B
POC1 centriolar protein homolog B (Chlamydomonas)
chr5_+_76114832 1.081 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr17_+_46185125 1.077 SNX11
sorting nexin 11
chr4_-_120548329 1.070 NM_033430
PDE5A
phosphodiesterase 5A, cGMP-specific
chr16_+_56659584 1.070 NM_175617
MT1E
metallothionein 1E
chr3_+_187086167 1.062 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr9_+_33025302 1.059 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr19_+_49109999 1.053 NM_133498
SPACA4
sperm acrosome associated 4
chr11_-_57335756 1.043 NM_198183
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr19_+_39138349 1.037 ACTN4
actinin, alpha 4
chr15_-_23086842 1.029 NM_001142275
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr11_-_3862137 1.028 RHOG
ras homolog gene family, member G (rho G)
chr14_+_55034633 1.018 SAMD4A
sterile alpha motif domain containing 4A
chr14_+_55034329 1.016 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr19_-_10514154 1.015 CDC37
cell division cycle 37 homolog (S. cerevisiae)
chr20_+_44746889 1.013 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr8_+_22224786 1.007 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr16_+_23690191 1.001 NM_005030
PLK1
polo-like kinase 1
chr11_-_10715032 0.996 NM_001100167
MRVI1
murine retrovirus integration site 1 homolog
chr9_+_100174179 0.995 NM_014290
TDRD7
tudor domain containing 7
chr1_+_79086087 0.990 NM_006820
IFI44L
interferon-induced protein 44-like
chr19_-_10514185 0.990 CDC37
cell division cycle 37 homolog (S. cerevisiae)
chr6_+_34204928 0.976 HMGA1
high mobility group AT-hook 1
chr5_+_76114881 0.954 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr6_-_82461857 0.951 FAM46A
family with sequence similarity 46, member A
chr3_+_11178778 0.935 NM_001098213
HRH1
histamine receptor H1
chr8_+_22224758 0.927 NM_001128431
NM_001135154
NM_015359
SLC39A14


solute carrier family 39 (zinc transporter), member 14


chr12_+_64238511 0.924 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr8_-_23261675 0.922 NM_002318
LOXL2
lysyl oxidase-like 2
chr6_+_126070813 0.917 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr16_+_50775960 0.915 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr9_+_33025207 0.908 NM_001539
DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr14_+_23352430 0.904 NM_173527
REM2
RAS (RAD and GEM)-like GTP binding 2
chr10_+_30723050 0.904 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr4_-_47983430 0.898 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr1_+_39456887 0.893 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr3_+_196594757 0.891 SENP5
SUMO1/sentrin specific peptidase 5
chr1_+_27153130 0.891 NM_032283
ZDHHC18
zinc finger, DHHC-type containing 18
chr12_+_55413728 0.889 NM_021191
NEUROD4
neurogenic differentiation 4
chr16_+_27325244 0.886 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr16_+_4714709 0.884 MGRN1
mahogunin, ring finger 1
chr21_+_27011588 0.883 NM_021219
JAM2
junctional adhesion molecule 2
chr16_+_27325269 0.882 IL4R
interleukin 4 receptor
chr19_+_4247049 0.880 NM_018074
CCDC94
coiled-coil domain containing 94
chr9_-_95896498 0.866 NM_004148
NINJ1
ninjurin 1
chr5_-_95768660 0.849 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr1_-_184943532 0.848 FAM129A
family with sequence similarity 129, member A
chr5_+_72861567 0.844 NM_032175
UTP15
UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
chr20_+_56136136 0.838 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_-_25141855 0.836 NM_004036
ADCY3
adenylate cyclase 3
chr6_+_80340971 0.835 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr17_-_32483550 0.832 NM_001094
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr9_+_103191795 0.831 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr20_+_53092131 0.828 NM_018431
DOK5
docking protein 5
chrX_+_152599544 0.816 NM_001080485
ZNF275
zinc finger protein 275
chr17_+_7517263 0.816 SHBG
sex hormone-binding globulin
chr4_-_153456152 0.813 NM_033632
FBXW7
F-box and WD repeat domain containing 7
chr6_-_83903632 0.809 NM_001199917
PGM3
phosphoglucomutase 3
chr17_-_34257285 0.807 NM_001163122
NM_001163124
NM_001163125
NM_001163130
RDM1



