Motif ID: MSX1,2.p2

Z-value: 0.519


Transcription factors associated with MSX1,2.p2:

Gene SymbolEntrez IDGene Name
MSX1 4487 msh homeobox 1
MSX2 4488 msh homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
MSX1chr4_+_4861371-0.203.4e-01Click!
MSX2chr5_+_174151531-0.019.6e-01Click!


Activity profile for motif MSX1,2.p2.

activity profile for motif MSX1,2.p2


Sorted Z-values histogram for motif MSX1,2.p2

Sorted Z-values for motif MSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_7618416 0.857 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr3_-_126327397 0.438 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr9_-_116840551 0.418 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_88896838 0.386 SPP1
secreted phosphoprotein 1
chr4_+_88896868 0.379 SPP1
secreted phosphoprotein 1
chr4_+_88896801 0.354 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr9_-_116840460 0.320 AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_88896899 0.309 SPP1
secreted phosphoprotein 1
chr6_+_16129285 0.308 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr9_-_116840604 0.287 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_+_31883020 0.268 NM_001199037
SERINC2
serine incorporator 2
chr1_+_31882411 0.264 NM_001199038
SERINC2
serine incorporator 2
chr5_+_59784004 0.261 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr15_-_43594452 0.255 NM_052955
TGM7
transglutaminase 7
chr14_-_94254765 0.249 NM_178013
PRIMA1
proline rich membrane anchor 1
chr3_-_74570262 0.245 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chrX_+_16668280 0.241 NM_004057
S100G
S100 calcium binding protein G
chr8_-_27115897 0.230 NM_030795
STMN4
stathmin-like 4
chr1_+_84767288 0.227 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr4_+_86699846 0.217 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr9_+_136501484 0.214 NM_000787
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr7_-_27159213 0.212 NM_030661
HOXA3
homeobox A3
chr4_+_90033967 0.202 NM_145715
TIGD2
tigger transposable element derived 2
chr2_+_113825546 0.197 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr12_+_53818864 0.184 AMHR2
anti-Mullerian hormone receptor, type II
chr3_-_148939784 0.183 NM_000096
CP
ceruloplasmin (ferroxidase)
chrX_+_99839789 0.181 NM_022144
TNMD
tenomodulin
chrX_-_11284094 0.180 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr8_-_8239188 0.180 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr3_-_151102536 0.174 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr1_+_78470593 0.174 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr10_+_7745354 0.173 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr9_-_116840545 0.172 AMBP
alpha-1-microglobulin/bikunin precursor
chr11_-_27681195 0.169 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chrX_-_133792497 0.160 NM_021796
PLAC1
placenta-specific 1
chr6_-_51952368 0.157 NM_138694
NM_170724
PKHD1

polycystic kidney and hepatic disease 1 (autosomal recessive)

chr10_+_7745325 0.152 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr8_-_27115935 0.147 STMN4
stathmin-like 4
chr6_+_16129321 0.146 MYLIP
myosin regulatory light chain interacting protein
chr3_+_8543539 0.143 LMCD1
LIM and cysteine-rich domains 1
chr2_-_180427314 0.139 NM_001113398
ZNF385B
zinc finger protein 385B
chr7_-_135613197 0.139 LUZP6
leucine zipper protein 6
chr8_+_32504250 0.135 NM_013959
NRG1
neuregulin 1
chr4_+_71062241 0.134 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr3_+_69812620 0.134 NM_001184967
MITF
microphthalmia-associated transcription factor
chr8_-_110620220 0.133 SYBU
syntabulin (syntaxin-interacting)
chr5_+_15500288 0.131 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr19_+_49376488 0.130 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr16_-_21289571 0.130 CRYM
crystallin, mu
chr19_-_14169970 0.129 NM_001145028
PALM3
paralemmin 3
chr4_+_77356252 0.129 NM_020859
SHROOM3
shroom family member 3
chr1_+_153232178 0.128 NM_000427
LOR
loricrin
chr13_-_70682458 0.125 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chr1_-_241799101 0.124 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr15_+_80364902 0.118 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr12_-_91398744 0.116 EPYC
epiphycan
chr1_-_108231122 0.115 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr5_+_139876504 0.111 ANKHD1
ankyrin repeat and KH domain containing 1
chr12_+_14538232 0.110 ATF7IP
activating transcription factor 7 interacting protein
chr9_-_116840673 0.108 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr1_+_120254418 0.108 NM_006623
PHGDH
phosphoglycerate dehydrogenase
chr9_-_97356007 0.108 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr10_+_7745284 0.106 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_-_62332666 0.103 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_-_189026401 0.102 NM_173553
TRIML2
tripartite motif family-like 2
chr5_-_179044835 0.101 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr2_+_219745243 0.101 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr11_-_58343308 0.101 NM_004811
LPXN
leupaxin
chr7_-_14025826 0.100 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chrX_-_19688991 0.099 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr7_+_39017608 0.098 NM_001166018
NM_007252
POU6F2

