Motif ID: MTF1.p2

Z-value: 1.028


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
MTF1chr1_-_383252240.331.1e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_95896498 2.516 NM_004148
NINJ1
ninjurin 1
chr3_-_39195034 1.676 CSRNP1
cysteine-serine-rich nuclear protein 1
chr3_-_39195101 1.662 NM_033027
CSRNP1
cysteine-serine-rich nuclear protein 1
chr7_+_86273867 1.160 GRM3
glutamate receptor, metabotropic 3
chr16_-_89007605 1.127 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr11_+_369723 1.122 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr9_+_137218324 1.118 RXRA
retinoid X receptor, alpha
chr16_+_56703725 1.109 NM_005951
MT1H
metallothionein 1H
chr7_-_139477437 1.096 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr16_+_56642477 1.088 NM_005953
MT2A
metallothionein 2A
chr21_+_42797977 1.074 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr9_+_116918230 1.074 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr3_-_45267804 1.044 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr6_-_143266283 1.007 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr17_-_37307888 0.997 NM_020405
PLXDC1
plexin domain containing 1
chr15_+_90544608 0.997 NM_198526
ZNF710
zinc finger protein 710
chr8_-_145515014 0.923 BOP1
block of proliferation 1
chr21_+_45285026 0.887 AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr20_+_6748744 0.828 NM_001200
BMP2
bone morphogenetic protein 2
chr16_+_56716378 0.822 NM_005952
MT1X
metallothionein 1X
chr7_+_86274076 0.818 GRM3
glutamate receptor, metabotropic 3
chr15_+_67358194 0.814 NM_005902
SMAD3
SMAD family member 3
chr9_-_134615216 0.807 RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr20_+_61273823 0.805 SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr22_-_50963961 0.803 NM_001169111
NM_005138
SCO2

SCO cytochrome oxidase deficient homolog 2 (yeast)

chr7_-_97501680 0.801 ASNS
asparagine synthetase (glutamine-hydrolyzing)
chr3_+_31574119 0.791 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr20_-_3766905 0.748 NM_001810
CENPB
centromere protein B, 80kDa
chr3_-_107809754 0.748 NM_001777
NM_198793
CD47

CD47 molecule

chr3_+_101568325 0.745 NM_031419
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr6_+_69344939 0.736 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr16_+_56659679 0.723 MT1E
metallothionein 1E
chr2_-_224903933 0.721 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr7_-_994008 0.710 ADAP1
ArfGAP with dual PH domains 1
chr17_+_74380676 0.708 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr7_+_86273951 0.705 GRM3
glutamate receptor, metabotropic 3
chr16_+_56691854 0.705 NM_005949
MT1F
metallothionein 1F
chr8_-_145515099 0.703 NM_015201
BOP1
block of proliferation 1
chr9_-_38069082 0.698 SHB
Src homology 2 domain containing adaptor protein B
chr19_-_50432647 0.688 IL4I1
interleukin 4 induced 1
chr16_+_56659584 0.688 NM_175617
MT1E
metallothionein 1E
chr19_-_50432672 0.678 IL4I1
interleukin 4 induced 1
chr21_+_45285101 0.668 NM_020132
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr8_+_144099900 0.665 NM_001127213
NM_002346
LY6E