RAD52 motif 1



chr11_-_35441501 0.806 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr3_-_58563070 0.803 FAM107A
family with sequence similarity 107, member A
chr2_+_234263153 0.801 DGKD
diacylglycerol kinase, delta 130kDa
chr18_-_23670533 0.801 NM_001007559
NM_005637
SS18

synovial sarcoma translocation, chromosome 18

chr17_+_38137106 0.799 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr10_+_115439425 0.791 NM_001227
NM_033338
NM_033339
CASP7


caspase 7, apoptosis-related cysteine peptidase


chr2_+_234263141 0.788 NM_152879
DGKD
diacylglycerol kinase, delta 130kDa
chr14_+_24605393 0.784 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr19_-_47735858 0.782 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr6_+_31126114 0.778 NM_001077511
NM_007109
TCF19

transcription factor 19

chr17_+_38137081 0.778 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr1_-_101360405 0.778 NM_001033025
NM_001439
EXTL2

exostoses (multiple)-like 2

chr3_-_156272909 0.778 NM_007107
SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr3_+_196594708 0.775 NM_152699
SENP5
SUMO1/sentrin specific peptidase 5
chr16_+_56966025 0.771 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr16_-_67694602 0.770 NM_001082486
NM_001082487
NM_022914
ACD


adrenocortical dysplasia homolog (mouse)


chr17_+_79885567 0.766 LOC92659
uncharacterized LOC92659

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.13 3.99e-10 GO:0009987 cellular process
1.29 2.74e-07 GO:0023052 signaling
1.31 3.33e-07 GO:0007165 signal transduction
1.27 6.67e-07 GO:0051716 cellular response to stimulus
1.15 6.34e-05 GO:0050789 regulation of biological process
1.16 1.09e-04 GO:0050794 regulation of cellular process
1.14 1.43e-04 GO:0065007 biological regulation
1.57 1.08e-03 GO:0007155 cell adhesion
1.57 1.08e-03 GO:0022610 biological adhesion
1.16 1.73e-03 GO:0050896 response to stimulus
1.38 2.07e-03 GO:0007399 nervous system development
1.53 2.75e-03 GO:0044093 positive regulation of molecular function
1.28 3.21e-03 GO:0006950 response to stress
1.60 3.28e-03 GO:0030030 cell projection organization
1.50 6.44e-03 GO:0033554 cellular response to stress
1.22 6.78e-03 GO:0071840 cellular component organization or biogenesis
1.32 7.36e-03 GO:0007166 cell surface receptor linked signaling pathway
1.65 1.11e-02 GO:0048858 cell projection morphogenesis
1.22 1.26e-02 GO:0016043 cellular component organization
1.63 1.58e-02 GO:0032990 cell part morphogenesis
1.67 1.88e-02 GO:0048812 neuron projection morphogenesis
1.24 2.02e-02 GO:0048518 positive regulation of biological process
1.26 2.65e-02 GO:0048522 positive regulation of cellular process
1.44 3.01e-02 GO:0048468 cell development
1.67 3.52e-02 GO:0007409 axonogenesis
1.65 3.53e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.45 4.45e-02 GO:0048699 generation of neurons
1.43 4.93e-02 GO:0022008 neurogenesis
1.50 4.99e-02 GO:0043085 positive regulation of catalytic activity

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 5.25e-06 GO:0044459 plasma membrane part
1.39 7.89e-04 GO:0031226 intrinsic to plasma membrane
1.47 1.47e-03 GO:0042995 cell projection
1.28 2.65e-03 GO:0005829 cytosol
1.37 4.41e-03 GO:0005887 integral to plasma membrane
1.95 1.90e-02 GO:0030424 axon
1.58 4.88e-02 GO:0043005 neuron projection

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.16 3.76e-06 GO:0005515 protein binding
1.06 3.43e-02 GO:0005488 binding