Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.272


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
TCF7chr5_+_1334512970.724.8e-05Click!
LEF1chr4_-_1090894440.527.7e-03Click!
TCF7L1chr2_+_853603730.414.0e-02Click!
TCF7L2chr10_+_1147107850.341.0e-01Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_29527477 6.519 UBD
ubiquitin D
chr6_-_29527701 6.503 NM_006398
UBD
ubiquitin D
chr9_-_123689172 6.461 NM_005658
TRAF1
TNF receptor-associated factor 1
chr2_+_228678556 4.721 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr11_-_72385411 3.418 NM_002599
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr2_-_231989755 3.249 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr15_+_62359175 2.923 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr5_-_16936290 2.869 MYO10
myosin X
chr4_-_139163222 2.758 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr8_-_8750739 2.730 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr6_+_37137882 2.707 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr16_+_57406398 2.699 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr21_+_43710190 2.645 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr7_+_73703704 2.612 NM_003388
NM_032421
CLIP2

CAP-GLY domain containing linker protein 2

chr5_+_131593377 2.525 PDLIM4
PDZ and LIM domain 4
chr5_+_131593331 2.511 NM_001131027
NM_003687
PDLIM4

PDZ and LIM domain 4

chr20_+_55966440 2.450 NM_017495
NM_183425
RBM38

RNA binding motif protein 38

chr6_-_11232900 2.412 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr2_-_208031570 2.402 KLF7
Kruppel-like factor 7 (ubiquitous)
chr5_-_16738346 2.360 MYO10
myosin X
chr5_+_131593388 2.265 PDLIM4
PDZ and LIM domain 4
chr10_-_101380217 2.232 NM_031212
SLC25A28
solute carrier family 25, member 28
chr10_-_101380160 2.229 SLC25A28
solute carrier family 25, member 28
chr10_-_101380086 2.186 SLC25A28
solute carrier family 25, member 28
chr21_+_26934440 2.132 MIR155HG
MIR155 host gene (non-protein coding)
chr2_+_152214105 2.057 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr9_-_74525846 1.827 FAM108B1
family with sequence similarity 108, member B1
chr6_+_83073954 1.693 NM_001166392
TPBG
trophoblast glycoprotein
chr14_-_35344450 1.655 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr3_-_15373807 1.606 SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr12_-_31477080 1.600 FAM60A
family with sequence similarity 60, member A
chr8_-_119964059 1.598 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr1_+_212738675 1.593 NM_001030287
ATF3
activating transcription factor 3
chr8_+_17104384 1.580 NM_001145152
NM_152415
VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr2_-_39348127 1.533 SOS1
son of sevenless homolog 1 (Drosophila)
chr12_+_78225068 1.528 NM_014903
NAV3
neuron navigator 3
chr4_+_77953942 1.509 SEPT11
septin 11
chr3_-_47823377 1.508 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr3_-_47823368 1.468 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr19_+_51152634 1.452 NM_001195076
C19orf81
chromosome 19 open reading frame 81
chr5_+_125800786 1.441 NM_001146322
GRAMD3
GRAM domain containing 3
chr20_-_43977023 1.379 NM_002999
SDC4
syndecan 4
chr8_+_120079423 1.327 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr3_+_133292404 1.313 NM_001134422
NM_017548
CDV3

CDV3 homolog (mouse)

chr3_-_47823343 1.281 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr18_+_55888799 1.277 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_128841432 1.261 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr15_+_67418053 1.253 NM_001145102
SMAD3
SMAD family member 3
chr11_-_117747331 1.233 FXYD6
FXYD domain containing ion transport regulator 6
chr3_-_79817058 1.225 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr14_-_35344080 1.196 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr1_+_182808436 1.187 NM_001357
DHX9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
chr11_-_46615584 1.184 AMBRA1
autophagy/beclin-1 regulator 1
chr18_+_55888838 1.180 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_+_39063851 1.174 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr6_-_11232883 1.171 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr14_-_35344852 1.170 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr20_+_32399046 1.159 NM_176812
CHMP4B
charged multivesicular body protein 4B
chr5_+_96211643 1.156 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr7_-_139876718 1.154 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr13_+_26828755 1.138 NM_001260
CDK8
cyclin-dependent kinase 8
chr6_+_26383323 1.129 NM_001197238
NM_001197239
NM_001197240
NM_006995
NM_181531
NM_001197237
BTN2A2