lymphocyte antigen 6 complex, locus E

chr11_+_73087670 0.654 NM_032871
RELT
RELT tumor necrosis factor receptor
chr6_+_32821924 0.654 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr19_+_10196972 0.650 C19orf66
chromosome 19 open reading frame 66
chr7_+_4722091 0.646 FOXK1
forkhead box K1
chr6_+_37137882 0.638 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr15_+_102501826 0.638 LOC100134445
WASH1
WASH3P
uncharacterized LOC100134445
WAS protein family homolog 1
WAS protein family homolog 3 pseudogene
chr13_+_100633977 0.630 NM_007129
ZIC2
Zic family member 2
chr22_+_41697452 0.629 NM_017590
ZC3H7B
zinc finger CCCH-type containing 7B
chr20_+_45523523 0.626 EYA2
eyes absent homolog 2 (Drosophila)
chr10_-_6019880 0.615 NM_001243539
IL15RA
interleukin 15 receptor, alpha
chr20_+_61273786 0.613 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr20_+_45523505 0.613 EYA2
eyes absent homolog 2 (Drosophila)
chr8_+_17354562 0.607 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr3_-_45267620 0.603 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr4_-_38666429 0.602 FLJ13197
uncharacterized FLJ13197
chr12_-_117319231 0.597 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr17_-_61777478 0.597 NM_030576
LIMD2
LIM domain containing 2
chr2_-_100721792 0.595 NM_001025108
AFF3
AF4/FMR2 family, member 3
chr22_+_39853534 0.590 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr7_-_994259 0.587 NM_006869
ADAP1
ArfGAP with dual PH domains 1
chr4_-_74964836 0.575 CXCL2
chemokine (C-X-C motif) ligand 2
chr10_+_6244839 0.570 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr3_+_53195214 0.570 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr2_-_100720934 0.567 AFF3
AF4/FMR2 family, member 3
chr11_+_69455978 0.562 CCND1
cyclin D1
chr8_-_119964059 0.561 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr16_+_56672577 0.558 NM_005946
MT1A
metallothionein 1A
chr20_-_10654139 0.553 JAG1
jagged 1
chr16_+_1203240 0.538 NM_001005407
NM_021098
CACNA1H

calcium channel, voltage-dependent, T type, alpha 1H subunit

chr8_-_145515071 0.537 BOP1
block of proliferation 1
chr1_-_33430285 0.535 NM_001127361
NM_153341
RNF19B

ring finger protein 19B

chr16_+_84002099 0.531 NM_019065
NECAB2
N-terminal EF-hand calcium binding protein 2
chr1_-_45308603 0.529 NM_001166292
NM_003738
PTCH2

patched 2

chr3_-_64673330 0.526 NM_182920
ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr2_+_112812799 0.522 NM_032824
TMEM87B
transmembrane protein 87B
chr7_+_55086922 0.518 EGFR
epidermal growth factor receptor
chr12_+_69004614 0.518 NM_001010942
NM_001251917
NM_001251918
NM_001251921
NM_001251922
NM_015646
RAP1B





RAP1B, member of RAS oncogene family





chr22_-_50970542 0.516 ODF3B
outer dense fiber of sperm tails 3B
chr4_-_2758018 0.516 NM_024309
TNIP2
TNFAIP3 interacting protein 2
chr4_-_2757750 0.511 NM_001161527
TNIP2
TNFAIP3 interacting protein 2
chr9_-_38069207 0.511 NM_003028
SHB
Src homology 2 domain containing adaptor protein B
chr5_+_14143287 0.510 NM_007118
TRIO
triple functional domain (PTPRF interacting)
chr11_+_69455938 0.509 CCND1
cyclin D1
chr7_-_150864866 0.508 NM_001098834
GBX1
gastrulation brain homeobox 1
chr16_+_2570322 0.500 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr6_-_32821743 0.499 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_-_53499055 0.498 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr22_+_38035683 0.497 NM_018957
SH3BP1
SH3-domain binding protein 1
chr2_-_239197091 0.491 NM_022817
PER2
period homolog 2 (Drosophila)
chr6_+_36646455 0.486 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr17_-_37307694 0.484 PLXDC1
plexin domain containing 1
chr22_-_50913270 0.479 NM_002972
SBF1
SET binding factor 1
chr19_-_50432679 0.477 NUP62
IL4I1
nucleoporin 62kDa
interleukin 4 induced 1
chr14_-_21566728 0.476 NM_016423
ZNF219
zinc finger protein 219
chr3_+_31574431 0.471 STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr5_+_118691549 0.470 NM_014350
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr19_-_47922339 0.468 MEIS3
Meis homeobox 3
chr17_-_71308118 0.468 NM_012121
CDC42EP4
CDC42 effector protein (Rho GTPase binding) 4
chr5_-_45695831 0.467 HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr9_+_137218313 0.466 NM_002957
RXRA
retinoid X receptor, alpha
chr17_+_8924822 0.463 NM_004822
NTN1
netrin 1
chr16_-_65155965 0.463 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr20_-_62205559 0.462 NM_001037335
PRIC285
peroxisomal proliferator-activated receptor A interacting complex 285
chr1_-_156721280 0.457 HDGF
hepatoma-derived growth factor
chr10_+_104154228 0.455 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr15_+_67358161 0.454 SMAD3
SMAD family member 3
chr17_+_1628032 0.452 NM_001163809
WDR81
WD repeat domain 81
chr19_+_36209125 0.447 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr19_-_50432734 0.446 NM_012346
NM_153718
NM_153719
NM_001193357
NM_172374
NUP62



