Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.677


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NKX2-5chr5_-_1726620850.232.6e-01Click!
NKX2-3chr10_+_101292689-0.232.6e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_79817058 16.871 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr1_-_150738232 7.215 CTSS
cathepsin S
chr4_+_90033967 7.146 NM_145715
TIGD2
tigger transposable element derived 2
chr17_+_41158741 5.538 NM_005533
IFI35
interferon-induced protein 35
chr9_+_109686436 5.358 ZNF462
zinc finger protein 462
chr1_+_79086087 4.491 NM_006820
IFI44L
interferon-induced protein 44-like
chr12_-_16760935 4.217 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr7_-_92777657 3.969 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr7_-_27205148 3.574 NM_152739
HOXA9
homeobox A9
chr12_-_16759430 3.573 LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_-_27205123 3.161 HOXA9
homeobox A9
chr4_-_122148620 3.102 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr9_+_109625347 3.057 NM_021224
ZNF462
zinc finger protein 462
chr1_+_205236591 2.992 TMCC2
transmembrane and coiled-coil domain family 2
chr7_-_115670774 2.797 TFEC
transcription factor EC
chr4_-_153273683 2.789 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr5_-_13944588 2.772 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr17_-_49124128 2.607 NM_001251971
SPAG9
sperm associated antigen 9
chr21_-_36421586 2.490 NM_001754
RUNX1
runt-related transcription factor 1
chr13_-_33780142 2.353 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr4_+_169013687 2.328 NM_007193
ANXA10
annexin A10
chr21_-_36421630 2.310 RUNX1
runt-related transcription factor 1
chrX_+_50027539 2.305 NM_033031
NM_033670
CCNB3

cyclin B3

chrX_+_144908927 2.295 NM_004709
CXorf1
chromosome X open reading frame 1
chr9_+_118916069 2.293 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr2_+_162272892 2.287 TBR1
T-box, brain, 1
chr1_-_150738255 2.258 CTSS
cathepsin S
chr6_-_46293404 2.255 RCAN2
regulator of calcineurin 2
chr11_-_104905849 2.090 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr12_+_12938540 2.028 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr4_+_70146216 1.949 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr7_-_107880492 1.929 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr3_-_52090090 1.877 NM_001947
DUSP7
dual specificity phosphatase 7
chr11_-_104972147 1.833 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr12_-_16759531 1.799 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_+_50681256 1.779 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr12_-_16757944 1.728 LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_-_58295758 1.718 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_+_136172802 1.699 NM_018945
PDE7B
phosphodiesterase 7B
chr5_-_131879172 1.697 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr4_-_40936640 1.675 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr12_-_4488707 1.658 NM_020638
FGF23
fibroblast growth factor 23
chr12_-_105322056 1.646 NM_032148
SLC41A2
solute carrier family 41, member 2
chr3_+_63884074 1.618 NM_001177387
ATXN7
ataxin 7
chrX_-_110654373 1.611 NM_000555
DCX
doublecortin
chr1_+_15990300 1.606


chr3_-_123411185 1.606 MYLK
myosin light chain kinase
chr7_+_107110501 1.598 NM_005295
GPR22
G protein-coupled receptor 22
chr2_-_163008913 1.598 NM_002054
GCG
glucagon
chr18_+_21572736 1.558 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr18_+_28898051 1.520 NM_001942
DSG1
desmoglein 1
chr12_-_16759733 1.513 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_+_32798478 1.497 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr5_-_59783885 1.495 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_+_152214105 1.489 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr9_-_15250113 1.482 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr12_+_41831484 1.459 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr7_-_112726143 1.449 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr3_+_130569368 1.417 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr7_-_41742666 1.409 NM_002192
INHBA
inhibin, beta A
chr1_-_203055088 1.386 MYOG
myogenin (myogenic factor 4)
chr4_+_77953942 1.358 SEPT11
septin 11
chr5_-_160279045 1.345 NM_025153
ATP10B
ATPase, class V, type 10B
chr15_+_100173182 1.345 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr17_+_78356710 1.328 RNF213
ring finger protein 213
chr11_-_16424391 1.315 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr2_+_103035148 1.302 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr9_+_130026755 1.265 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr5_+_34687663 1.257 NM_001145523
RAI14
retinoic acid induced 14
chr10_+_111765725 1.247 NM_019903
ADD3
adducin 3 (gamma)
chr1_+_50574601 1.225 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr17_-_78450247 1.215 NM_002522
NPTX1
neuronal pentraxin I
chr6_-_114384008 1.205 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr12_-_16759939 1.204 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chrX_+_153448084 1.183 NM_000513
NM_001048181
OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chr5_-_150467220 1.176 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr8_+_104831415 1.166 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr3_+_173116243 1.162 NM_014932
NLGN1
neuroligin 1
chr1_-_203055376 1.140 NM_002479
MYOG
myogenin (myogenic factor 4)
chr2_+_171571800 1.136 NM_001003845
SP5
Sp5 transcription factor
chr3_-_119963141 1.136 NM_001168271
NM_153002
GPR156

