• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: NHLH1,2.p2

Z-value: 1.267

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_39261640	4.519	NM_001146041	KRTAP4-9	keratin associated protein 4-9
chr6_-_154831652	3.576		CNKSR3	CNKSR family member 3
chr6_-_154831788	3.531		CNKSR3	CNKSR family member 3
chr6_-_154831704	3.403	NM_173515	CNKSR3	CNKSR family member 3
chr2_+_231577536	3.322	NM_016289	CAB39	calcium binding protein 39
chr13_-_72440557	2.966		DACH1	dachshund homolog 1 (Drosophila)
chr2_+_231577624	2.884		CAB39	calcium binding protein 39
chr1_-_6662681	2.512		KLHL21	kelch-like 21 (Drosophila)
chr13_-_72440143	2.508		DACH1	dachshund homolog 1 (Drosophila)
chr5_+_113698304	2.470		KCNN2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr5_+_113698015	2.228	NM_021614	KCNN2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr5_+_56111379	2.025		MAP3K1	mitogen-activated protein kinase kinase kinase 1
chr5_+_76114881	1.931		F2RL1	coagulation factor II (thrombin) receptor-like 1
chr17_-_39296702	1.801	NM_030976	KRTAP4-6	keratin associated protein 4-6
chr21_+_46293925	1.771
chr6_+_126112057	1.737		NCOA7	nuclear receptor coactivator 7
chr13_-_26625164	1.730	NM_001007538	SHISA2	shisa homolog 2 (Xenopus laevis)
chr7_+_150147882	1.715		GIMAP8	GTPase, IMAP family member 8
chr5_+_76114832	1.662	NM_005242	F2RL1	coagulation factor II (thrombin) receptor-like 1
chr7_+_150148078	1.577		GIMAP8	GTPase, IMAP family member 8
chr17_-_17399494	1.545	NM_001199989 NM_016084	RASD1	RAS, dexamethasone-induced 1
chr19_+_41699140	1.524		CYP2S1	cytochrome P450, family 2, subfamily S, polypeptide 1
chr11_-_10830034	1.472		EIF4G2	eukaryotic translation initiation factor 4 gamma, 2
chr1_+_100818052	1.387		CDC14A	CDC14 cell division cycle 14 homolog A (S. cerevisiae)
chr2_+_79740171	1.293		CTNNA2	catenin (cadherin-associated protein), alpha 2
chr9_-_123691442	1.284	NM_001190945	TRAF1	TNF receptor-associated factor 1
chr1_-_6662898	1.262	NM_014851	KLHL21	kelch-like 21 (Drosophila)
chr1_-_47184790	1.252
chr16_-_57318574	1.215	NM_015993	PLLP	plasmolipin
chr7_+_150147936	1.211	NM_175571	GIMAP8	GTPase, IMAP family member 8
chr12_-_129308293	1.155	NM_145648	SLC15A4	solute carrier family 15, member 4
chr6_+_144471631	1.144	NM_003764	STX11	syntaxin 11
chr18_-_48723689	1.128		MEX3C	mex-3 homolog C (C. elegans)
chr12_+_103352021	1.072		ASCL1	achaete-scute complex homolog 1 (Drosophila)
chr6_+_142622797	1.062	NM_001032394 NM_001032395 NM_020455 NM_198569	GPR126	G protein-coupled receptor 126
chr4_+_41362750	1.057	NM_001112717 NM_001112718 NM_014988	LIMCH1	LIM and calponin homology domains 1
chr17_-_31204071	1.056		MYO1D	myosin ID
chr16_+_30406711	1.029	NM_152652	ZNF48	zinc finger protein 48
chr4_-_120549827	1.018	NM_001083	PDE5A	phosphodiesterase 5A, cGMP-specific
chr17_+_32597239	0.995	NM_006273	CCL7	chemokine (C-C motif) ligand 7
chr13_-_72441312	0.982	NM_004392 NM_080759 NM_080760	DACH1	dachshund homolog 1 (Drosophila)
chr21_+_33784751	0.969	NM_058187	C21orf63	chromosome 21 open reading frame 63
chr6_-_47277640	0.964		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr6_-_31550065	0.945	NM_002341 NM_009588	LTB	lymphotoxin beta (TNF superfamily, member 3)
chr14_-_76127526	0.940	NM_007176	C14orf1	chromosome 14 open reading frame 1
chr6_+_14117857	0.933	NM_001040280 NM_004233	CD83	CD83 molecule
chr8_+_142138684	0.929	NM_014957	DENND3	DENN/MADD domain containing 3
chr4_+_74735107	0.916	NM_001511	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr1_-_57045129	0.888		PPAP2B	phosphatidic acid phosphatase type 2B
