Motif ID: NFE2.p2

Z-value: 0.996


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NFE2chr12_-_54694717,
chr12_-_54689536,
chr12_-_54694647		-0.358.6e-02Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_76944585 14.236 NM_001565
 CXCL10
chemokine (C-X-C motif) ligand 10
chr9_-_123688352 8.398 TRAF1
TNF receptor-associated factor 1
chr15_+_89182038 7.389 NM_002201
 ISG20
interferon stimulated exonuclease gene 20kDa
chr11_-_102668892 5.829 NM_001145938
NM_002421
 MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr4_+_74606222 5.769 NM_000584
 IL8
interleukin 8
chr11_-_102668822 5.768 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr10_-_6019880 5.617 NM_001243539
 IL15RA
interleukin 15 receptor, alpha
chr2_+_152214105 5.281 NM_007115
 TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr10_-_6019454 5.237 NM_002189
NM_172200
 IL15RA

interleukin 15 receptor, alpha

chr1_+_183155393 5.229 LAMC2
laminin, gamma 2
chr19_+_4229494 4.742 NM_005755
 EBI3
Epstein-Barr virus induced 3
chr12_+_78225068 4.683 NM_014903
 NAV3
neuron navigator 3
chr1_+_183155173 4.200 NM_005562
NM_018891
 LAMC2

laminin, gamma 2

chr6_-_31550065 4.037 NM_002341
NM_009588
 LTB

lymphotoxin beta (TNF superfamily, member 3)

chr1_+_183155361 3.657 LAMC2
laminin, gamma 2
chr1_-_89488412 3.233 NM_018284
 GBP3
guanylate binding protein 3
chr5_+_35856990 3.169 NM_002185
 IL7R
interleukin 7 receptor
chrX_+_9431314 3.067 NM_001139466
NM_001139467
NM_001139468
 TBL1X


transducin (beta)-like 1X-linked


chr12_+_56075329 3.028 NM_152637
 METTL7B
methyltransferase like 7B
chr12_+_56075418 3.002 METTL7B
methyltransferase like 7B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 75 entries
enrichment   p-value GO term description
12.40 3.72e-02 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
10.83 1.41e-02 GO:0060600 dichotomous subdivision of an epithelial terminal unit
5.24 5.64e-04 GO:0006521 regulation of cellular amino acid metabolic process
4.88 5.87e-04 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
4.88 5.87e-04 GO:0072395 signal transduction involved in cell cycle checkpoint
4.88 5.87e-04 GO:0072401 signal transduction involved in DNA integrity checkpoint
4.88 5.87e-04 GO:0072404 signal transduction involved in G1/S transition checkpoint
4.88 5.87e-04 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
4.88 5.87e-04 GO:0072422 signal transduction involved in DNA damage checkpoint
4.88 5.87e-04 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
4.88 5.87e-04 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
4.65 1.15e-03 GO:0033238 regulation of cellular amine metabolic process
4.65 1.15e-03 GO:0071158 positive regulation of cell cycle arrest
4.38 2.65e-03 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
4.19 4.74e-03 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.15 1.19e-02 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
3.97 2.03e-02 GO:0051352 negative regulation of ligase activity
3.97 2.03e-02 GO:0051444 negative regulation of ubiquitin-protein ligase activity
3.92 2.69e-03 GO:0030330 DNA damage response, signal transduction by p53 class mediator
3.87 6.63e-03 GO:0051351 positive regulation of ligase activity

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
11.03 1.14e-02 GO:0005838 proteasome regulatory particle
9.92 3.84e-03 GO:0022624 proteasome accessory complex
5.67 3.87e-07 GO:0000502 proteasome complex
1.79 1.57e-02 GO:0030054 cell junction
1.78 5.33e-04 GO:0005626 insoluble fraction
1.71 4.79e-03 GO:0005624 membrane fraction
1.61 3.64e-03 GO:0000267 cell fraction
1.46 3.22e-04 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
13.23 4.70e-02 GO:0061133 endopeptidase activator activity
2.76 2.24e-03 GO:0005126 cytokine receptor binding
2.61 4.34e-02 GO:0061135 endopeptidase regulator activity
1.71 1.68e-02 GO:0019899 enzyme binding
1.64 4.89e-03 GO:0005102 receptor binding
1.24 3.72e-06 GO:0005515 protein binding