Motif ID: MYFfamily.p2

Z-value: 2.223


Transcription factors associated with MYFfamily.p2:

Gene SymbolEntrez IDGene Name
MYF5 4617 myogenic factor 5
MYF6 4618 myogenic factor 6 (herculin)
MYOD1 4654 myogenic differentiation 1
MYOG 4656 myogenin (myogenic factor 4)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
MYOGchr1_-_203055088-0.462.1e-02Click!
MYOD1chr11_+_17741109-0.433.2e-02Click!
MYF5chr12_+_81110689-0.358.6e-02Click!
MYF6chr12_+_81101407-0.067.8e-01Click!


Activity profile for motif MYFfamily.p2.

activity profile for motif MYFfamily.p2


Sorted Z-values histogram for motif MYFfamily.p2

Sorted Z-values for motif MYFfamily.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MYFfamily.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_72440143 35.788 DACH1
dachshund homolog 1 (Drosophila)
chr13_-_72440557 33.252 DACH1
dachshund homolog 1 (Drosophila)
chr18_-_22931970 11.953 ZNF521
zinc finger protein 521
chr5_+_137801178 10.629 NM_001964
EGR1
early growth response 1
chr18_-_22932109 10.393 NM_015461
ZNF521
zinc finger protein 521
chr17_+_39382878 10.215 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr2_+_148778573 9.766 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr8_+_37654757 9.754 GPR124
G protein-coupled receptor 124
chr3_-_18466759 9.156 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr14_-_105634708 9.006 JAG2
jagged 2
chr1_-_231114617 8.427 NM_001122835
NM_024525
TTC13

tetratricopeptide repeat domain 13

chr1_-_231114596 8.196 TTC13
tetratricopeptide repeat domain 13
chr2_+_191745546 8.178 NM_014905
GLS
glutaminase
chr8_+_37654833 8.090 GPR124
G protein-coupled receptor 124
chr12_-_76425375 7.296 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr2_+_191745791 7.177 GLS
glutaminase
chr5_+_137801166 7.062 EGR1
early growth response 1
chr6_-_32191779 7.052 NM_004557
NOTCH4
notch 4
chr16_+_90168671 6.989 FAM157C
family with sequence similarity 157, member C
chr14_-_105635114 6.957 NM_002226
NM_145159
JAG2

jagged 2

chrX_-_119694492 6.396 CUL4B
cullin 4B
chr13_+_36050885 6.393 NM_001204197
NBEA
neurobeachin
chr8_+_37654395 6.264 NM_032777
GPR124
G protein-coupled receptor 124
chr1_-_59042827 6.213 TACSTD2
tumor-associated calcium signal transducer 2
chr12_-_76424474 6.084 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr1_-_231114580 6.019 TTC13
tetratricopeptide repeat domain 13
chr8_+_37654406 5.979 GPR124
G protein-coupled receptor 124
chr12_-_76425207 5.970 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr2_+_191745568 5.894 GLS
glutaminase
chr13_-_110438896 5.752 NM_003749
IRS2
insulin receptor substrate 2
chr3_-_124774735 5.481 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr7_-_11871735 5.477 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr1_+_221053000 5.448 HLX
H2.0-like homeobox
chr2_-_160654736 5.321 NM_001198763
NM_001198764
NM_014880
CD302


CD302 molecule


chr20_-_23066828 5.203 NM_012072
CD93
CD93 molecule
chr1_+_231114839 4.962


chr2_-_160654668 4.954 CD302
CD302 molecule
chr9_-_84304378 4.887 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr4_-_186697065 4.853 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr11_-_33891485 4.771 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33891361 4.748 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_+_157099203 4.574


