Motif ID: NFATC1..3.p2

Z-value: 1.851


Transcription factors associated with NFATC1..3.p2:

Gene SymbolEntrez IDGene Name
NFATC1 4772 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 4773 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 4775 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NFATC1chr18_+_772533240.768.8e-06Click!
NFATC3chr16_+_681193500.672.6e-04Click!
NFATC2chr20_-_501793380.232.6e-01Click!


Activity profile for motif NFATC1..3.p2.

activity profile for motif NFATC1..3.p2


Sorted Z-values histogram for motif NFATC1..3.p2

Sorted Z-values for motif NFATC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_116444374 15.339 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr18_+_20735788 12.970 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr10_-_116444112 11.788 ABLIM1
actin binding LIM protein 1
chr5_-_88199868 10.351 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr2_-_188312872 9.693 NM_005795
CALCRL
calcitonin receptor-like
chr12_+_13349720 9.349 EMP1
epithelial membrane protein 1
chr2_-_225266710 7.758 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr3_-_18480203 7.542 NM_001131010
SATB1
SATB homeobox 1
chr12_+_13349601 7.454 NM_001423
EMP1
epithelial membrane protein 1
chr21_-_27945267 7.280 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr6_-_76203256 6.865 NM_015687
FILIP1
filamin A interacting protein 1
chr4_+_41614911 6.478 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr3_-_149051258 6.386 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr4_+_41614933 6.117 LIMCH1
LIM and calponin homology domains 1
chr10_+_35484829 5.747 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr4_-_149363498 5.165 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr17_+_39382878 4.956 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr1_+_84630014 4.831 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr8_-_93075190 4.719 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr18_-_53068755 4.644 TCF4
transcription factor 4
chr1_+_78470593 4.593 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr12_+_9142136 4.433 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr7_-_64023444 4.358


chr4_-_186697065 4.350 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr9_-_74675498 4.122 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr1_+_45274153 4.102 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr8_-_80993009 4.085 NM_001025252
TPD52
tumor protein D52
chr9_+_79115548 3.953 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr1_+_100111430 3.916 NM_017734
PALMD
palmdelphin
chr4_-_70626429 3.872 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr18_+_77155714 3.858 NM_006162
NM_172388
NM_172390
NFATC1


nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1


chr18_+_77155927 3.843 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr13_-_49110117 3.615 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr2_+_189839132 3.612 COL3A1
collagen, type III, alpha 1
chrX_-_135863104 3.596 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr17_-_67138013 3.521 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr5_+_42565963 3.512 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr19_+_36727325 3.502 ZNF146
zinc finger protein 146
chr4_-_90759446 3.290 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr4_-_159093523 3.286 FAM198B
family with sequence similarity 198, member B
chr3_+_39851028 3.271 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chrX_-_135863033 3.268 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chrX_-_63005212 3.242 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr5_+_61874561 3.221 NM_181506
LRRC70
leucine rich repeat containing 70
chr11_+_123986103 3.206 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chr1_+_164528586 3.144 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr1_+_84768333 3.115 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr6_+_116832807 3.081 NM_153711
FAM26E
family with sequence similarity 26, member E
chr19_+_36726883 3.067 ZNF146
zinc finger protein 146
chr1_+_84764048 3.048 NM_001010971
SAMD13
sterile alpha motif domain containing 13
chr5_-_78282356 3.009 NM_000046
ARSB
arylsulfatase B
chr2_+_189839078 3.000 NM_000090
COL3A1
collagen, type III, alpha 1
chr5_+_43609261 2.992 NNT
nicotinamide nucleotide transhydrogenase
chrX_-_10544852 2.978 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr7_+_94024201 2.940 COL1A2
collagen, type I, alpha 2
chr20_+_42574535 2.896 NM_001098798
TOX2
TOX high mobility group box family member 2
chr1_+_61547388 2.854 NM_001145512
NFIA
nuclear factor I/A
chr12_-_9268513 2.824 A2M
alpha-2-macroglobulin
chr7_-_131833385 2.802 PLXNA4
plexin A4
chr7_-_64023331 2.801 ZNF680
zinc finger protein 680
chr8_-_22550057 2.779 NM_001199881
EGR3
early growth response 3
chr15_+_25101697 2.770 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr3_-_93692898 2.727 NM_000313
PROS1
protein S (alpha)
chr4_+_156587861 2.704 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chrX_-_117119282 2.690 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr4_-_186577858 2.676 SORBS2
sorbin and SH3 domain containing 2
chr4_-_16900348 2.654 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr5_-_111093792 2.643 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr5_+_68800003 2.601 NM_001205255
OCLN
occludin
chr19_-_54692132 2.594 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr8_-_28243941 2.586 NM_018660
ZNF395
zinc finger protein 395
chr7_+_106685007 2.583 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr19_+_11200037 2.569 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr1_+_164818083 2.561 PBX1
pre-B-cell leukemia homeobox 1
chr17_-_8424217 2.559 MYH10
myosin, heavy chain 10, non-muscle
chr9_+_115631814 2.431 SNX30
sorting nexin family member 30
chr5_+_42565562 2.407 NM_001242406
GHR
growth hormone receptor
chr5_+_140602914 2.404 NM_018934
PCDHB14
protocadherin beta 14
chr2_-_111230651 2.403 NM_001205288
NM_033514
LIMS3-LOC440895
LIMS3L
LIMS3
LIMS3-LOC440895 readthrough
LIM and senescent cell antigen-like domains 3-like
LIM and senescent cell antigen-like domains 3
chr12_-_7848324 2.402 NM_020634
GDF3
growth differentiation factor 3
chr2_+_110656008 2.395 NM_001205288
NM_033514
LIMS3-LOC440895
LIMS3L
LIMS3
LIMS3-LOC440895 readthrough
LIM and senescent cell antigen-like domains 3-like
LIM and senescent cell antigen-like domains 3
chr17_-_49337370 2.395 NM_017643
MBTD1
mbt domain containing 1
chr18_+_77155966 2.391 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr4_-_16900256 2.362 LDB2
LIM domain binding 2
chr18_-_22931970 2.362 ZNF521
zinc finger protein 521
chr9_-_129884998 2.312 NM_012098
ANGPTL2
angiopoietin-like 2
chr12_-_9268475 2.304 A2M
alpha-2-macroglobulin
chr9_+_131388167 2.299 SPTAN1
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
chr2_-_191878908 2.237 STAT1
signal transducer and activator of transcription 1, 91kDa
chr12_-_6055397 2.219 NM_020373
ANO2
anoctamin 2
chr1_+_78354199 2.219 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr12_+_79258588 2.217 SYT1
synaptotagmin I
chr6_-_110736748 2.200 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr17_+_47288068 2.176 ABI3
ABI family, member 3
chr21_+_18885104 2.167 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr12_-_15038724 2.161 NM_000900
NM_001190839
MGP