butyrophilin, subfamily 2, member A2





chr2_+_169923531 1.128 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr14_-_35344526 1.109 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr6_-_11232901 1.108 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr3_+_11178778 1.096 NM_001098213
HRH1
histamine receptor H1
chr3_+_46448678 1.094 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr19_+_36726883 1.093 ZNF146
zinc finger protein 146
chr1_-_231005334 1.087 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr14_-_35344490 1.075 BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr2_+_185463437 1.072 ZNF804A
zinc finger protein 804A
chr20_+_32399128 1.053 CHMP4B
charged multivesicular body protein 4B
chr10_+_6244839 1.045 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr15_+_66694216 1.033 MAP2K1
mitogen-activated protein kinase kinase 1
chr3_-_47823419 1.019 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr16_-_87525317 0.998 NM_015144
ZCCHC14
zinc finger, CCHC domain containing 14
chr3_-_160283071 0.991 KPNA4
karyopherin alpha 4 (importin alpha 3)
chrX_+_69488154 0.985 NM_004312
ARR3
arrestin 3, retinal (X-arrestin)
chr11_+_69455978 0.983 CCND1
cyclin D1
chr3_-_160283166 0.982 KPNA4
karyopherin alpha 4 (importin alpha 3)
chr1_+_100818052 0.960 CDC14A
CDC14 cell division cycle 14 homolog A (S. cerevisiae)
chr6_+_155538096 0.959 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr5_+_70944968 0.958 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr8_-_6914251 0.951 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr17_+_19990334 0.939 NM_001033553
NM_152904
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr14_+_23845932 0.924 NM_001037288
NM_138460
CMTM5

CKLF-like MARVEL transmembrane domain containing 5

chr2_+_234296799 0.919 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr12_+_54426831 0.918 NM_018953
HOXC5
homeobox C5
chr17_+_16945766 0.914 NM_015134
NM_201274
MPRIP

myosin phosphatase Rho interacting protein

chr12_+_26205490 0.911 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr6_+_83073501 0.899 TPBG
trophoblast glycoprotein
chr15_+_65134081 0.898 NM_001195059
NM_025201
PLEKHO2

pleckstrin homology domain containing, family O member 2

chrX_+_1455508 0.896 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr5_+_125758818 0.886 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr6_-_11382501 0.877 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_+_69455938 0.868 CCND1
cyclin D1
chr6_+_108881010 0.858 NM_201559
FOXO3
forkhead box O3
chrY_+_1405508 0.855 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr4_-_76957139 0.855 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr2_+_169926084 0.852 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr9_-_34381497 0.843 NM_001252195
NM_147168
NM_147169
C9orf24


chromosome 9 open reading frame 24


chr5_+_66124603 0.840 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr17_-_39093671 0.826 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr1_+_13911966 0.820 NM_001006624
NM_001006625
PDPN

podoplanin

chr11_+_125753508 0.819 NM_145014
HYLS1
hydrolethalus syndrome 1
chr17_+_56315786 0.817 NM_001160102
NM_006151
LPO

lactoperoxidase

chr1_-_183559463 0.786 NCF2
neutrophil cytosolic factor 2
chr11_+_69455884 0.783 CCND1
cyclin D1
chr17_+_57642885 0.782 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr18_-_65182507 0.766 DSEL
dermatan sulfate epimerase-like
chr15_+_94841429 0.764 NM_001159643
NM_018349
MCTP2

