Motif ID: NFE2L2.p2

Z-value: 1.238


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NFE2L2chr2_-_178129294-0.433.0e-02Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_6019880 5.803 NM_001243539
 IL15RA
interleukin 15 receptor, alpha
chr10_-_6019454 5.472 NM_002189
NM_172200
 IL15RA

interleukin 15 receptor, alpha

chr9_-_123688352 4.812 TRAF1
TNF receptor-associated factor 1
chr4_-_76944585 4.643 NM_001565
 CXCL10
chemokine (C-X-C motif) ligand 10
chr15_+_89182038 3.636 NM_002201
 ISG20
interferon stimulated exonuclease gene 20kDa
chr11_-_102668822 3.463 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr5_+_35856990 3.382 NM_002185
 IL7R
interleukin 7 receptor
chr12_+_56075329 2.875 NM_152637
 METTL7B
methyltransferase like 7B
chr12_+_56075418 2.800 METTL7B
methyltransferase like 7B
chr6_-_32821743 2.379 NM_000593
 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_-_102668892 2.354 NM_001145938
NM_002421
 MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr16_+_57662301 2.264 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
 GPR56




G protein-coupled receptor 56




chr12_-_10151689 2.238 NM_001099431
NM_016509
 CLEC1B

C-type lectin domain family 1, member B

chr7_-_115670774 2.236 TFEC
transcription factor EC
chrX_-_154563735 2.174 NM_001289
 CLIC2
chloride intracellular channel 2
chr1_-_89488412 2.084 NM_018284
 GBP3
guanylate binding protein 3
chr12_+_78225068 2.045 NM_014903
 NAV3
neuron navigator 3
chr6_-_138428477 2.021 NM_022121
 PERP
PERP, TP53 apoptosis effector
chr1_+_36554452 1.994 NM_017825
 ADPRHL2
ADP-ribosylhydrolase like 2
chr6_-_84140854 1.700 NM_002395
 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 49 entries
enrichment   p-value GO term description
7.71 4.15e-08 GO:0006521 regulation of cellular amino acid metabolic process
7.09 5.19e-08 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
7.09 5.19e-08 GO:0072395 signal transduction involved in cell cycle checkpoint
7.09 5.19e-08 GO:0072401 signal transduction involved in DNA integrity checkpoint
7.09 5.19e-08 GO:0072404 signal transduction involved in G1/S transition checkpoint
7.09 5.19e-08 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
7.09 5.19e-08 GO:0072422 signal transduction involved in DNA damage checkpoint
7.09 5.19e-08 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
7.09 5.19e-08 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
6.76 1.27e-07 GO:0071158 positive regulation of cell cycle arrest
6.71 4.24e-08 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
6.38 1.15e-06 GO:0033238 regulation of cellular amine metabolic process
6.10 2.51e-06 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
6.09 8.32e-07 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
5.85 5.75e-07 GO:0031575 mitotic cell cycle G1/S transition checkpoint
5.85 5.75e-07 GO:0071779 G1/S transition checkpoint
5.84 5.21e-06 GO:0051352 negative regulation of ligase activity
5.84 5.21e-06 GO:0051444 negative regulation of ubiquitin-protein ligase activity
5.62 3.46e-06 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
5.57 1.44e-06 GO:0051351 positive regulation of ligase activity

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
13.35 4.12e-03 GO:0005838 proteasome regulatory particle
10.01 2.33e-02 GO:0022624 proteasome accessory complex
8.01 1.22e-11 GO:0000502 proteasome complex
7.21 3.64e-02 GO:0005839 proteasome core complex
1.58 3.86e-02 GO:0000267 cell fraction
1.40 2.15e-02 GO:0044459 plasma membrane part

Nothing significant found in function category.