Motif ID: NKX3-1.p2

Z-value: 0.694


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NKX3-1chr8_-_23540401-0.291.6e-01Click!


Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_20724797 2.761 NM_001244683
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr1_+_84630575 1.205 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr15_+_25281105 1.204 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr4_+_41614911 0.887 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr4_+_41614933 0.858 LIMCH1
LIM and calponin homology domains 1
chr6_+_144612872 0.804 NM_007124
UTRN
utrophin
chr11_+_33363104 0.785 HIPK3
homeodomain interacting protein kinase 3
chr8_-_124749573 0.757 NM_001003954
NM_004306
ANXA13

annexin A13

chr15_+_66585632 0.727 NM_133375
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr17_+_61086897 0.727 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr9_-_13250313 0.725 NM_003829
MPDZ
multiple PDZ domain protein
chr18_-_22930826 0.713


chr17_+_74463629 0.707 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr1_+_84768333 0.672 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr7_+_115863004 0.666 NM_152829
TES
testis derived transcript (3 LIM domains)
chr9_+_90112754 0.662 NM_004938
DAPK1
death-associated protein kinase 1
chr2_+_173686314 0.653 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr9_-_75567915 0.622 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr4_-_186697065 0.593 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr16_-_31439650 0.585 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr10_+_116697914 0.514 NM_139169
TRUB1
TruB pseudouridine (psi) synthase homolog 1 (E. coli)
chr19_-_1021122 0.513 NM_001033026
NM_033420
C19orf6

chromosome 19 open reading frame 6

chr12_+_50869531 0.510 LARP4
La ribonucleoprotein domain family, member 4
chr9_+_90112419 0.507 DAPK1
death-associated protein kinase 1
chr1_+_84630374 0.502 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr6_+_153019029 0.498 NM_025107
MYCT1
myc target 1
chr4_+_41614725 0.495 LIMCH1
LIM and calponin homology domains 1
chr16_+_82068958 0.494 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chrX_+_107683015 0.476 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr16_+_82068830 0.471 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr3_-_197300193 0.463 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr7_+_150688143 0.461 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr18_+_6834431 0.460 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr1_-_244006885 0.459 NM_001206729
AKT3
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
chr3_+_132318980 0.443 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chr2_-_188419049 0.442 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_-_44586854 0.439 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chr7_+_86273219 0.436 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr4_+_41540187 0.430 LIMCH1
LIM and calponin homology domains 1
chrX_+_66788682 0.425 NM_001011645
AR
androgen receptor
chr14_-_106471439 0.423 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr12_-_6055397 0.422 NM_020373
ANO2
anoctamin 2
chr4_-_186732047 0.407 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr21_+_47269874 0.406 NM_001130141
NM_020528
PCBP3

poly(rC) binding protein 3

chr16_+_82068910 0.398 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr5_+_43609261 0.397 NNT
nicotinamide nucleotide transhydrogenase
chr4_+_41540320 0.392 LIMCH1
LIM and calponin homology domains 1
chr10_+_124670216 0.390 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr10_-_116444374 0.389 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr4_+_88896868 0.385 SPP1
secreted phosphoprotein 1
chr2_+_234959345 0.376 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr9_-_21305311 0.373 NM_002169
IFNA5
interferon, alpha 5
chr2_-_191872322 0.373 STAT1
signal transducer and activator of transcription 1, 91kDa
chr10_+_94594469 0.369 NM_001013848
EXOC6
exocyst complex component 6
chr5_+_61874561 0.366 NM_181506
LRRC70
leucine rich repeat containing 70
chr4_+_88896801 0.366 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr2_-_188419185 0.366 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr4_-_138453628 0.360 NM_019035
PCDH18
protocadherin 18
chr4_+_88896899 0.358 SPP1
secreted phosphoprotein 1
chr9_+_21409132 0.351 NM_002170
IFNA8
interferon, alpha 8
chr1_+_66458389 0.350 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr20_+_30697291 0.346 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr19_+_36726883 0.343 ZNF146
zinc finger protein 146
chr19_+_2819942 0.339 ZNF554
zinc finger protein 554
chr15_-_62457481 0.338 NM_001007595
C2CD4B
C2 calcium-dependent domain containing 4B
chr4_+_88896838 0.331 SPP1
secreted phosphoprotein 1
chr20_+_30697512 0.331 TM9SF4
transmembrane 9 superfamily protein member 4
chr8_-_110620220 0.328 SYBU
syntabulin (syntaxin-interacting)
chr17_+_3377346 0.327 NM_001128085
ASPA
aspartoacylase
chr8_-_6420454 0.327 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr2_-_188312872 0.325 NM_005795
CALCRL
calcitonin receptor-like
chrX_-_77395108 0.322 NM_015975
TAF9B
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
chr17_-_67057046 0.321 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr2_+_48807725 0.321 NM_001198594
STON1
STON1-GTF2A1L
stonin 1
STON1-GTF2A1L readthrough
chr5_+_159614373 0.319 NM_001130958
FABP6
fatty acid binding protein 6, ileal
chr17_-_7493389 0.312 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr1_+_192127591 0.307 NM_130782
RGS18
regulator of G-protein signaling 18
chr12_-_29937691 0.306 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr12_-_80084742 0.306 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr12_+_85430098 0.302 NM_001079910
LRRIQ1
leucine-rich repeats and IQ motif containing 1
chrX_+_102883647 0.301 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr4_+_130017281 0.299 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr8_-_86253863 0.298 NM_001164830
CA1
carbonic anhydrase I
chr7_-_143582363 0.298 NM_001206941
FAM115A
family with sequence similarity 115, member A
chr1_+_212475147 0.294 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr9_+_127119114 0.290


