Motif ID: IKZF2.p2

Z-value: 0.791


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
IKZF2chr2_-_214016332-0.223.0e-01Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_101185195 1.791 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr21_+_26934440 1.452 MIR155HG
MIR155 host gene (non-protein coding)
chr2_+_228678556 1.429 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr8_-_6420454 1.180 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr3_+_112051914 1.043 NM_001004196
NM_005944
CD200

CD200 molecule

chr6_+_106546736 1.040 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr2_+_128928040 1.007 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr1_+_100111430 0.986 NM_017734
PALMD
palmdelphin
chr6_-_143266283 0.958 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chrX_-_117119282 0.923 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr3_+_46448678 0.917 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr20_-_62436855 0.883 NM_025224
ZBTB46
zinc finger and BTB domain containing 46
chr19_+_11200124 0.875 LDLR
low density lipoprotein receptor
chr17_-_67138013 0.873 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr11_-_33890931 0.854 LMO2
LIM domain only 2 (rhombotin-like 1)
chr3_-_149051258 0.840 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr2_-_28113954 0.836 LOC100302650
uncharacterized LOC100302650
chr4_-_101439071 0.790 NM_001159694
NM_016242
EMCN

endomucin

chr6_-_10412606 0.764 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr10_-_116444374 0.721 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr1_+_47489239 0.697 NM_178033
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr17_-_8424217 0.685 MYH10
myosin, heavy chain 10, non-muscle
chr17_-_38938785 0.684 NM_181537
KRT27
keratin 27
chr19_+_11200146 0.680 LDLR
low density lipoprotein receptor
chr4_-_159093523 0.680 FAM198B
family with sequence similarity 198, member B
chrX_-_135863104 0.678 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr5_+_43609261 0.674 NNT
nicotinamide nucleotide transhydrogenase
chr1_-_57045235 0.667 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr7_+_94024201 0.656 COL1A2
collagen, type I, alpha 2
chr12_-_49259549 0.650 NM_014470
RND1
Rho family GTPase 1
chr18_-_53089722 0.648 NM_001243233
TCF4
transcription factor 4
chr8_+_39771327 0.647 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr17_-_66951381 0.636 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr4_+_74702272 0.630 NM_002993
CXCL6
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chr14_+_64680858 0.611 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr1_-_155948934 0.591 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr5_-_146460991 0.580 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr1_-_57045214 0.576 PPAP2B
phosphatidic acid phosphatase type 2B
chr10_+_73555527 0.574 NM_001171933
NM_001171934
CDH23

cadherin-related 23

chr2_+_189839132 0.571 COL3A1
collagen, type III, alpha 1
chr9_+_12774988 0.566 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr5_-_111091947 0.566 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr15_+_75550898 0.565 NM_001164404
GOLGA6A
GOLGA6C
golgin A6 family, member A
golgin A6 family, member C
chr9_+_132897342 0.551 GPR107
G protein-coupled receptor 107
chr3_+_112052020 0.549 CD200
CD200 molecule
chr1_+_61869699 0.543 NFIA
nuclear factor I/A
chr9_+_92219926 0.543 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr2_+_189839078 0.526 NM_000090
COL3A1
collagen, type III, alpha 1
chr10_+_35484829 0.517 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr5_-_16738346 0.516 MYO10
myosin X
chr21_-_27945267 0.512 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr6_+_155411422 0.504 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chrX_-_135863033 0.498 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr8_-_17942304 0.497 ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr1_+_84647342 0.486 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chrX_+_135251454 0.484 NM_001159704
FHL1
four and a half LIM domains 1
chr8_+_90770201 0.477 RIPK2
receptor-interacting serine-threonine kinase 2
chr5_-_140013034 0.473 NM_000591
CD14
CD14 molecule
chr14_+_39649711 0.471 PNN
pinin, desmosome associated protein
chr6_+_106534188 0.458 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr10_+_35426709 0.457 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr3_-_187452669 0.448 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr11_-_33891258 0.447 LMO2
LIM domain only 2 (rhombotin-like 1)
chr15_-_59665053 0.443 MYO1E
myosin IE
chr4_-_16900348 0.437 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr7_+_102553343 0.428 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr4_-_159093717 0.427 NM_016613
FAM198B
family with sequence similarity 198, member B
chr5_+_140602914 0.425 NM_018934
PCDHB14
protocadherin beta 14
chrX_+_135730335 0.423 NM_000074
CD40LG
CD40 ligand
chr22_-_43343046 0.421 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr19_-_14992166 0.416 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr22_+_33196801 0.415 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr10_-_116444112 0.413 ABLIM1
actin binding LIM protein 1
chr19_+_36727325 0.410 ZNF146
zinc finger protein 146
chr12_+_21168629 0.408 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chrX_-_63005212 0.402 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr6_-_154831652 0.395 CNKSR3
CNKSR family member 3
chr18_-_53071225 0.395 NM_001243232
TCF4
transcription factor 4
chr15_-_59665069 0.392 NM_004998
MYO1E
myosin IE
chr5_+_140809957 0.389 PCDHGA12
protocadherin gamma subfamily A, 12
chr3_-_27764197 0.388 EOMES
eomesodermin
chr20_-_17641122 0.387 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr7_+_150690838 0.385 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr8_+_90769974 0.383 NM_003821
RIPK2
receptor-interacting serine-threonine kinase 2
chr2_+_169923531 0.382 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_-_234743488 0.379 IRF2BP2
interferon regulatory factor 2 binding protein 2
chr10_-_21435487 0.378 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr12_-_7848324 0.374 NM_020634
GDF3
growth differentiation factor 3
chr1_-_173020011 0.370 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr8_+_75896707 0.368 NM_031461
CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr4_-_70725792 0.367 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr17_+_26369935 0.364 NLK
nemo-like kinase
chr5_+_32173481 0.359 LOC153546
uncharacterized LOC153546
chr1_-_155649597 0.354 NM_001198899
YY1AP1
YY1 associated protein 1
chr4_+_134070443 0.351 NM_020815
NM_032961
PCDH10