POU class 6 homeobox 2

chr5_-_59783885 0.097 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_+_155838336 0.096 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr18_+_21572736 0.095 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr17_-_4890920 0.092 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr11_-_85397215 0.091 NM_152723
CCDC89
coiled-coil domain containing 89
chr20_-_49253425 0.091 NM_080829
FAM65C
family with sequence similarity 65, member C
chr4_-_41884568 0.091


chr3_+_69812961 0.090 NM_006722
MITF
microphthalmia-associated transcription factor
chr7_-_115670828 0.090 NM_001018058
NM_012252
TFEC

transcription factor EC

chr19_+_6772705 0.090 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chr5_+_68667280 0.090 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr4_-_76957139 0.090 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr9_+_120466625 0.089 TLR4
toll-like receptor 4
chr1_-_190446701 0.089 NM_199051
FAM5C
family with sequence similarity 5, member C
chr12_-_71551564 0.087 TSPAN8
tetraspanin 8
chr12_-_53171104 0.087 NM_015848
KRT76
keratin 76
chr1_+_22979681 0.087 NM_000491
C1QB
complement component 1, q subcomponent, B chain
chr3_-_79817058 0.087 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr8_-_102803196 0.086 NCALD
neurocalcin delta
chr17_+_18086813 0.086 NM_017758
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr16_+_31469456 0.085 ARMC5
armadillo repeat containing 5
chr10_+_7745341 0.085 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_-_137851123 0.084 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr11_-_115088628 0.084 CADM1
cell adhesion molecule 1
chr6_+_87969619 0.083 ZNF292
zinc finger protein 292
chr12_-_52585686 0.083 NM_001081492
NM_182507
KRT80

keratin 80

chr11_+_117070039 0.081 NM_001001522
NM_003186
TAGLN

transgelin

chr17_-_9929567 0.080 NM_001130831
GAS7
growth arrest-specific 7
chr12_-_6484557 0.080 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr1_-_169599349 0.079 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr16_-_73092533 0.078 NM_001164766
ZFHX3
zinc finger homeobox 3
chr22_-_25777543 0.078 NM_001135772
LRP5L
low density lipoprotein receptor-related protein 5-like
chr14_+_21756135 0.078 NM_020366
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr5_+_140529619 0.078 NM_018939
PCDHB6
protocadherin beta 6
chr3_+_100238063 0.078 TMEM45A
transmembrane protein 45A
chr14_-_65409445 0.078 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr10_-_62149487 0.077 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chrX_+_66788682 0.076 NM_001011645
AR
androgen receptor
chr6_+_147527102 0.075 STXBP5
syntaxin binding protein 5 (tomosyn)
chr7_+_114066554 0.074 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr17_+_4854383 0.073 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr19_+_36203829 0.072 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr12_-_15114495 0.072 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr4_+_113970784 0.070 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr17_+_65936590 0.070 BPTF
bromodomain PHD finger transcription factor
chr12_+_54891539 0.070 NCKAP1L
NCK-associated protein 1-like
chrX_+_119737743 0.069 NM_014060
MCTS1
malignant T cell amplified sequence 1
chr2_+_61389628 0.067 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr3_+_130569368 0.066 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr16_+_82068958 0.066 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr13_+_52598678 0.065 NM_021645
ALG11
UTP14C
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr17_-_47841468 0.065 FAM117A
family with sequence similarity 117, member A
chr20_+_43850009 0.063 NM_003008
SEMG2
semenogelin II
chr17_-_4890664 0.063 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr7_-_115670774 0.062 TFEC
transcription factor EC
chr12_-_6484389 0.061 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr3_+_56591182 0.061 NM_001012506
NM_001141947
CCDC66

coiled-coil domain containing 66

chr16_+_82068910 0.060 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_-_46655262 0.060 SHCBP1
SHC SH2-domain binding protein 1
chr11_-_83393436 0.059 NM_001142702
DLG2
discs, large homolog 2 (Drosophila)
chr12_+_54891522 0.058 NCKAP1L
NCK-associated protein 1-like
chr8_-_102803178 0.058 NCALD
neurocalcin delta
chr1_+_104198140 0.057 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr3_+_127641901 0.056 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr22_+_40573879 0.056 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr2_-_105467912 0.055 LOC100506421
uncharacterized LOC100506421
chr7_+_27282163 0.055 NM_001989
EVX1
even-skipped homeobox 1
chr6_+_71136141 0.054 NM_001162529
FAM135A
family with sequence similarity 135, member A
chr1_-_104239071 0.054 NM_001008221
AMY1A
amylase, alpha 1A (salivary)
chr6_+_31973358 0.053 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr10_+_114133838 0.052 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_28718937 0.050 NM_001170585
NM_153021
PLB1

