Motif ID: NFIX.p2

Z-value: 1.144


Transcription factors associated with NFIX.p2:

Gene SymbolEntrez IDGene Name
NFIX 4784 nuclear factor I/X (CCAAT-binding transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NFIXchr19_+_131353680.733.5e-05Click!


Activity profile for motif NFIX.p2.

activity profile for motif NFIX.p2


Sorted Z-values histogram for motif NFIX.p2

Sorted Z-values for motif NFIX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_184943673 10.949 NM_052966
FAM129A
family with sequence similarity 129, member A
chr1_-_184943532 8.629 FAM129A
family with sequence similarity 129, member A
chr6_-_31550065 6.147 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr11_-_72353435 5.304 NM_001143839
NM_001243784
PDE2A

phosphodiesterase 2A, cGMP-stimulated

chr15_+_67358161 5.276 SMAD3
SMAD family member 3
chr15_+_67358194 5.022 NM_005902
SMAD3
SMAD family member 3
chr8_+_104383701 3.516 CTHRC1
collagen triple helix repeat containing 1
chr8_+_104383785 3.416 NM_138455
CTHRC1
collagen triple helix repeat containing 1
chr15_+_67430358 3.372 NM_001145103
SMAD3
SMAD family member 3
chr1_+_79086087 3.359 NM_006820
IFI44L
interferon-induced protein 44-like
chr7_-_77045706 3.150 NM_017439
PION
pigeon homolog (Drosophila)
chr16_-_11680146 2.811 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr9_-_38069082 2.598 SHB
Src homology 2 domain containing adaptor protein B
chr2_-_163174816 2.577 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr12_+_26348268 2.561 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr4_-_120549115 2.352 NM_033437
PDE5A
phosphodiesterase 5A, cGMP-specific
chr7_+_65670256 2.247 NM_003596
TPST1
tyrosylprotein sulfotransferase 1
chr2_+_201983419 2.235 CFLAR
CASP8 and FADD-like apoptosis regulator
chr22_+_31644368 2.173 LIMK2
LIM domain kinase 2
chr9_+_115913227 2.162 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr14_-_24615772 2.118 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chrX_-_68385249 2.107 NM_001032396
NM_022368
NM_145119
PJA1


praja ring finger 1


chr6_-_3227776 2.093 NM_178012
TUBB2B
tubulin, beta 2B class IIb
chr14_-_24615794 2.068 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr17_-_28562953 2.005 NM_001045
SLC6A4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
chr9_-_123691442 1.948 NM_001190945
TRAF1
TNF receptor-associated factor 1
chr21_+_43933983 1.929 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr6_+_14117486 1.910 NM_001251901
CD83
CD83 molecule
chr9_-_32526164 1.826 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr8_+_86089641 1.785


chr1_-_156722023 1.769 NM_001126051
NM_001126050
HDGF

hepatoma-derived growth factor

chr22_+_31644314 1.754 NM_001031801
NM_016733
LIMK2

LIM domain kinase 2

chr5_-_59783885 1.740 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_+_39261640 1.664 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr4_-_120548329 1.653 NM_033430
PDE5A
phosphodiesterase 5A, cGMP-specific
chr9_-_123676849 1.648 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr2_+_111878450 1.645 NM_001204106
NM_001204107
NM_001204108
NM_001204109
NM_001204110
NM_001204111
NM_001204112
NM_001204113
NM_006538
NM_138621
NM_138622
NM_138623
NM_138624
NM_138625
NM_138626
NM_138627
NM_207002
NM_207003
BCL2L11

















BCL2-like 11 (apoptosis facilitator)

















chr11_-_441995 1.623 NM_001012302
ANO9
anoctamin 9
chr8_+_86089618 1.616 NM_001083588
NM_001951
E2F5