chr12_+_57482886	0.872		NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr11_-_64645925	0.855		EHD1	EH-domain containing 1
chr6_-_143266283	0.851	NM_006734	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2
chr3_+_30648372	0.850		TGFBR2	transforming growth factor, beta receptor II (70/80kDa)
chr5_+_130599745	0.849		CDC42SE2	CDC42 small effector 2
chr2_+_16081945	0.843		MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr22_-_37882214	0.842	NM_001166343 NM_002405	MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_-_11871735	0.836	NM_015204	THSD7A	thrombospondin, type I, domain containing 7A
chr2_+_106682111	0.832	NM_032411	C2orf40	chromosome 2 open reading frame 40
chr5_+_139027868	0.819		CXXC5	CXXC finger protein 5
chr12_-_120554453	0.815		RAB35	RAB35, member RAS oncogene family
chr19_+_38755422	0.808		SPINT2	serine peptidase inhibitor, Kunitz type, 2
chr6_+_14118002	0.807		CD83	CD83 molecule
chr2_-_288181	0.803	NM_001002919	FAM150B	family with sequence similarity 150, member B
chr12_+_57482922	0.798		NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr3_-_32022734	0.793		OSBPL10	oxysterol binding protein-like 10
chr6_+_126111782	0.786	NM_001122842 NM_001199621 NM_181782	NCOA7	nuclear receptor coactivator 7
chr10_+_30723050	0.785		MAP3K8	mitogen-activated protein kinase kinase kinase 8
chr6_+_37137882	0.784	NM_001243186 NM_002648	PIM1	pim-1 oncogene
chr6_-_167040659	0.783		RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr9_+_116226006	0.783	NM_017790	RGS3	regulator of G-protein signaling 3
chr16_-_57318452	0.782		PLLP	plasmolipin
chr1_+_89990396	0.771	NM_001134476	LRRC8B	leucine rich repeat containing 8 family, member B
chr5_+_10564431	0.770	NM_001164440	ANKRD33B	ankyrin repeat domain 33B
chr1_-_41328002	0.768	NM_133467	CITED4	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr20_-_43977023	0.756	NM_002999	SDC4	syndecan 4
chr1_-_27339448	0.746		FAM46B	family with sequence similarity 46, member B
chr13_-_99738639	0.744	NM_001130049 NM_015296	DOCK9	dedicator of cytokinesis 9
chr5_+_139027955	0.743		CXXC5	CXXC finger protein 5
chr12_+_79258588	0.743		SYT1	synaptotagmin I
chr5_+_139027907	0.738		CXXC5	CXXC finger protein 5
chr12_+_79258517	0.719		SYT1	synaptotagmin I
chr8_+_97506020	0.717		SDC2	syndecan 2
chr1_+_100818007	0.713	NM_003672 NM_033312 NM_033313	CDC14A	CDC14 cell division cycle 14 homolog A (S. cerevisiae)
chr1_+_90098693	0.711		LRRC8C	leucine rich repeat containing 8 family, member C
chr6_+_53659738	0.709	NM_018214	LRRC1	leucine rich repeat containing 1
chr8_+_97506071	0.705		SDC2	syndecan 2
chr1_+_218519576	0.704		TGFB2	transforming growth factor, beta 2
chr5_-_94620277	0.694	NM_024717	MCTP1	multiple C2 domains, transmembrane 1
chr11_-_59436366	0.680		PATL1	protein associated with topoisomerase II homolog 1 (yeast)
chr17_+_20108298	0.679		SPECC1	sperm antigen with calponin homology and coiled-coil domains 1
chr16_-_23160509	0.677	NM_020718	USP31	ubiquitin specific peptidase 31
chr16_+_215972	0.674	NM_001003938	HBM	hemoglobin, mu
chr1_-_57045214	0.670		PPAP2B	phosphatidic acid phosphatase type 2B
chr10_+_30722856	0.664	NM_001244134 NM_005204	MAP3K8	mitogen-activated protein kinase kinase kinase 8
chr11_-_59436488	0.658	NM_152716	PATL1	protein associated with topoisomerase II homolog 1 (yeast)
chr12_+_27933162	0.646	NM_020782	KLHDC5	kelch domain containing 5
chr3_+_11196213	0.645	NM_001098212	HRH1	histamine receptor H1
chr9_-_80646150	0.640	NM_002072	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide
chr8_+_97506478	0.636		SDC2	syndecan 2