IL4I1
nucleoporin 62kDa



interleukin 4 induced 1
chr9_-_110252045 0.443 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr6_+_44095357 0.442 NM_018426
TMEM63B
transmembrane protein 63B
chr22_+_38035718 0.439 SH3BP1
SH3-domain binding protein 1
chr5_-_146889618 0.436 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr15_+_69591272 0.432 NM_017705
PAQR5
progestin and adipoQ receptor family member V
chr16_-_56701904 0.430 NM_005950
MT1G
metallothionein 1G
chr20_+_45523247 0.429 NM_005244
NM_172110
EYA2

eyes absent homolog 2 (Drosophila)

chr19_-_6424536 0.429 KHSRP
KH-type splicing regulatory protein
chr17_+_74380943 0.428 SPHK1
sphingosine kinase 1
chr19_-_50432731 0.425 NUP62
nucleoporin 62kDa
chr12_-_1703330 0.425 NM_152441
FBXL14
F-box and leucine-rich repeat protein 14
chr3_-_122283423 0.425 NM_001146103
NM_031458
PARP9

poly (ADP-ribose) polymerase family, member 9

chr9_+_100174369 0.423 TDRD7
tudor domain containing 7
chr19_-_10679620 0.422 NM_001800
NM_079421
CDKN2D

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

chr19_+_36208917 0.422 NM_014727
MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr11_+_35639734 0.422 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr3_-_45267068 0.419 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr6_+_34204690 0.419 HMGA1
high mobility group AT-hook 1
chr12_+_57610577 0.419 NM_007224
NXPH4
neurexophilin 4
chr19_-_50432678 0.418 NUP62
nucleoporin 62kDa
chr2_+_75061234 0.417 HK2
hexokinase 2
chr11_-_9286832 0.417 NM_001243254
NM_015213
DENND5A

DENN/MADD domain containing 5A

chr2_+_946534 0.417 NM_018968
SNTG2
syntrophin, gamma 2
chr16_-_65155984 0.412 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr16_-_65155881 0.411 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr1_-_27481400 0.411 NM_003047
SLC9A1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
chr9_+_116930778 0.411 COL27A1
collagen, type XXVII, alpha 1
chr19_+_676346 0.410 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr9_+_100174179 0.409 NM_014290
TDRD7
tudor domain containing 7
chr5_-_179780314 0.405 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr14_-_21566497 0.404 ZNF219
zinc finger protein 219
chr17_+_1627833 0.402 NM_001163811
WDR81
WD repeat domain 81
chr2_-_106810735 0.402 UXS1
UDP-glucuronate decarboxylase 1
chr19_+_10982369 0.402 CARM1
coactivator-associated arginine methyltransferase 1
chr9_-_140353785 0.400 NM_001130969
NM_001130970
NM_001130971
NM_001178064
NM_015537
NELF




nasal embryonic LHRH factor




chr10_-_101380217 0.400 NM_031212
SLC25A28
solute carrier family 25, member 28
chr1_-_33815498 0.399 NM_004427
PHC2
polyhomeotic homolog 2 (Drosophila)
chr11_+_67806454 0.398 NM_006019
TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr8_+_106331146 0.397 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr1_-_156721501 0.394 NM_004494
HDGF
hepatoma-derived growth factor
chr4_+_74735107 0.394 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr14_+_105780903 0.393 PACS2
phosphofurin acidic cluster sorting protein 2
chr7_+_44788175 0.392 ZMIZ2
zinc finger, MIZ-type containing 2
chr19_+_10197023 0.392 C19orf66
chromosome 19 open reading frame 66
chr3_+_122283139 0.392 NM_138287
DTX3L
deltex 3-like (Drosophila)
chr7_-_98741681 0.391 NM_001199847
NM_020429
NM_181349
SMURF1