matrix Gla protein

chr5_+_68788387 2.148 NM_001205254
OCLN
occludin
chr8_-_17942304 2.142 ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr12_+_79258794 2.135 SYT1
synaptotagmin I
chr2_-_191878924 2.127 NM_007315
NM_139266
STAT1

signal transducer and activator of transcription 1, 91kDa

chr7_+_104681378 2.091 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr20_-_45976626 2.088 ZMYND8
zinc finger, MYND-type containing 8
chr8_-_9008138 2.073 NM_024607
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr1_+_158979681 2.072 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr12_-_9268522 2.070 NM_000014
A2M
alpha-2-macroglobulin
chr13_-_52980628 2.046 NM_018676
NM_199263
THSD1

thrombospondin, type I, domain containing 1

chr2_-_191878883 2.043 STAT1
signal transducer and activator of transcription 1, 91kDa
chr15_-_71055745 2.031 NM_018003
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr13_-_48987017 2.030 LPAR6
lysophosphatidic acid receptor 6
chr14_-_23284565 2.030 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr3_+_132316080 2.025 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr18_-_500583 2.018 NM_130386
COLEC12
collectin sub-family member 12
chr5_+_68788118 2.005 NM_002538
OCLN
occludin
chr11_-_118134986 1.953 MPZL2
myelin protein zero-like 2
chr2_+_128928040 1.933 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr12_-_10022457 1.931 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr10_+_35484054 1.930 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr4_+_41540320 1.926 LIMCH1
LIM and calponin homology domains 1
chr2_+_179184970 1.920 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr17_-_63822660 1.913 NM_001037325
CEP112
centrosomal protein 112kDa
chr1_+_84630575 1.904 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr11_-_102714240 1.899 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chrX_-_117107700 1.896 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr11_+_65266642 1.887


chr1_+_66999805 1.882 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr2_-_191878882 1.863 STAT1
signal transducer and activator of transcription 1, 91kDa
chr19_+_11200146 1.855 LDLR
low density lipoprotein receptor
chr12_+_93963597 1.847 NM_003877
SOCS2
suppressor of cytokine signaling 2
chr4_+_87968191 1.841 AFF1
AF4/FMR2 family, member 1
chr14_-_23284617 1.834 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr6_+_15245702 1.808 JARID2
jumonji, AT rich interactive domain 2
chr10_-_64578926 1.807 NM_001136178
EGR2
early growth response 2
chr9_-_13279562 1.806 MPDZ
multiple PDZ domain protein
chr16_+_29827707 1.797 C16orf53
chromosome 16 open reading frame 53
chr7_+_150413597 1.781 NM_001199577
NM_130759
GIMAP1-GIMAP5
GIMAP1
GIMAP1-GIMAP5 readthrough
GTPase, IMAP family member 1
chr1_+_84647342 1.773 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_-_101439071 1.752 NM_001159694
NM_016242
EMCN

