Motif ID: NKX3-2.p2

Z-value: 1.013


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NKX3-2chr4_-_135460370.242.4e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_57406398 6.824 NM_002996
 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr5_+_118604504 6.124 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr5_+_118604417 5.992 NM_001077654
 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr2_+_102979096 4.116 NM_003855
 IL18R1
interleukin 18 receptor 1
chr6_-_31550065 3.434 NM_002341
NM_009588
 LTB

lymphotoxin beta (TNF superfamily, member 3)

chr2_+_228678556 3.377 NM_001130046
NM_004591
 CCL20

chemokine (C-C motif) ligand 20

chr1_-_169703178 2.608 NM_000450
 SELE
selectin E
chr1_+_101185195 2.607 NM_001078
NM_001199834
NM_080682
 VCAM1


vascular cell adhesion molecule 1


chr5_+_131409484 2.143 NM_000758
 CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr15_+_67358161 1.968 SMAD3
SMAD family member 3
chr5_-_150467220 1.950 NM_001252390
 TNIP1
TNFAIP3 interacting protein 1
chr1_-_95007139 1.844 NM_001178096
NM_001993
 F3

coagulation factor III (thromboplastin, tissue factor)

chr3_+_53195214 1.773 NM_006254
NM_212539
 PRKCD

protein kinase C, delta

chr5_-_150466696 1.765 NM_001252391
NM_001252392
 TNIP1

TNFAIP3 interacting protein 1

chr8_+_123793894 1.661 NM_014943
 ZHX2
zinc fingers and homeoboxes 2
chr8_+_123793988 1.602 ZHX2
zinc fingers and homeoboxes 2
chr19_+_676346 1.507 NM_005860
 FSTL3
follistatin-like 3 (secreted glycoprotein)
chr8_+_123794043 1.505 ZHX2
zinc fingers and homeoboxes 2
chr11_-_8892909 1.462 ST5
suppression of tumorigenicity 5
chr11_-_128457452 1.417 NM_001143820
 ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
1.56 3.88e-02 GO:0010627 regulation of intracellular protein kinase cascade
1.51 4.76e-03 GO:0006928 cellular component movement
1.48 4.68e-02 GO:0009967 positive regulation of signal transduction
1.41 3.27e-02 GO:0006915 apoptosis
1.39 4.83e-02 GO:0012501 programmed cell death
1.35 2.47e-02 GO:0042127 regulation of cell proliferation
1.29 1.09e-02 GO:0007399 nervous system development
1.27 6.20e-06 GO:0048518 positive regulation of biological process
1.27 2.60e-05 GO:0048522 positive regulation of cellular process
1.24 2.75e-02 GO:0010467 gene expression
1.22 9.40e-03 GO:0048519 negative regulation of biological process
1.18 2.08e-03 GO:0023052 signaling
1.17 1.61e-02 GO:0007165 signal transduction
1.17 2.63e-02 GO:0051179 localization
1.16 4.14e-03 GO:0044260 cellular macromolecule metabolic process
1.14 1.79e-02 GO:0043170 macromolecule metabolic process
1.10 7.17e-10 GO:0009987 cellular process
1.10 6.05e-03 GO:0065007 biological regulation
1.10 6.88e-03 GO:0050789 regulation of biological process

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
1.21 1.40e-02 GO:0005829 cytosol
1.08 7.93e-03 GO:0005737 cytoplasm
1.06 7.11e-03 GO:0044424 intracellular part
1.05 4.59e-02 GO:0005622 intracellular

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.21 3.39e-18 GO:0005515 protein binding
1.07 7.84e-06 GO:0005488 binding