SMAD specific E3 ubiquitin protein ligase 1


chr7_-_97501424 0.387 NM_001178077
NM_133436
ASNS

asparagine synthetase (glutamine-hydrolyzing)

chr22_-_21386837 0.387 NM_004173
SLC7A4
solute carrier family 7 (orphan transporter), member 4
chr7_-_139762339 0.385 PARP12
poly (ADP-ribose) polymerase family, member 12
chr12_+_2162388 0.385 NM_000719
NM_001129827
NM_001129829
NM_001129830
NM_001129831
NM_001129832
NM_001129833
NM_001129834
NM_001129835
NM_001129836
NM_001129837
NM_001129838
NM_001129839
NM_001129840
NM_001129841
NM_001129842
NM_001129843
NM_001129844
NM_001129846
NM_001167623
NM_001167624
NM_001167625
NM_199460
CACNA1C






















calcium channel, voltage-dependent, L type, alpha 1C subunit






















chr22_-_50964573 0.385 NM_001169110
SCO2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chrX_+_68725077 0.384 NM_015686
FAM155B
family with sequence similarity 155, member B
chr6_-_17987693 0.384 KIF13A
kinesin family member 13A
chr6_-_44233244 0.382 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr11_-_75062650 0.381 NM_004041
NM_020251
ARRB1

arrestin, beta 1

chr6_+_36646489 0.380 CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr3_-_10749715 0.379 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr1_+_4715104 0.378 NM_001042478
NM_018836
AJAP1

adherens junctions associated protein 1

chr16_-_84651519 0.378 COTL1
coactosin-like 1 (Dictyostelium)
chr11_+_69455837 0.378 NM_053056
CCND1
cyclin D1
chr2_+_74757158 0.373 HTRA2
HtrA serine peptidase 2
chr1_+_23037329 0.372 NM_004442
NM_017449
EPHB2

EPH receptor B2

chr9_-_131790434 0.371 NM_020145
SH3GLB2
SH3-domain GRB2-like endophilin B2
chr19_+_15218141 0.370 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr1_-_186649421 0.369 NM_000963
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr9_-_110251308 0.369 KLF4
Kruppel-like factor 4 (gut)
chr10_+_6186758 0.369 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr11_-_72353435 0.367 NM_001143839
NM_001243784
PDE2A

phosphodiesterase 2A, cGMP-stimulated

chr14_+_21538339 0.366 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr17_-_77813049 0.365 NM_003655
CBX4
chromobox homolog 4
chr12_-_129308293 0.360 NM_145648
SLC15A4
solute carrier family 15, member 4
chr20_-_35492069 0.360 NM_080627
KIAA0889
KIAA0889
chr19_+_40697516 0.359 NM_002446
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr22_+_20119354 0.358 NM_001185024
NM_013373
ZDHHC8

zinc finger, DHHC-type containing 8

chr10_+_6186878 0.358 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr2_+_30454396 0.356 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr12_+_52627007 0.354 KRT7
keratin 7
chr8_-_12293806 0.354 NM_001137610
FAM86B2
FAM86B1
family with sequence similarity 86, member B2
family with sequence similarity 86, member B1
chr16_-_84651639 0.354 NM_021149
COTL1
coactosin-like 1 (Dictyostelium)
chr19_+_10196757 0.353 NM_018381
C19orf66
chromosome 19 open reading frame 66
chr2_+_234263153 0.353 DGKD
diacylglycerol kinase, delta 130kDa
chr11_+_47430045 0.353 NM_001128225
NM_152264
SLC39A13