E2F transcription factor 5, p130-binding

chr12_+_108909049 1.607 NM_007076
FICD
FIC domain containing
chr11_-_118781612 1.598 NM_182557
BCL9L
B-cell CLL/lymphoma 9-like
chr17_-_28088267 1.590 SSH2
slingshot homolog 2 (Drosophila)
chr4_+_15704691 1.576 BST1
bone marrow stromal cell antigen 1
chr11_-_61735108 1.565 NM_002032
FTH1
ferritin, heavy polypeptide 1
chr21_+_33784751 1.546 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr14_+_51955854 1.474 NM_001042481
FRMD6
FERM domain containing 6
chr15_+_66679107 1.469 NM_002755
MAP2K1
mitogen-activated protein kinase kinase 1
chr4_+_15704752 1.436 BST1
bone marrow stromal cell antigen 1
chr2_+_201983268 1.405 NM_001127183
CFLAR
CASP8 and FADD-like apoptosis regulator
chr11_-_441956 1.396 ANO9
anoctamin 9
chr1_+_212788359 1.392 NM_001206486
ATF3
activating transcription factor 3
chr4_+_15704572 1.361 NM_004334
BST1
bone marrow stromal cell antigen 1
chr11_+_113775517 1.357 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr2_-_106810781 1.340 NM_025076
UXS1
UDP-glucuronate decarboxylase 1
chr7_-_1199785 1.261 ZFAND2A
zinc finger, AN1-type domain 2A
chr8_-_119123804 1.255 NM_000127
EXT1
exostosin 1
chr1_+_212738675 1.239 NM_001030287
ATF3
activating transcription factor 3
chr5_+_115298136 1.236 NM_173800
AQPEP
laeverin
chr3_-_50374795 1.191 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr10_-_75173724 1.185 ANXA7
annexin A7
chr6_+_109761887 1.183 NM_003080
SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr9_+_115913266 1.179 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr2_-_106810756 1.167 UXS1
UDP-glucuronate decarboxylase 1
chr16_+_57406398 1.163 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr15_-_80263460 1.163 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr6_+_109762043 1.138 SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr20_-_48530275 1.135 NM_001135773
SPATA2
spermatogenesis associated 2
chr7_-_1199813 1.122 ZFAND2A
zinc finger, AN1-type domain 2A
chr6_+_109762204 1.114 SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr21_-_43373938 1.112 NM_015500
C2CD2
C2 calcium-dependent domain containing 2
chr2_-_106810735 1.105 UXS1
UDP-glucuronate decarboxylase 1
chr4_+_77870944 1.093 SEPT11
septin 11
chr22_+_50919970 1.084 NM_024866
NM_001253845
ADM2

adrenomedullin 2

chr12_+_26348488 1.083 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr1_-_156721501 1.080 NM_004494
HDGF
hepatoma-derived growth factor
chr3_+_122399665 1.074 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr1_+_2518464 1.059 FAM213B
family with sequence similarity 213, member B
chr3_+_53195214 1.045 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr2_-_225907312 1.013 NM_014689
DOCK10
dedicator of cytokinesis 10
chr7_-_1199822 1.007 NM_182491
ZFAND2A
zinc finger, AN1-type domain 2A
chr21_+_26934440 1.005 MIR155HG
MIR155 host gene (non-protein coding)
chr17_+_77020278 1.000 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr18_+_23806385 0.990 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr10_-_75173789 0.986 ANXA7
annexin A7
chr12_+_7942025 0.982 NANOG
Nanog homeobox
chr7_-_80548666 0.975 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr11_+_93862143 0.970 PANX1
pannexin 1
chr1_-_11042093 0.962 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr19_+_40146533 0.943 NM_001190441
LGALS16
lectin, galactoside-binding, soluble, 16
chr3_-_50374749 0.940 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr22_+_30476452 0.936 NM_152510
HORMAD2
HORMA domain containing 2
chr19_+_30156326 0.910 NM_024310
PLEKHF1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
chr21_+_42792441 0.906 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr17_-_49198084 0.877 NM_001130527
NM_001130528
NM_003971
SPAG9


sperm associated antigen 9


chr15_+_74466887 0.871 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr5_+_65017993 0.867 NM_020726
NLN
neurolysin (metallopeptidase M3 family)
chr20_+_43344005 0.865 WISP2
WNT1 inducible signaling pathway protein 2
chr11_+_45825873 0.861 SLC35C1
solute carrier family 35, member C1
chr5_+_34656595 0.856 NM_001145520
RAI14
retinoic acid induced 14
chr10_-_75173807 0.852 NM_001156
NM_004034
ANXA7

annexin A7

chr11_-_61735067 0.845 FTH1
CPSF7
ferritin, heavy polypeptide 1
cleavage and polyadenylation specific factor 7, 59kDa
chr11_+_93862060 0.844 NM_015368
PANX1
pannexin 1
chr12_-_121734474 0.833 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr16_+_31044849 0.829 STX4
syntaxin 4
chr11_-_117698727 0.797 NM_021603
FXYD2
FXYD domain containing ion transport regulator 2
chr2_+_11886739 0.791 NM_145693
LPIN1
lipin 1
chr11_-_36531767 0.784 NM_004620
NM_145803
TRAF6