chr11_-_66115016 4.570 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr6_+_107811272 4.423 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr7_+_72569025 4.331 GTF2IP1
general transcription factor IIi, pseudogene 1
chr18_+_72998258 4.312 TSHZ1
teashirt zinc finger homeobox 1
chr4_-_102267952 4.293 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr4_+_134073180 4.289 PCDH10
protocadherin 10
chr14_-_54423448 4.271 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr7_-_74867340 4.056 NM_001145064
GTF2IP1
GATSL2
general transcription factor IIi, pseudogene 1
GATS protein-like 2
chr9_-_98270830 3.999 NM_000264
PTCH1
patched 1
chr6_+_157099262 3.973 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr3_-_32022734 3.950 OSBPL10
oxysterol binding protein-like 10
chr11_-_33891258 3.868 LMO2
LIM domain only 2 (rhombotin-like 1)
chr2_-_220436010 3.795 OBSL1
obscurin-like 1
chr2_-_188312872 3.790 NM_005795
CALCRL
calcitonin receptor-like
chrX_-_119694719 3.786 NM_001079872
CUL4B
cullin 4B
chr1_+_153747767 3.786 NM_024330
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr9_-_14313899 3.709 NFIB
nuclear factor I/B
chr1_+_25943958 3.705 NM_020379
MAN1C1
mannosidase, alpha, class 1C, member 1
chr2_-_152684963 3.682 NM_001037174
NM_012097
NM_177985
ARL5A


ADP-ribosylation factor-like 5A


chr2_-_190445466 3.680 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr3_+_20081523 3.668 NM_003884
KAT2B
K(lysine) acetyltransferase 2B
chr2_-_190445521 3.595 NM_014585
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr1_+_78354199 3.554 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr6_+_157099041 3.537 NM_017519
NM_020732
ARID1B

AT rich interactive domain 1B (SWI1-like)

chr8_-_28243589 3.505 ZNF395
zinc finger protein 395
chr1_+_47489239 3.497 NM_178033
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr2_-_152684933 3.484 ARL5A
ADP-ribosylation factor-like 5A
chr2_-_190445612 3.465 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr4_-_103682050 3.445 MANBA
mannosidase, beta A, lysosomal
chr2_-_152684882 3.427 ARL5A
ADP-ribosylation factor-like 5A
chr17_+_40913211 3.379 NM_005854
RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr17_-_47841517 3.359 NM_030802
FAM117A
family with sequence similarity 117, member A
chr17_-_47841468 3.355 FAM117A
family with sequence similarity 117, member A
chr4_-_102268333 3.333 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr1_+_87797371 3.316 LMO4
LIM domain only 4
chr12_+_53440809 3.303 NM_198316
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr2_+_191745547 3.270 GLS
glutaminase
chr12_+_79258517 3.211 SYT1
synaptotagmin I
chr3_+_32280154 3.207 NM_178868
CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr11_+_125034558 3.192 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr7_+_1097140 3.158 NM_138445
GPR146
G protein-coupled receptor 146
chr17_+_61554420 3.128 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr1_+_231114794 3.119 NM_022786
ARV1
ARV1 homolog (S. cerevisiae)
chr15_+_96873845 3.119 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr2_-_220436267 3.116 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr6_-_111136330 3.067 CDK19
cyclin-dependent kinase 19
chr9_-_14314036 3.062 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr16_+_30406711 3.036 NM_152652
ZNF48
zinc finger protein 48
chr19_-_19051112 3.034 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr5_-_112824526 3.018 NM_001085377
MCC
mutated in colorectal cancers
chr1_-_92351476 3.006 TGFBR3
transforming growth factor, beta receptor III
chr6_+_7727010 2.988 NM_001718
BMP6
bone morphogenetic protein 6
chr2_-_74667553 2.934 NM_001015056
NM_033046
RTKN

rhotekin

chr18_+_77659446 2.925


chr1_+_153651050 2.871 NM_000906
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr11_+_71238312 2.821 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr11_-_33890931 2.796 LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_+_125034604 2.788 PKNOX2
PBX/knotted 1 homeobox 2
chr2_+_203499819 2.732 NM_173511
FAM117B
family with sequence similarity 117, member B
chr17_-_34122547 2.711 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr3_-_169381417 2.687 NM_001205194
NM_004991
MECOM