solute carrier family 39 (zinc transporter), member 13

chr11_-_117747618 0.351 NM_001204268
NM_001243598
NM_001164832
NM_001164836
NM_001164837
NM_022003
FXYD6-FXYD2

FXYD6



FXYD6-FXYD2 readthrough

FXYD domain containing ion transport regulator 6



chr8_-_145515089 0.351 BOP1
block of proliferation 1
chr4_-_120549827 0.351 NM_001083
PDE5A
phosphodiesterase 5A, cGMP-specific
chr1_-_1535446 0.348 NM_001242659
LOC643988
uncharacterized LOC643988
chr6_+_34204928 0.347 HMGA1
high mobility group AT-hook 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.11 1.86e-19 GO:0009987 cellular process
1.48 7.48e-17 GO:0007399 nervous system development
1.17 9.48e-15 GO:0050794 regulation of cellular process
1.16 2.54e-14 GO:0050789 regulation of biological process
1.42 2.92e-14 GO:0023051 regulation of signaling
1.57 1.53e-13 GO:0022008 neurogenesis
1.33 1.65e-13 GO:0048519 negative regulation of biological process
1.15 2.14e-13 GO:0065007 biological regulation
1.57 1.11e-12 GO:0048699 generation of neurons
1.34 1.74e-12 GO:0048523 negative regulation of cellular process
1.25 4.33e-12 GO:0007275 multicellular organismal development
1.28 6.22e-12 GO:0048731 system development
1.26 7.04e-12 GO:0048856 anatomical structure development
1.29 8.42e-12 GO:0048518 positive regulation of biological process
1.23 9.99e-12 GO:0032502 developmental process
1.42 1.18e-11 GO:0009966 regulation of signal transduction
1.24 1.55e-11 GO:0023052 signaling
1.30 6.35e-11 GO:0048522 positive regulation of cellular process
1.58 2.98e-10 GO:0030182 neuron differentiation
1.32 5.34e-10 GO:0030154 cell differentiation
1.30 2.49e-09 GO:0048869 cellular developmental process
1.46 2.75e-09 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.44 4.50e-09 GO:0010646 regulation of cell communication
1.53 6.54e-09 GO:2000026 regulation of multicellular organismal development
1.20 8.17e-09 GO:0051716 cellular response to stimulus
1.22 9.76e-09 GO:0007165 signal transduction
1.39 9.77e-09 GO:0051239 regulation of multicellular organismal process
1.35 2.18e-08 GO:0009653 anatomical structure morphogenesis
1.45 5.05e-08 GO:0050793 regulation of developmental process
1.52 8.75e-08 GO:0045595 regulation of cell differentiation
1.43 3.93e-07 GO:0048468 cell development
1.65 4.05e-07 GO:0007409 axonogenesis
1.20 4.76e-07 GO:0031323 regulation of cellular metabolic process
1.59 4.94e-07 GO:0000904 cell morphogenesis involved in differentiation
1.20 5.65e-07 GO:0080090 regulation of primary metabolic process
1.20 6.65e-07 GO:0060255 regulation of macromolecule metabolic process
1.59 7.39e-07 GO:0031175 neuron projection development
1.62 8.21e-07 GO:0048812 neuron projection morphogenesis
1.63 8.28e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
1.18 1.68e-06 GO:0019222 regulation of metabolic process
1.53 2.19e-06 GO:0048666 neuron development
1.50 3.02e-06 GO:0030030 cell projection organization
1.41 3.26e-06 GO:0010605 negative regulation of macromolecule metabolic process
1.39 3.60e-06 GO:0009892 negative regulation of metabolic process
1.48 4.08e-06 GO:0031327 negative regulation of cellular biosynthetic process
1.47 5.35e-06 GO:0009890 negative regulation of biosynthetic process
1.68 5.50e-06 GO:0007411 axon guidance
1.27 6.93e-06 GO:0048583 regulation of response to stimulus
1.55 7.78e-06 GO:0007417 central nervous system development
1.58 1.12e-05 GO:0051094 positive regulation of developmental process
1.27 1.14e-05 GO:0006464 protein modification process
1.40 1.20e-05 GO:0031324 negative regulation of cellular metabolic process
1.49 1.37e-05 GO:0010629 negative regulation of gene expression
1.68 1.40e-05 GO:0060284 regulation of cell development
1.63 1.48e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.48 1.50e-05 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.31 1.68e-05 GO:0035556 intracellular signal transduction
1.51 1.76e-05 GO:0051253 negative regulation of RNA metabolic process
1.52 2.07e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.46 2.54e-05 GO:0010558 negative regulation of macromolecule biosynthetic process
1.47 2.58e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.60 3.49e-05 GO:0007264 small GTPase mediated signal transduction
1.21 3.52e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.76 3.63e-05 GO:0050767 regulation of neurogenesis
1.56 3.95e-05 GO:0032583 regulation of gene-specific transcription
1.47 4.32e-05 GO:0051172 negative regulation of nitrogen compound metabolic process
1.45 4.87e-05 GO:0007167 enzyme linked receptor protein signaling pathway
1.47 5.29e-05 GO:0000902 cell morphogenesis
1.70 5.61e-05 GO:0051960 regulation of nervous system development