chr1_-_57044980	0.636		PPAP2B	phosphatidic acid phosphatase type 2B
chr1_-_47184730	0.630	NM_014774	KIAA0494	KIAA0494
chr11_-_64646053	0.625	NM_006795	EHD1	EH-domain containing 1
chr12_+_79258448	0.620	NM_005639	SYT1	synaptotagmin I
chr5_+_139028483	0.619		CXXC5	CXXC finger protein 5
chr8_+_42995628	0.611		HGSNAT	heparan-alpha-glucosaminide N-acetyltransferase
chr16_-_87525317	0.610	NM_015144	ZCCHC14	zinc finger, CCHC domain containing 14
chr12_-_120554558	0.608		RAB35	RAB35, member RAS oncogene family
chr4_+_95373044	0.605		PDLIM5	PDZ and LIM domain 5
chr6_-_47277646	0.604	NM_014452	TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr5_+_130599701	0.603	NM_001038702 NM_020240	CDC42SE2	CDC42 small effector 2
chr3_+_5021305	0.597		BHLHE40	basic helix-loop-helix family, member e40
chr6_-_47277511	0.595		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chrX_-_20284910	0.593		RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr8_+_97506141	0.589		SDC2	syndecan 2
chr9_-_72287097	0.582	NM_001163	APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1
chr1_+_78511588	0.580	NM_017655	GIPC2	GIPC PDZ domain containing family, member 2
chr7_+_48128738	0.579	NM_003364	UPP1	uridine phosphorylase 1
chr20_-_57582303	0.574	NM_001336	CTSZ	cathepsin Z
chr12_-_29936685	0.572	NM_001193451	TMTC1	transmembrane and tetratricopeptide repeat containing 1
chr13_-_27745952	0.570	NM_182488	USP12	ubiquitin specific peptidase 12
chr21_+_34697197	0.568	NM_000629	IFNAR1	interferon (alpha, beta and omega) receptor 1
chr8_+_104383785	0.554	NM_138455	CTHRC1	collagen triple helix repeat containing 1
chr9_-_22009270	0.552	NM_004936 NM_078487	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr1_+_110453232	0.550	NM_000757 NM_172210 NM_172212	CSF1	colony stimulating factor 1 (macrophage)
chr12_+_19592777	0.549		AEBP2	AE binding protein 2
chr1_+_16174358	0.549	NM_015001	SPEN	spen homolog, transcriptional regulator (Drosophila)
chr14_-_89020888	0.548	NM_007039	PTPN21	protein tyrosine phosphatase, non-receptor type 21
chr8_+_104383701	0.542		CTHRC1	collagen triple helix repeat containing 1
chr3_+_182511412	0.542
chr12_-_120554551	0.540		RAB35	RAB35, member RAS oncogene family
chr9_-_38069082	0.539		SHB	Src homology 2 domain containing adaptor protein B
chr17_+_28705960	0.537		CPD	carboxypeptidase D
chr7_-_33148897	0.528	NM_203288	RP9	retinitis pigmentosa 9 (autosomal dominant)
chr12_-_71003622	0.525	NM_001206971 NM_001206972 NM_002837	PTPRB	protein tyrosine phosphatase, receptor type, B
chr16_+_30406432	0.522	NM_001214909	ZNF48	zinc finger protein 48
chr2_+_65283485	0.522	NM_015147	CEP68	centrosomal protein 68kDa
chr13_-_114566951	0.521		GAS6	growth arrest-specific 6
chr19_+_17666381	0.520		GLT25D1	glycosyltransferase 25 domain containing 1
chr12_-_49259549	0.520	NM_014470	RND1	Rho family GTPase 1
chr2_-_235405692	0.518	NM_005737	ARL4C	ADP-ribosylation factor-like 4C
chr18_+_3247825	0.514		MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric
chr1_+_233749917	0.512		KCNK1	potassium channel, subfamily K, member 1
chr7_+_77166331	0.509		PTPN12	protein tyrosine phosphatase, non-receptor type 12
chr17_+_15848230	0.509	NM_000676	ADORA2B	adenosine A2b receptor
chr16_-_75498231	0.506		TMEM170A	transmembrane protein 170A
chr8_+_17354562	0.501	NM_001008539	SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr22_+_29279573	0.498	NM_001206998	ZNRF3	zinc and ring finger 3
chr1_-_33338081	0.497	NM_001171941	FNDC5	fibronectin type III domain containing 5
chr18_+_60383895	0.497		PHLPP1	PH domain and leucine rich repeat protein phosphatase 1