TNF receptor-associated factor 6

chr4_-_185747051 0.781 ACSL1
acyl-CoA synthetase long-chain family member 1
chrX_-_136113832 0.775 NM_054021
GPR101
G protein-coupled receptor 101
chr1_+_25071906 0.771 CLIC4
chloride intracellular channel 4
chr17_+_19281013 0.770 NM_139032
NM_139033
MAPK7

mitogen-activated protein kinase 7

chr11_+_18417812 0.765 NM_001165414
LDHA
lactate dehydrogenase A
chr1_-_159869897 0.764 NM_012337
CCDC19
coiled-coil domain containing 19
chr15_+_91769329 0.755 SV2B
synaptic vesicle glycoprotein 2B
chr5_+_34656367 0.752 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr14_+_77924367 0.750 NM_012111
AHSA1
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
chr1_+_1072274 0.749 LOC254099
uncharacterized LOC254099
chr4_+_77870864 0.749 NM_018243
SEPT11
septin 11
chr1_+_113217278 0.745 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr8_+_11627144 0.737 NM_001135746
NM_001135747
NM_001135748
NM_145043
NEIL2



nei endonuclease VIII-like 2 (E. coli)



chr7_+_108210188 0.734 NM_012328
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr7_+_108210291 0.731 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr13_-_102068705 0.725 NM_052867
NALCN
sodium leak channel, non-selective
chr3_+_154797435 0.720 NM_000902
MME
membrane metallo-endopeptidase
chr11_+_75526211 0.719 NM_003369
UVRAG
UV radiation resistance associated gene
chr1_-_6614552 0.710 NOL9
nucleolar protein 9
chr3_+_10290204 0.705 TATDN2
TatD DNase domain containing 2
chr6_-_46459010 0.704 NM_001251974
RCAN2
regulator of calcineurin 2
chr1_-_205782135 0.703 NM_173854
SLC41A1
solute carrier family 41, member 1
chr12_+_75874512 0.703 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr15_-_66648991 0.702 NM_017858
TIPIN
TIMELESS interacting protein
chr5_+_34656482 0.697 RAI14
retinoic acid induced 14
chr15_+_63336274 0.691 TPM1
tropomyosin 1 (alpha)
chr3_+_190231839 0.687 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr20_-_47894570 0.681 ZNFX1
zinc finger, NFX1-type containing 1
chr7_-_80548322 0.679 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr22_-_50964856 0.678 NM_001169109
SCO2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chr12_+_7941994 0.676 NM_024865
NANOG
Nanog homeobox
chr16_+_31044881 0.675 NM_004604
STX4
syntaxin 4
chr7_+_108210308 0.674 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr9_+_112810877 0.670 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr16_+_56703725 0.670 NM_005951
MT1H
metallothionein 1H
chr20_-_8000370 0.667 NM_021156
TMX4
thioredoxin-related transmembrane protein 4
chr11_-_61734896 0.667 FTH1
ferritin, heavy polypeptide 1
chr4_-_177116713 0.667 NM_144644
SPATA4
spermatogenesis associated 4
chr6_+_14117857 0.664 NM_001040280
NM_004233
CD83

CD83 molecule

chr1_-_160990862 0.660 F11R
F11 receptor
chr2_+_73441344 0.652 NM_006062
SMYD5
SMYD family member 5
chr12_+_102271349 0.649 DRAM1
DNA-damage regulated autophagy modulator 1
chr5_-_65017874 0.639 NM_019072
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr3_+_10290357 0.638 TATDN2
TatD DNase domain containing 2
chr20_-_47894591 0.638 NM_021035
ZNFX1
zinc finger, NFX1-type containing 1
chr9_+_137001243 0.637 WDR5
WD repeat domain 5
chr14_+_75348592 0.634 NM_001244883
NM_001933
DLST

dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)

