Motif ID: NFKB1_REL_RELA.p2

Z-value: 6.611


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
RELAchr11_-_654302140.961.0e-13Click!
NFKB1chr4_+_1034227300.905.6e-10Click!
RELchr2_+_611087020.077.5e-01Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_4229494 62.747 NM_005755
 EBI3
Epstein-Barr virus induced 3
chr6_-_29527701 45.285 NM_006398
 UBD
ubiquitin D
chr4_-_120549115 44.814 NM_033437
 PDE5A
phosphodiesterase 5A, cGMP-specific
chr4_-_76944585 43.598 NM_001565
 CXCL10
chemokine (C-X-C motif) ligand 10
chr6_-_29527477 42.988 UBD
ubiquitin D
chr10_+_104154228 41.808 NM_001077493
NM_001077494
 NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr16_+_50776012 38.943 NM_001042412
 CYLD
cylindromatosis (turban tumor syndrome)
chr1_+_101185195 37.018 NM_001078
NM_001199834
NM_080682
 VCAM1


vascular cell adhesion molecule 1


chr10_+_104155431 36.937 NM_002502
 NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr5_-_150466696 35.943 NM_001252391
NM_001252392
 TNIP1

TNFAIP3 interacting protein 1

chr16_+_50775960 35.624 NM_001042355
NM_015247
 CYLD

cylindromatosis (turban tumor syndrome)

chr19_+_45504686 34.019 NM_006509
 RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr4_+_74702272 32.258 NM_002993
 CXCL6
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chr11_+_102188180 31.760 NM_001165
NM_182962
 BIRC3

baculoviral IAP repeat containing 3

chr2_+_228678556 31.655 NM_001130046
NM_004591
 CCL20

chemokine (C-C motif) ligand 20

chr4_+_103422730 29.876 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr4_-_76957139 29.536 NM_005409
 CXCL11
chemokine (C-X-C motif) ligand 11
chr1_-_184943532 28.268 FAM129A
family with sequence similarity 129, member A
chr4_+_103422822 25.440 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr4_+_103422479 24.723 NM_001165412
NM_003998
 NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 121 entries
enrichment   p-value GO term description
3.28 1.77e-03 GO:0002756 MyD88-independent toll-like receptor signaling pathway
3.24 1.24e-03 GO:0034130 toll-like receptor 1 signaling pathway
3.24 1.24e-03 GO:0034134 toll-like receptor 2 signaling pathway
3.23 4.47e-03 GO:0034138 toll-like receptor 3 signaling pathway
3.08 1.94e-03 GO:0008063 Toll signaling pathway
3.08 1.94e-03 GO:0034142 toll-like receptor 4 signaling pathway
3.06 3.66e-03 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
2.87 4.51e-03 GO:0002224 toll-like receptor signaling pathway
2.85 2.33e-02 GO:0002699 positive regulation of immune effector process
2.82 4.34e-02 GO:0045785 positive regulation of cell adhesion
2.76 5.97e-03 GO:0002758 innate immune response-activating signal transduction
2.74 1.10e-02 GO:0002221 pattern recognition receptor signaling pathway
2.70 9.15e-03 GO:0002218 activation of innate immune response
2.54 7.46e-05 GO:0031349 positive regulation of defense response
2.52 4.90e-03 GO:0045089 positive regulation of innate immune response
2.41 3.74e-04 GO:0045088 regulation of innate immune response
2.29 7.23e-03 GO:0051272 positive regulation of cellular component movement
2.28 4.44e-02 GO:0050870 positive regulation of T cell activation
2.24 2.51e-02 GO:0040017 positive regulation of locomotion
2.23 1.05e-02 GO:0051251 positive regulation of lymphocyte activation

Gene overrepresentation in compartment category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
10.16 4.34e-03 GO:0033256 I-kappaB/NF-kappaB complex
1.30 1.39e-03 GO:0044459 plasma membrane part
1.26 3.29e-02 GO:0005829 cytosol
1.18 1.79e-02 GO:0071944 cell periphery
1.18 1.86e-02 GO:0005886 plasma membrane
1.11 9.14e-03 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
3.31 1.57e-02 GO:0008009 chemokine activity
3.19 1.45e-02 GO:0042379 chemokine receptor binding
2.26 5.43e-04 GO:0005126 cytokine receptor binding
2.10 3.94e-03 GO:0005125 cytokine activity
1.50 2.99e-02 GO:0043565 sequence-specific DNA binding
1.49 1.07e-03 GO:0001071 nucleic acid binding transcription factor activity
1.49 1.07e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.22 9.54e-12 GO:0005515 protein binding
1.07 6.59e-03 GO:0005488 binding