1.25 6.03e-05 GO:0043412 macromolecule modification
1.51 7.18e-05 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.66 8.38e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.20 9.65e-05 GO:0051171 regulation of nitrogen compound metabolic process
1.57 1.07e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.76 1.10e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.50 1.30e-04 GO:0048858 cell projection morphogenesis
1.45 1.37e-04 GO:0032989 cellular component morphogenesis
1.18 1.38e-04 GO:0016043 cellular component organization
1.20 1.42e-04 GO:0071842 cellular component organization at cellular level
1.37 1.45e-04 GO:0006351 transcription, DNA-dependent
1.55 1.77e-04 GO:0009968 negative regulation of signal transduction
1.17 1.93e-04 GO:0071840 cellular component organization or biogenesis
1.34 2.04e-04 GO:0006793 phosphorus metabolic process
1.34 2.04e-04 GO:0006796 phosphate metabolic process
1.20 2.19e-04 GO:0071841 cellular component organization or biogenesis at cellular level
1.49 2.44e-04 GO:0032990 cell part morphogenesis
1.61 2.53e-04 GO:0045597 positive regulation of cell differentiation
2.03 2.72e-04 GO:0007265 Ras protein signal transduction
1.25 2.86e-04 GO:0007166 cell surface receptor linked signaling pathway
1.52 3.25e-04 GO:0023057 negative regulation of signaling
1.42 3.54e-04 GO:0010628 positive regulation of gene expression
1.21 6.52e-04 GO:0042221 response to chemical stimulus
1.50 6.95e-04 GO:0010648 negative regulation of cell communication
1.14 7.63e-04 GO:0044260 cellular macromolecule metabolic process
1.38 9.94e-04 GO:0006468 protein phosphorylation
1.19 1.06e-03 GO:0031326 regulation of cellular biosynthetic process
1.74 1.07e-03 GO:0045664 regulation of neuron differentiation
1.19 1.29e-03 GO:0010468 regulation of gene expression
1.20 1.36e-03 GO:0051252 regulation of RNA metabolic process
1.32 1.40e-03 GO:0032879 regulation of localization
1.91 1.75e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.19 1.80e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.18 2.00e-03 GO:0009889 regulation of biosynthetic process
1.53 2.10e-03 GO:0007420 brain development
1.63 2.23e-03 GO:0045596 negative regulation of cell differentiation
1.32 2.28e-03 GO:0042127 regulation of cell proliferation
1.45 4.39e-03 GO:0072358 cardiovascular system development
1.45 4.39e-03 GO:0072359 circulatory system development
1.30 5.15e-03 GO:0007154 cell communication
1.20 5.22e-03 GO:0006355 regulation of transcription, DNA-dependent
1.98 5.25e-03 GO:0010720 positive regulation of cell development
1.10 5.49e-03 GO:0044237 cellular metabolic process
1.33 5.79e-03 GO:0051128 regulation of cellular component organization
1.18 6.46e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.24 6.69e-03 GO:0065009 regulation of molecular function
1.43 9.00e-03 GO:0048585 negative regulation of response to stimulus
1.43 1.08e-02 GO:0030001 metal ion transport
1.36 1.19e-02 GO:0051254 positive regulation of RNA metabolic process
1.43 1.26e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.37 1.43e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.34 1.52e-02 GO:0051049 regulation of transport
1.41 1.61e-02 GO:0006935 chemotaxis
1.41 1.61e-02 GO:0042330 taxis
1.27 1.74e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.35 1.86e-02 GO:0009719 response to endogenous stimulus
1.51 1.96e-02 GO:0051093 negative regulation of developmental process
1.35 1.97e-02 GO:0019220 regulation of phosphate metabolic process
1.35 1.97e-02 GO:0051174 regulation of phosphorus metabolic process
1.31 2.03e-02 GO:0009888 tissue development
1.20 2.20e-02 GO:0048513 organ development
1.82 2.29e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.34 2.42e-02 GO:0009790 embryo development
1.39 2.52e-02 GO:0023056 positive regulation of signaling
2.00 2.64e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.31 2.67e-02 GO:0016310 phosphorylation
1.28 2.73e-02 GO:0009605 response to external stimulus
1.36 2.90e-02 GO:0001932 regulation of protein phosphorylation
1.81 3.00e-02 GO:0022604 regulation of cell morphogenesis
1.72 3.15e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.32 3.68e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.41 3.83e-02 GO:0045859 regulation of protein kinase activity
1.52 4.13e-02 GO:0001944 vasculature development
1.68 4.24e-02 GO:0030900 forebrain development
1.48 4.27e-02 GO:0007389 pattern specification process
2.43 4.47e-02 GO:0007266 Rho protein signal transduction
1.38 4.47e-02 GO:0010647 positive regulation of cell communication
1.64 4.83e-02 GO:0032582 negative regulation of gene-specific transcription