phospholipase B1

chr13_-_99910548 0.050 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr8_-_102803438 0.049 NM_032041
NCALD
neurocalcin delta
chrX_+_129139163 0.049 NM_021946
BCORL1
BCL6 corepressor-like 1
chr12_+_54891491 0.048 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr1_-_154832187 0.048 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr9_+_1050367 0.047 DMRT2
doublesex and mab-3 related transcription factor 2
chr11_-_72463416 0.046 NM_001040118
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr1_+_54359859 0.046 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chrX_-_62975005 0.046 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chr12_+_101188373 0.046 NM_178826
ANO4
anoctamin 4
chr2_-_65090710 0.045


chr12_+_107078476 0.045 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr10_+_114133775 0.044 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_-_240322692 0.044 HDAC4
histone deacetylase 4
chr12_-_16759733 0.044 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_-_15095791 0.044 NM_139167
SGCZ
sarcoglycan, zeta
chr1_+_153330329 0.043 NM_002965
S100A9
S100 calcium binding protein A9
chr19_-_17958773 0.043 JAK3
Janus kinase 3
chr12_-_105627182 0.043 NM_001251905
APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr6_-_13408368 0.042 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr19_+_48325098 0.042 NM_000554
CRX
cone-rod homeobox
chr10_+_94833646 0.042 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr1_+_100316530 0.041 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr4_+_86699858 0.041 ARHGAP24
Rho GTPase activating protein 24
chr20_+_18122867 0.041 NM_020536
CSRP2BP
CSRP2 binding protein
chr9_+_130830447 0.040 NM_001006641
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr1_-_201915715 0.039 NM_012134
LMOD1
leiomodin 1 (smooth muscle)
chr17_-_15168590 0.039 NM_000304
PMP22
peripheral myelin protein 22
chr10_-_74714479 0.038 NM_032562
PLA2G12B
phospholipase A2, group XIIB
chr6_-_139309017 0.038 REPS1
RALBP1 associated Eps domain containing 1
chr3_+_9944511 0.037 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr17_-_78450247 0.037 NM_002522
NPTX1
neuronal pentraxin I
chr6_+_154331630 0.037 NM_001145279
NM_001145280
NM_001145281
OPRM1


opioid receptor, mu 1


chr17_+_37856224 0.036 ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr7_-_99717463 0.035 NM_001190415
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr6_+_132859426 0.035 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr1_+_15764934 0.035 NM_007272
CTRC
chymotrypsin C (caldecrin)
chr12_+_109554391 0.035 ACACB
acetyl-CoA carboxylase beta
chr12_-_11214892 0.034 NM_176887
TAS2R46
taste receptor, type 2, member 46
chr20_+_43835637 0.034 NM_003007
SEMG1
semenogelin I
chr6_-_32920812 0.034 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr6_-_119470336 0.034 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr10_+_7745229 0.034 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_-_89744154 0.033 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr16_+_89984286 0.033 NM_002386
MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr21_-_37852387 0.033 NM_001146079
NM_144492
CLDN14

claudin 14

chr20_+_23345020 0.033 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr1_+_84864214 0.033 NM_021233
DNASE2B
deoxyribonuclease II beta
chr3_+_9944295 0.032 NM_153483
IL17RE
interleukin 17 receptor E
chr19_-_17375522 0.032 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chrX_-_19988381 0.032 NM_198279
CXorf23
chromosome X open reading frame 23
chr9_+_18474078 0.032 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr4_+_110749149 0.032 NM_006583
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr7_-_16505292 0.032 NM_015464
SOSTDC1
sclerostin domain containing 1
chr14_-_105259937 0.031 NM_005163
AKT1
v-akt murine thymoma viral oncogene homolog 1
chr6_-_39693110 0.031 NM_145027
KIF6
kinesin family member 6
chr4_-_66536182 0.031 EPHA5
EPH receptor A5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.45 1.62e-03 GO:0032501 multicellular organismal process
1.63 2.83e-03 GO:0048856 anatomical structure development
1.56 3.49e-03 GO:0032502 developmental process
1.67 4.19e-03 GO:0048731 system development
2.00 4.75e-03 GO:0007399 nervous system development
1.55 1.56e-02 GO:0007275 multicellular organismal development
1.64 1.92e-02 GO:0048518 positive regulation of biological process
1.77 3.67e-02 GO:0048583 regulation of response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.65 1.26e-02 GO:0044459 plasma membrane part

Nothing significant found in function category.