Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.272


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
TCF7chr5_+_1334512970.724.8e-05Click!
LEF1chr4_-_1090894440.527.7e-03Click!
TCF7L1chr2_+_853603730.414.0e-02Click!
TCF7L2chr10_+_1147107850.341.0e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_29527477 6.519 UBD
ubiquitin D
chr6_-_29527701 6.503 NM_006398
 UBD
ubiquitin D
chr9_-_123689172 6.461 NM_005658
 TRAF1
TNF receptor-associated factor 1
chr2_+_228678556 4.721 NM_001130046
NM_004591
 CCL20

chemokine (C-C motif) ligand 20

chr11_-_72385411 3.418 NM_002599
 PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr2_-_231989755 3.249 NM_000867
 HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr15_+_62359175 2.923 NM_207322
 C2CD4A
C2 calcium-dependent domain containing 4A
chr5_-_16936290 2.869 MYO10
myosin X
chr4_-_139163222 2.758 NM_014331
 SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr8_-_8750739 2.730 NM_004225
 MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr6_+_37137882 2.707 NM_001243186
NM_002648
 PIM1

pim-1 oncogene

chr16_+_57406398 2.699 NM_002996
 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr21_+_43710190 2.645 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr7_+_73703704 2.612 NM_003388
NM_032421
 CLIP2

CAP-GLY domain containing linker protein 2

chr5_+_131593377 2.525 PDLIM4
PDZ and LIM domain 4
chr5_+_131593331 2.511 NM_001131027
NM_003687
 PDLIM4

PDZ and LIM domain 4

chr20_+_55966440 2.450 NM_017495
NM_183425
 RBM38

RNA binding motif protein 38

chr6_-_11232900 2.412 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr2_-_208031570 2.402 KLF7
Kruppel-like factor 7 (ubiquitous)
chr5_-_16738346 2.360 MYO10
myosin X

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
5.53 3.27e-02 GO:0030282 bone mineralization
1.93 1.64e-04 GO:0006935 chemotaxis
1.93 1.64e-04 GO:0042330 taxis
1.75 2.54e-05 GO:0040011 locomotion
1.75 1.06e-02 GO:0006928 cellular component movement
1.66 3.78e-03 GO:0007155 cell adhesion
1.66 3.78e-03 GO:0022610 biological adhesion
1.63 8.66e-04 GO:0022008 neurogenesis
1.62 3.55e-03 GO:0048699 generation of neurons
1.53 1.36e-02 GO:0009605 response to external stimulus
1.50 3.41e-04 GO:0007399 nervous system development
1.34 3.11e-03 GO:0048522 positive regulation of cellular process
1.32 2.03e-03 GO:0048518 positive regulation of biological process
1.30 6.93e-03 GO:0048731 system development
1.28 1.79e-03 GO:0007275 multicellular organismal development
1.28 6.26e-03 GO:0048856 anatomical structure development
1.24 1.70e-02 GO:0032502 developmental process
1.16 6.91e-04 GO:0065007 biological regulation
1.08 4.70e-02 GO:0009987 cellular process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
2.58 1.99e-02 GO:0017124 SH3 domain binding
1.14 5.21e-03 GO:0005515 protein binding
1.07 1.85e-02 GO:0005488 binding