chr7_-_64023331 0.287 ZNF680
zinc finger protein 680
chr20_-_34117447 0.284 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr5_+_140602914 0.277 NM_018934
PCDHB14
protocadherin beta 14
chrX_-_2882288 0.276 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr21_-_31864274 0.276 NM_181609
KRTAP19-3
keratin associated protein 19-3
chr9_+_21440452 0.273 NM_024013
IFNA1
interferon, alpha 1
chr8_-_17752847 0.269 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr10_+_102121371 0.266 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr18_-_53177999 0.265 NM_001243231
TCF4
transcription factor 4
chrX_+_57313109 0.263 NM_174912
FAAH2
fatty acid amide hydrolase 2
chr6_+_35995583 0.258 MAPK14
mitogen-activated protein kinase 14
chr8_-_17743062 0.256 FGL1
fibrinogen-like 1
chr4_-_159093523 0.256 FAM198B
family with sequence similarity 198, member B
chr1_+_84647342 0.253 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr6_+_16143281 0.253 MYLIP
myosin regulatory light chain interacting protein
chr17_+_37844325 0.252 NM_001005862
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr9_-_21202201 0.249 NM_021057
IFNA7
interferon, alpha 7
chr5_-_52405287 0.247 NM_004531
MOCS2
molybdenum cofactor synthesis 2
chr1_+_115572414 0.244 NM_000549
TSHB
thyroid stimulating hormone, beta
chr9_+_66553254 0.243 MGC21881
uncharacterized locus MGC21881
chr2_-_20512016 0.242 PUM2
pumilio homolog 2 (Drosophila)
chr17_-_16097882 0.242 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr15_+_25068793 0.238 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr12_+_74931622 0.237 ATXN7L3B
ataxin 7-like 3B
chr10_+_118350470 0.233 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr4_+_88529680 0.229 NM_014208
DSPP
dentin sialophosphoprotein
chr10_+_112344076 0.228 SMC3
structural maintenance of chromosomes 3
chr2_-_183387063 0.227 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr18_+_19353635 0.226 MIB1
mindbomb homolog 1 (Drosophila)
chr1_+_145524989 0.225 NM_003637
ITGA10
integrin, alpha 10
chr12_-_50595303 0.222 NM_001243775
LIMA1
LIM domain and actin binding 1
chr8_-_110693233 0.222 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr6_+_136172802 0.222 NM_018945
PDE7B
phosphodiesterase 7B
chrX_-_100548044 0.221 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr11_+_128564130 0.221 FLI1
Friend leukemia virus integration 1
chr17_+_34087915 0.220 NM_145272
C17orf50
chromosome 17 open reading frame 50
chr10_-_65028825 0.220 NM_004241
JMJD1C
jumonji domain containing 1C
chr16_-_72206023 0.220 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr11_+_99426872 0.216 NM_175566
CNTN5
contactin 5
chr1_+_207262583 0.215 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr1_-_86043932 0.214 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr10_-_7682741 0.214 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr6_-_75970566 0.213 TMEM30A
transmembrane protein 30A
chr9_-_125941304 0.207 STRBP
spermatid perinuclear RNA binding protein
chr10_+_96522457 0.206 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr5_+_179132676 0.205 CANX
calnexin
chr9_+_125376947 0.203 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr6_+_143929316 0.201 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr15_+_86220267 0.200 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr6_+_35995513 0.200 MAPK14
mitogen-activated protein kinase 14
chr19_+_39899749 0.199