MDS1 and EVI1 complex locus

chr4_-_102268626 2.676 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr13_-_114567011 2.673 GAS6
growth arrest-specific 6
chr8_-_22550708 2.667 NM_004430
EGR3
early growth response 3
chr1_-_92351613 2.650 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr4_+_41540320 2.646 LIMCH1
LIM and calponin homology domains 1
chr14_+_61788398 2.627 NM_006255
PRKCH
protein kinase C, eta
chr2_+_217498205 2.616 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chrX_+_46433191 2.610 NM_019886
CHST7
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
chr12_+_79258588 2.608 SYT1
synaptotagmin I
chr6_+_157099873 2.572 ARID1B
AT rich interactive domain 1B (SWI1-like)
chr14_+_65879694 2.524 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr9_+_22447064 2.519


chr13_-_114567034 2.518 GAS6
growth arrest-specific 6
chr6_+_34857021 2.516 NM_015245
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr2_-_152684689 2.483 ARL5A
ADP-ribosylation factor-like 5A
chr16_-_88772807 2.483 NM_178841
RNF166
ring finger protein 166
chrX_-_54522318 2.480 NM_004463
FGD1
FYVE, RhoGEF and PH domain containing 1
chr5_-_88199868 2.448 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr11_+_64879294 2.444 NM_003273
TM7SF2
transmembrane 7 superfamily member 2
chr4_-_186577858 2.404 SORBS2
sorbin and SH3 domain containing 2
chr2_+_217498082 2.390 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr4_+_41540187 2.389 LIMCH1
LIM and calponin homology domains 1
chr1_-_32707198 2.383 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr14_-_54421269 2.360 NM_130851
BMP4
bone morphogenetic protein 4
chr13_+_78271820 2.355 NM_001242868
SLAIN1
SLAIN motif family, member 1
chr6_-_111136407 2.339 NM_015076
CDK19
cyclin-dependent kinase 19
chr16_-_88772732 2.338 NM_001171815
RNF166
ring finger protein 166
chr13_-_114567040 2.328 NM_000820
GAS6
growth arrest-specific 6
chr6_-_150185161 2.304 LRP11
low density lipoprotein receptor-related protein 11
chr9_-_8733893 2.302 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr1_+_87794576 2.300 LMO4
LIM domain only 4
chr7_-_120498128 2.285 NM_012338
TSPAN12
tetraspanin 12
chr2_-_99347430 2.277 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr17_+_38599651 2.245 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr20_-_35374530 2.227 NM_022477
NM_032013
NDRG3

NDRG family member 3

chr1_+_84767288 2.214 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chrX_-_54521866 2.203 FGD1
FYVE, RhoGEF and PH domain containing 1
chr16_-_74640915 2.197 GLG1
golgi glycoprotein 1
chr13_-_77460432 2.177 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr12_+_6937570 2.172 NM_014262
LEPREL2
leprecan-like 2
chr9_+_127539382 2.167 NM_182487
OLFML2A
olfactomedin-like 2A
chr16_-_74640997 2.136 GLG1
golgi glycoprotein 1
chr4_-_186578122 2.127 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr13_-_114566951 2.123 GAS6
growth arrest-specific 6
chrX_+_86772714 2.121 NM_019117
NM_057162
KLHL4

kelch-like 4 (Drosophila)

chr15_-_34659245 2.119 NM_153613
LPCAT4
lysophosphatidylcholine acyltransferase 4
chr9_+_35906188 2.116 NM_001039792
HRCT1
histidine rich carboxyl terminus 1
chr3_+_32148000 2.112 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr12_+_6937764 2.105 LEPREL2
leprecan-like 2
chr12_-_118541655 2.096 NM_019086
VSIG10
V-set and immunoglobulin domain containing 10
chrX_-_19905605 2.083 SH3KBP1
SH3-domain kinase binding protein 1
chr19_+_35760002 2.080 USF2
upstream transcription factor 2, c-fos interacting
chr3_+_110790460 2.073 NM_001243286
NM_015480
PVRL3

poliovirus receptor-related 3

chr3_+_32280211 2.062 CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr8_-_4852262 2.056 NM_033225
CSMD1
CUB and Sushi multiple domains 1
chr12_-_95044205 2.036 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr20_-_35374468 2.018 NDRG3
NDRG family member 3
chr6_-_108395939 1.997 NM_014028
OSTM1
osteopetrosis associated transmembrane protein 1
chr3_-_4508955 1.979 NM_001164674
NM_001164675
NM_182760
SUMF1