multiple C2 domains, transmembrane 2

chr18_+_55888750 0.757 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_137540504 0.751 IFNGR1
interferon gamma receptor 1
chr8_+_32579350 0.743 NM_001159996
NRG1
neuregulin 1
chr5_+_140753480 0.736 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr5_-_16936371 0.734 NM_012334
MYO10
myosin X
chr1_+_209878135 0.697 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr11_+_69455837 0.695 NM_053056
CCND1
cyclin D1
chr7_+_29519485 0.692 NM_001039936
CHN2
chimerin (chimaerin) 2
chr17_-_39507055 0.690 NM_004138
KRT33A
keratin 33A
chr15_+_73344824 0.689 NM_001172623
NM_001172624
NM_002499
NEO1


neogenin 1


chr9_+_91003987 0.689 SPIN1
spindlin 1
chr13_+_111138079 0.680 COL4A2
collagen, type IV, alpha 2
chr15_+_89631625 0.667 ABHD2
abhydrolase domain containing 2
chr16_-_46865039 0.667 NM_001001436
C16orf87
chromosome 16 open reading frame 87
chr3_+_9476506 0.665


chr16_+_70333058 0.661 NM_001014449
NM_001014451
NM_007242
DDX19B


DEAD (Asp-Glu-Ala-As) box polypeptide 19B


chr20_-_656443 0.656


chr17_-_76719671 0.656 CYTH1
cytohesin 1
chr12_-_16759531 0.652 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_+_140734767 0.644 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr5_+_140797243 0.638 NM_018927
PCDHGB7
protocadherin gamma subfamily B, 7
chr19_+_13135368 0.638 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr15_+_89631731 0.634 ABHD2
abhydrolase domain containing 2
chr6_-_3227776 0.629 NM_178012
TUBB2B
tubulin, beta 2B class IIb
chr10_+_7745284 0.620 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr5_+_118604417 0.620 NM_001077654
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr10_+_71562275 0.618 COL13A1
collagen, type XIII, alpha 1
chr1_+_170633312 0.605 NM_006902
NM_022716
PRRX1

paired related homeobox 1

chr1_+_100818007 0.598 NM_003672
NM_033312
NM_033313
CDC14A


CDC14 cell division cycle 14 homolog A (S. cerevisiae)


chr5_-_58334936 0.596 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr15_+_89631695 0.596 ABHD2
abhydrolase domain containing 2
chr7_-_137620651 0.594 CREB3L2
cAMP responsive element binding protein 3-like 2
chr6_-_108279212 0.594 SEC63
SEC63 homolog (S. cerevisiae)
chr5_+_118604504 0.588 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr10_-_93669184 0.586 NM_152429
FGFBP3
fibroblast growth factor binding protein 3
chr5_+_149546340 0.585 NM_001804
CDX1
caudal type homeobox 1
chr3_+_182971592 0.584 B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr2_-_166060552 0.584 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr10_+_7745354 0.578 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr16_-_12897632 0.577 CPPED1
calcineurin-like phosphoesterase domain containing 1
chr9_+_112887780 0.577 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr17_-_39623476 0.575 NM_002278
KRT32
keratin 32
chr12_+_10331556 0.573 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr4_-_5894695 0.569 NM_001014809
CRMP1
collapsin response mediator protein 1
chr7_+_150065330 0.566 REPIN1
replication initiator 1
chrX_+_111119278 0.566 NM_001195576
NM_001195578
LOC100329135

uncharacterized LOC100329135

chr7_-_106301329 0.561 NM_175884
C7orf74
chromosome 7 open reading frame 74
chr2_+_233734993 0.561 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr5_+_133450353 0.559 NM_003202
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr10_+_7745341 0.558 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr7_+_29234111 0.557 NM_004067
CHN2
chimerin (chimaerin) 2
chr3_-_197024879 0.556 DLG1
discs, large homolog 1 (Drosophila)
chr20_+_6748744 0.553 NM_001200
BMP2
bone morphogenetic protein 2
chrX_+_122993536 0.551 NM_001204401
NM_001167
XIAP