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 1.53e-11 GO:0044424 intracellular part
1.08 2.05e-11 GO:0005622 intracellular
1.11 1.54e-08 GO:0005737 cytoplasm
1.14 1.99e-07 GO:0005634 nucleus
1.09 3.35e-07 GO:0043227 membrane-bounded organelle
1.09 4.24e-07 GO:0043231 intracellular membrane-bounded organelle
1.07 2.60e-05 GO:0043226 organelle
1.07 4.35e-05 GO:0043229 intracellular organelle
1.21 8.12e-05 GO:0044459 plasma membrane part
1.23 2.16e-04 GO:0031981 nuclear lumen
1.24 2.71e-03 GO:0005654 nucleoplasm
1.18 4.18e-03 GO:0070013 intracellular organelle lumen
1.18 4.46e-03 GO:0044428 nuclear part
1.18 6.38e-03 GO:0005829 cytosol
1.17 1.09e-02 GO:0043233 organelle lumen
1.16 1.46e-02 GO:0031974 membrane-enclosed lumen
1.40 1.89e-02 GO:0045202 synapse
1.27 2.01e-02 GO:0042995 cell projection
1.33 2.03e-02 GO:0030054 cell junction
1.30 2.06e-02 GO:0044451 nucleoplasm part
1.03 3.54e-02 GO:0044464 cell part
1.03 3.72e-02 GO:0005623 cell
1.24 4.41e-02 GO:0005794 Golgi apparatus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 8.35e-14 GO:0005515 protein binding
1.08 3.85e-10 GO:0005488 binding
1.44 7.96e-10 GO:0030528 transcription regulator activity
1.38 9.24e-07 GO:0001071 nucleic acid binding transcription factor activity
1.38 9.24e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.43 2.05e-05 GO:0043565 sequence-specific DNA binding
1.62 5.68e-05 GO:0016564 transcription repressor activity
1.51 6.39e-05 GO:0019904 protein domain specific binding
1.61 6.83e-05 GO:0016563 transcription activator activity
1.37 1.29e-04 GO:0016301 kinase activity
1.37 2.96e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.33 4.50e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.38 1.49e-03 GO:0004672 protein kinase activity
1.22 1.53e-03 GO:0016740 transferase activity
1.33 3.04e-03 GO:0019899 enzyme binding
1.83 6.70e-03 GO:0030674 protein binding, bridging
1.19 9.13e-03 GO:0032553 ribonucleotide binding
1.19 9.13e-03 GO:0032555 purine ribonucleotide binding
1.79 9.71e-03 GO:0060090 binding, bridging
1.19 1.21e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.19 1.31e-02 GO:0017076 purine nucleotide binding
1.59 1.71e-02 GO:0000975 regulatory region DNA binding
1.59 1.71e-02 GO:0001067 regulatory region nucleic acid binding
1.59 1.71e-02 GO:0044212 transcription regulatory region DNA binding
1.16 2.13e-02 GO:0000166 nucleotide binding
1.59 2.85e-02 GO:0010843 promoter binding
2.89 3.94e-02 GO:0005326 neurotransmitter transporter activity