G protein-coupled receptor 156

chr9_-_19786886 1.121 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chrM_+_1670 1.114


chr7_+_114066554 1.110 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr5_+_31193852 1.095 CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chrX_+_22050920 1.084 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr10_-_105845556 1.073 COL17A1
collagen, type XVII, alpha 1
chr4_-_123542165 1.062 NM_001207006
NM_021803
IL21

interleukin 21

chr4_+_71494460 1.049 NM_031889
ENAM
enamelin
chr2_+_201390848 1.049 NM_001160033
NM_001160046
NM_152524
SGOL2


shugoshin-like 2 (S. pombe)


chr15_+_89739234 1.049 ABHD2
abhydrolase domain containing 2
chr4_-_68749698 1.046 NM_004262
TMPRSS11D
transmembrane protease, serine 11D
chr20_+_5987897 1.034 NM_001127458
CRLS1
cardiolipin synthase 1
chr17_+_39405938 1.031 NM_033191
KRTAP9-4
keratin associated protein 9-4
chr6_-_46293628 1.029 NM_005822
RCAN2
regulator of calcineurin 2
chr8_-_30706532 1.022 NM_031271
TEX15
testis expressed 15
chr6_-_11779279 1.021 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr5_-_35938736 1.020 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr11_-_57195052 1.019 NM_017611
SLC43A3
solute carrier family 43, member 3
chr12_-_52761254 1.019 NM_002283
KRT85
keratin 85
chr10_-_105845619 1.009 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr10_+_91152321 0.990 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr13_-_95131718 0.986 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr8_-_72268720 0.983 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr4_-_83347222 0.979 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr2_+_102508333 0.960 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr14_-_61191027 0.960 SIX4
SIX homeobox 4
chr22_-_38506532 0.954 BAIAP2L2
BAI1-associated protein 2-like 2
chrX_-_132162297 0.946 NM_031907
USP26
ubiquitin specific peptidase 26
chr3_-_112218383 0.931 NM_001085357
NM_181780
BTLA

B and T lymphocyte associated

chr11_-_27742224 0.911 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr7_+_114055048 0.911 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr3_+_39509069 0.897 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr7_-_92747317 0.897 NM_001193307
NM_017654
SAMD9

sterile alpha motif domain containing 9

chr10_+_69869249 0.890 NM_032578
MYPN
myopalladin
chr4_+_100495972 0.888 MTTP
microsomal triglyceride transfer protein
chr1_+_167298280 0.885 NM_001198783
POU2F1
POU class 2 homeobox 1
chr17_-_3030844 0.883 NM_003555
OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr1_-_206945725 0.883 NM_000572
IL10
interleukin 10
chr1_-_23886284 0.863 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr13_-_103719195 0.862 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr2_-_55199894 0.857


chr10_-_31288420 0.853 NM_001143769
ZNF438
zinc finger protein 438
chr7_-_92747269 0.852 SAMD9
sterile alpha motif domain containing 9
chr5_-_41261539 0.852 NM_001115131
C6
complement component 6
chr7_+_148287656 0.852 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr12_+_8975149 0.852 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr5_+_67588395 0.851 NM_001242466
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr13_-_34250899 0.848 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_+_102953716 0.847 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr2_+_143886969 0.843 ARHGAP15
Rho GTPase activating protein 15
chr8_+_145064167 0.843 NM_000837
NM_001009184
GRINA

glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)

chr5_+_52776479 0.836 FST
follistatin
chr2_-_99871569 0.835 NM_175735
LYG2
lysozyme G-like 2
chr1_+_50569581 0.831 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_-_222763081 0.831 NM_001201536
NM_005681
NM_139352
TAF1A


TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa


chr5_-_149669400 0.829 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr1_-_89530890 0.826 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr6_+_26402464 0.824 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr12_-_53994783 0.823 NM_001130059
ATF7
activating transcription factor 7
chrX_+_9431314 0.821 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr4_-_70505359 0.817 NM_001105677
UGT2A2
UDP glucuronosyltransferase 2 family, polypeptide A2
chr13_-_47470967 0.808 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr6_+_26440699 0.801 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr5_+_147258273 0.794 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr10_-_52645384 0.780 A1CF
APOBEC1 complementation factor
chr7_-_115670828 0.779 NM_001018058
NM_012252
TFEC

