Motif ID: NKX2-3_NKX2-5.p2

Z-value: 1.677


Transcription factors associated with NKX2-3_NKX2-5.p2:

Gene SymbolEntrez IDGene Name
NKX2-3 159296 NK2 transcription factor related, locus 3 (Drosophila)
NKX2-5 1482 NK2 transcription factor related, locus 5 (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NKX2-5chr5_-_1726620850.232.6e-01Click!
NKX2-3chr10_+_101292689-0.232.6e-01Click!


Activity profile for motif NKX2-3_NKX2-5.p2.

activity profile for motif NKX2-3_NKX2-5.p2


Sorted Z-values histogram for motif NKX2-3_NKX2-5.p2

Sorted Z-values for motif NKX2-3_NKX2-5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-3_NKX2-5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_79817058 16.871 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr1_-_150738232 7.215 CTSS
cathepsin S
chr4_+_90033967 7.146 NM_145715
TIGD2
tigger transposable element derived 2
chr17_+_41158741 5.538 NM_005533
IFI35
interferon-induced protein 35
chr9_+_109686436 5.358 ZNF462
zinc finger protein 462
chr1_+_79086087 4.491 NM_006820
IFI44L
interferon-induced protein 44-like
chr12_-_16760935 4.217 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr7_-_92777657 3.969 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr7_-_27205148 3.574 NM_152739
HOXA9
homeobox A9
chr12_-_16759430 3.573 LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_-_27205123 3.161 HOXA9
homeobox A9
chr4_-_122148620 3.102 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr9_+_109625347 3.057 NM_021224
ZNF462
zinc finger protein 462
chr1_+_205236591 2.992 TMCC2
transmembrane and coiled-coil domain family 2
chr7_-_115670774 2.797 TFEC
transcription factor EC
chr4_-_153273683 2.789 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr5_-_13944588 2.772 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr17_-_49124128 2.607 NM_001251971
SPAG9
sperm associated antigen 9
chr21_-_36421586 2.490 NM_001754
RUNX1
runt-related transcription factor 1
chr13_-_33780142 2.353 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
6.32 4.08e-02 GO:0008038 neuron recognition
1.82 1.60e-03 GO:2000026 regulation of multicellular organismal development
1.81 3.10e-04 GO:0009888 tissue development
1.76 2.47e-02 GO:0045595 regulation of cell differentiation
1.70 3.46e-02 GO:0007267 cell-cell signaling
1.69 5.57e-03 GO:0050793 regulation of developmental process
1.53 4.15e-05 GO:0030154 cell differentiation
1.49 2.61e-04 GO:0048869 cellular developmental process
1.48 3.01e-02 GO:0007399 nervous system development
1.46 4.96e-06 GO:0048731 system development
1.45 8.14e-03 GO:0048513 organ development
1.45 1.19e-02 GO:0007166 cell surface receptor linked signaling pathway
1.41 2.37e-05 GO:0048856 anatomical structure development
1.40 1.07e-05 GO:0007275 multicellular organismal development
1.38 6.37e-06 GO:0032502 developmental process
1.36 6.02e-09 GO:0032501 multicellular organismal process
1.31 3.59e-03 GO:0023052 signaling

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
5.79 4.10e-02 GO:0001533 cornified envelope
4.24 9.64e-06 GO:0045095 keratin filament
2.57 4.62e-03 GO:0005882 intermediate filament
2.32 1.97e-02 GO:0045111 intermediate filament cytoskeleton
1.49 1.21e-02 GO:0031226 intrinsic to plasma membrane
1.49 1.52e-02 GO:0005887 integral to plasma membrane
1.43 6.56e-04 GO:0005576 extracellular region
1.40 1.45e-03 GO:0044459 plasma membrane part
1.25 5.53e-03 GO:0071944 cell periphery
1.25 6.56e-03 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
2.51 2.14e-02 GO:0008083 growth factor activity