chr19_+_38755238	0.497		SPINT2	serine peptidase inhibitor, Kunitz type, 2
chr5_+_130599770	0.497		CDC42SE2	CDC42 small effector 2
chr6_+_111195986	0.495	NM_001634 NM_001033059	AMD1	adenosylmethionine decarboxylase 1
chr9_-_139581900	0.494	NM_001012727 NM_006412	AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
chr17_+_15848422	0.492		ADORA2B	adenosine A2b receptor
chr13_-_114567011	0.488		GAS6	growth arrest-specific 6
chr1_-_33336289	0.487	NM_001171940 NM_153756	FNDC5	fibronectin type III domain containing 5
chr2_+_170590454	0.487		KLHL23	kelch-like 23 (Drosophila)
chr4_+_78079302	0.484		CCNG2	cyclin G2
chr15_+_67418053	0.479	NM_001145102	SMAD3	SMAD family member 3
chr8_+_90914761	0.477	NM_001126111	OSGIN2	oxidative stress induced growth inhibitor family member 2
chr8_-_17941614	0.475		ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr20_+_37434294	0.474	NM_001172735 NM_015568	PPP1R16B	protein phosphatase 1, regulatory subunit 16B
chr16_-_75498497	0.473		TMEM170A	transmembrane protein 170A
chr21_+_34442550	0.471		OLIG1	oligodendrocyte transcription factor 1
chr9_+_132815984	0.468	NM_001136557 NM_001136558 NM_020960	GPR107	G protein-coupled receptor 107
chr7_+_150434679	0.467		GIMAP5	GTPase, IMAP family member 5
chr9_-_139581868	0.466		AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
chr21_+_37507209	0.464	NM_001236	CBR3	carbonyl reductase 3
chr4_-_186697065	0.463	NM_001145673	SORBS2	sorbin and SH3 domain containing 2
chr9_+_114659023	0.461	NM_003358	UGCG	UDP-glucose ceramide glucosyltransferase
chr2_+_203241044	0.460	NM_001204	BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr10_+_6244839	0.458	NM_004566	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr12_+_19592311	0.458	NM_001114176 NM_153207	AEBP2	AE binding protein 2
chr10_-_116392099	0.456		ABLIM1	actin binding LIM protein 1
chr7_+_150434435	0.455	NM_018384	GIMAP5	GTPase, IMAP family member 5
chr8_-_38008332	0.455	NM_000349	STAR	steroidogenic acute regulatory protein
chr5_+_31639424	0.452		PDZD2	PDZ domain containing 2
chr21_+_46494433	0.451	NM_001112 NM_001160230 NM_015833 NM_015834	ADARB1	adenosine deaminase, RNA-specific, B1
chr11_-_35547144	0.451	NM_001001991 NM_015430	PAMR1	peptidase domain containing associated with muscle regeneration 1
chr12_+_79258794	0.448		SYT1	synaptotagmin I
chr13_-_114567034	0.447		GAS6	growth arrest-specific 6
chr17_+_70117154	0.446	NM_000346	SOX9	SRY (sex determining region Y)-box 9
chr1_-_27339326	0.446	NM_052943	FAM46B	family with sequence similarity 46, member B
chr1_-_180991979	0.445		STX6	syntaxin 6
chr14_-_65346554	0.445		SPTB	spectrin, beta, erythrocytic
chr6_-_13711484	0.445		RANBP9	RAN binding protein 9
chr4_+_156588811	0.443	NM_001130684	GUCY1A3	guanylate cyclase 1, soluble, alpha 3
chr3_+_49059046	0.443	NM_199069 NM_199070	NDUFAF3	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr6_-_47277354	0.441		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr9_-_139581823	0.441		AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
chr11_-_627172	0.440	NM_021920	SCT	secretin
chr2_-_220436010	0.438		OBSL1	obscurin-like 1
chr20_+_825284	0.437	NM_031424	FAM110A	family with sequence similarity 110, member A
chr17_-_66596736	0.436		FAM20A	family with sequence similarity 20, member A
chr11_-_65430214	0.435		RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr8_-_8750739	0.434	NM_004225	MFHAS1	malignant fibrous histiocytoma amplified sequence 1
chr19_+_18111923	0.434	NM_001025604	ARRDC2	arrestin domain containing 2