chr7_+_80275967 0.196 CD36
CD36 molecule (thrombospondin receptor)
chr10_+_5488521 0.196 NM_005863
NET1
neuroepithelial cell transforming 1
chrX_+_89176939 0.193 NM_138960
TGIF2LX
TGFB-induced factor homeobox 2-like, X-linked
chr5_-_88199868 0.191 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr6_+_35995585 0.191 MAPK14
mitogen-activated protein kinase 14
chr19_+_24269877 0.191 NM_203282
ZNF254
zinc finger protein 254
chr5_-_9630462 0.190 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr8_-_16050147 0.187 MSR1
macrophage scavenger receptor 1
chr17_+_48821106 0.184 LUC7L3
LUC7-like 3 (S. cerevisiae)
chrM_+_4770 0.182


chr5_-_94224601 0.182 MCTP1
multiple C2 domains, transmembrane 1
chr11_+_87032428 0.181 TMEM135
transmembrane protein 135
chr13_-_78493902 0.179 NM_001201397
EDNRB
endothelin receptor type B
chr1_-_110933635 0.177 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr15_+_94899163 0.177 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr6_-_76203256 0.175 NM_015687
FILIP1
filamin A interacting protein 1
chr7_-_38948776 0.175 NM_014396
NM_080631
VPS41

vacuolar protein sorting 41 homolog (S. cerevisiae)

chr21_-_31538970 0.174 NM_012131
CLDN17
claudin 17
chr10_-_116444112 0.173 ABLIM1
actin binding LIM protein 1
chr1_-_33841142 0.172 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr7_+_94539209 0.169 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr18_+_33234532 0.169 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr15_-_56388662 0.169 RFX7
regulatory factor X, 7
chr12_-_10022457 0.168 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr1_-_60539425 0.166 NM_152377
C1orf87
chromosome 1 open reading frame 87
chr10_+_89264222 0.164 NM_001178117
NM_004897
MINPP1

multiple inositol-polyphosphate phosphatase 1

chr5_+_112849352 0.164 NM_022828
YTHDC2
YTH domain containing 2
chr2_+_109204904 0.164 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_+_164818083 0.161 PBX1
pre-B-cell leukemia homeobox 1
chr11_+_55578842 0.161 NM_001004738
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr4_+_141264596 0.160 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr7_+_104681378 0.159 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr16_-_90096308 0.159 NM_001214
C16orf3
chromosome 16 open reading frame 3
chr8_-_93115453 0.157 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr4_+_156587861 0.155 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr5_-_88119604 0.155 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr16_+_55515468 0.155 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr5_-_160112266 0.155 ATP10B
ATPase, class V, type 10B
chr3_-_15839674 0.155 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr1_+_236557643 0.154 NM_145861
EDARADD
EDAR-associated death domain
chr6_+_155411422 0.153 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr7_+_99816870 0.152 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr7_-_27166638 0.150 NM_153631
HOXA3
homeobox A3
chr11_-_57158103 0.150 NM_001243245
NM_002728
PRG2

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

chr12_+_27175501 0.148 MED21
mediator complex subunit 21
chr12_+_8276227 0.148 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr2_+_177016112 0.147 NM_014621
HOXD4
homeobox D4
chr12_+_47610244 0.146 FAM113B
family with sequence similarity 113, member B
chr10_-_50342052 0.145 NM_001164484
FAM170B
family with sequence similarity 170, member B
chr5_+_134303595 0.144 NM_178019
CATSPER3
cation channel, sperm associated 3
chr5_+_140782367 0.144 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr6_+_28317687 0.142 NM_001242894
NM_001242895
NM_024493
ZKSCAN3


zinc finger with KRAB and SCAN domains 3


chr20_-_35274557 0.141 NM_032214
NM_175077
SLA2

Src-like-adaptor 2

chr3_-_105421044 0.140 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr13_+_111839172 0.140 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr5_+_92918924 0.139 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr9_-_97402530 0.139 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr5_-_158757469 0.136 NM_002187
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
chr18_+_29769986 0.135 NM_005925
MEP1B
meprin A, beta
chr7_-_93519990 0.135 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr3_+_49568370 0.133 DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr11_-_3803310 0.132 NUP98
nucleoporin 98kDa
chr17_-_34195745 0.132 NM_152781
C17orf66
chromosome 17 open reading frame 66

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.72 7.04e-04 GO:0016337 cell-cell adhesion
2.02 1.78e-03 GO:0002682 regulation of immune system process
3.55 2.61e-03 GO:0007156 homophilic cell adhesion
2.26 3.98e-03 GO:0050776 regulation of immune response
6.52 3.55e-02 GO:0060338 regulation of type I interferon-mediated signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 1.28e-04 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
15.28 2.58e-03 GO:0005132 interferon-alpha/beta receptor binding
1.83 1.81e-02 GO:0005509 calcium ion binding