Motif ID: IRF1,2,7.p3

Z-value: 10.966


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
IRF7chr11_-_615998,
chr11_-_615649		0.921.1e-10Click!
IRF2chr4_-_1853956160.536.0e-03Click!
IRF1chr5_-_1318264260.385.8e-02Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_79086087 162.424 NM_006820
 IFI44L
interferon-induced protein 44-like
chr10_+_91087601 119.038 NM_001549
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr12_+_113376001 118.809 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr10_+_91152321 118.540 NM_001548
 IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr10_+_91092238 117.946 NM_001031683
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr6_-_29527701 115.439 NM_006398
 UBD
ubiquitin D
chr2_-_7005764 113.141 NM_207315
 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr6_-_29527477 111.327 UBD
ubiquitin D
chr4_-_76944585 106.843 NM_001565
 CXCL10
chemokine (C-X-C motif) ligand 10
chr21_+_42792441 101.777 NM_001144925
 MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113376301 95.813 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr16_-_67970651 92.098 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr17_-_40264687 88.325 NM_024119
 DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr16_-_67970734 80.337 NM_002801
 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr12_+_113416267 78.756 NM_001032731
NM_002535
NM_016817
 OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr22_+_18632841 78.101 USP18
ubiquitin specific peptidase 18
chr22_+_18632704 76.713 NM_017414
 USP18
ubiquitin specific peptidase 18
chr6_+_32821924 73.342 NM_002800
 PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr13_-_43566301 70.549 NM_001002264
NM_033255
 EPSTI1

epithelial stromal interaction 1 (breast)

chr12_+_113376226 67.224 NM_006187
 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
17.95 1.20e-03 GO:0002483 antigen processing and presentation of endogenous peptide antigen
17.95 1.20e-03 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
15.38 4.41e-04 GO:0019883 antigen processing and presentation of endogenous antigen
11.04 2.01e-04 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
8.08 1.06e-03 GO:0048002 antigen processing and presentation of peptide antigen
7.41 1.84e-13 GO:0034340 response to type I interferon
7.24 1.40e-12 GO:0060337 type I interferon-mediated signaling pathway
7.24 1.40e-12 GO:0071357 cellular response to type I interferon
4.49 1.99e-02 GO:0032479 regulation of type I interferon production
4.11 1.06e-09 GO:0009615 response to virus
3.64 1.30e-02 GO:0043900 regulation of multi-organism process
3.61 1.46e-08 GO:0019221 cytokine-mediated signaling pathway
3.43 2.04e-08 GO:0071345 cellular response to cytokine stimulus
3.30 5.51e-14 GO:0045087 innate immune response
3.00 2.26e-10 GO:0044419 interspecies interaction between organisms
2.98 2.88e-08 GO:0034097 response to cytokine stimulus
2.69 4.63e-02 GO:0002697 regulation of immune effector process
2.64 3.80e-16 GO:0006955 immune response
2.45 2.16e-04 GO:0031347 regulation of defense response
2.43 1.22e-13 GO:0006952 defense response

Gene overrepresentation in compartment category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
6.28 2.09e-02 GO:0005839 proteasome core complex

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
5.98 4.93e-02 GO:0004298 threonine-type endopeptidase activity
5.98 4.93e-02 GO:0070003 threonine-type peptidase activity
4.38 3.26e-02 GO:0043021 ribonucleoprotein binding
1.64 1.31e-02 GO:0003723 RNA binding
1.19 1.76e-04 GO:0005515 protein binding
1.11 8.43e-05 GO:0005488 binding