protocadherin 10

chr14_-_73453651 0.350 NM_178441
ZFYVE1
zinc finger, FYVE domain containing 1
chr3_+_9476506 0.349


chr10_+_35464514 0.349 NM_182769
NM_182770
CREM

cAMP responsive element modulator

chrX_+_100333835 0.347 NM_021637
TMEM35
transmembrane protein 35
chr14_+_63671101 0.347 NM_020663
RHOJ
ras homolog gene family, member J
chr17_+_26369617 0.343 NM_016231
NLK
nemo-like kinase
chr5_-_78282356 0.342 NM_000046
ARSB
arylsulfatase B
chr7_+_28452143 0.341 NM_182898
CREB5
cAMP responsive element binding protein 5
chr14_-_54423448 0.339 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr14_-_107099379 0.336 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr5_-_16742336 0.335 MYO10
myosin X
chr3_-_18480203 0.334 NM_001131010
SATB1
SATB homeobox 1
chr5_-_32388595 0.333 ZFR
zinc finger RNA binding protein
chr12_-_71551564 0.333 TSPAN8
tetraspanin 8
chr7_+_93551015 0.333 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chrX_+_70765479 0.332 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr1_+_61547388 0.332 NM_001145512
NFIA
nuclear factor I/A
chr5_-_111093792 0.331 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr4_-_186733372 0.328 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr11_-_33891361 0.328 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_8892909 0.326 ST5
suppression of tumorigenicity 5
chr3_-_172241060 0.326 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr1_-_110155672 0.326 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr6_-_46825942 0.324 GPR116
G protein-coupled receptor 116
chr19_+_7049349 0.324 NM_144614
MBD3L2
methyl-CpG binding domain protein 3-like 2
chr6_-_154831704 0.322 NM_173515
CNKSR3
CNKSR family member 3
chr6_-_76203256 0.322 NM_015687
FILIP1
filamin A interacting protein 1
chr11_+_122526339 0.321 NM_032873
UBASH3B
ubiquitin associated and SH3 domain containing B
chr12_-_50616425 0.319 NM_001113547
LIMA1
LIM domain and actin binding 1
chr4_-_186577858 0.318 SORBS2
sorbin and SH3 domain containing 2
chr8_-_17555158 0.318 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr1_+_33004969 0.314 ZBTB8A
zinc finger and BTB domain containing 8A
chr7_+_94297448 0.314 PEG10
paternally expressed 10
chr2_+_189839113 0.311 COL3A1
collagen, type III, alpha 1
chr10_-_121602030 0.311 MCMBP
minichromosome maintenance complex binding protein
chrX_-_102565805 0.310 NM_001168399
NM_001168400
NM_001168401
NM_032621
BEX2



brain expressed X-linked 2



chr4_+_41700736 0.308 LIMCH1
LIM and calponin homology domains 1
chr11_+_114167197 0.308 NNMT
nicotinamide N-methyltransferase
chr5_-_138211054 0.307 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr21_-_35899046 0.306 NM_203418
RCAN1
regulator of calcineurin 1
chr22_+_50528307 0.305 NM_001164104
NM_018995
MOV10L1

Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)

chr8_+_123794043 0.303 ZHX2
zinc fingers and homeoboxes 2
chr11_+_114167168 0.301 NNMT
nicotinamide N-methyltransferase
chr1_+_65886315 0.298 NM_001003679
NM_001003680
NM_002303
NM_001198681
LEPR


LEPROT
leptin receptor


leptin receptor overlapping transcript
chr12_+_93963597 0.297 NM_003877
SOCS2
suppressor of cytokine signaling 2
chr13_+_36050885 0.295 NM_001204197
NBEA
neurobeachin
chr2_+_234296799 0.294 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr1_+_84630575 0.293 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr11_-_65314049 0.291 LTBP3
latent transforming growth factor beta binding protein 3
chr5_-_42811959 0.291 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr18_+_77155714 0.291 NM_006162
NM_172388
NM_172390
NFATC1


nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1


chr7_+_112092112 0.288 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr2_-_101767714 0.288 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr1_+_33004771 0.288 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chrX_+_135251795 0.284 NM_001167819
FHL1
four and a half LIM domains 1
chr12_-_56321658 0.280 WIBG
within bgcn homolog (Drosophila)
chrX_-_135863502 0.278 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr17_-_53800074 0.277 NM_018286
TMEM100
transmembrane protein 100
chr4_+_156680125 0.277 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr11_-_71746966 0.277


chr9_-_107690336 0.276 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr11_+_101983170 0.276 NM_001195045
YAP1
Yes-associated protein 1
chr8_+_17396285 0.273 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr1_+_24645914 0.272 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr2_-_165551178 0.269 COBLL1
COBL-like 1
chr1_-_21377452 0.268 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr10_+_97515408 0.267 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr10_-_74283693 0.266 NM_001195519
MICU1
mitochondrial calcium uptake 1
chr1_-_67266930 0.263 NM_005478
INSL5
insulin-like 5
chr5_+_140557370 0.263 NM_019120
PCDHB8
protocadherin beta 8
chr18_-_22930826 0.262


chr2_+_48796158 0.262 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr17_-_17740288 0.260 SREBF1
sterol regulatory element binding transcription factor 1
chr3_-_187454247 0.260 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr17_-_35656691 0.260 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chrX_+_28605558 0.260 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr19_-_14260728 0.260 LPHN1
latrophilin 1
chr3_+_149192367 0.259 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chrX_-_117107700 0.259 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr1_+_84630014 0.259 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr10_+_35416089 0.258 CREM
cAMP responsive element modulator
chr1_+_212475147 0.256 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr1_+_226016428 0.255 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chrX_+_135230736 0.255 NM_001159700
FHL1
four and a half LIM domains 1
chr5_-_140012730 0.255 CD14
CD14 molecule
chr6_+_155538096 0.254 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr1_-_57045129 0.254 PPAP2B
phosphatidic acid phosphatase type 2B
chr22_-_43355886 0.253 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr3_-_112358510 0.253 CCDC80
coiled-coil domain containing 80
chr4_+_95376396 0.252 PDLIM5
PDZ and LIM domain 5
chr8_-_117023 0.251 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr14_-_23284565 0.249 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chrX_-_119249774 0.249 NM_139282
RHOXF1
Rhox homeobox family, member 1
chr5_+_140810126 0.248 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr1_-_154928595 0.248 PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr7_+_1126442 0.247 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr2_+_27301693 0.247 EMILIN1
elastin microfibril interfacer 1
chr7_+_112063131 0.246 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr14_-_23284617 0.245 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chrX_+_135278912 0.244 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr16_-_71748697 0.242 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr13_+_97794050 0.240 MBNL2
muscleblind-like 2 (Drosophila)
chr6_-_68598987 0.240 ERVH-3
endogenous retrovirus group H, member 3
chr5_+_31799030 0.239 NM_178140
PDZD2
PDZ domain containing 2
chr7_-_108142934 0.239 PNPLA8
patatin-like phospholipase domain containing 8

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.55 1.26e-03 GO:0007155 cell adhesion
1.55 1.26e-03 GO:0022610 biological adhesion
1.37 1.27e-02 GO:0002376 immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.93 2.67e-02 GO:0070161 anchoring junction
1.96 3.63e-02 GO:0005912 adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 3.66e-03 GO:0005515 protein binding