sulfatase modifying factor 1


chr17_+_47866119 1.963 KAT7
K(lysine) acetyltransferase 7
chr13_+_31480311 1.960 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr2_-_27531113 1.949 NM_003353
UCN
urocortin
chr3_-_64211111 1.948 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr20_+_2673193 1.933 NM_001110514
EBF4
early B-cell factor 4
chr7_+_94023872 1.902 NM_000089
COL1A2
collagen, type I, alpha 2
chr14_+_24867926 1.898 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr11_-_33913835 1.885 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr9_+_2015218 1.869 NM_003070
NM_139045
SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr17_-_7760740 1.865 LSMD1
LSM domain containing 1
chr12_+_93771607 1.839 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr16_-_74641014 1.829 NM_001145666
NM_001145667
NM_012201
GLG1


golgi glycoprotein 1


chr16_-_31214054 1.829 NM_013258
NM_145182
PYCARD

PYD and CARD domain containing

chr4_+_126237566 1.783 NM_024582
FAT4
FAT tumor suppressor homolog 4 (Drosophila)
chr7_+_94024201 1.777 COL1A2
collagen, type I, alpha 2
chr18_-_500583 1.775 NM_130386
COLEC12
collectin sub-family member 12
chrX_-_118827116 1.759 SEPT6
septin 6
chr15_+_41221530 1.755 NM_019074
DLL4
delta-like 4 (Drosophila)
chr5_+_42423811 1.744 NM_000163
GHR
growth hormone receptor
chr5_-_88179278 1.705 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr1_-_59043165 1.702 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr10_-_116392099 1.694 ABLIM1
actin binding LIM protein 1
chr13_-_37494370 1.688 NM_001127217
NM_005905
SMAD9

SMAD family member 9

chrX_-_118827155 1.686 SEPT6
septin 6
chr11_+_64001974 1.684 NM_001243733
NM_003377
VEGFB

vascular endothelial growth factor B

chr12_-_71003622 1.676 NM_001206971
NM_001206972
NM_002837
PTPRB


protein tyrosine phosphatase, receptor type, B


chr4_-_103682150 1.667 NM_005908
MANBA
mannosidase, beta A, lysosomal
chr5_+_52284903 1.657 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr9_-_111882209 1.649 NM_032012
C9orf5
chromosome 9 open reading frame 5
chr11_+_68079999 1.644 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr6_+_30856462 1.640 NM_001202521
NM_001202522
NM_013994
DDR1


discoidin domain receptor tyrosine kinase 1


chr11_+_65658101 1.639 CCDC85B
coiled-coil domain containing 85B
chr7_+_128828712 1.635 NM_005631
SMO
smoothened, frizzled family receptor
chr15_-_56035176 1.623 NM_173814
PRTG
protogenin
chr10_-_21805715 1.621 C10orf140
chromosome 10 open reading frame 140
chr12_-_29936685 1.618 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr5_+_139060058 1.615 CXXC5
CXXC finger protein 5
chr16_+_29823557 1.611 PRRT2
proline-rich transmembrane protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.23 1.18e-04 GO:0048731 system development
1.21 4.49e-04 GO:0048856 anatomical structure development
1.20 5.27e-04 GO:0007275 multicellular organismal development
4.47 1.87e-03 GO:0001937 negative regulation of endothelial cell proliferation
1.17 2.37e-03 GO:0032502 developmental process
1.07 7.17e-03 GO:0009987 cellular process
1.52 1.39e-02 GO:0006325 chromatin organization
4.88 1.68e-02 GO:0043537 negative regulation of blood vessel endothelial cell migration
1.27 2.12e-02 GO:0007399 nervous system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 2.79e-03 GO:0005783 endoplasmic reticulum
1.28 3.72e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 3.87e-03 GO:0005515 protein binding
2.06 6.72e-03 GO:0019838 growth factor binding