Motif ID: NFY{A,B,C}.p2

Z-value: 2.598


Transcription factors associated with NFY{A,B,C}.p2:

Gene SymbolEntrez IDGene Name
NFYA 4800 nuclear transcription factor Y, alpha
NFYB 4801 nuclear transcription factor Y, beta
NFYC 4802 nuclear transcription factor Y, gamma

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NFYCchr1_+_412045090.717.1e-05Click!
NFYBchr12_-_1045318750.442.6e-02Click!
NFYAchr6_+_41040891-0.377.2e-02Click!


Activity profile for motif NFY{A,B,C}.p2.

activity profile for motif NFY{A,B,C}.p2


Sorted Z-values histogram for motif NFY{A,B,C}.p2

Sorted Z-values for motif NFY{A,B,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFY{A,B,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_8543508 10.761 NM_014583
 LMCD1
LIM and cysteine-rich domains 1
chr3_+_8543539 8.149 LMCD1
LIM and cysteine-rich domains 1
chr1_+_221052735 7.239 NM_021958
 HLX
H2.0-like homeobox
chr1_+_221052845 7.227 HLX
H2.0-like homeobox
chr14_-_91526912 7.185 NM_004755
NM_182398
 RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr1_+_221053000 6.685 HLX
H2.0-like homeobox
chr17_-_47841468 6.250 FAM117A
family with sequence similarity 117, member A
chr3_+_193853937 6.123 HES1
hairy and enhancer of split 1, (Drosophila)
chr3_+_193853930 5.684 NM_005524
 HES1
hairy and enhancer of split 1, (Drosophila)
chr2_-_240322620 5.217 NM_006037
 HDAC4
histone deacetylase 4
chr6_+_160183510 4.922 ACAT2
acetyl-CoA acetyltransferase 2
chr10_+_112631675 4.465 PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)
chr15_-_23378217 4.448 HERC2P2
hect domain and RLD 2 pseudogene 2
chr6_+_160183062 4.342 ACAT2
acetyl-CoA acetyltransferase 2
chr8_+_11660272 4.300 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr6_+_160182988 4.292 NM_005891
 ACAT2
acetyl-CoA acetyltransferase 2
chr8_+_11660179 4.204 NM_004462
 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr8_+_11660207 4.156 FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr10_+_112631552 4.134 NM_001199492
NM_014456
NM_145341
 PDCD4


programmed cell death 4 (neoplastic transformation inhibitor)


chr12_+_79258588 4.074 SYT1
synaptotagmin I

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 75 entries
enrichment   p-value GO term description
10.01 8.56e-05 GO:0002566 somatic diversification of immune receptors via somatic mutation
10.01 8.56e-05 GO:0016446 somatic hypermutation of immunoglobulin genes
7.04 1.79e-10 GO:0006695 cholesterol biosynthetic process
6.52 9.55e-11 GO:0016126 sterol biosynthetic process
5.63 6.47e-03 GO:0008299 isoprenoid biosynthetic process
4.04 2.24e-09 GO:0006334 nucleosome assembly
3.95 2.18e-09 GO:0031497 chromatin assembly
3.82 1.39e-09 GO:0065004 protein-DNA complex assembly
3.75 1.12e-08 GO:0034728 nucleosome organization
3.62 8.93e-09 GO:0071824 protein-DNA complex subunit organization
3.46 5.71e-09 GO:0006323 DNA packaging
3.45 2.15e-06 GO:0006694 steroid biosynthetic process
3.25 4.71e-08 GO:0006333 chromatin assembly or disassembly
3.12 6.26e-08 GO:0071103 DNA conformation change
3.12 1.48e-03 GO:0000236 mitotic prometaphase
3.04 2.83e-04 GO:0016125 sterol metabolic process
3.03 9.13e-04 GO:0008203 cholesterol metabolic process
2.84 4.52e-05 GO:0006310 DNA recombination
2.58 2.12e-02 GO:0007126 meiosis
2.58 2.12e-02 GO:0051327 M phase of meiotic cell cycle

Gene overrepresentation in compartment category:

Showing 1 to 20 of 45 entries
enrichment   p-value GO term description
9.38 1.36e-02 GO:0032389 MutLalpha complex
6.57 1.02e-02 GO:0032300 mismatch repair complex
4.50 3.38e-08 GO:0000786 nucleosome
3.67 3.02e-08 GO:0032993 protein-DNA complex
3.57 1.49e-02 GO:0008287 protein serine/threonine phosphatase complex
2.84 6.69e-11 GO:0000785 chromatin
2.82 3.06e-02 GO:0034399 nuclear periphery
2.63 4.86e-02 GO:0000779 condensed chromosome, centromeric region
2.54 3.00e-04 GO:0000775 chromosome, centromeric region
2.44 6.08e-14 GO:0044427 chromosomal part
2.39 7.98e-16 GO:0005694 chromosome
2.27 1.37e-02 GO:0000793 condensed chromosome
2.25 2.39e-03 GO:0044454 nuclear chromosome part
2.04 7.96e-03 GO:0000228 nuclear chromosome
1.94 8.49e-03 GO:0005759 mitochondrial matrix
1.65 1.92e-09 GO:0005654 nucleoplasm
1.65 4.38e-04 GO:0015630 microtubule cytoskeleton
1.63 8.02e-04 GO:0044429 mitochondrial part
1.61 1.22e-15 GO:0070013 intracellular organelle lumen
1.59 6.23e-15 GO:0043233 organelle lumen

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
9.65 2.09e-03 GO:0032404 mismatch repair complex binding
9.38 2.03e-02 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
6.43 4.66e-03 GO:0030983 mismatched DNA binding
5.00 4.91e-02 GO:0008601 protein phosphatase type 2A regulator activity
1.46 4.39e-09 GO:0003677 DNA binding
1.41 4.84e-02 GO:0030528 transcription regulator activity
1.33 2.12e-07 GO:0003676 nucleic acid binding
1.18 5.86e-07 GO:0005515 protein binding
1.13 8.72e-13 GO:0005488 binding