endomucin

chr12_-_9268440 1.750 A2M
alpha-2-macroglobulin
chr20_+_33759773 1.749 NM_006404
PROCR
protein C receptor, endothelial
chr14_+_63671101 1.748 NM_020663
RHOJ
ras homolog gene family, member J
chr14_+_100531745 1.744 NM_016337
EVL
Enah/Vasp-like
chr3_+_69134057 1.741 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr14_+_100531764 1.736 EVL
Enah/Vasp-like
chr5_-_111091947 1.730 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr11_-_124973204 1.718 NM_001080546
TMEM218
transmembrane protein 218
chr4_+_41540187 1.714 LIMCH1
LIM and calponin homology domains 1
chr10_+_17851342 1.709 NM_002438
MRC1
mannose receptor, C type 1
chr10_-_105212149 1.706 NM_015916
CALHM2
calcium homeostasis modulator 2
chr11_+_5509914 1.706 NM_001005163
OR52D1
olfactory receptor, family 52, subfamily D, member 1
chr11_-_71746966 1.692


chr3_-_15839674 1.689 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr3_-_93692592 1.687 PROS1
protein S (alpha)
chr1_+_82266081 1.685 NM_012302
LPHN2
latrophilin 2
chr3_-_112359863 1.685 CCDC80
coiled-coil domain containing 80
chr17_-_62084282 1.672 NM_000873
ICAM2
intercellular adhesion molecule 2
chr18_-_22932109 1.669 NM_015461
ZNF521
zinc finger protein 521
chr12_-_29937691 1.669 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chrX_+_54947228 1.665 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr14_-_92413738 1.658 FBLN5
fibulin 5
chr10_-_72141347 1.654 NM_207119
LRRC20
leucine rich repeat containing 20
chr3_+_25470067 1.654 RARB
retinoic acid receptor, beta
chrX_+_138612894 1.653 NM_000133
F9
coagulation factor IX
chr14_-_36278335 1.652 NM_014990
NM_194301
RALGAPA1

Ral GTPase activating protein, alpha subunit 1 (catalytic)

chr19_-_41859830 1.650 NM_000660
TGFB1
transforming growth factor, beta 1
chr16_-_88770024 1.645 NM_001171816
RNF166
ring finger protein 166
chr6_-_112575708 1.633 LAMA4
laminin, alpha 4
chr13_+_58205788 1.630 NM_001040429
PCDH17
protocadherin 17
chrX_-_117250624 1.626 NM_001168302
NM_001168303
KLHL13

kelch-like 13 (Drosophila)

chr4_+_159131400 1.626 NM_018342
TMEM144
transmembrane protein 144
chr3_+_49208979 1.620 NM_173546
KLHDC8B
kelch domain containing 8B
chrX_+_135229536 1.618 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr12_+_79258448 1.610 NM_005639
SYT1
synaptotagmin I
chr1_-_94703252 1.608 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr10_-_79628870 1.605 DLG5
discs, large homolog 5 (Drosophila)
chr1_+_185703470 1.604 NM_031935
HMCN1
hemicentin 1
chr4_+_40198526 1.602 NM_004310
RHOH
ras homolog gene family, member H
chr18_-_53071225 1.597 NM_001243232
TCF4
transcription factor 4
chr3_+_159557745 1.597 SCHIP1
schwannomin interacting protein 1
chr2_+_33701320 1.590 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_+_136172802 1.576 NM_018945
PDE7B
phosphodiesterase 7B
chr9_-_21202201 1.552 NM_021057
IFNA7
interferon, alpha 7
chr17_-_5487767 1.546 NM_001033053
NM_014922
NM_033004
NM_033006
NM_033007
NLRP1




NLR family, pyrin domain containing 1




chr8_-_6420454 1.523 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr5_-_73937248 1.514 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr17_+_47287588 1.509 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr2_+_33701678 1.509 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_78444922 1.508 DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chrX_-_135863502 1.504 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_76076762 1.490 NM_001130058
NM_152697
SLC44A5

solute carrier family 44, member 5

chr13_+_103459495 1.490 NM_001204425
BIVM-ERCC5
BIVM
BIVM-ERCC5 readthrough
basic, immunoglobulin-like variable motif containing
chr2_-_192711923 1.475 NM_004657
SDPR
serum deprivation response
chr7_+_93551015 1.465 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr9_-_21077804 1.455 NM_002176
IFNB1
interferon, beta 1, fibroblast
chr5_-_135290521 1.446 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr4_-_89744154 1.444 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr18_-_52988916 1.442 NM_001243234
NM_001243235
TCF4

transcription factor 4

chr5_+_180794268 1.441 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr6_-_112575766 1.430 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr10_-_105212022 1.424 CALHM2
calcium homeostasis modulator 2
chr19_+_18118921 1.420 NM_015683
ARRDC2
arrestin domain containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.79 6.06e-07 GO:0042060 wound healing
1.86 7.60e-07 GO:0007599 hemostasis
1.86 1.13e-06 GO:0007596 blood coagulation
1.86 1.13e-06 GO:0050817 coagulation
1.73 2.06e-05 GO:0050878 regulation of body fluid levels
1.55 4.16e-05 GO:0009611 response to wounding
1.25 2.13e-02 GO:0006950 response to stress
1.11 3.91e-02 GO:0065007 biological regulation
1.75 4.05e-02 GO:0016337 cell-cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.73 4.52e-02 GO:0016323 basolateral plasma membrane

Nothing significant found in function category.