transcription factor EC

chr6_-_160679789 0.777 NM_003058
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr6_+_12717036 0.775 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr17_-_29624249 0.775 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr3_-_57234279 0.774 NM_003865
HESX1
HESX homeobox 1
chrX_+_38211735 0.771 NM_000531
OTC
ornithine carbamoyltransferase
chr6_-_52774460 0.770 NM_000847
GSTA3
glutathione S-transferase alpha 3
chr22_-_36562224 0.769 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr1_+_167298382 0.769 POU2F1
POU class 2 homeobox 1
chr5_-_149669187 0.764 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr16_+_7382750 0.762 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr6_+_64286348 0.760 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_-_152131703 0.760 NM_001122965
RPTN
repetin
chr7_-_83824216 0.759 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr10_-_61900659 0.759 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr8_-_110342107 0.750 NM_001128211
NUDCD1
NudC domain containing 1
chr18_-_13915534 0.748 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr17_-_39306053 0.748 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr20_+_20037289 0.747 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chr1_+_14031349 0.744 NM_012231
NM_015866
PRDM2

PR domain containing 2, with ZNF domain

chr10_-_32667543 0.744 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr7_-_27166638 0.731 NM_153631
HOXA3
homeobox A3
chr1_+_50574589 0.729 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr8_-_40755328 0.724 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr10_-_14372807 0.721 NM_018027
FRMD4A
FERM domain containing 4A
chr6_-_119252887 0.718 NM_017696
MCM9
minichromosome maintenance complex component 9
chr1_+_209878135 0.718 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr2_+_143886898 0.707 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chrX_+_68835910 0.707 NM_001005609
NM_001005610
NM_001005612
NM_001005613
NM_001399
EDA




ectodysplasin A




chr14_+_92788924 0.703 NM_153648
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr21_-_37852387 0.699 NM_001146079
NM_144492
CLDN14

claudin 14

chr20_+_9198036 0.696 NM_182797
PLCB4
phospholipase C, beta 4
chr12_-_24103842 0.694 SOX5
SRY (sex determining region Y)-box 5
chr10_+_24755459 0.689 KIAA1217
KIAA1217
chr2_+_169757749 0.685 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr1_-_183622447 0.682 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr12_-_10151689 0.681 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr17_+_39555993 0.675 GAST
gastrin
chr22_-_17747520 0.674 CECR3
cat eye syndrome chromosome region, candidate 3 (non-protein coding)
chr21_-_36421578 0.671 RUNX1
runt-related transcription factor 1
chr10_+_7745284 0.660 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_+_100054649 0.660 NM_021620
PRDM13
PR domain containing 13
chr5_-_75008245 0.654 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr4_+_88754120 0.654 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chr1_-_54199876 0.653 NM_147193
GLIS1
GLIS family zinc finger 1
chr3_-_157221362 0.651 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr7_-_14025826 0.650 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr2_-_128100673 0.649 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr2_+_29038862 0.647 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr17_+_28268622 0.646 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr4_-_111563278 0.646 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr9_-_134585107 0.643 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr3_-_11623829 0.643 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr2_-_214015053 0.640 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.36 6.02e-09 GO:0032501 multicellular organismal process
1.46 4.96e-06 GO:0048731 system development
1.38 6.37e-06 GO:0032502 developmental process
1.40 1.07e-05 GO:0007275 multicellular organismal development
1.41 2.37e-05 GO:0048856 anatomical structure development
1.53 4.15e-05 GO:0030154 cell differentiation
1.49 2.61e-04 GO:0048869 cellular developmental process
1.81 3.10e-04 GO:0009888 tissue development
1.82 1.60e-03 GO:2000026 regulation of multicellular organismal development
1.31 3.59e-03 GO:0023052 signaling
1.69 5.57e-03 GO:0050793 regulation of developmental process
1.45 8.14e-03 GO:0048513 organ development
1.45 1.19e-02 GO:0007166 cell surface receptor linked signaling pathway
1.76 2.47e-02 GO:0045595 regulation of cell differentiation
1.48 3.01e-02 GO:0007399 nervous system development
1.70 3.46e-02 GO:0007267 cell-cell signaling
6.32 4.08e-02 GO:0008038 neuron recognition

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.24 9.64e-06 GO:0045095 keratin filament
1.43 6.56e-04 GO:0005576 extracellular region
1.40 1.45e-03 GO:0044459 plasma membrane part
2.57 4.62e-03 GO:0005882 intermediate filament
1.25 5.53e-03 GO:0071944 cell periphery
1.25 6.56e-03 GO:0005886 plasma membrane
1.49 1.21e-02 GO:0031226 intrinsic to plasma membrane
1.49 1.52e-02 GO:0005887 integral to plasma membrane
2.32 1.97e-02 GO:0045111 intermediate filament cytoskeleton
5.79 4.10e-02 GO:0001533 cornified envelope

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.51 2.14e-02 GO:0008083 growth factor activity