Motif ID: NHLH1,2.p2

Z-value: 1.267


Transcription factors associated with NHLH1,2.p2:

Gene SymbolEntrez IDGene Name
NHLH1 4807 nescient helix loop helix 1
NHLH2 4808 nescient helix loop helix 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NHLH2chr1_-_1163833230.116.0e-01Click!
NHLH1chr1_+_160336856-0.116.1e-01Click!


Activity profile for motif NHLH1,2.p2.

activity profile for motif NHLH1,2.p2


Sorted Z-values histogram for motif NHLH1,2.p2

Sorted Z-values for motif NHLH1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NHLH1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_39261640 4.519 NM_001146041
 KRTAP4-9
keratin associated protein 4-9
chr6_-_154831652 3.576 CNKSR3
CNKSR family member 3
chr6_-_154831788 3.531 CNKSR3
CNKSR family member 3
chr6_-_154831704 3.403 NM_173515
 CNKSR3
CNKSR family member 3
chr2_+_231577536 3.322 NM_016289
 CAB39
calcium binding protein 39
chr13_-_72440557 2.966 DACH1
dachshund homolog 1 (Drosophila)
chr2_+_231577624 2.884 CAB39
calcium binding protein 39
chr1_-_6662681 2.512 KLHL21
kelch-like 21 (Drosophila)
chr13_-_72440143 2.508 DACH1
dachshund homolog 1 (Drosophila)
chr5_+_113698304 2.470 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr5_+_113698015 2.228 NM_021614
 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr5_+_56111379 2.025 MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr5_+_76114881 1.931 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr17_-_39296702 1.801 NM_030976
 KRTAP4-6
keratin associated protein 4-6
chr21_+_46293925 1.771


chr6_+_126112057 1.737 NCOA7
nuclear receptor coactivator 7
chr13_-_26625164 1.730 NM_001007538
 SHISA2
shisa homolog 2 (Xenopus laevis)
chr7_+_150147882 1.715 GIMAP8
GTPase, IMAP family member 8
chr5_+_76114832 1.662 NM_005242
 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr7_+_150148078 1.577 GIMAP8
GTPase, IMAP family member 8

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
1.62 2.61e-02 GO:0006897 endocytosis
1.62 2.61e-02 GO:0010324 membrane invagination
1.60 1.42e-04 GO:0007264 small GTPase mediated signal transduction
1.42 1.56e-04 GO:0016192 vesicle-mediated transport
1.36 5.86e-07 GO:0035556 intracellular signal transduction
1.36 3.89e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.34 2.40e-02 GO:2000026 regulation of multicellular organismal development
1.32 1.09e-02 GO:0050793 regulation of developmental process
1.31 3.77e-02 GO:0016265 death
1.31 3.85e-02 GO:0008219 cell death
1.30 9.20e-05 GO:0007399 nervous system development
1.28 3.60e-02 GO:0043067 regulation of programmed cell death
1.26 2.90e-02 GO:0051641 cellular localization
1.25 4.64e-02 GO:0051239 regulation of multicellular organismal process
1.24 8.53e-03 GO:0023051 regulation of signaling
1.21 5.24e-03 GO:0065008 regulation of biological quality
1.20 3.00e-06 GO:0007165 signal transduction
1.20 1.62e-02 GO:0048523 negative regulation of cellular process
1.19 2.04e-06 GO:0023052 signaling
1.18 2.77e-03 GO:0048731 system development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
1.63 3.68e-04 GO:0000323 lytic vacuole
1.63 3.68e-04 GO:0005764 lysosome
1.54 4.38e-04 GO:0048471 perinuclear region of cytoplasm
1.54 1.70e-03 GO:0005773 vacuole
1.32 5.91e-03 GO:0031982 vesicle
1.29 4.35e-02 GO:0031410 cytoplasmic vesicle
1.28 5.63e-03 GO:0005794 Golgi apparatus
1.20 3.44e-02 GO:0012505 endomembrane system
1.18 7.90e-03 GO:0031090 organelle membrane
1.18 9.13e-03 GO:0044459 plasma membrane part
1.16 6.24e-19 GO:0005737 cytoplasm
1.16 6.73e-11 GO:0044444 cytoplasmic part
1.12 2.11e-04 GO:0044446 intracellular organelle part
1.12 2.12e-04 GO:0044422 organelle part
1.09 9.33e-13 GO:0044424 intracellular part
1.09 1.18e-06 GO:0043226 organelle
1.08 3.19e-11 GO:0005622 intracellular
1.08 2.20e-06 GO:0043229 intracellular organelle
1.07 2.07e-03 GO:0043227 membrane-bounded organelle
1.07 3.03e-03 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.92 3.48e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.48 1.20e-03 GO:0019904 protein domain specific binding
1.41 2.68e-02 GO:0004674 protein serine/threonine kinase activity
1.37 2.07e-02 GO:0008092 cytoskeletal protein binding
1.21 3.14e-04 GO:0000166 nucleotide binding
1.21 2.02e-03 GO:0017076 purine nucleotide binding
1.21 2.50e-03 GO:0032553 ribonucleotide binding
1.21 2.50e-03 GO:0032555 purine ribonucleotide binding
1.21 3.78e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.13 3.13e-08 GO:0005515 protein binding
1.06 3.30e-04 GO:0005488 binding