chr4_+_38869346 0.630 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr5_+_131746579 0.628 C5orf56
chromosome 5 open reading frame 56
chr16_-_28608367 0.620 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr5_+_76114881 0.620 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr14_-_77965100 0.615 NM_182509
NM_199296
ISM2

isthmin 2 homolog (zebrafish)

chr20_-_44539542 0.613 PLTP
phospholipid transfer protein
chr15_+_78441737 0.603 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr19_-_58090071 0.602 NM_017879
ZNF416
zinc finger protein 416
chr19_-_1237840 0.602 NM_152769
C19orf26
chromosome 19 open reading frame 26
chr3_+_10290169 0.598 NM_014760
TATDN2
TatD DNase domain containing 2
chr1_+_6266140 0.595 NM_207396
RNF207
ring finger protein 207
chr5_+_173315313 0.586 NM_030627
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr5_+_70883179 0.583 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr1_+_68150858 0.580 NM_001199741
NM_001199742
NM_001924
GADD45A


growth arrest and DNA-damage-inducible, alpha


chr15_+_89164522 0.578 NM_022767
AEN
apoptosis enhancing nuclease
chr1_+_113217574 0.575 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr22_-_41593466 0.571


chr5_+_170847059 0.571 FGF18
fibroblast growth factor 18
chr9_+_137001216 0.571 WDR5
WD repeat domain 5
chr15_-_23086290 0.569 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr8_+_90769974 0.568 NM_003821
RIPK2
receptor-interacting serine-threonine kinase 2
chr15_-_55581969 0.567 NM_183235
RAB27A
RAB27A, member RAS oncogene family
chr19_-_58090254 0.566 ZNF416
zinc finger protein 416
chr5_+_52083685 0.561 NM_181501
NM_015946
ITGA1
PELO
integrin, alpha 1
pelota homolog (Drosophila)
chr17_+_56270085 0.560 NM_000502
EPX
eosinophil peroxidase
chr11_-_7694685 0.559 NM_016229
CYB5R2
cytochrome b5 reductase 2
chr5_+_70883132 0.556 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr6_+_99282597 0.549 POU3F2
POU class 3 homeobox 2
chr20_-_8000254 0.548 TMX4
thioredoxin-related transmembrane protein 4
chr5_+_169780880 0.542 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr17_-_30186217 0.538 NM_018405
C17orf79
chromosome 17 open reading frame 79
chr17_+_19282058 0.535 MAPK7
mitogen-activated protein kinase 7
chr17_+_19281726 0.531 NM_002749
NM_139034
MAPK7

mitogen-activated protein kinase 7

chr6_+_41040713 0.530 NFYA
nuclear transcription factor Y, alpha
chr5_+_34684611 0.529 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr19_+_10397642 0.526 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chrX_-_63615332 0.525 NM_017677
MTMR8
myotubularin related protein 8
chr8_-_70745624 0.519 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr17_+_26662547 0.516 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr9_-_136857285 0.513 NM_001134398
NM_003371
VAV2

vav 2 guanine nucleotide exchange factor

chr3_+_63953419 0.511 NM_001128149
ATXN7
ataxin 7
chr15_+_84841241 0.508 NM_001243531
LOC100505679
uncharacterized LOC100505679
chr18_-_33709204 0.508 NM_001099406
NM_012319
SLC39A6

solute carrier family 39 (zinc transporter), member 6

chr11_-_22647329 0.507 NM_022725
FANCF
Fanconi anemia, complementation group F
chr1_+_24286300 0.501 NM_017761
PNRC2
proline-rich nuclear receptor coactivator 2
chr2_+_131100470 0.500 NM_033416
IMP4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.51 8.97e-03 GO:0006936 muscle contraction
2.31 4.93e-02 GO:0003012 muscle system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 3.38e-05 GO:0005737 cytoplasm
1.19 2.04e-03 GO:0044422 organelle part
1.18 2.93e-03 GO:0044446 intracellular organelle part
1.08 7.27e-03 GO:0044424 intracellular part
1.16 1.52e-02 GO:0044444 cytoplasmic part
1.10 1.90e-02 GO:0043226 organelle
1.09 3.79e-02 GO:0043229 intracellular organelle
1.34 4.53e-02 GO:0012505 endomembrane system

Nothing significant found in function category.