chr12_+_122459791	0.434	NM_001024808 NM_020993	BCL7A	B-cell CLL/lymphoma 7A
chr17_-_41738901	0.431	NM_004527 NM_013999	MEOX1	mesenchyme homeobox 1
chr1_-_85930733	0.430	NM_012137	DDAH1	dimethylarginine dimethylaminohydrolase 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.09	2.63e-09	GO:0009987	cellular process
1.36	5.86e-07	GO:0035556	intracellular signal transduction
1.19	2.04e-06	GO:0023052	signaling
1.20	3.00e-06	GO:0007165	signal transduction
1.10	7.22e-05	GO:0065007	biological regulation
1.30	9.20e-05	GO:0007399	nervous system development
1.60	1.42e-04	GO:0007264	small GTPase mediated signal transduction
1.42	1.56e-04	GO:0016192	vesicle-mediated transport
1.16	2.15e-04	GO:0051716	cellular response to stimulus
1.17	2.62e-04	GO:0032502	developmental process
1.10	5.20e-04	GO:0050789	regulation of biological process
1.10	1.21e-03	GO:0050794	regulation of cellular process
1.17	1.55e-03	GO:0048856	anatomical structure development
1.16	2.47e-03	GO:0007275	multicellular organismal development
1.18	2.77e-03	GO:0048731	system development
1.16	3.09e-03	GO:0051179	localization
1.21	5.24e-03	GO:0065008	regulation of biological quality
1.17	7.86e-03	GO:0051234	establishment of localization
1.24	8.53e-03	GO:0023051	regulation of signaling
1.32	1.09e-02	GO:0050793	regulation of developmental process
1.20	1.62e-02	GO:0048523	negative regulation of cellular process
1.16	1.69e-02	GO:0006810	transport
1.34	2.40e-02	GO:2000026	regulation of multicellular organismal development
1.62	2.61e-02	GO:0006897	endocytosis
1.62	2.61e-02	GO:0010324	membrane invagination
1.26	2.90e-02	GO:0051641	cellular localization
1.18	3.13e-02	GO:0048519	negative regulation of biological process
1.28	3.60e-02	GO:0043067	regulation of programmed cell death
1.31	3.77e-02	GO:0016265	death
1.31	3.85e-02	GO:0008219	cell death
1.36	3.89e-02	GO:0007167	enzyme linked receptor protein signaling pathway
1.18	4.48e-02	GO:0042221	response to chemical stimulus
1.25	4.64e-02	GO:0051239	regulation of multicellular organismal process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.16	6.24e-19	GO:0005737	cytoplasm
1.09	9.33e-13	GO:0044424	intracellular part
1.08	3.19e-11	GO:0005622	intracellular
1.16	6.73e-11	GO:0044444	cytoplasmic part
1.09	1.18e-06	GO:0043226	organelle
1.08	2.20e-06	GO:0043229	intracellular organelle
1.12	2.11e-04	GO:0044446	intracellular organelle part
1.12	2.12e-04	GO:0044422	organelle part
1.63	3.68e-04	GO:0000323	lytic vacuole
1.63	3.68e-04	GO:0005764	lysosome
1.54	4.38e-04	GO:0048471	perinuclear region of cytoplasm
1.54	1.70e-03	GO:0005773	vacuole
1.07	2.07e-03	GO:0043227	membrane-bounded organelle
1.07	3.03e-03	GO:0043231	intracellular membrane-bounded organelle
1.28	5.63e-03	GO:0005794	Golgi apparatus
1.32	5.91e-03	GO:0031982	vesicle
1.18	7.90e-03	GO:0031090	organelle membrane
1.18	9.13e-03	GO:0044459	plasma membrane part
1.20	3.44e-02	GO:0012505	endomembrane system
1.29	4.35e-02	GO:0031410	cytoplasmic vesicle

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.13	3.13e-08	GO:0005515	protein binding
1.21	3.14e-04	GO:0000166	nucleotide binding
1.06	3.30e-04	GO:0005488	binding
1.48	1.20e-03	GO:0019904	protein domain specific binding
1.21	2.02e-03	GO:0017076	purine nucleotide binding
1.21	2.50e-03	GO:0032553	ribonucleotide binding
1.21	2.50e-03	GO:0032555	purine ribonucleotide binding
1.21	3.78e-03	GO:0035639	purine ribonucleoside triphosphate binding
1.37	2.07e-02	GO:0008092	cytoskeletal protein binding
1.41	2.68e-02	GO:0004674	protein serine/threonine kinase activity
1.92	3.48e-02	GO:0005088	Ras guanyl-nucleotide exchange factor activity