X-linked inhibitor of apoptosis

chr1_+_100818031 0.550 CDC14A
CDC14 cell division cycle 14 homolog A (S. cerevisiae)
chr10_+_7745325 0.549 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr16_+_57673206 0.546 NM_001145774
GPR56
G protein-coupled receptor 56
chr1_+_160160284 0.543 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr6_-_137540544 0.543 IFNGR1
interferon gamma receptor 1
chr17_-_46035109 0.540 NM_024320
PRR15L
proline rich 15-like
chr4_-_109089444 0.540 NM_001130713
NM_001130714
NM_016269
LEF1


lymphoid enhancer-binding factor 1


chr9_-_35650852 0.536 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr12_+_69979447 0.533 NM_001198842
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr2_+_171571800 0.532 NM_001003845
SP5
Sp5 transcription factor
chr20_-_13971256 0.529 NM_025229
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr11_+_118477212 0.528 NM_015157
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr6_-_33548017 0.527 NM_001188
BAK1
BCL2-antagonist/killer 1
chr11_-_61658853 0.526 NM_021727
FADS3
fatty acid desaturase 3
chr12_-_52779362 0.523 NM_033045
KRT84
keratin 84
chr1_-_213020947 0.515 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr10_+_81107228 0.509 PPIF
peptidylprolyl isomerase F
chr10_-_27444194 0.508 YME1L1
YME1-like 1 (S. cerevisiae)
chr11_+_113848221 0.508 NM_001161772
HTR3A
5-hydroxytryptamine (serotonin) receptor 3A
chr11_-_8739398 0.504 ST5
suppression of tumorigenicity 5
chr16_+_10837673 0.503 NM_002484
NUBP1
nucleotide binding protein 1
chr2_+_102314162 0.503 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr6_+_41040713 0.503 NFYA
nuclear transcription factor Y, alpha
chr5_-_139422725 0.498 NRG2
neuregulin 2
chr10_+_114043413 0.495 NM_058222
TECTB
tectorin beta
chr6_-_89827605 0.493 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr1_+_16010838 0.491 PLEKHM2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr1_+_200993041 0.486


chr20_+_36149606 0.485 NM_005386
NM_181689
NNAT

neuronatin

chr4_+_106067031 0.484 NM_017628
TET2
tet methylcytosine dioxygenase 2
chr3_-_123339423 0.484 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr17_+_26662547 0.481 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr3_+_182970853 0.481 NM_032047
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr8_+_142138684 0.480 NM_014957
DENND3
DENN/MADD domain containing 3
chr2_-_74753311 0.478 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.75 2.54e-05 GO:0040011 locomotion
1.93 1.64e-04 GO:0006935 chemotaxis
1.93 1.64e-04 GO:0042330 taxis
1.50 3.41e-04 GO:0007399 nervous system development
1.16 6.91e-04 GO:0065007 biological regulation
1.63 8.66e-04 GO:0022008 neurogenesis
1.28 1.79e-03 GO:0007275 multicellular organismal development
1.32 2.03e-03 GO:0048518 positive regulation of biological process
1.34 3.11e-03 GO:0048522 positive regulation of cellular process
1.62 3.55e-03 GO:0048699 generation of neurons
1.66 3.78e-03 GO:0007155 cell adhesion
1.66 3.78e-03 GO:0022610 biological adhesion
1.28 6.26e-03 GO:0048856 anatomical structure development
1.30 6.93e-03 GO:0048731 system development
1.75 1.06e-02 GO:0006928 cellular component movement
1.53 1.36e-02 GO:0009605 response to external stimulus
1.24 1.70e-02 GO:0032502 developmental process
5.53 3.27e-02 GO:0030282 bone mineralization
1.08 4.70e-02 GO:0009987 cellular process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.14 5.21e-03 GO:0005515 protein binding
1.07 1.85e-02 GO:0005488 binding
2.58 1.99e-02 GO:0017124 SH3 domain binding